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Fludarabine-based chemoimmunotherapy with rituximab is frequently used in patients with indolent and mantle-cell lymphomas who relapse after alkylating chemotherapy. We aimed to compare the efficacy and safety of rituximab with bendamustine or fludarabine in patients with relapsed, indolent, non-Hodgkin lymphoma and mantle-cell lymphoma. For this randomised, non-inferiority, open-label, phase 3 trial, we recruited patients from 55 centres in Germany, who were subsequently randomised centrally according to prespecified randomisation lists with permuted blocks of randomly variable block size to rituximab (375 mg/m2, day 1) plus either bendamustine (90 mg/m2, days 1 and 2) or fludarabine (25 mg/m2, days 1–3) every 28 days for a maximum of six 28-day cycles. Patients were aged 18 years or older with a WHO performance status of 0–2 and had relapsed or refractory indolent or mantle-cell lymphoma; patients refractory to regimens that included rituximab, bendamustine, or purine analogue drugs were excluded. Patients were stratified by histological subtypes of lymphoma and by their latest previous therapies. Treatment allocation was not masked. The primary endpoint was progression-free survival and the final analysis was completed per protocol. Non-inferiority of bendamustine plus rituximab versus fludarabine plus rituximab was defined as a difference of less than 15% in 1-year progression-free survival. The protocol was amended in July, 2006, after approval of rituximab maintenance (375 mg/m2 every 3 months for up to 2 years), which was then given to patients achieving a response to either trial treatment. This study is registered with ClinicalTrials.gov, number NCT01456351 (closed to enrolment, follow-up is ongoing). Between Oct 8, 2003, and Aug 5, 2010, we randomly assigned 230 patients to treatment groups (116 bendamustine plus rituximab, 114 fludarabine plus rituximab). 11 patients were excluded for protocol violations and were not followed up further (two in the bendamustine plus rituximab group and nine in the fludarabine plus rituximab group). Thus, 219 patients were included in the per-protocol analysis (114 bendamustine plus rituximab, 105 fludarabine plus rituximab). 1-year progression-free survival with bendamustine plus rituximab was 0·76 (95% CI 0·68–0·84) and 0·48 (0·39–0·58) with fludarabine plus rituximab (non-inferiority p<0·0001). At a median follow-up of 96 months (IQR 73·2–112·9), median progression-free survival with bendamustine plus rituximab was 34·2 months (95% CI 23·5–52·7) and 11·7 months (8·0–16·1) with fludarabine plus rituximab (hazard ratio [HR] 0·54 [95% CI 0·38–0·72], log-rank test p<0·0001). Safety outcomes were similar in both groups, with 46 serious adverse events recorded (23 in the bendamustine plus rituximab group and 23 in the fludarabine plus rituximab group), most commonly myelosuppression and infections. In combination with rituximab, bendamustine was more effective than fludarabine, suggesting that bendamustine plus rituximab may be the preferred treatment option for patients with relapsed indolent and mantle-cell lymphomas. Roche Pharma AG, Ribosepharm GmbH, Mundipharma GmbH, Studiengruppe indolente Lymphome (StiL).

Many algorithms for sequence analysis rely on word matching or word statistics. Often, these approaches can be improved if binary patterns representing match and don't-care positions are used as a filter, such that only those positions of words are considered that correspond to the match positions of the patterns. The performance of these approaches, however, depends on the underlying patterns. Herein, we show that the overlap complexity of a pattern set that was introduced by Ilie and Ilie is closely related to the variance of the number of matches between two evolutionarily related sequences with respect to this pattern set. We propose a modified hill-climbing algorithm to optimize pattern sets for database searching, read mapping and alignment-free sequence comparison of nucleic-acid sequences; our implementation of this algorithm is called rasbhari. Depending on the application at hand, rasbhari can either minimize the overlap complexity of pattern sets, maximize their sensitivity in database searching or minimize the variance of the number of pattern-based matches in alignment-free sequence comparison. We show that, for database searching, rasbhari generates pattern sets with slightly higher sensitivity than existing approaches. In our Spaced Words approach to alignment-free sequence comparison, pattern sets calculated with rasbhari led to more accurate estimates of phylogenetic distances than the randomly generated pattern sets that we previously used. Finally, we used rasbhari to generate patterns for short read classification with CLARK-S. Here too, the sensitivity of the results could be improved, compared to the default patterns of the program. We integrated rasbhari into Spaced Words; the source code of rasbhari is freely available at http://rasbhari.gobics.de/.

