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For Chinese Generation Z fans, the reperformances of musical theatre have empowered them to realize self-transformation while performing in public—without the constraints of formal physical training or special creative ability. By reperforming musicals with the themes of idealism and revolution, these youth re-create song-and-dance gestures as a rite of passage in everyday life, striving for individual idealized identities while playing disciplined social roles under the control of official ideology.

The North Huicheng Basin strike-slip fault system is on the northeastern frontier of the Tibetan Plateau and separates the West and East Qinling differential orogeny. However, the deformation mechanism of this strike-slip fault system and its exact tectonic significance are unclear. Here, we carried out systematic field structural analysis, physical analog modeling, and multiproxy geochronological dating to address these issues. The field structural analysis indicates that the North Huicheng Basin strike-slip fault system was induced from the plate-like movement of the West and East Qinling Orogens, which underwent multiple left-lateral strike-slip faulting and controlled salient and recessed structures. The scaled physical analog experiment results confirm this hypothesis and reveal the primary spatial-temporal deformational kinematic process. Combined with published works, multiproxy geochronological dating (zircon U-Pb age of 213 Ma, biotite 40Ar/39Ar age of 203 Ma, and apatite fission-track age of 56 Ma) outlines the main thermal history of the hanging wall. Based on the above facts, the integrated research suggests that multistage strike-slip faulting played a significant role in the main tectonic events, that is, Late Triassic magmatic emplacement, Jurassic/Cretaceous local pull-apart, and Cenozoic rapid exhumation driven by Tibetan Plateau growth.

Mountainous areas have become among the most developed areas of geological hazards due to special geological environmental conditions and intensive human engineering activities. Geological hazards are a main threat to urbanization, rural revitalization, and new rural construction in complex mountainous areas. It is of great strategic significance to conduct large-scale geological hazard investigation and risk assessment in urban areas, control the risk of geological hazards at the source and propose risk control measures. In this paper, we established the technical methods of geologic hazard risk assessment and control in complex mountain towns by taking Longlin Town in the mountainous region of Gansu Longnan, China as the study area, with the Quanjia bay debris flows and Panping Village landslides as the typical pilot investigation and assessment. The methods consist of six stages—risk identification, hazard disaster model investigation, risk analysis, vulnerability assessment, risk evaluation and risk management and control measures and proposals. On this basis, the results of geological hazards with different precipitation frequencies (5%, 2%, 1%) are presented. The results show that 75.23% of the regions remained at low risk levels; 24.38% of the regions increased a risk level with decreasing precipitation frequency, and 0.39% of the regions remained at extremely high risk levels under different precipitation frequency conditions. For the Quanjia bay debris flows and Panping Village landslides case, we discussed the geological hazards risk source control contents, management and control technologies, engineering and non-engineering measures of disaster prevention and control for urban disasters and specific disaster areas. This research can provide technical support and reference for disaster prevention and mitigation, and territorial spatial planning.

为实现复杂动态背景下快速、准确地检测运动目标，提出一种改进二进制鲁棒不变尺度特征(BRISK)算法的运动目标检测方法。首先对图像进行分块，利用图像熵对图像块进行筛选；然后针对特征匹配过程中存在大量误匹配的问题，采用k近邻算法与欧氏距离进行特征匹配；最后通过改进的顺序抽样一致性算法进行特征点提纯，进一步完成背景运动补偿，从而利用形态学处理分割运动目标。采用多组视频图像进行验证，本文算法在原BRISK算法的基础上去除了32.7%的特征点，并且匹配效率提高了75%，处理速度比以往算法快，并且具有较强的抗噪性能。

This study examines the relationship between industrial agglomeration and industrial pollution. The empirical results for the entire sample show that industrial pollution has a significant spatial spillover effect. Specifically, for every 1% point increase in industrial pollution in neighboring regions, industrial pollution in the region increases by 0.33% points. Industrial pollution shows an inverse U -shaped change with industrial agglomeration. There is a significant positive linear relationship between domestic industrial agglomeration and industrial pollution. And there is a significant inverted U -shaped relationship between domestic industrial agglomeration and industrial pollution. Furthermore, heterogeneous results are observed among different urban agglomerations, with a significant inverse U-shaped relationship between industrial agglomeration and pollution in the Guangdong–Hong Kong–Macao—Great Bay Area, the Yangtze River Delta, and the Middle Reaches of Yangtze River and a significant U -shaped relationship in Beijing–Tianjin–Hebei.

Ultrasound (US) imaging is a widely used diagnostic method in clinics. Real-time-generated US images are used for rapid diagnosis without harm to patients. The quality of US imaging highly depends on the skill of the physician due to the differences among physicians. Techniques for autonomous robotic ultrasound (AU-RUS) acquisitions are expected to become an effective means to improve the level of US diagnosis, reduce the workload of physicians, and improve the standardization of US imaging quality. This paper aims to summarize the current research status of techniques for AU-RUS acquisitions, and to discuss the research trends and challenges regarding related technologies. Firstly, the techniques for AU-RUS acquisitions and systems are outlined. The techniques for teleoperated or autonomous US acquisitions are briefly discussed. Representative RUS acquisition systems are introduced. Then, the current research status of AU-RUS acquisitions is reviewed from four research directions: force sensitivity and control, scanning path-planning and positioning, US treatment guidance, and US image processing technology and quality assessment optimization. This review provides a decision-oriented autonomy perspective by mapping typical methods to workflow components across the stages of perception, decision-making, and execution. We identify major deployment bottlenecks, including safety-verifiable autonomy and failure recovery, motion compensation under deformation, and the lack of standardized, clinically meaningful US image quality metrics. Finally, the shortcomings of current research are summarized and analyzed, and the research trends and challenges for AU-RUS acquisitions are prospected.

