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The Intergovernmental Panel on Climate Change (IPCC) Special Report on Global Warming of 1.5°C points to the need for carbon neutrality by mid‐century. Achieving this in the United States in only 30 years will be challenging, and practical pathways detailing the technologies, infrastructure, costs, and tradeoffs involved are needed. Modeling the entire U.S. energy and industrial system with new analysis tools that capture synergies not represented in sector‐specific or integrated assessment models, we created multiple pathways to net zero and net negative CO2 emissions by 2050. They met all forecast U.S. energy needs at a net cost of 0.2–1.2% of GDP in 2050, using only commercial or near‐commercial technologies, and requiring no early retirement of existing infrastructure. Pathways with constraints on consumer behavior, land use, biomass use, and technology choices (e.g., no nuclear) met the target but at higher cost. All pathways employed four basic strategies: energy efficiency, decarbonized electricity, electrification, and carbon capture. Least‐cost pathways were based on >80% wind and solar electricity plus thermal generation for reliability. A 100% renewable primary energy system was feasible but had higher cost and land use. We found multiple feasible options for supplying low‐carbon fuels for non‐electrifiable end uses in industry, freight, and aviation, which were not required in bulk until after 2035. In the next decade, the actions required in all pathways were similar: expand renewable capacity 3.5 fold, retire coal, maintain existing gas generating capacity, and increase electric vehicle and heat pump sales to >50% of market share. This study provides a playbook for carbon neutrality policy with concrete near‐term priorities. Plain Language Summary We created multiple blueprints for the United States to reach zero or negative CO2 emissions from the energy system by 2050 to avoid the most damaging impacts of climate change. By methodically increasing energy efficiency, switching to electric technologies, utilizing clean electricity (especially wind and solar power), and deploying a small amount of carbon capture technology, the United States can reach zero emissions without requiring changes to behavior. Cost is about $1 per person per day, not counting climate benefits; this is significantly less than estimates from a few years ago because of recent technology progress. Models with more detail than used in the past revealed unexpected synergies, counterintuitive results, and tradeoffs. The lowest‐cost electricity systems get >80% of energy from wind and solar power but need other resources to provide reliable service. Eliminating fossil fuel use altogether is possible but higher cost. Restricting biomass use and land for renewables is possible but could require nuclear power to compensate. All blueprints for the United States agree on the key tasks for the 2020s: increasing the capacity of wind and solar power by 3.5 times, retiring coal plants, and increasing electric vehicle and electric heat pump sales to >50% of market share. Key Points The United States can reach zero net CO2 emissions from energy and industry in 2050 at a net cost of 0.2–1.2% of GDP, not counting climate benefits Multiple feasible pathways exist, all based on energy efficiency, clean electricity, electrification, and carbon capture for use or storage Least‐cost electricity systems obtain >80% of their energy from wind and solar, with existing types of thermal generation for reliability

The Paris Agreement introduces long-term strategies as an instrument to inform progressively more ambitious emission reduction objectives, while holding development goals paramount in the context of national circumstances. In the lead up to the twenty-first Conference of the Parties, the Deep Decarbonization Pathways Project developed mid-century low-emission pathways for 16 countries, based on an innovative pathway design framework. In this Perspective, we describe this framework and show how it can support the development of sectorally and technologically detailed, policy-relevant and country-driven strategies consistent with the Paris Agreement climate goal. We also discuss how this framework can be used to engage stakeholder input and buy-in; design implementation policy packages; reveal necessary technological, financial and institutional enabling conditions; and support global stocktaking and increasing of ambition.The Deep Decarbonization Pathways Project develops a framework to design low-emission development pathways. This Perspective discusses the framework and how it can support the development of national strategies to meet climate targets, as well as help achieve stakeholder engagement.

CLARION Sports Comment HAVE YOUR SAY ON: Alfie Langer TWO years ago Alfie Langer retired from State of Origin.

Rising environmental compliance costs and high costs mitigation options combine to create a real dilemma for utilities seeking to mitigate shareholder risk and keep their rates low and affordable for all customers. Applying a simple revenue requirement model to Duke Energy Carolinas as a case study, this analysis demonstrates that high electric vehicle (EV) penetration, combined with increased natural gas fired generation, can result in lower costs to consumers, lower risk to utility shareholders, and lower greenhouse gas emissions than a business-as-usual, coal- and nuclear-dominated scenario. However, at least three policy changes must be implemented in order to achieve this beneficial outcome. These are: 1. Implement utility GHG emissions accounting rules to share emissions savings benefits from electric vehicles. 2. Allow electric vehicles to count as part of a utility's flexible compliance strategy with other energy policies and emission reduction goals. 3. Utilize smart meter technologies to sub-meter and incentivize off-peak electric vehicle charging.

Officers and member of Cissel-Saxon Post 41, deeply regret his passing on March 12, 1992. We extend our sympathies to his family. Viewing at Ft. Lincoin Funeral Home, Brentwood, MD, on Sunday, 3 to 5 and 7 to 9

BROWN, GEORGE Officers and members of Silver Spring American Legion Post No. 41 are hereby of the passing of Comrade GEORGE BROWN, on January 11, 1992.

The Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to be understood. Our study makes the unexpected finding that Hippo suppresses nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) signaling in pancreatic progenitors to permit cell differentiation and epithelial morphogenesis. We find that pancreas-specific deletion of the large tumor suppressor kinases 1 and 2 (Lats1/2PanKO) from mouse progenitor epithelia results in failure to differentiate key pancreatic lineages: acinar, ductal, and endocrine. We carried out an unbiased transcriptome analysis to query differentiation defects in Lats1/2PanKO. This analysis revealed increased expression of NFκB activators, including the pantetheinase vanin1 (Vnn1). Using in vivo and ex vivo studies, we show that VNN1 activates a detrimental cascade of processes in Lats1/2PanKO epithelium, including (1) NFκB activation and (2) aberrant initiation of epithelial-mesenchymal transition (EMT), which together disrupt normal differentiation. We show that exogenous stimulation of VNN1 or NFκB can trigger this cascade in wild-type (WT) pancreatic progenitors. These findings reveal an unexpected requirement for active suppression of NFκB by LATS1/2 during pancreas development, which restrains a cell-autonomous deleterious transcriptional program and thereby allows epithelial differentiation.

Objectives. To test a community health worker (CHW)-led health literacy intervention on mammogram and Papanicolaou test screening among Korean American women. Methods. We conducted a cluster-randomized trial at 23 ethnic churches in the Baltimore, Maryland–Washington, DC, metropolitan area between 2010 and 2014. Trained CHWs enrolled 560 women. The intervention group received an individually tailored cancer-screening brochure followed by CHW-led health literacy training and monthly telephone counseling with navigation assistance. Study outcomes included receipt of an age-appropriate cancer screening test, health literacy, cancer knowledge, and perceptions about cancer screening at 6 months. Results. The odds of having received a mammogram were 18.5 (95% confidence interval [CI] = 9.2, 37.4) times higher in the intervention than in the control group, adjusting for covariates. The odds of receiving a Papanicolaou test were 13.3 (95% CI = 7.9, 22.3) times higher; the odds of receiving both tests were 17.4 (95% CI = 7.5, 40.3) times higher. Intervention effects also included increases in health literacy and positive perceptions about cancer screening. Conclusions. A health literacy–focused CHW intervention successfully promoted cancer-screening behaviors and related cognitive and attitudinal outcomes in Korean American women.