Thermoelectric generators (TEG) offer the potential to convert waste heat into electricity and thus contribute to reduce CO 2 emissions. The conversion of electrical energy is based on the Seebeck effect of two electrically conductive materials without any mechanical conversion and therefore without wear. The application of conventional TEG modules is limited due to cost-intensive materials and production technology of TEG, and a limited structure design for the integration of Thermoelectric Elements (TE). To address this research challenge, this work presents the development of thermoelectric composite modules based on glass fiber reinforced warp knitted spacer fabrics. In a double needle bed warp knitting machine, glass fibers in warp, weft and pile direction are integrated. The contacting of TE in the form of wires with 45 TE cm −2 were implemented. A TEG module with 20.25 cm 2 in size showed a maximum output power of 2.7 μ W at a temperature difference of 60 K. The Seebeck factor of S = 142 μ V K −1 was determined using this composite TEG with 10 TE strands and nearly 400 thermocouples. A thermoelectric model was developed for the calculation and the modules were characterized. For the first time, thermoelectric composite modules with sufficient structural-mechanical properties in terms of compressive and bending stiffness were realized based on spacer warp knitted fabrics, which can be used for the operation of sensors or small devices.

Of all industrial sectors, the construction industry accounts for about 37% of carbon dioxide (CO2) emissions. This encompasses the complete life cycle of buildings, from the construction phase to service life to component disposal. The main source of emissions of climate-damaging greenhouse gases such as CO2, with a share of 9% of global emissions, is the production of ordinary cement as the main binder of concrete. The use of innovative approaches such as impregnated carbon yarns as non-corrosive reinforcement embedded in concrete has the potential to dramatically reduce the amount of concrete required in construction, since no excessive concrete cover is needed to protect against corrosion, as is the case with steel reinforcement. At the same time, architectural design options are expanded via this approach. This is achieved above all using novel robotic manufacturing technologies to enable no-cut direct fiber placement. This innovative technological approach to fabricating 2D and 3D biologically inspired textiles, including non-metallic structures for textile-reinforced concrete (TRC) components, will promote an automatable construction method that reduces greenhouse gas emissions. Furthermore, the impregnated yarn which is fabricated enables the production of load-adapted and gradual non-metallic reinforcement components. Novel and improved design strategies with innovative reinforcement patterns allow the full mechanical potential of TRC to be realized. The development of a robotic fabrication technology has gone beyond the state of the art to implement spatially branched, biologically inspired 3D non-metallic reinforcement structures. A combined robotic fabrication technology, based on the developed flexible 3D yarn-guiding and impregnation module and a 3D yarn fixation module, is required to implement this sophisticated approach to fabricate freely formed 3D non-metallic reinforcement structures. This paper presents an overview of the development process of the innovative technological concept.

Textile-reinforced concrete (TRC) is a composite material consisting of a concrete matrix with a high-performance reinforcement made of technical textiles. TRC offers unique mechanical properties for the construction industry, enabling the construction of lightweight, material-minimized structures with high load-bearing potential. In addition, compared with traditional concrete design, TRC offers unique possibilities to realize free-form, double-curved structures. After more than 20 years of research, TRC is increasingly entering the market, with several demonstrator elements and buildings completed and initial commercialization successfully finished. Nevertheless, research into this highly topical area is still ongoing. In this paper, the authors give an overview of the current and future trends in the research and application of textiles in concrete construction applications. These trends include topics such as maximizing the textile utilization rate by improving the mechanical load-bearing performance (e.g., by adapting bond behavior), increasing design freedom by utilizing novel manufacturing methods (e.g., based on robotics), adding further value to textile reinforcements by the integration of additional functions in smart textile solutions (e.g., in textile sensors), and research into increasing the sustainability of TRC (e.g., using recycled fibers).

The increasing popularity of carbon-reinforced concrete (CRC) is attributed to its exceptional tensile properties, low density, no corrosion phenomenon, and remarkable flexibility, allowing it to be easily shaped into various forms. However, there is a pressing need to explore this innovative and sustainable alternative to traditional steel reinforcement. This motivates research and investigation of the feasibility of using a special 2D Netzgitterträger (NetzGT) reinforcement system, featuring a net-shaped fabricated textile made of multiple diagonally offset rovings with overlapping edge strands, as a viable alternative to traditional steel reinforcement in concrete beams. This 2D NetzGT reinforcement system has also been transformed into a 3D configuration for the development of a hollow core slab system. It is manufactured from carbon rovings with three different diagonal angles of 50°, 60°, and 70°. Laboratory experiments were conducted to assess the mechanical behavior of beams reinforced with the 2D NetzGT reinforcement. Tensile tests on strands were also performed with an increasing number of overlapped rovings to analyze their tensile strength. Additionally, single yarn pull-out tests were also conducted to examine the influence of the roving angle on the bond strength between the carbon textile roving and the concrete matrix.

