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"Hamilton, David"
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Rehabilitation of brachial plexus injury in contact sport: Where are the data that underpin clinical management? A scoping review
2024
Although a common injury there is a lack of published primary data to inform clinical management of sports related brachial plexus injuries.
A systematic search was completed in Medline, CINAHL, PubMed, SPORTDiscus and Web of Science databases and Google Scholar from inception to August 2023 according to the PRISMA-ScR guidelines. Methodological quality assessment of included articles was with the Joanna Briggs Institute tool. Studies providing primary data as to the rehabilitative management of diagnosed or suspected brachial plexus injuries sustained when playing contact sports were included.
Sixty-five studies were identified and screened, of which, 8 case reports were included, incorporating 10 participants with a mean age of 19.8 (±4.09) years. There was wide heterogeneity in injury severity, injury reporting, physical examination and imaging approaches documented. 9 of 10 participants returned to competitive sports, though follow-up periods also varied widely. Whilst return to play criteria varied between studies, the most consistent indicator was pain-free shoulder range of motion and strength.
There is a distinct lack of data available to inform evidence-based rehabilitation management of sports related brachial plexus injury. Only 8 individual case reports contain published data reporting on 10 athletes. Further reporting is critical to inform clinical management.
Journal Article
Methods to control harmful algal blooms: a review
2022
The recent rise of red tide harmful algal blooms has induced ecosystem degradation, economic losses, and aquaculture damage, yet little is known on prevention and mitigation of red tides. Actual control methods involve physical, chemical, and biological processes, with varying success. Here, we review physical, chemical, and biological control methods applicable to red tide species in marine and estuarine water bodies. We discuss mechanisms of algal blooms outbreak and their applications to prevent outbreaks.
Journal Article
High Levels of Structural Diversity Observed in Microcystins from Microcystis CAWBG11 and Characterization of Six New Microcystin Congeners
by
Puddick, Jonathan
,
Cary, Stephen
,
Hamilton, David
in
Amino Acid Sequence
,
Amino acids
,
Chromatography, Liquid - methods
2014
Microcystins (MCs) are cyclic peptides produced by cyanobacteria, which can be harmful to humans and animals when ingested. Differences in the coding of the non‑ribosomal peptide synthetase/polyketide synthase enzyme complex responsible for microcystin production have resulted in more than 100 microcystin variants being reported to date. The microcystin diversity of Microcystis CAWBG11 was investigated using matrix-assisted laser desorption/ionization-time of flight mass spectrometry and liquid chromatography-mass spectrometry. This revealed that CAWBG11 simultaneously produced 21 known microcystins and six new congeners: [Asp3] MC-RA, [Asp3] MC-RAba, [Asp3] MC-FA, [Asp3] MC-WA, MC-FAba and MC-FL. The new congeners were putatively characterized by tandem mass spectrometry and chemical derivatization. A survey of the microcystin congeners produced by 49 cyanobacterial strains documented in scientific literature showed that cyanobacteria generally produce four microcystin congeners, but strains which produce up to 47 microcystin congeners have been reported. Microcystis CAWBG11 (which produces at least 27 congeners) was positioned in the top ten percentile of the strains surveyed, and showed fluidity of the amino acids incorporated into both position two and position four.
Journal Article
Homogeneous Catalysis: New Approaches to Catalyst Separation, Recovery, and Recycling
2003
Homogeneous catalysts have many attractive properties, such as high selectivities. However, many homogeneous catalytic systems cannot be commercialized because of difficulties associated with separating the products from the catalyst. Recent approaches to tackling this problem are reviewed and compared.
Journal Article
Do digital interventions increase adherence to home exercise rehabilitation? A systematic review of randomised controlled trials
by
Lang, Sabine
,
MacDonald, Donnie
,
Hamilton, David F.
in
Adherence
,
Bias
,
Chiropractic Medicine
2022
Background
Home exercise regimes are a well-utilised rehabilitation intervention for many conditions; however, adherence to prescribed programmes remains low. Digital interventions are recommended as an adjunct to face-to-face interventions by the National Health Service in the UK and may offer increased exercise adherence, however the evidence for this is conflicting.
Method
A systematic review was undertaken using MEDLINE and CINAHL databases using the PRISMA guidelines. Randomised controlled trials in any clinical population evaluating the adherence to prescribed home exercise interventions with and without additional digital interventions were included. Publication quality was assessed using the Cochrane Risk of Bias tool.
Results
The search strategy returned a total of 1336 articles, of which 10 randomised controlled trials containing data for 1117 participants were eligible for inclusion. 565 participants were randomised to receive the interventions, and 552 to the control. Seven of the ten trials reported a significant difference in adherence between the control and intervention groups favouring an additional digital intervention. Three trials reported equivalent findings. These three reported longer-term outcomes, suggesting an interaction between adherence and duration of intervention. There was substantial heterogeneity in outcome assessment metrics used across the trials prohibiting formal meta-analysis. This included studies were of low to moderate quality in terms of risk of bias.
Conclusion
The addition of a digital interventions to prescribed home exercise programmes can likely increase exercise adherence in the short term, with longer term effects less certain.
Journal Article