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The older adult population in Japan is expected to increase. Therefore, long-term care and frailty prevention are important. However, the relationship between masticatory performance, nutritional intake, and frailty remains unclear. This cross-sectional study aimed to examine energy, protein, and vitamin D intake and its association with frailty and masticatory performance in older adults. Patients between January 2022 and January 2023 were recruited and divided into robust and frail groups. Masticatory performance, nutrition, frailty, and other data, such as age and sex, were evaluated through onsite measurements and a questionnaire. Logistic regression analysis was conducted with frailty as a dependent variable and masticatory performance as an independent variable, adjusting for age, sex, skeletal muscle mass, living alone, energy intake, protein–energy ratio, and vitamin D intake. No significant differences were observed between the groups regarding age or sex. The robust group showed significantly better results for protein–energy ratio, vitamin D intake, and subjective and objective masticatory performance than the frail group. Logistic regression analysis revealed a significant correlation between skeletal muscle mass, protein–energy ratio, and objective masticatory performance with frailty. Masticatory performance was associated with frailty, independent of the intake of nutrients such as energy, protein, and vitamin D.

Background With the global rise in the aging population, the relationship between oral function and risk of long-term care is attracting attention. One method for subjective assessment of masticatory function is the use of a food acceptance questionnaire. Although it is hypothesized that objective oral functions such as tongue pressure and swallowing function are associated with subjective masticatory performance, this relationship has yet to be investigated. The aim of this study is to elucidate the association between overall oral function and subjective masticatory performance using a food questionnaire. Methods Patients aged ≥ 65 years were recruited from an outpatient dental clinic at Tokyo Medical and Dental University. Subjective masticatory performance was assessed using the food acceptance score as described in a previous study. Seven oral function parameters defined by the Japanese Society of Gerodontology, were measured. Age, sex, number of functional teeth, geriatric depression, cognitive function, and oral health-related quality of life were assessed. Variables for which normality was rejected were transformed into tertile values. Multiple regression analysis was conducted with the food acceptance score as the objective variable, and each oral function parameter and other items as explanatory variables. Results This study included 201 participants (87 males and 114 females). Multiple regression analysis revealed that the number of functional teeth, geriatric depression, oral health-related quality of life, objective masticatory performance, tongue pressure, and swallowing function were substantially associated with the food acceptance scores. Conclusions This study demonstrated that subjective masticatory performance was independently associated with tongue pressure, objective masticatory performance, swallowing function, number of functional teeth, geriatric depression, and oral health-related quality of life.

Background An increase in the number of elderly edentulous patients likely leads to a greater demand for dentures and denture adhesives. As denture adhesives have both positive and negative features, dentists need to know the types of denture adhesive users to be able to provide instruction to denture wearers on how to use denture adhesives effectively. This study aims to examine the utilization of denture adhesives and associated factors. Methods Seven closed-ended questionnaires were developed for a web-based survey. After that, Fisher’s exact tests were performed to determine the difference in the denture adhesive usage rate by gender, type of denture, last dental visit, and smoking status. A multivariate-adjusted logistic regression analysis was performed with denture adhesive use or non-use as the dependent variable and the other items as independent variables. Next, Fisher’s exact tests and a multivariate-adjusted logistic regression analysis were performed with the type of denture adhesives as the dependent variable in the same way. Statistical analyses were performed for all denture wearers, complete denture wearers, and partial denture wearers. The level of statistical significance was set at p  = 0.05. Results A total of 1470 denture wearers in Japan participated in this study. Of these, 318 used denture adhesives, while 212 (66.7%) used cream; 74 (23.3%) used home liner; 25 (7.9%) used powder; four (1.3%) used sheets; and three (0.9%) used several types. The Fisher’s exact tests revealed that the ratios of using denture adhesives were significantly higher for complete denture wearers ( p  < 0.001), last dental visit over 1 year ( p  = 0.005), and smokers ( p  = 0.005). For partial denture wearers, the ratio was significantly higher in smokers ( p  = 0.262). The multivariate adjusted logistic regression revealed that denture adhesive use or non-use were significantly associated with the type of denture and smoking status in all denture wearers, and just smoking status in partial denture wearers. There were no significant results about the type of denture adhesive selection. Conclusions From all denture wearers, complete denture wearers and smokers are more likely to use denture adhesives. In addition, smokers significantly use denture adhesives if they are partial denture wearers.

