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This research examines, during the human-AI interaction process, how generative AI’s depiction of human bodies reflects and perpetuates able-bodied norms, positioning disabled or grotesque bodies as “errors.” Through a feminist and disability studies lens and employing archival research and visual analysis, this research challenges traditional notions of bodily normativity, advocating for inclusivity in AI-generated imagery. It underscores how labeling nonconformity as an error perpetuates able-bodied standards while erasing the visibility and autonomy of disabled bodies. By critiquing generative AI’s role in reinforcing societal norms, this study calls for reimagining human-AI interactions with a shift in perception and advocates for an approach that neither devalues nor excludes disabled bodies.

With the depletion of shallow resources, deep resource mining has become a trend. However, the high temperature and complex stress environment in deep mines make resource extraction extremely challenging. This paper developed a thermal insulation grouting material made of glazed hollow beads, sodium silicate, and cement and tested the compressive strength, gelation time, and stone rate under various curing days in light of the issue of high temperature heat damage in high ground temperature mines and the impact of mining on roadway grouting bolt support. Fatigue strength, fatigue deformation, load-residual strain, energy evolution and microscopic features were studied and analyzed in relation to the damage law of graded cyclic loading and unloading under the number of varying cycles. The findings demonstrate that cyclic loading and unloading strength is lower than uniaxial compressive strength. The fatigue strength is significantly decreased when the number of cycles reaches its limit. Residual strain is less sensitive to changes in stress than load strain. The fitting correlation coefficients of total output energy and elastic energy are higher than 0.71.

Inappropriate cervical cancer screening practices, including over- and under-screening, pose significant healthcare burdens in low-resource settings. This study analyzed screening behaviors and determinants among 33,362 women aged 35-64 in Wuxiang County, China, using longitudinal cohort data. Screening events were classified as guideline-adherent, over-screened, under-screened, or unscreened based on prior methods (HPV, cytology, or co-testing) and results, using cause-specific frailty models for analysis. Overall, only 19.9% of events were guideline-adherent, while 29.5% were over-screened and 50.6% were under- or unscreened. Notably, the implementation of a county-wide Electronic Medical Record (EMR) platform in 2022 coincided with a sharp decline in over-screening from 36.7% to 15.7%. Compared with primary HPV testing, prior co-testing increased the hazard of both over- and under-screening, whereas prior cytology was strongly associated with under-screening. Women with low-grade abnormalities (≤CIN1) showed a substantially higher risk of under-screening compared to those with negative results. Additionally, community residents were more prone to over-screening, while village residents faced higher under-screening risks. These findings suggest that transitioning to HPV-based screening and integrating EMR systems effectively reduces unnecessary testing, though enhanced reminder systems are crucial to address persistent under-screening in resource-constrained regions.

Fluoro-ruby was injected into the posterior funiculus of the spinal cord in the cervical （C5-T2） and lumbar （L3-6） segments of adult guinea pigs. The spinal cord was cut into serial frozen sections. The Fluoro-ruby labeling was clearly delineated from the surrounding structure. The labeling traversed the cervical, thoracic and lumbar segments, and was located on the ventral portion of the posterior funiculus on the injected side, proximal to the intermediate zone of the dorsal gray matter. The fluorescence area narrowed rostro-caudally. The spinal cord, spinal cord gray matter and corticospinal tract were reconstructed using 3D-DOCTOR 4.0 software, resulting in a robust three-dimensional profile. Using functionality provided by the reconstruction software, free multi-angle observation and sectioning could be conducted on the spinal cord and corticospinal tract. Our experimental findings indicate that the Fluoro-ruby retrograde fluorescent tracing technique can accurately display the anatomical location of corticospinal tract in the guinea pig and that three-dimensional reconstruction software can be used to provide a three-dimensional image of the corticospinal tract.

Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the activity of MAVS. Here, we demonstrate that a mitochondria-localized deubiquitinase USP18 specifically interacts with MAVS, promotes K63-linked polyubiquitination and subsequent aggregation of MAVS. USP18 upregulates the expression and production of type I interferon following infection with Sendai virus (SeV) or Encephalomyocarditis virus (EMCV). Mice with a deficiency of USP18 are more susceptible to RNA virus infection. USP18 functions as a scaffold protein to facilitate the re-localization of TRIM31 and enhances the interaction between TRIM31 and MAVS in mitochondria. Our results indicate that USP18 functions as a post-translational modulator of MAVS-mediated antiviral signaling. Ubiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating the ubiquitination of MAVS via promotion of interaction between MAVS and TRIM31.

Biomechanical cues play an essential role in sculpting organ formation. Comprehending how cardiac cells perceive and respond to biomechanical forces is a biological process with significant medical implications that remains poorly understood. Here, we show that biomechanical forces activate endocardial id2b (inhibitor of DNA-binding 2b) expression, thereby promoting cardiac contractility and valve formation in zebrafish. Taking advantage of the unique strengths of zebrafish, particularly the viability of embryos lacking heartbeats, we systematically compared the transcriptomes of hearts with impaired contractility to those of control hearts. This comparison identified id2b as a gene sensitive to blood flow. By generating a knock-in reporter line, our results unveiled the presence of id2b in the endocardium, and its expression is sensitive to both pharmacological and genetic perturbations of contraction. Furthermore, id2b loss-of-function resulted in progressive heart malformation and early lethality. Combining RNA-seq analysis, electrophysiology, calcium imaging, and echocardiography, we discovered profound impairment in atrioventricular (AV) valve formation and defective excitation-contraction coupling in id2b mutants. Mechanistically, deletion of id2b reduced AV endocardial cell proliferation and led to a progressive increase in retrograde blood flow. In the myocardium, id2b directly interacted with the bHLH component tcf3b (transcription factor 3b) to restrict its activity. Inactivating id2b unleashed its inhibition on tcf3b , resulting in enhanced repressor activity of tcf3b , which subsequently suppressed the expression of nrg1 (neuregulin 1), an essential mitogen for heart development. Overall, our findings identify id2b as an endocardial cell-specific, biomechanical signaling-sensitive gene, which mediates intercellular communications between endocardium and myocardium to sculpt heart morphogenesis and function.

Modern image-based deblurring methods usually show degenerate performance in low-light conditions since the images often contain most of the poorly visible dark regions and a few saturated bright regions, making the amount of effective features that can be extracted for deblurring limited. In contrast, event cameras can trigger events with a very high dynamic range and low latency, which hardly suffer from saturation and naturally encode dense temporal information about motion. However, in low-light conditions existing event-based deblurring methods would become less robust since the events triggered in dark regions are often severely contaminated by noise, leading to inaccurate reconstruction of the corresponding intensity values. Besides, since they directly adopt the event-based double integral model to perform pixel-wise reconstruction, they can only handle low-resolution grayscale active pixel sensor images provided by the DAVIS camera, which cannot meet the requirement of daily photography. In this paper, to apply events to deblurring low-light images robustly, we propose a unified two-stage framework along with a motion-aware neural network tailored to it, reconstructing the sharp image under the guidance of high-fidelity motion clues extracted from events. Besides, we build an RGB-DAVIS hybrid camera system to demonstrate that our method has the ability to deblur high-resolution RGB images due to the natural advantages of our two-stage framework. Experimental results show our method achieves state-of-the-art performance on both synthetic and real-world images.

This study investigated the association between serum albumin concentration and 12-weeks mortality of HIV/AIDS with late diagnosis in China. This retrospective cohort study included, 1079 inpatients diagnosis with late HIV/AIDS between January 2018 and December 2021. Disease progression was estimated based on the 12-weeks mortality rate. Cox proportional hazards regression models were used to evaluate the relationship between serum albumin levels and disease progression. The effects of serum albumin levels on mortality was estimated via Kaplan–Meier curves. The mortality risk decreased by 7% with every 1 g/L increase in serum albumin after adjustment ([HR] = 0.93, 95% CI: 0.88–0.97). Compared with that of the low (< 28 g/L) serum albumin group, the middle (28–34 g/L) group’s mortality risk decreased by 70% (HR = 0.30, 95% CI: 0.15–0.59), and that of the high (≥ 34 g/L) group decreased by 40% (HR = 0.6, 95% CI: 0.29–1.23) after adjustment. Our findings suggest a positive correlation between the increase in serum albumin levels upon admission and a decrease in mortality at 12 weeks post-discharge among patients with late AIDS/HIV diagnosis. Further research is needed to characterize the role of serum albumin in 12-weeks mortality prevention in patients with a late diagnosis.

