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This tutorial paper provides a step-by-step workflow for building and analysing semantic networks from short creative texts. We introduce and compare two widely used text-to-network approaches: word co-occurrence networks and textual forma mentis networks (TFMNs). We also demonstrate how they can be used in machine learning to predict human creativity ratings. Using a corpus of 1029 short stories, we guide readers through text preprocessing, network construction, feature extraction (structural measures, spreading-activation indices, and emotion scores), and application of regression models. We evaluate how network-construction choices influence both network topology and predictive performance. Across all modelling settings, TFMNs consistently outperformed co-occurrence networks through lower prediction errors (best MAE = 0.581 for TFMN, vs 0.592 for co-occurrence with window size 3). Network-structural features dominated predictive performance (MAE = 0.591 for TFMN), whereas emotion features performed worse (MAE = 0.711 for TFMN) and spreading-activation measures contributed little (MAE = 0.788 for TFMN). This paper offers practical guidance for researchers interested in applying network-based methods for cognitive fields like creativity research. we show when syntactic networks are preferable to surface co-occurrence models, and provide an open, reproducible workflow accessible to newcomers in the field, while also offering deeper methodological insight for experienced researchers.

Creativity is a complex cognitive ability that relies on knowledge organisation and retrieval from semantic memory. Yet most research uses a single task to measure it, capturing only a fraction of this complexity. This study investigates multiplex networks - layered semantic networks obtained from six cognitive tasks - as a more comprehensive approach to modelling the associative knowledge underlying creativity. We collected data from N=518 individuals from four countries (Austria, USA, Singapore, Italy). From their responses to verbal fluency, sentence-chain, free association, and narrative writing tasks, we constructed semantic networks and assembled them in a multiplex structure. AI persona-based responses provided a comparison baseline. Structural reducibility analyses showed that different task layers captured distinct, non-redundant information about semantic organisation, supporting the use of multiple tasks over any single one. The networks from high- and low-creative groups remained structurally distinct, while AI-generated networks showed near-identical structures regardless of creativity group. Finally, we used 12 features (network measures, emotional scores, and spreading activation simulations) in a machine learning model using ridge regression to predict individual creativity scores. The combination of structurally similar layers, as identified in the previous stage, improved a proof-of-concept prediction accuracy by 50%. Structural measures showed the highest feature importance, with spreading activation dynamics providing additional predictive power. Together, these findings indicate that multiplex semantic networks capture a richer, cross-cultural picture of associative knowledge underlying creativity. We also release our diverse dataset and code to foster diverse computational approaches within the creativity community.

Attitudes toward STEM develop from the interaction of conceptual knowledge, educational experiences, and affect. Here we use cognitive network science to reconstruct group mindsets as behavioural forma mentis networks (BFMNs). In this case, nodes are cue words and free associations, edges are empirical associative links, and each concept is annotated with perceived valence. We analyse BFMNs from N = 994 observations spanning high school students, university students, and early-career STEM experts, alongside LLM (GPT-oss) \"digital twins\" prompted to emulate comparable profiles. Focusing also on semantic neighbourhoods (\"frames\") around key target concepts (e.g., STEM subjects or educational actors/places), we quantify frames in terms of valence auras, emotional profiles, network overlap (Jaccard similarity), and concreteness relative to null baselines. Across student groups, science and research are consistently framed positively, while their core quantitative subjects (mathematics and statistics) exhibit more negative and anxiety related auras, amplified in higher math-anxiety subgroups, evidencing a STEM-science cognitive and emotional dissonance. High-anxiety frames are also less concrete than chance, suggesting more abstract and decontextualised representations of threatening quantitative domains. Human networks show greater overlapping between mathematics and anxiety than GPT-oss. The results highlight how BFMNs capture cognitive-affective signatures of mindsets towards the target domains and indicate that LLM-based digital twins approximate cultural attitudes but miss key context-sensitive, experience-based components relevant to replicate human educational anxiety.

We introduce SpreadPy as a Python library for simulating spreading activation in cognitive single-layer and multiplex networks. Our tool is designed to perform numerical simulations testing structure-function relationships in cognitive processes. By comparing simulation results with grounded theories in knowledge modelling, SpreadPy enables systematic investigations of how activation dynamics reflect cognitive, psychological and clinical phenomena. We demonstrate the library's utility through three case studies: (1) Spreading activation on associative knowledge networks distinguishes students with high versus low math anxiety, revealing anxiety-related structural differences in conceptual organization; (2) Simulations of a creativity task show that activation trajectories vary with task difficulty, exposing how cognitive load modulates lexical access; (3) In individuals with aphasia, simulated activation patterns on lexical networks correlate with empirical error types (semantic vs. phonological) during picture-naming tasks, linking network structure to clinical impairments. SpreadPy's flexible framework allows researchers to model these processes using empirically derived or theoretical networks, providing mechanistic insights into individual differences and cognitive impairments. The library is openly available, supporting reproducible research in psychology, neuroscience, and education research.

Understanding attitudes towards STEM means quantifying the cognitive and emotional ways in which individuals, and potentially large language models too, conceptualise such subjects. This study uses behavioural forma mentis networks (BFMNs) to investigate the STEM-focused mindset, i.e. ways of associating and perceiving ideas, of 177 human participants and 177 artificial humans simulated by GPT-3.5. Participants were split in 3 groups - trainees, experts and academics - to compare the influence of expertise level on their mindset. The results revealed that human forma mentis networks exhibited significantly higher clustering coefficients compared to GPT-3.5, indicating that human mindsets displayed a tendency to form and close triads of conceptual associations while recollecting STEM ideas. Human experts, in particular, demonstrated robust clustering coefficients, reflecting better integration of STEM concepts into their cognitive networks. In contrast, GPT-3.5 produced sparser mindsets. Furthermore, both human and GPT mindsets framed mathematics in neutral or positive terms, differently from STEM high schoolers, researchers and other large language models sampled in other works. This research contributes to understanding how mindset structure can provide cognitive insights about memory structure and machine limitations.

