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In the standard Bell scenario, when making a local projective measurement on each system component, the amount of randomness generated is restricted. However, this limitation can be surpassed through the implementation of sequential measurements. Nonetheless, a rigorous definition of random numbers in the context of sequential measurements is yet to be established, except for the lower quantification in device-independent scenarios. In this paper, we define quantum intrinsic randomness in sequential measurements and quantify the randomness in the Collins–Gisin–Linden–Massar–Popescu inequality sequential scenario. Initially, we investigate the quantum intrinsic randomness of the mixed states under sequential projective measurements and the intrinsic randomness of the sequential positive-operator-valued measure (POVM) under pure states. Naturally, we rigorously define quantum intrinsic randomness under sequential POVM for arbitrary quantum states. Furthermore, we apply our method to one-Alice and two-Bobs sequential measurement scenarios, and quantify the quantum intrinsic randomness of the maximally entangled state and maximally violated state by giving an extremal decomposition. Finally, using the sequential Navascues–Pironio–Acin hierarchy in the device-independent scenario, we derive lower bounds on the quantum intrinsic randomness of the maximally entangled state and maximally violated state.

Simultaneous ascending auctions find extensive applications in spectrum licensing and advertising space allocation. However, existing quantum sealed-bid auction protocols suffer from dual limitations: they cannot support multi-item simultaneous bidding scenarios, and their reliance on complex quantum resources along with requiring full quantum operational capabilities from bidders fails to accommodate practical constraints of quantum resource-limited users. To address these challenges, this paper proposes a multi-party semi-quantum simultaneous ascending auction protocol based on single-particle states. The protocol employs a trusted honest third party (HTP) responsible for quantum state generation, distribution, and security verification. Bidders determine their groups through quantum measurements and privately encode their bid vectors. Upon successful HTP authentication, each bidder obtains a unique identity code. During the bidding phase, HTP dynamically updates quantum sequences, allowing bidders to submit bids for multiple items by performing only simple unitary operations. HTP announces the highest bid for each item in real time and iteratively generates auction sequences until no new highest bid emerges, thereby achieving simultaneous ascending auctions for multiple items. It acts as a quantum-secured signaling layer, ensuring unconditional security for bid transmission and identity verification while maintaining classical auction logic. Quantum circuit simulations validate the protocol’s feasibility with current technology while satisfying critical security requirements, including anonymity, verifiability, non-repudiation, and privacy preservation. It provides a scalable semi-quantum auction solution for resource-constrained scenarios.

In the standard Bell scenario, when making a local projective measurement on each system component, the amount of randomness generated is restricted. However, this limitation can be surpassed through the implementation of sequential measurements. Nonetheless, a rigorous definition of random numbers in the context of sequential measurements is yet to be established, except for the lower quantification in device-independent scenarios. In this paper, we define quantum intrinsic randomness in sequential measurements and quantify the randomness in the Collins-Gisin-Linden-Massar-Popescu (CGLMP) inequality sequential scenario. Initially, we investigate the quantum intrinsic randomness of the mixed states under sequential projective measurements and the intrinsic randomness of the sequential positive-operator-valued measure (POVM) under pure states. Naturally, we rigorously define quantum intrinsic randomness under sequential POVM for arbitrary quantum states. Furthermore, we apply our method to one-Alice and two-Bobs sequential measurement scenarios, and quantify the quantum intrinsic randomness of the maximally entangled state and maximally violated state by giving an extremal decomposition. Finally, using the sequential Navascues-Pironio-Acin (NPA) hierarchy in the device-independent scenario, we derive lower bounds on the quantum intrinsic randomness of the maximally entangled state and maximally violated state.

Weak ergodicity breaking, particularly through quantum many-body scars (QMBS), has become a significant focus in many-body physics. Krylov state complexity quantifies the spread of quantum states within the Krylov basis and serves as a powerful diagnostic for analyzing nonergodic dynamics. In this work, we study spin-one XXZ magnets and reveal nonergodic behavior tied to QMBS. For the XY model, the nematic Néel state exhibits periodic revivals in Krylov complexity. In the generic XXZ model, we identify spin helix states as weakly ergodicity-breaking states, characterized by low entanglement and nonthermal dynamics. Across different scenarios, the Lanczos coefficients for scarred states display an elliptical pattern, reflecting a hidden SU(2) algebra that enables analytical results for Krylov complexity and fidelity. These findings, which exemplify the rare capability to characterize QMBS analytically, are feasible with current experimental techniques and offer deep insights into the nonergodic dynamics of interacting quantum systems.