Background Immunotherapy has revolutionized cancer treatment, but most patients are refractory to immunotherapy or acquire resistance, with the underlying mechanisms remaining to be explored. Methods We characterized the transcriptomes of ~92,000 single cells from 3 pre-treatment and 12 post-treatment patients with non-small cell lung cancer (NSCLC) who received neoadjuvant PD-1 blockade combined with chemotherapy. The 12 post-treatment samples were categorized into two groups based on pathologic response: major pathologic response (MPR; n = 4) and non-MPR (NMPR; n = 8). Results Distinct therapy-induced cancer cell transcriptomes were associated with clinical response. Cancer cells from MPR patients exhibited a signature of activated antigen presentation via major histocompatibility complex class II (MHC-II). Further, the transcriptional signatures of FCRL4+FCRL5+ memory B cells and CD16+CX3CR1+ monocytes were enriched in MPR patients and are predictors of immunotherapy response. Cancer cells from NMPR patients exhibited overexpression of estrogen metabolism enzymes and elevated serum estradiol. In all patients, therapy promoted expansion and activation of cytotoxic T cells and CD16+ NK cells, reduction of immunosuppressive Tregs, and activation of memory CD8+T cells into an effector phenotype. Tissue-resident macrophages were expanded after therapy, and tumor-associated macrophages (TAMs) were remodeled into a neutral instead of an anti-tumor phenotype. We revealed the heterogeneity of neutrophils during immunotherapy and identified an aged CCL3+ neutrophil subset was decreased in MPR patients. The aged CCL3+ neutrophils were predicted to interact with SPP1+ TAMs through a positive feedback loop to contribute to a poor therapy response. Conclusions Neoadjuvant PD-1 blockade combined with chemotherapy led to distinct NSCLC tumor microenvironment transcriptomes that correlated with therapy response. Although limited by a small patient sample size subjected to combination therapy, this study provides novel biomarkers to predict therapy response and suggests potential strategies to overcome immunotherapy resistance.

Sea ice type classification is of great significance for the exploration of waterways, fisheries, and offshore operations in the Arctic. However, to date, there is no multiple remote sensing method to detect sea ice type in the Arctic. This study develops a multiple sea ice type algorithm using the HaiYang-2B Scatterometer (HY-2B SCA). First, the parameters most applicable to classify sea ice type are selected through feature extraction, and a stacking model is established for the first time, which integrates decision tree and image segmentation algorithms. Finally, multiple sea ice types are classified in the Arctic, comprising Nilas, Young Ice, First Year Ice, Old Ice, and Fast Ice. Comparing the results with the Ocean and Sea Ice Satellite Application Facility (OSI-SAF) Sea Ice Type dataset (SIT) indicates that the sea ice type classified by HY-2B SCA (Stacking-HY2B) is similar to OSI-SAF SIT with regard to the changing trends in extent of sea ice. We use the Copernicus Marine Environment Monitoring Service (CMEMS) high-resolution sea ice type data and EM-Bird ice thickness data to validate the result, and accuracies of 87% and 88% are obtained, respectively. This indicates that the algorithm in this work is comparable with the performance of OSI-SAF dataset, while providing information of multiple sea ice types.

Different from the existing literatures, this study innovatively explores the impact of China’s quasi market on pollution. This study examines the impact of local government interventions in the land market and structural distortions on industrial pollution in Chinese cities, using data from 287 prefecture-level cities between 2007 and 2017. Our findings reveal three key results: (1) The level of land marketization has a significant inverted-U relationship with industrial wastewater and sulfur dioxide emissions, indicating that land market liberalization initially exacerbates pollution but eventually leads to improvements. (2) Distortions in land supply exacerbate industrial pollution, with structural supply factors significantly contributing to water, air, and waste pollution. (3) Regional differences exist, with land marketization and supply distortions having varying effects across eastern, central, and western regions. These results suggest that local governments’ land policies play a crucial role in shaping environmental outcomes and provide insights into how land use regulations could be adjusted to balance industrial growth and environmental protection. Despite its contributions, the study has limitations, including the use of data from a specific time period, potential biases in the sampling method. Future research could address these limitations by exploring longer time frames, using more representative samples, and incorporating additional data sources to enhance the robustness of the findings.

The reticular chemistry strategy presents a powerful molecule-design tool to tailor the physical and chemical properties of metal-organic framework (MOF). In this work, we for the first time investigated the effect of organic ligands on the radionuclide sequestration (TcO 4 − ) of thorium-organic framework. Through a coordination modulation technique, two novel isoreticular thorium-organic frameworks, namely Th-MOF-67 and Th-MOF-68, were obtained. Relative to the antetype MOF of Th-MOF-66 that shows extremely low uptake of ReO 4 − (a chemical surrogate of radioactive TcO 4 − ), the isoreticular MOFs of Th-MOF-67 and Th-MOF-68 enable ultrahigh uptake of ReO 4 − , giving an impressively 36.8-fold or 56-fold enhancement, respectively. The adsorption capacity of Th-MOF-68 is as high as 560 mg/g, exceeding most reported adsorbents for such use. The mechanism for such exceptional outstanding performance, as unveiled by both the single crystal X-ray diffraction and theoretical calculation, is due to coordination interaction for Th-MOF-67, when a tetrazolate ligand was used, or a combined effect from both coordination interaction and anion-exchange for Th-MOF-68, if using a triazolate ligand.