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This paper examines the foundations of economic neoliberalism and underlines the implications of the foundations of this economic theory in its reliance on economic value as ownership, property, and commodity which misdirects economic inquiry from the real value of human capital as the proper foundation of a viable economic system. It focuses on the role of a selective emphasis on rules of international law for the protection of private property. These rules indirectly influence economic theory in general in the sense that commodity is made to be near absolute, and to be insulated from regulation. The paper explores these ideas in the context of major neoliberal theorists and stresses flaws of the theory of ownership as well as the flaws in the myth of the market as a form of economic activity immune to rational regulation. The paper goes on to stress the emphasis of the destruction of the so called \"deep state.\" The attack on the deep state is reinforced by an academic interest group loosely styled \"The Law and Economics Movement.\" The paper emphasizes the politico economic costs of the the demolition of the so called deep state, which is essentially a social democratic state. One of the consequences of this form of economic advocacy is the possibility of rule by plutocracy. This will mean the destruction of the constitutional foundations of the state. The paper also underlines an important aspect of the jurisprudence of neoliberalism which is rooted in the theory that law must be done from the point of view of the bad man and be completely separated from basic morality and values. This is applied to economic theory and makes for a sharp chasm and basic human rights values. There is clearly a need for more effective forms of interest representation representing the vital importance of human capital.

In the light of the countless hours invested in the development of the Sustainable Development Goals-the set of targets and indicators relating to future international human and sustainable development, which replaced the Millennium Development Goals (MDGs) at the end of 2015 -by hundreds of the world's top minds, in addition to more than twenty-five years of analysis associated with the development, implementation, monitoring, and evaluation of the MDGs, international lawyers and economists may wonder whether there is room for a new theory of sustainable development. It might seem counterintuitive to presume that new light might be shed on this vastly over-analyzed concept. However, the goal of this article is indeed to bring a new understanding to this important idea by assaying the current dominant legal theory of neo-liberalism and the radical inequality it promotes, and unpacking processes and identifying insights from advanced legal theory for the development of a new theory of sustainable development, with a primary focus on counteracting radical inequality.

Issue Title: Special Issue: Protecting and sustaining indigenous people's traditional environmental knowledge and cultural practice

The need for evidence-based decision making at all levels of government is perhaps greatest in fragile settings.Data deficiencies contribute to state fragility and exacerbate constraints on the capacity to provide basic services, public security, and the rule of law.

The purpose of this article is to broadly outline a problem in the context of relatively recent activity in the Amazon Basin. My colleagues and I found the Policy Sciences framework to be a useful blueprint for comprehensive issue analysis. The five intellectual tasks of the policy-oriented approach to solving problems helped us to clarify the apparent goals of the primary actors involved; identify certain trends associated with the problem, including estimations of their magnitude and implications; understand several conditioning factors which could impact (or have already had an impact on) the achievement of the goals identified; recognize several projections anticipated from a normative standpoint in light of the trends examined; and make some observations, including possible strategies and their alternatives, which might enable the Shuar to maximize benefits and minimize costs.

This paper critically reviews the strengths and weaknesses of various objective and subjective indicators of corruption.

Sustainable Development Goal 16 is explicitly committed to measuring aspects of corruption over time, and the identification of robust indicators to do so is an important endeavor. This paper critically reviews the strengths and weaknesses of various objective and subjective indicators of corruption, using the standard criteria of validity and reliability to identify indicators most salient to measuring Sustainable Development Goal 16. Consistent with the large literature in the field, the paper finds that the aggregate survey-based indicators of corruption, especially the Corruption Perceptions Index and the World Bank's Control of Corruption indicator, despite some important reservations and limitations, are the most valid measures of the magnitude of overall corruption in many country contexts. However, in every case, the initial results using one indicator should be cross checked with the use of the other indicator, as there are some minor differences between how the two indicators are constructed, and in practice it is difficult to establish a priori which indicator is marginally more efficient. Furthermore, whenever possible, subjective indicators should be cross checked with objective indicators, even when the latter may be of a more narrow scope and time limited availability.

Many intrinsically disordered proteins self-assemble into liquid droplets that function as membraneless organelles. Because of their biological importance and ability to colocalize molecules at high concentrations, these protein compartments represent a compelling target for bio-inspired materials engineering. Here we manipulated the intrinsically disordered, arginine/glycine-rich RGG domain from the P granule protein LAF-1 to generate synthetic membraneless organelles with controllable phase separation and cargo recruitment. First, we demonstrate enzymatically triggered droplet assembly and disassembly, whereby miscibility and RGG domain valency are tuned by protease activity. Second, we control droplet composition by selectively recruiting cargo molecules via protein interaction motifs. We then demonstrate protease-triggered controlled release of cargo. Droplet assembly and cargo recruitment are robust, occurring in cytoplasmic extracts and in living mammalian cells. This versatile system, which generates dynamic membraneless organelles with programmable phase behavior and composition, has important applications for compartmentalizing collections of proteins in engineered cells and protocells. Designer organelles with new biochemical functionalities are of great interest in synthetic biology and cellular engineering. Here the authors present a single-protein-based platform for generating synthetic membraneless compartments that is capable of enzymatically-triggered alterations to phase behavior and of recruiting and concentrating cargo proteins.

Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the formation of membraneless organelles, which compartmentalize molecules intracellularly in the absence of a lipid membrane. Identifying the protein sequence features responsible for IDP phase separation is critical for understanding physiological roles and pathological consequences of biomolecular condensation, as well as for harnessing phase separation for applications in bioinspired materials design. To expand our knowledge of sequence determinants of IDP phase separation, we characterized variants of the intrinsically disordered RGG domain from LAF-1, a model protein involved in phase separation and a key component of P granules. Based on a predictive coarse-grained IDP model, we identified a region of the RGG domain that has high contact probability and is highly conserved between species; deletion of this region significantly disrupts phase separation in vitro and in vivo. We determined the effects of charge patterning on phase behavior through sequence shuffling. We designed sequences with significantly increased phase separation propensity by shuffling the wild-type sequence, which contains well-mixed charged residues, to increase charge segregation. This result indicates the natural sequence is under negative selection to moderate this mode of interaction. We measured the contributions of tyrosine and arginine residues to phase separation experimentally through mutagenesis studies and computationally through direct interrogation of different modes of interaction using all-atom simulations. Finally, we show that despite these sequence perturbations, the RGG-derived condensates remain liquid-like. Together, these studies advance our fundamental understanding of key biophysical principles and sequence features important to phase separation.