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"Han, Han"
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3D graphics for game programming
\"Many of computer graphics classes in colleges are focused on real-time rendering and animation. However, it is not easy to nd an appropriate textbook, which presents the state of the art in interactive graphics, is balanced between theory and practicality, and is of a proper length to be covered in a semester. This book is written for answering the need and presents the must-know in interactive graphics. This book ts the advanced undergraduate or beginning graduate classes for 'Computer Graphics' and 'Game Programming.' Another primary reader group of this book may be composed of game developers, who have experience in graphics APIs and shader programming but have felt lack of theoretical background in 3D graphics. A lot of programming manual-like books can be found in the bookstore, but they do not provide a sufficient level of mathematical background for the game developers. Assuming that the readers have minimal understanding of vectors and matrices, this book provides an opportunity to combine their experiences with the background theory of computer graphics\"-- Provided by publisher.
Book
Current landscape of mRNA technologies and delivery systems for new modality therapeutics
Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects. In this regard, lipid nanoparticles have been successfully utilized to improve mRNA delivery and protect the cargo from extracellular degradation. Encapsulation in lipid nanoparticles was an essential factor in the successful clinical application of mRNA vaccines, which conclusively demonstrated the technology's potential to yield approved medicines. In this review, we begin by describing current advances in mRNA modifications, design of novel lipids and development of lipid nanoparticle components for mRNA-based drugs. Then, we summarize key points pertaining to preclinical and clinical development of mRNA therapeutics. Finally, we cover topics related to targeted delivery systems, including endosomal escape and targeting of immune cells, tumors and organs for use with mRNA vaccines and new treatment modalities for human diseases.
Journal Article
Dancing on the edge
A young girl from a dysfunctional family creates for herself an alternative world which nearly results in her death but which ultimately leads her to reality.
Book
Impact of physical exercise on sleep quality in college students: A Chain mediating role of self-efficacy and emotional control
The study aims to examine the impact of physical exercise on sleep quality among college students and elucidate the mediating roles of self-efficacy and emotional control in this relationship.
Data were obtained from the 2024 China College Students' Physical Activity and Health Tracking Survey (CPAHLS-CS). A sample of 10,970 college students was included. Physical exercise levels were measured using the Physical Activity Rating Scale-3 (PARS-3), sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), self-efficacy was measured using the General Self-Efficacy Scale (GSES), and emotional control was assessed using the Adolescent Psychological Resilience Scale. Regression analysis and Bootstrap mediation analysis were employed to test the hypothesised relationships.
(1) The direct effect of physical exercise on sleep quality was not significant (β = 0.011, P > 0.05). However, the total effect was negative (β = -0.056, P < 0.001), indicating that indirect effects comprised the predominant mechanism. (2) Self-efficacy (effect size = -0.024) and emotional control (effect size = -0.022) each independently mediated the relationship between physical exercise and sleep quality. (3) In the pathway through which physical exercise influences sleep quality, self-efficacy, and emotional control functioned as independent mediating variables. Specifically, physical exercise indirectly improved sleep quality by enhancing self-efficacy while positively impacting sleep quality through a distinct mediating mechanism involving strengthening emotional control.
This study demonstrates the influence of physical exercise, self-efficacy, and emotional control on sleep quality. The findings suggest that physical exercise indirectly optimises sleep quality through a dynamic and synergistic mechanism involving the enhancement of self-efficacy and emotional control. This study provides theoretical support and practical pathways for sleep quality interventions in college students.