The type of denture adhesive, cream or home-liner, chosen by regular denture adhesive users and oral conditions contributing to this selection require elucidation. The factors associated with denture adhesive selection were investigated through a face-to-face survey on oral and denture conditions. Age, sex, oral moisture, masticatory performance, retention and stability of the removable denture, ridge shape, mucosal thickness, and duration of denture use were examined in cream and home-liner-type denture adhesive users who did not regularly visit a dentist. Univariate analysis and multivariate analyses were performed. There were 38 and 40 cream-type and home-liner-type adhesive users, respectively. The type of denture adhesive was significantly associated with the oral moisture value, retention, ridge shape, mucosal thickness, and duration of denture use in univariate analyses. The residual ridge conditions with large factor loadings for ridge shape and mucosal thickness and duration of denture use were significantly related to the denture adhesive selection in multivariate logistic analysis. The residual ridge conditions and duration of denture use were significant factors in the selection of cream- and home-liner-type denture adhesives. These results can provide appropriate guidance based on the adhesives patients without dental supervision are more likely to choose.

Background: An increase in the number of elderly edentulous patients likely leads to a greater demand for dentures and denture adhesives. As denture adhesives have both positive and negative features, dentists need to know the types of denture adhesive users to be able to provide instruction to denture wearers on how to use denture adhesives effectively. This study aims to examine the utilization of denture adhesives and associated factors. Methods: Seven closed-ended questionnaires were developed for a web-based survey. After that, Fisher’s exact tests were performed to determine the difference in the denture adhesive usage rate by gender, type of denture, last dental visit, and smoking status. A multivariate-adjusted logistic regression analysis was performed with denture adhesive use or non-use as the dependent variable and the other items as independent variables. Next, Fisher’s exact tests and a multivariate-adjusted logistic regression analysis were performed with the type of denture adhesives as the dependent variable in the same way. Statistical analyses were performed for all denture wearers, complete denture wearers, and partial denture wearers. The level of statistical significance was set at p=0.05. Results: A total of 1470 denture wearers in Japan participated in this study. Of these, 318 used denture adhesives, while 212 (66.7%) used cream; 74 (23.3%) used home liner; 25 (7.9%) used powder; four (1.3%) used sheets; and three (0.9%) used several types. The Fisher’s exact tests revealed that the ratios of using denture adhesives were significantly higher for complete denture wearers (p<0.001), last dental visit over one year (p=0.005), and smokers (p=0.005). For partial denture wearers, the ratio was significantly higher in smokers (p=0.262). The multivariate adjusted logistic regression revealed that denture adhesive use or non-use were significantly associated with the type of denture and smoking status in all denture wearers, and just smoking status in partial denture wearers. There were no significant results about the type of denture adhesive selection. Conclusions: From all denture wearers, complete denture wearers and smokers are more likely to use denture adhesives. In addition, smokers significantly use denture adhesives if they are partial denture wearers.

Abstract Background Among middle-aged and elderly individuals, dietary habits have previously been reported to differ between patients with and without periodontal disease. However, in young adults, there are only a few reports that show a correlation between nutrient/food intake and periodontal disease. Moreover, no report has assessed the correlation between dietary habits measured by a self-administered diet history questionnaire (DHQ) and periodontal disease. Therefore, we assessed the correlation between dietary habits, determined using a DHQ, and periodontal disease in young adult women who are likely to develop a periodontal disease. Methods The participants were 120 healthy, non-smoking, female college students (mean age, 20.4 ± 1.1 years) from two universities who did not have any systemic disease. The participants were assessed for periodontal disease according to community periodontal index (CPI) and were divided into two groups. Subjects with a CPI code of 0, 1, or 2 were assigned to non-periodontal disease group (non-PD), and subjects with a CPI code of 3 or 4 were assigned to periodontal disease group (PD). Dietary habits were assessed using a DHQ. In addition, physical status, level of difficulty in chewing food (dietary hardness), masticatory performance, and quality of life (QoL) were assessed. Results The PD group had a significantly lower nutrient intake of minerals, fat, water-soluble vitamins, and dietary fiber than the non-PD group. In terms of food groups, the PD group consumed significantly lesser amounts of green and yellow vegetables than the non-PD group. In addition, the PD group consumed significantly lesser amounts of hard foods than the non-PD group. Conclusion Young adult women with a periodontal disease had a significantly lower nutrient/food intake than young adult women without a periodontal disease.