Renal Artery Sympathetic Denervation (RDN) can lower blood pressure. Different ablation catheters (single electrode, multi‐electrode) have different scopes of ablation (renal artery main stem and branches). Few studies have compared the advantages and disadvantages of different ablation catheters and different procedures in terms of antihypertensive efficacy. To compare the efficacy and safety of 3D reconstruction radiofrequency ablation (3DRA) and basket multi‐electrode radiofrequency ablation (BMRA) in Renal Artery Sympathetic Denervation. Fifty‐three patients with Refractory hypertension (RHT) were divided into BMRA, ( n  = 28) and 3DRA( n  = 25). BMRA group used a stereobasket multi‐electrode ablation catheter with a controlled ablation temperature of 60°C and an ablation time of 120 s per site. 3DRA group used a NavStar pressure‐monitored perfusion monopolar ablation catheter with a controlled ablation temperature of 40°C, an ablation time of 40 s per site, and an ablation energy of 12 W. Baseline and RDN parameters and complications were compared in both groups. Home and 24 h ambulatory blood pressure, type of anti‐hypertensive medication taken, and serum creatinine were followed up at 1, 3, 6, 12, and 24 months after the RDN. There were no differences in baseline characteristics between the two groups. (23.14 ± 2.00)months of follow‐up in the BMRA group resulted in a total of (25.86 ± 8.61) loci ablation. (19.28 ± 7.40)months of follow‐up in the 3DRA group resulted in a total of (21.04 ± 6.47)loci ablation. Home SBP was significantly lower in both groups at 1 month after RDN treatment compared to baseline(H‐SBP/mmHg: BMRA 149.9 ± 10.59 vs. baseline 168.36 ± 12.76; 3DRA 152.6 ± 14.91 vs. 164.89 ± 12.96, both p  < .05). The proportion of people with 24 h ambulatory SBP attainment was significantly higher in both groups and was maintained for 24 months. At each follow‐up time point, there were no differences in home and 24‐h flow SBP, DBP, or Scr between the two groups. There were two cases of severe renal artery complications from implanted vascular stents and one case of femoral artery pseudoaneurysm in the 3DRA group. At follow‐up, 1 (1.9%) patient in the 3DRA group died of unexplained death and 1 (1.9%) patient developed heart failure, and 1 (1.9%) patient in the BMRA group died of unexplained death. Basket multi‐electrode radiofrequency ablation and 3D reconstruction radiofrequency ablation of the renal artery applied to RDN have comparable efficacy in reducing systolic blood pressure.

Based on the principle of quantum interference, with excellent accuracy, sensitivity, and stability, miniaturized and portable atomic gravimeters are gradually exploring the possibility of applying them to mobile platforms such as ships. However, the vibration noise brought by the dynamic environment has a great influence on it. To explore the stability and reliability of the atomic gravimeter in the mobile platform, we built a dynamic measurement system of the atomic gravimeter in the laboratory. With the help of the swing test bench, the swing of the roll and pitch directions was added to the system to simulate the wave environment, and the dynamic swing experiment was carried out. By changing different swing levels, the system can work in different vibration environments and measure the gravity value. The experimental results show that the atomic gravimeter can work normally in various swing environments, and the internal coincidence accuracy of 1.861 mGal is achieved. The measurement standard deviation of 2.194 mGal and the resolution of 1.160 mGal@48 s are obtained under static conditions. The measurement standard deviation of 34.200 mGal and the resolution of 9.538 mGal@48s are obtained under mixed swing conditions. Under the condition of mixed rolling, the standard deviation of the interference phase noise of the atomic gravimeter and its contribution to the resolution of gravity measurement reach 23.121 π mrad and 2.045×10 −6 g/shot, respectively. Our work provides a new reference for the research of high-precision atomic gravimeters based on quantum sensing technology in the field of gravity measurement in ship-borne environments.