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Background This study aimed to investigate the factors influencing subjective ratings of comfort, vision quality, dryness, and satisfaction at both initial and end-of-day wear among young Asian wearers of silicone hydrogel contact lenses. Methods Participants aged 20 to 24 years who were satisfied wearers of silicone hydrogel daily disposable contact lenses were recruited. Each participant attended two scheduled visits. During the first visit (Day 1), ocular health, refractive error, visual acuity, first and average non-invasive tear break-up time (F-NITBUT and A-NITBUT), and subjective ratings were measured without lenses and 15 min after wearing Somofilcon A daily disposable lenses. On the second visit (Day 7), follow-up data were collected after seven consecutive days of lens wear. Results A total of 59 healthy participants (mean age: 20.86 ± 1.29 years) participated in this study. Visual acuity demonstrated a significant negative correlation with comfort, vision quality, and satisfaction after 15 min of Somofilcon A lens wear on Day 1 and a positive correlation with dryness. Additionally, A-NITBUT was significantly positively correlated with vision quality. On Day 7, visual acuity was negatively correlated with overall vision quality after 8 h of wear. However, residual refraction and F-NITBUT showed no significant correlation with comfort, vision quality, dryness, or satisfaction after 15 min of wear on Day 1–8 h on Day 7. Conclusions The results suggest that higher visual acuity at initial lens wear was strongly associated with improved subjective comfort, vision quality, and overall satisfaction, as well as reduced dryness. Furthermore, a longer average tear break-up time was associated with improved vision quality. For prolonged lens use, visual acuity was only associated with vision quality. Visual acuity plays a significant role in subjective ratings at the initial lens wear, while tear break-up time may serve as a predictor for subjective vision quality.

Background Continuous performance tests (CPTs) are a popular tool for evaluating the symptoms of attention-deficit/hyperactivity disorder (ADHD). Performance measurements are typically linked to the biological features and cognitive functions of individuals. To determine the validity of specific CPT indices in differentiating between school-aged children with ADHD from with non-ADHD, each student’s sex, chronological age, and cognitive abilities should be considered. Methods In this prospective case–control study, a total of 30 non-ADHD students and 26 with ADHD who were aged 6 to 12 years were from general education classrooms. All students completed the Continuous Performance Tests (CPTs) and the Peabody Picture Vocabulary Test-revised (Mandarin-Chinese version). Demographic data were collected from the students’ parents. Results Detectability, Omissions, Commissions, and Hit Reaction Time Standard Deviation (HRT SD) yielded higher T-scores in children with ADHD than those without. Compared with non-ADHD students, those with ADHD had higher classification scores for Detectability, Omissions, Perseverations, and HRT SD. For each CPT index, after individual factors were controlled for, logistic regression revealed that only students with positive scores for Detectability, Omission, and HRT SD (adjusted odds ratios = 4.627, 9.977, and 3.908, P s < 0.05) were likely to receive a diagnosis of ADHD. Furthermore, after individual characteristics were controlled for, Logistic regression also revealed that the cumulative positive scores of the Detectability, Omission, or and HRT SD remained associated with an increased risk of ADHD (adjusted odds ratio = 3.116, P  < 0.01). Conclusions Compared with school-aged children with non-ADHD in general education classrooms, those with ADHD exhibited significantly lower performance in inattention-related CPT indices. To reach an accurate diagnosis through CPTs, clinicians should pay attention to Detectability, Omission, and HRT SD. Compared with other CPT indices, Detectability, Omission, and HRT SD may function as more suitable indicators for distinguishing between school-aged children with and non-ADHD in general education classrooms. These indicators are robust and unobscured by individual characteristics.

To evaluate both subjective grading and objective assessments associated with switching from habitual silicone hydrogel daily disposable contact lenses to verofilcon A lenses (study lenses) among young Asian individuals, and to investigate the relationship between these subjective and objective measures. 58 participants wore study lenses for 8-10 hours daily for a week. Subjective assessments, including comfort, visual quality, and eye dryness, were conducted using a numerical rating scale (0-100) on the first and seventh day. Noninvasive tear breakup time (NITBUT), bulbar conjunctival redness (BR), tear meniscus height (TMH), and meibography were measured with the Keratograph M5 at baseline, the first and the seventh day. After the seventh day, subjective ratings showed increased comfort and decreased visual quality and dryness. Comfort and visual quality scores on the first and seventh days were above 85 points, with no significant differences. The average NITBUT significantly improved 15 minutes and 8 hours post-lens application compared to baseline measures ( = 0.019). Tear meniscus height was highest at baseline, with a marginal decrease observed following both 15 minutes and 8 hours of study lenses wear ( < 0.001). The most pronounced bulbar conjunctival redness was noted at baseline, decreasing significantly after switching to study lenses ( = 0.002). Notably, NITBUT was found to be significantly positively correlated with comfort ( < 0.05). The switch to daily disposable study lenses resulted in maintained comfort and improved tear film stability in the young Asian population. A significant positive correlation was observed between NITBUT and subjective measures of comfort.