Heme oxygenase (HO)‐1 has anti‐oxidative, anti‐inflammatory, and anti‐apoptotic activities. However, little is known about the regulation of HO‐1 in human primary acute myeloid leukemia (AML) cells. Here we investigated the expression of HO‐1 in primary and established AML cells as well as other types of leukemic cells and normal monocytes, and its regulatory mechanism by the transcriptional repressor, BTB and CNC homology 1 (Bach1), and the activator, nuclear factor erythroid‐derived 2 related factor 2 (Nrf2). Leukemic cell lines such as U937 expressed little HO‐1, whereas most freshly isolated AML cells and monocytes expressed substantial amounts of HO‐1, along with Bach1 and Nrf2. When U937 cells were treated with phorbol myristate acetate (PHA) or γ‐interferon, they significantly expressed both HO‐1 and Bach1, like primary AML cells. Treatment with lipopolysaccharide (LPS) enhanced HO‐1 expression in U937 cells but suppressed it in primary monocytes and PMA‐treated U937 cells. In HO‐1‐expressing cells, Bach1 was localized in the cytoplasm, but Nrf2 was localized in the nuclei. Chromatin immunoprecipitation assay of these cells revealed the preferential binding of Nrf2 over Bach1 to Maf‐recognition elements, the enhancer regions of the HO‐1 gene. The downregulation of the HO‐1 gene with siRNA increased a cytotoxic effect of an anticancer drug on primary AML cells, whereas the downregulation of Bach1 increased HO‐1 expression, leading to enhanced survival. These and other results show that Bach1 plays a critical role in regulating HO‐1 gene expression in AML cells and its expression suppresses their survival by downregulating HO‐1 expression. Thus, functional upregulation of Bach1 is a potential strategy for antileukemic therapy. (Cancer Sci 2010)

Structural variations disrupting the 3′ region of PD-L1 are shown to aid immune evasion in a number of human cancers, including adult T-cell leukaemia/lymphoma, and in a mouse tumour model, CRISPR/Cas9-mediated deletion of the 3'-UTR of Pd-l1 is also shown to result in immune escape, suggesting that PD-L1 3′-UTR disruption could provide a diagnostic marker to identify patients who will benefit from anti-PD-1/PD-L1 therapy. A marker for responsiveness to anti-PD-1/PD-L1 therapy In some patients, cancer therapy with antibodies against programmed cell death 1 (PD-1) and its ligand (PD-L1) is ineffective due to immune evasion. Here Seishi Ogawa and colleagues show that structural variations disrupting the 3′-region of PD-L1 lead to overexpression of the PD-L1 protein, promoting immune evasion in a number of human cancers, including adult T-cell leukaemia and diffuse large B-cell lymphoma. Crispr-Cas9-mediated deletion of the 3′-UTR of Pd-l1 is also shown to result in immune escape in a mouse tumour model, suggesting that PD-L1 3′-UTR disruption could provide a diagnostic marker to identify patients who will benefit from anti-PD-1/PD-L1 therapy. Successful treatment of many patients with advanced cancer using antibodies against programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known as CD274) has highlighted the critical importance of PD-1/PD-L1-mediated immune escape in cancer development 1 , 2 , 3 , 4 , 5 , 6 . However, the genetic basis for the immune escape has not been fully elucidated, with the exception of elevated PD-L1 expression by gene amplification and utilization of an ectopic promoter by translocation, as reported in Hodgkin and other B-cell lymphomas, as well as stomach adenocarcinoma 6 , 7 , 8 , 9 , 10 . Here we show a unique genetic mechanism of immune escape caused by structural variations (SVs) commonly disrupting the 3′ region of the PD-L1 gene. Widely affecting multiple common human cancer types, including adult T-cell leukaemia/lymphoma (27%), diffuse large B-cell lymphoma (8%), and stomach adenocarcinoma (2%), these SVs invariably lead to a marked elevation of aberrant PD-L1 transcripts that are stabilized by truncation of the 3′-untranslated region (UTR). Disruption of the Pd-l1 3′-UTR in mice enables immune evasion of EG7-OVA tumour cells with elevated Pd-l1 expression in vivo , which is effectively inhibited by Pd-1/Pd-l1 blockade, supporting the role of relevant SVs in clonal selection through immune evasion. Our findings not only unmask a novel regulatory mechanism of PD-L1 expression, but also suggest that PD-L1 3′-UTR disruption could serve as a genetic marker to identify cancers that actively evade anti-tumour immunity through PD-L1 overexpression.