Entangled two-qubit states are the core building blocks for constructing quantum communication networks. Their accurate verification is crucial to the functioning of the networks, especially for untrusted networks. In this work we study the self-testing of two-qubit entangled states via steering inequalities, with robustness analysis against noise. More precisely, steering inequalities are constructed from the tilted Clauser-Horne-Shimony-Holt inequality and its general form, to verify the general two-qubit entangled states. The study provides a good robustness bound, using both local extraction map and numerical semidefinite-programming methods. In particular, optimal local extraction maps are constructed in the analytical method, which yields the theoretical optimal robustness bound. To further improve the robustness of one-sided self-testing, we propose a family of three measurement settings steering inequalities. The result shows that three-setting steering inequality demonstrates an advantage over two-setting steering inequality on robust self-testing with noise. Moreover, to construct a practical verification protocol, we clarify the sample efficiency of our protocols in the one-sided device-independent scenario.

Self-testing, which refers to device independent characterization of the state and the measurement, enables the security of quantum information processing task certified independently of the operation performed inside the devices. Quantum states lie in the core of self-testing as key resources. However, for the different entangled states, usually different measurement settings should be taken in self-testing recipes. This may lead to the redundancy of measurement resources. In this work, we use fixed two-binary measurements and answer the question that what states can be self-tested with the same settings. By investigating the structure of generalized tilted-CHSH Bell operators with sum of squares decomposition method, we show that a family of two-qubit entangled states can be self-tested by the same measurement settings. The robustness analysis indicates that our scheme is feasible for practical experiment instrument. Moreover, our results can be applied to various quantum information processing tasks.

The partial states of a multipartite quantum state may carry a lot of information: in some cases, they determine the global state uniquely. This result is known for tomographic information, that is for fully characterized measurements. We extend it to the device-independent framework by exhibiting sets of two-party correlations that self-test pure three-qubit states.

Self-testing refers to a device-independent way to uniquely identify the state and the measurement for uncharacterized quantum devices. The only information required comprises the number of measurements, the number of outputs of each measurement, and the statistics of each measurement. Earlier results on self-testing of multipartite state were restricted either to Dicke states or graph states. In this paper, we propose self-testing schemes for a large family of symmetric three-qubit states, namely the superposition of W state and GHZ state. We first propose and analytically prove a self-testing criterion for the special symmetric state with equal coefficients of the canonical basis, by designing subsystem self-testing of partially and maximally entangled state simultaneously. Then we demonstrate for the general case, the states can be self-tested numerically by the swap method combining semi-definite programming (SDP) in high precision.

Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, the chromatin accessibility landscape and gene regulatory network of pancreatic cancer are largely uncharacterized. Here, we integrate the chromatin accessibility profiles of 84 pancreatic cancer organoid lines with whole-genome sequencing data, transcriptomic sequencing data and the results of drug sensitivity analysis of 283 epigenetic-related chemicals and 5 chemotherapeutic drugs. We identify distinct transcription factors that distinguish molecular subtypes of pancreatic cancer, predict numerous chromatin accessibility peaks associated with gene regulatory networks, discover regulatory noncoding mutations with potential as cancer drivers, and reveal the chromatin accessibility signatures associated with drug sensitivity. These results not only provide the chromatin accessibility atlas of pancreatic cancer but also suggest a systematic approach to comprehensively understand the gene regulatory network of pancreatic cancer in order to advance diagnosis and potential personalized medicine applications. The chromatin accessibility landscape and gene regulatory network of pancreatic cancer has not been fully characterised. Here, the authors perform multi-omics analysis of 84 pancreatic cancer organoid lines and reveal gene regulatory networks and distinct molecular subtypes.

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global public health threat. The efficacy of several repurposed drugs has been evaluated in clinical trials. Among these drugs, a second-generation antiandrogen agent, enzalutamide, was proposed because it reduces the expression of transmembrane serine protease 2 (TMPRSS2), a key component mediating SARS-CoV-2-driven entry, in prostate cancer cells. However, definitive evidence for the therapeutic efficacy of enzalutamide in COVID-19 is lacking. Here, we evaluated the antiviral efficacy of enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and Ad-ACE2-transduced mice. Tmprss2 knockout significantly inhibited SARS-CoV-2 infection in vivo. Enzalutamide effectively inhibited SARS-CoV-2 infection in human prostate cells, however, such antiviral efficacy was lacking in human lung cells and organoids. Accordingly, enzalutamide showed no antiviral activity due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells. Moreover, we observed distinct AR binding patterns between prostate cells and lung cells and a lack of direct binding of AR to TMPRSS2 regulatory locus in human lung cells. Thus, our findings do not support the postulated protective role of enzalutamide in treating COVID-19 through reducing TMPRSS2 expression in lung cells. Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.