Creativity is a fundamental skill of human cognition. We use textual forma mentis networks (TFMN) to extract network (semantic/syntactic associations) and emotional features from approximately one thousand human- and GPT3.5-generated stories. Using Explainable Artificial Intelligence (XAI), we test whether features relative to Mednick's associative theory of creativity can explain creativity ratings assigned by humans and GPT-3.5. Using XGBoost, we examine three scenarios: (i) human ratings of human stories, (ii) GPT-3.5 ratings of human stories, and (iii) GPT-3.5 ratings of GPT-generated stories. Our findings reveal that GPT-3.5 ratings differ significantly from human ratings not only in terms of correlations but also because of feature patterns identified with XAI methods. GPT-3.5 favours 'its own' stories and rates human stories differently from humans. Feature importance analysis with SHAP scores shows that: (i) network features are more predictive for human creativity ratings but also for GPT-3.5's ratings of human stories; (ii) emotional features played a greater role than semantic/syntactic network structure in GPT-3.5 rating its own stories. These quantitative results underscore key limitations in GPT-3.5's ability to align with human assessments of creativity. We emphasise the need for caution when using GPT-3.5 to assess and generate creative content, as it does not yet capture the nuanced complexity that characterises human creativity.

Rapid and sensitive screening tools for SARS-CoV-2 infection are essential to limit the spread of COVID-19 and to properly allocate national resources. Here, we developed a new point-of-care, non-contact thermal imaging tool to detect COVID-19, based on advanced image processing algorithms. We captured thermal images of the backs of individuals with and without COVID-19 using a portable thermal camera that connects directly to smartphones. Our novel image processing algorithms automatically extracted multiple texture and shape features of the thermal images and achieved an area under the curve (AUC) of 0.85 in COVID-19 detection with up to 92% sensitivity. Thermal imaging scores were inversely correlated with clinical variables associated with COVID-19 disease progression. In summary, we show, for the first time, that a hand-held thermal imaging device can be used to detect COVID-19. Non-invasive thermal imaging could be used to screen for COVID-19 in out-of-hospital settings, especially in low-income regions with limited imaging resources.

The COVID-19 pandemic caused by SARS-CoV-2 imposes an urgent need for rapid development of an efficient and cost-effective vaccine, suitable for mass immunization. Here, we show the development of a replication competent recombinant VSV-∆G-spike vaccine, in which the glycoprotein of VSV is replaced by the spike protein of SARS-CoV-2. In-vitro characterization of this vaccine indicates the expression and presentation of the spike protein on the viral membrane with antigenic similarity to SARS-CoV-2. A golden Syrian hamster in-vivo model for COVID-19 is implemented. We show that a single-dose vaccination results in a rapid and potent induction of SARS-CoV-2 neutralizing antibodies. Importantly, vaccination protects hamsters against SARS-CoV-2 challenge, as demonstrated by the abrogation of body weight loss, and  alleviation of the extensive tissue damage and viral loads in lungs and nasal turbinates. Taken together, we suggest the recombinant VSV-∆G-spike as a safe, efficacious and protective vaccine against SARS-CoV-2. Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and suggests a desirable Th1-biased response to the vaccine.

Reachability and distance queries in graphs are fundamental to numerous applications, ranging from geographic navigation systems to Internet routing. Some of these applications involve huge graphs and yet require fast query answering. We propose a new data structure for representing all distances in a graph. The data structure is distributed in the sense that it may be viewed as assigning labels to the vertices, such that a query involving vertices u and v may be answered using only the labels of u and v. Our labels are based on 2-hop covers of the shortest paths, or of all paths, in a graph. For shortest paths, such a cover is a collection S of shortest paths such that, for every two vertices u and v, there is a shortest path from u to v that is a concatenation of two paths from S. We describe an efficient algorithm for finding an almost optimal 2-hop cover of a given collection of paths. Our approach is general and can be applied to directed or undirected graphs, exact or approximate shortest paths, or to reachability queries. We study the proposed data structure using a combination of theoretical and experimental means. We implemented our algorithm and checked the size of the resulting data structure on several real-life networks from different application areas. Our experiments show that the total size of the labels is typically not much larger than the network itself, and is usually considerably smaller than an explicit representation of the transitive closure of the network.

ObjectiveTo assess the association between time of birth and mortality among preterm infants.Study designPopulation-based study of infants born 22–36 weeks gestation (GA) in Canada from 2010 to 2015 (n = 173 789). Multivariable logistic regression models assessed associations between timing of birth and mortality.ResultAmong infants 22–27 weeks GA, evening birth was associated with higher mortality than daytime birth (adjusted odds ratio [AOR] 1.14, 95% CI 1.01–1.29). Among infants 28–32 weeks GA and 33–36 weeks GA, night birth was associated with lower mortality than daytime birth (AOR 0.75, 95% CI 0.59–0.95; AOR 0.78, 95% CI 0.62–0.99, respectively). Sensitivity analysis excluding infants with major congenital anomaly revealed that associations between hour of birth and mortality among infants born 28–32 and 33–36 weeks GA decreased or were not statistically significant.ConclusionHigher mortality among extremely preterm infants during off-peak hours may suggest variations in available resources based on time of day.