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How to transcend land grab economies, even by means of art?The reader REALTY moves from the safety of critique to the vulgarity of suggestions.The pandemic's effect on mobility presents a historic opportunity.Rarely has criticism of our extractive artworld logic of one-place-after-another been louder.

Nello scorso mese di dicembre la leggen- daria Stalinallee di Berlino, vale a dire la piu lunga costruzione monumentale del- la Repubblica Federale Tedesca, è passa- ta per contratto dalle mani del comune a quelle di una societa gemella della Deut- sche Pfandbrief- und Hypothekenbank AG. I 2.950 alloggi, insieme ad altri spar- si per tutta la regione (nell'insieme un 15% del patrimonio complessivo), sono stati privatizzati a saldo dei vecchi debiti del Wohnungsbau della DDR, come san- cito dal contratto di riunificazione dei due stati tedeschi.

Glioblastoma is the most common malignant primary brain tumor. To date, clinically relevant biomarkers are restricted to isocitrate dehydrogenase (IDH) gene 1 or 2 mutations and O6-methylguanine DNA methyltransferase ( MGMT ) promoter methylation. Long non-coding RNAs (lncRNAs) have been shown to contribute to glioblastoma pathogenesis and could potentially serve as novel biomarkers. The clinical significance of HOXA Transcript Antisense RNA, Myeloid-Specific 1 ( HOTAIRM1 ) was determined by analyzing HOTAIRM1 in multiple glioblastoma gene expression data sets for associations with prognosis, as well as, IDH mutation and MGMT promoter methylation status. Finally, the role of HOTAIRM1 in glioblastoma biology and radiotherapy resistance was characterized in vitro and in vivo. We identified HOTAIRM1 as a candidate lncRNA whose up-regulation is significantly associated with shorter survival of glioblastoma patients, independent from IDH mutation and MGMT promoter methylation. Glioblastoma cell line models uniformly showed reduced cell viability, decreased invasive growth and diminished colony formation capacity upon HOTAIRM1 down-regulation. Integrated proteogenomic analyses revealed impaired mitochondrial function and determination of reactive oxygen species (ROS) levels confirmed increased ROS levels upon HOTAIRM1 knock-down. HOTAIRM1 knock-down decreased expression of transglutaminase 2 (TGM2), a candidate protein implicated in mitochondrial function, and knock-down of TGM2 mimicked the phenotype of HOTAIRM1 down-regulation in glioblastoma cells. Moreover, HOTAIRM1 modulates radiosensitivity of glioblastoma cells both in vitro and in vivo. Our data support a role for HOTAIRM1 as a driver of biological aggressiveness, radioresistance and poor outcome in glioblastoma. Targeting HOTAIRM1 may be a promising new therapeutic approach.

Coleoid cephalopods, a subclass of mollusks, exhibit remarkable adaptations, including the largest brains among invertebrates, camera-like eyes, and a distinctive embryonic development. They possess an advanced behavioral repertoire including dynamic camouflage. The common cuttlefish Sepia officinalis has served as a key model organism in various research fields, spanning biophysics, neurobiology, behavior, evolution, ecology and biomechanics. More recently, it has become a model to investigate the neural mechanisms underlying cephalopod camouflage, using quantitative behavioral approaches alongside molecular techniques to characterize the identity, evolution and development of neuronal cell types. Despite significant interest in this animal, a high-quality, annotated genome of its species is still lacking. To address this, we sequenced and assembled a chromosome-scale genome for S. officinalis. The final assembly spans 5.68 billion base pairs and comprises 47 repeat-rich chromosomes. Gene linkage analysis confirms the existence of 47 chromosomes, revealing clear homologies with related species such as Euprymna scolopes and Doryteuthis pealeii. Our work includes a comprehensive gene annotation and full-length transcript predictions that should be helpful for further evolutionary and single-cell expression studies. This genome provides a valuable resource for future research on the evolution, brain organization, information processing, development, and behavior in this important clade.

We present results from a search for X-ray/gamma-ray counterparts of gravitational-wave (GW) candidates from the third observing run (O3) of the LIGO-Virgo-KAGRA (LVK) network using the Swift Burst Alert Telescope (Swift-BAT). The search includes 636 GW candidates received in low latency, 86 of which have been confirmed by the offline analysis and included in the third cumulative Gravitational-Wave Transient Catalogs (GWTC-3). Targeted searches were carried out on the entire GW sample using the maximum--likelihood NITRATES pipeline on the BAT data made available via the GUANO infrastructure. We do not detect any significant electromagnetic emission that is temporally and spatially coincident with any of the GW candidates. We report flux upper limits in the 15-350 keV band as a function of sky position for all the catalog candidates. For GW candidates where the Swift-BAT false alarm rate is less than 10\\(^{-3}\\) Hz, we compute the GW--BAT joint false alarm rate. Finally, the derived Swift-BAT upper limits are used to infer constraints on the putative electromagnetic emission associated with binary black hole mergers.