Background Gemcitabine/erlotinib treatment offers limited benefit in unselected patients with pancreatic ductal adenocarcinoma (PDAC). Development of skin rash has been associated with favorable outcomes in patients treated with gemcitabine/erlotinib. This study aimed to extend knowledge on the effectiveness of gemcitabine/erlotinib in metastatic PDAC in the context of clinical practice and with focus on skin rash. Methods This multicenter, non-interventional study enrolled 376 patients with metastatic PDAC receiving gemcitabine/erlotinib. The primary endpoint was overall survival (OS) in patients with skin rash versus no skin rash. Secondary endpoints included progression-free survival (PFS), treatment satisfaction and safety. All data were analyzed using descriptive statistics. Survival time and time to disease progression were estimated using the Kaplan-Meier method. Effectiveness endpoints were analyzed for subgroups by skin rash grade (no rash, rash grade 1, rash grade ≥ 2), duration of erlotinib treatment (≤8 weeks, > 8 weeks), Eastern Cooperative Oncology Group (ECOG) performance status at baseline (0–1, 2) and age (≤65 years, > 65 years). Results Within the full analysis set (FAS; N  = 270), 48 patients (17.8%) developed grade 1 rash, 51 patients (18.9%) grade ≥ 2 rash, while 171 patients (63.3%) did not develop a rash. Median OS of all patients was 9.11 months with an OS of 9.93 months in rash-positive and 8.68 months in rash-negative patients. Median PFS was 5.06 months for rash-positive and 4.11 months for rash-negative patients. PFS was longer in patients with rash grade ≥ 2 and in older patients (> 65 years). Examination using a multivariate Cox proportional model revealed that an age > 65 years was associated with longer OS (hazard ratio 0.640; p  = 0.0327) and PFS (hazard ratio 0.642; p  = 0.0026). Out of the 338 patients in the SAF, 310 patients (91.7%) experienced at least one AE, and 176 patients (52.1%) experienced skin-related side effects, all of which were CTC grade 1 to 3. Conclusions Comparing rash-positive with rash-negative patients showed no significant difference in survival. While patients with rash grade ≥ 2 and older patients (independent of skin reactions) showed longer PFS, this did not translate into prolonged OS. The study did not reveal new safety signals. Trial registration ClinicalTrials.gov Identifier: NCT01782690 , retrospectively registered on 4 February 2013.

Fibre-reinforced composites (FRCs) are already well established in several industrial sectors such as aerospace, automotive, plant engineering, shipbuilding and construction. The technical advantages of FRCs over metallic materials are well researched and proven. The key factors for an even wider industrial application of FRCs are the maximisation of resource and cost efficiency in the production and processing of the textile reinforcement materials. Due to its technology, warp knitting is the most productive and therefore cost-effective textile manufacturing process. In order to produce resource-efficient textile structures with these technologies, a high degree of prefabrication is required. This reduces costs by reducing the number of ply stacks, and by reducing the number of extra operations through final path and geometric yarn orientation of the preforms. It also reduces waste in post-processing. Furthermore, a high degree of prefabrication through functionalisation offers the potential to extend the application range of textile structures as purely mechanical reinforcements by integrating additional functions. So far, there is a gap in terms of an overview of the current state-of-the-art of relevant textile processes and products, which this work aims to fill. The focus of this work is therefore to provide an overview of warp knitted 3D structures.

Textile reinforcements have established themselves as a convincing alternative to conventional steel reinforcements in the building industry. In contrast to ribbed steel bars that ensure a stable mechanical interlock with concrete (form fit), the bonding force of smooth carbon rovings has so far been transmitted primarily by an adhesive bonding with the concrete matrix (material fit). However, this material fit does not enable the efficient use of the mechanical load capacity of the textile reinforcement. Solutions involving surface-profiled rods promise significant improvements in the bonding behavior by creating an additional mechanical interlock with the concrete matrix. An initial analysis was carried out to determine the effect of a braided rod geometry on the bonding behavior. For this purpose, novel braided rods with defined surface profiling consisting of several carbon filament yarns were developed and characterized in their tensile and bond properties. Further fundamental examinations to determine the influence of the impregnation as well as the application of a pre-tension during its consolidation in order to minimize the rod elongation under load were carried out. The investigations showed a high potential of the impregnated surface-profiled braided rods for a highly efficient application in concrete reinforcements. Hereby, a complete impregnation of the rod with a stiff polymer improved the tensile and bonding properties significantly. Compared to unprofiled reinforcement structures, the specific bonding stress could be increased up to 500% due to the strong form-fit effect of the braided rods while maintaining the high tensile properties.

Textile reinforcements are increasingly establishing their position in the construction industry due to their high tensile properties and corrosion resistance for concrete applications. In contrast to ribbed monolithic steel bars with a defined form-fit effect, the conventional carbon rovings’ bond force is transmitted primarily by an adhesive bond (material fit) between the textile surface and the surrounding concrete matrix. As a result, relatively large bonding lengths are required to transmit bond forces, resulting in inefficient material utilization. Novel solutions such as tetrahedral profiled rovings promise significant improvements in the bonding behavior of textile reinforcements by creating an additional mechanical interlock with the concrete matrix while maintaining the high tensile properties of carbon fibers. Therefore, simulative investigations of tensile and bond behavior have been conducted to increase the transmittable bond force and bond stiffness of profiled rovings through a defined roving geometry. Geometric and material models were thus hereby developed, and tensile and pullout tests were simulated. The results of the simulations and characterizations could enable the optimization of the geometric parameters of tetrahedral profiled rovings to achieve better bond and tensile properties and provide basic principles for the simulative modeling of profiled textile reinforcements.