Journal Article
Incidence and mechanism of early neurological deterioration after endovascular thrombectomy
BackgroundWe investigated the prevalence and mechanisms of neurological deterioration after endovascular thrombectomy.MethodsBetween January 2011 and October 2017, acute ischemic stroke patients treated by endovascular thrombectomy in a tertiary university hospital were included. Early neurological deterioration (END) was defined as an increase of 2 or more National Institute of Health Stroke Scale (NIHSS) compared to the best neurological status after stroke within 7 days. The END mechanism was categorized into ischemia progression, symptomatic hemorrhage, and brain edema.ResultsA total of 125 acute ischemic stroke patients received endovascular thrombectomy. Neurological deterioration was detected in 44 patients, and 38 cases (86.4% of END) occurred within 72 h. The END mechanism included 20 ischemia progression, 16 brain edema and 8 hemorrhagic transformation cases. Multivariable logistic regression analysis revealed that the patients who experienced END were more likely to have poor functional outcome defined as modified Rankin scale 3–6 at 90 days than neurologically stable patients (odds ratio (OR) = 4.06, confidence interval (CI) = 1.39–11.9). The risk factor of END due to ischemia progression was stroke subtype of large artery atherosclerosis (OR = 6.28, CI = 1.79–22.0). Successful recanalization (OR = 0.11, CI = 0.03–0.39) and NIHSS after endovascular thrombectomy (OR = 1.15 per one-point increase, CI = 1.06–1.24) were significantly associated with END due to hemorrhage or brain edema.ConclusionNeurological deterioration frequently occurs after endovascular thrombectomy, and the risk factors of END differ according to the mechanism of END.
Journal Article
We'll always have summer : a Summer novel
The summer after her first year of college, Isobel \"Belly\" Conklin is faced with a choice between Jeremiah and Conrad Fisher, brothers she has always loved, when Jeremiah proposes marriage and Conrad confesses that he still loves her.
BOOK
Correlation between bilateral lateral rectus muscle recession and myopic progression in children with intermittent exotropia
Although several studies have reported about the relationship between the surgical correction of intermittent exotropia and myopic progression, it remains unclear, unlike the relationship between esotropia and hyperopia. Thus, this retrospective case control study evaluated the impact of bilateral lateral rectus recession in intermittent exotropia on myopic progression. This study included 388 patients with intermittent exotropia. The refractive errors and degree of exodeviation at each follow up period were analyzed. The rate of myopic progression was −0.46 ± 0.62 diopter (D)/year in patients who underwent surgery and −0.58 ± 0.78 D/year in patients who did not, with no significant difference between them (
p
= 0.254). Patients who had recurrences of more than 10 prism diopters were compared with patients who did not have. The rate of myopic progression was −0.57 ± 0.72 D/year in the recurrent group and −0.44 ± 0.61 D/year in the non-recurrent group, with no significant difference between them (
p
= 0.237). Patients with fast myopic progression had more recurrence than patients with slow progression (
p
= 0.042). Moreover, recurrence had a positive correlation with fast myopic progression (OR = 2.537,
p
= 0.021). Conclusively, the surgical correction of intermittent exotropia did not influence myopic progression.
Journal Article
Insulin Resistance-Varying Associations of Adiposity Indices with Cerebral Perfusion in Older Adults: A Population-Based Study
Excessive accumulation of adipose tissue may accelerate brain aging, but the underlying mechanisms are poorly understood. Several adiposity indices were proposed to assess obesity, while their linkage with brain health in older adults remained unclear. Here we aimed to examine the associations of adiposity indices with global and regional cerebral blood flow (CBF) in older adults, while considering insulin resistance.
This was a cross-sectional population-based study that included older adults derived from the baseline participants in the ongoing Multimodal Interventions to Delay Dementia and Disability in rural China (MIND-China) study.
The study included 103 Chinese rural-dwelling older adults (age≥60 years; 69.9% women) who underwent brain magnetic resonance imaging scans.
We estimated eight adiposity indices based on anthropometric measures. We automatically quantified global and regional CBF using the arterial spin labeling scans. Insulin resistance was assessed using the triglyceride-glucose index and then dichotomized into high and low levels according to the median. Data were analyzed using general linear model and voxel-wise analysis.
Of the eight examined adiposity indices, only higher waist-to-height ratio (WHtR) and body roundness index (BRI) were associated with reduced global CBF (multivariable-adjusted β-coefficients and 95%CI: −1.76; −3.25, −0.27 and −1.77; −3.25, −0.30, respectively) and hypoperfusion in bilateral middle temporal gyri, angular gyri and superior temporal gyri, left middle cingulum and precuneus (P<0.05). There were statistical interactions of WHtR and BRI with levels of insulin resistance on CBF, such that the significant associations of higher WHtR and BRI with lower global and regional CBF existed only in people with high insulin resistance (P<0.05).
Higher WHtR and BRI are associated with cerebral hypoperfusion in older adults, especially in people with high insulin resistance. This may highlight the pathological role of visceral fat in vascular brain aging.
Journal Article