Patients with NTG or POAG with more than one outpatient or discharge diagnosis from the ophthalmology department were included in the study. These data were merged with the PM2.5 data from the Air Quality Monitoring Network for analysis. This was a case–control study, with 1006 participants in the NTG group and 2533 in the POAG group. To investigate fine particulate matter (PM2.5) exposure levels in patients with normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG), patient data were obtained from Taiwan’s Longitudinal Health Insurance Database 2000 for the 2008 to 2013 period. We used a multivariate logic regression model to assess the risk for each participant. The PM2.5 exposure levels were divided into four groups: <25th percentile (Q1), <617 μg/mm3; 25th to 50th percentile (Q2), 617 to 1297 μg/mm3; 50th to 75th percentile (Q3), 1297 to 2113 μg/mm3; and >75th percentile (Q4), >2113 μg/mm3. The results are expressed in terms of odds ratio (OR) and 95% CI. A multiple logistic regression was used to compare the results of the NTG group with those of the POAG group. Compared with the PM2.5 Q1 level, the OR of the PM2.5 Q2 level was 1.009 (95% CI 0.812–1.254), the PM2.5 Q3 level was 1.241 (95% CI 1.241–1.537, p < 0.05), and the PM2.5 Q4 level was 1.246 (95% CI 1.008–1.539, p < 0.05). Our research reveals that compared with POAG, the risk of developing NTG is more closely related with PM2.5 exposure, and PM2.5 has a concentration–dose effect. It is hoped that in the future, in the clinical judgment of NTG and POAG, the level of PM2.5 in the environment can be taken as a risk factor.

In this study, we aimed to validate a novel light field virtual reality (LFVR) system for estimating refractive errors in the human eye. Fifty participants with an average age of 22.12 ± 2.2 years (range 20–30 years) were enrolled. The present study compared spherical equivalent (SE) and focal line measurements (F1 and F2) obtained by the LFVR system with those obtained by established methods, including closed-field and open-field autorefractors, retinoscopy, and subjective refraction. The results showed substantial agreement between the LFVR system and the traditional methods, with intraclass correlation coefficients (ICC) for SE ranging from 82.7% to 86.7% (p < 0.01), and for F1 and F2 from 80.7% to 86.4% (p < 0.01). Intra-repeatability for F1 and F2 demonstrated strong agreement, with ICC values of 88.8% and 97.5%, respectively. These findings suggest that the LFVR system holds potential as a primary tool for refractive error measurement in optical care, offering high agreement and repeatability compared to conventional methods.

Taiwan is commonly noted for its high prevalence of myopia, as well as a long history of more than 20 years of using atropine to control myopia. However, the clinical implications are rarely discussed. This is a cross-sectional study investigating the influence of topical atropine instillation on ocular physiology, visual function, and visual discomfort in children. Aged 7 to 12 years, 212 schoolchildren were recruited and divided into the atropine group and the non-atropine group. Physiological characteristics such as pupil size and intraocular pressure were measured, and a variety of visual functions was also evaluated. A questionnaire was used to investigate the side effects and visual complaints caused by atropine treatment. There was a significant difference in pupil size (OD: 5.40 ± 0.90 vs. 6.60 ± 1.01 mm; OS: 5.42 ± 0.87 vs. 6.64 ± 1.00 mm, p < 0.001) between the two groups. Reductions in near visual acuity, accommodation, convergence ability, and stereopsis were observed in the atropine group. The horizontal pupil diameter enlarged, and visual functions were greatly affected after administration of topical atropine. The changes in visual function during atropine therapy need to be carefully monitored by clinicians, while patient compliance is usually the key to success.

Purpose. To compare the patterns of relative peripheral refractions of myopic children who were currently on atropine treatment for myopia control and myopic children who did not use atropine. Methods. Chinese children (n = 209) aged 7 to 12 years participated in the study, 106 used atropine and 103 did not. Participants were also classified into three groups: emmetropes (SE: +0.50 to −0.50 D), low myopes (SE: −0.50 to −3.00 D), and moderate myopes (SE: −3.00 to −6.00 D). The central and peripheral refractions along the horizontal meridians (for both nasal and temporal fields) were measured in 10-degree steps to 30 degrees. Results. There were no statistically significant differences in spherical equivalent and astigmatism of the three refractive groups in either the nasal or temporal retina. The atropine group showed a significant relative myopia in the temporal 30° field in spherical equivalent compared to the emmetropic group (t49 = 3.36, P=0.02). In eyes with low myopia, the atropine group had significant relative myopia in the nasal 30° and temporal 30° fields (t118 = 2.59, P=0.01; t118 = 2.06, P=0.04), and it is also observed at 20° and 30° of the nasal field for the moderate myopic group (t36 = 2.37, P=0.02; t2.84 = 2.84, P=0.01). Conclusion. Significant differences in relative peripheral refraction were found between the atropine group and its controls. The findings suggested that the eyes that received atropine may have a less prolate shape and thus explain why using atropine is effective in controlling myopia progression.

The aim of this study was to determine the relationship between relative peripheral refraction and retinal shape by 2-D magnetic resonance imaging in high myopes. Thirty-five young adults aged 20 to 30 years participated in this study with 16 high myopes (spherical equivalent < −6.00 D) and 19 emmetropes (+0.50 to −0.50 D). An open field autorefractor was used to measure refractions from the center out to 60° in the horizontal meridian and out to around 20° in the vertical meridian, with a step of 3 degrees. Axial length was measured by using A-scan ultrasonography. In addition, images of axial, sagittal, and tangential sections were obtained using 2-D magnetic resonance imaging. The highly myopic group had a significantly relative peripheral hyperopic refraction and showed a prolate ocular shape compared to the emmetropic group. The highly myopic group had relative peripheral hyperopic refraction and showed a prolate ocular form. Significant differences in the ratios of height/axial (1.01 ± 0.02 vs. 0.94 ± 0.03) and width/axial (0.99 ± 0.17 vs. 0.93 ± 0.04) were found from the MRI images between the emmetropic and the highly myopic eyes (p < 0.001). There was a negative correlation between the retina’s curvature and relative peripheral refraction for both temporal (Pearson r = −0.459; p < 0.01) and nasal (Pearson r = −0.277; p = 0.011) retina. For the highly myopic eyes, the amount of peripheral hyperopic defocus is correlated to its ocular shape deformation. This could be the first study investigating the relationship between peripheral refraction and ocular dimension in high myopes, and it is hoped to provide useful knowledge of how the development of myopia changes human eye shape.

The objective was to investigate different comorbidities developed in normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG) patients. This was a case-control study, with 1489 people in the NTG group and 5120 people in the POAG group. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008–2013 period. The chi-square test was used to compare categorical variables, such as gender, income and urbanisation level, between NTG and POAG patients, and the two-tailed t test was used to compare continuity between the two groups. We use a multivariate logic regression model to assess the risk of each participant. The results are expressed in terms of odds ratio (OR) and 95% confidence intervals (CI). Patients with NTG had significantly higher proportions of hypotension (adjusted OR, 1.984; 95% CI, 1.128–3.490), sleep disturbances (adjusted OR, 1.323; 95% CI, 1.146–1.528), peptic ulcers (adjusted OR, 1.383; 95% CI, 1.188–1.609) and allergic rhinitis (adjusted OR, 1.484; 95% CI, 1.290–1.707) than those with POAG. Conversely, arterial hypertension (adjusted OR, 0.767; 95% CI, 0.660–0.893), diabetes (adjusted OR, 0.850; 95% CI, 0.728–0.993) and atopic dermatitis (adjusted OR, 0.869; 95% CI, 0.763–0.990) had a lower risk in the NTG group than in the POAG group. We found that comorbidities such a hypotension, sleep disturbances and peptic ulcer and allergic rhinitis are more highly associated to NTG than POAG.

Primary open-angle glaucoma (POAG) is the most common type of glaucoma. However, little is known about POAG in adults and exposure to air pollution. The current study aims to investigate whether exposure to particulate matter with a mass median aerodynamic diameter of ≤2.5 μm (PM2.5) is associated with POAG diagnosis. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008–2013 period. PM2.5 concentration data, collected from the Ambient Air Quality Monitoring Network established by the Environmental Protection Administration of Taiwan, were categorized into four groups according to World Health Organization (WHO) exposure standards for PM2.5. We estimated the odds ratios (ORs) and 95% CIs for risk factors for POAG with logistic regression. The OR of per WHO standard level increase was 1.193 (95% CI 1.050–1.356). Compared with the normal level, the OR of WHO 2.0 level was 1.668 (95% CI 1.045–2.663, P < 0.05). After excluding confounding risk factors for POAG in this study, we determined that increased PM2.5 exposure is related to POAG risk (ORs > 1, P < 0.05). In this study, PM2.5 was an independent factor associated with open-angle glaucoma. Further research is required to better understand the mechanisms connecting PM2.5 and open-angle glaucoma.