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"Hancock, P J"
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A radio transient with unusually slow periodic emission
The high-frequency radio sky is bursting with synchrotron transients from massive stellar explosions and accretion events, but the low-frequency radio sky has, so far, been quiet beyond the Galactic pulsar population and the long-term scintillation of active galactic nuclei. The low-frequency band, however, is sensitive to exotic coherent and polarized radio-emission processes, such as electron-cyclotron maser emission from flaring M dwarfs
1
, stellar magnetospheric plasma interactions with exoplanets
2
and a population of steep-spectrum pulsars
3
, making Galactic-plane searches a prospect for blind-transient discovery. Here we report an analysis of archival low-frequency radio data that reveals a periodic, low-frequency radio transient. We find that the source pulses every 18.18 min, an unusual periodicity that has, to our knowledge, not been observed previously. The emission is highly linearly polarized, bright, persists for 30–60 s on each occurrence and is visible across a broad frequency range. At times, the pulses comprise short-duration (<0.5 s) bursts; at others, a smoother profile is observed. These profiles evolve on timescales of hours. By measuring the dispersion of the radio pulses with respect to frequency, we have localized the source to within our own Galaxy and suggest that it could be an ultra-long-period magnetar.
Analysis of archival low-frequency radio data from the Murchison Widefield Array reveals a periodic transient with an unusual periodicity of 18.18 min, the source of which is localized to our Galaxy and could be an ultra-long-period magnetar.
Journal Article
Quantitative analysis of chimerism after allogeneic bone marrow transplantation using immunomagnetic selection and fluorescent microsatellite PCR
LEUKEMIA: (2003) 17, 247-251. doi:10.1038/sj.leu.2402759
Journal Article
Groundwater Ecosystems Vary with Land Use across a Mixed Agricultural Landscape
Changes in surface land use may threaten groundwater quality and ecosystem integrity, particularly in shallow aquifers where links between groundwater and surface activities are most intimate. In this study we examine the response of groundwater ecosystem to agricultural land uses in the shallow alluvial aquifer of the Gwydir River valley, New South Wales, Australia. We compared groundwater quality and microbial and stygofauna assemblages among sites under irrigated cropping, non‐irrigated cropping and grazing land uses. Stygofauna abundance and richness was greatest at irrigated sites, with the composition of the assemblage suggestive of disturbance. Microbial assemblages and water quality also varied with land use. Our study demonstrates significant differences in the composition of groundwater ecosystems in areas with different surface land use, and highlights the utility of groundwater biota for biomonitoring, particularly in agricultural landscapes.
Journal Article
Human Impacts on the Stream-Groundwater Exchange Zone
Active exchanges of water and dissolved material between the stream and groundwater in many porous sand- and gravel-bed rivers create a dynamic ecotone called the hyporheic zone. Because it lies between two heavily exploited freshwater resources-rivers and groundwater-the hyporheic zone is vulnerable to impacts coming to it through both of these habitats. This review focuses on the direct and indirect effects of human activity on ecosystem functions of the hyporheic zone. River regulation, mining, agriculture, urban, and industrial activities all have the potential to impair interstitial bacterial and invertebrate biota and disrupt the hydrological connections between the hyporheic zone and stream, groundwater, riparian, and floodplain ecosystems. Until recently, our scientific ignorance of hyporheic processes has perhaps excused the inclusion of this ecotone in river management policy. However, this no longer is the case as we become increasingly aware of the central role that the hyporheic zone plays in the maintenance of water quality and as a habitat and refuge for fauna. To fully understand the impacts of human activity on the hyporheic zone, river managers need to work with scientists to conduct long-term studies over large stretches of river. River rehabilitation and protection strategies need to prevent the degradation of linkages between the hyporheic zone and surrounding habitats while ensuring that it remains isolated from toxicants. Strategies that prevent anthropogenic restriction of exchanges may include the periodic release of environmental flows to flush silt and reoxygenate sediments, maintenance of riparian buffers, effective land use practices, and suitable groundwater and surface water extraction policies.
Journal Article
The Crystal Structure of Human Protein Farnesyltransferase Reveals the Basis for Inhibition by CaaX Tetrapeptides and Their Mimetics
Protein farnesyltransferase (FTase) catalyzes the attachment of a farnesyl lipid group to the cysteine residue located in the C-terminal tetrapeptide of many essential signal transduction proteins, including members of the Ras superfamily. Farnesylation is essential both for normal functioning of these proteins, and for the transforming activity of oncogenic mutants. Consequently FTase is an important target for anti-cancer therapeutics. Several FTase inhibitors are currently undergoing clinical trials for cancer treatment. Here, we present the crystal structure of human FTase, as well as ternary complexes with the TKCVFM hexapeptide substrate, CVFM non-substrate tetrapeptide, and L-739,750 peptidomimetic with either farnesyl diphosphate (FPP), or a nonreactive analogue. These structures reveal the structural mechanism of FTase inhibition. Some CaaX tetrapeptide inhibitors are not farnesylated, and are more effective inhibitors than farnesylated CaaX tetrapeptides. CVFM and L-739,750 are not farnesylated, because these inhibitors bind in a conformation that is distinct from the TKCVFM hexapeptide substrate. This non-substrate binding mode is stabilized by an ion pair between the peptide N terminus and the α-phosphate of the FPP substrate. Conformational mapping calculations reveal the basis for the sequence specificity in the third position of the CaaX motif that determines whether a tetrapeptide is a substrate or non-substrate. The presence of β-branched amino acids in this position prevents formation of the non-substrate conformation; all other aliphatic amino acids in this position are predicted to form the non-substrate conformation, provided their N terminus is available to bind to the FPP α-phosphate. These results may facilitate further development of FTase inhibitors.
Journal Article
The early radio afterglow of short GRB 230217A
We present the radio afterglow of short gamma-ray burst (GRB) 230217A, which was detected less than 1 day after the gamma-ray prompt emission with the Australia Telescope Compact Array (ATCA) and the Karl G. Jansky Very Large Array (VLA). The ATCA rapid-response system automatically triggered an observation of GRB 230217A following its detection by the Neil Gehrels Swift Observatory and began observing the event just 32 minutes post-burst at 5.5 and 9 GHz for 7 hours. Dividing the 7-hour observation into three time-binned images allowed us to obtain radio detections with logarithmic central times of 1, 2.8 and 5.2 hours post-burst, the first of which represents the earliest radio detection of any GRB to date. The decline of the light curve is consistent with reverse shock emission if the observing bands are below the spectral peak and not affected by synchrotron self-absorption. This makes GRB 230217A the fifth short GRB with radio detections attributed to a reverse shock at early times (\\(<1\\) day post-burst). Following brightness temperature arguments, we have used our early radio detections to place the highest minimum Lorentz factor (\\({\\Gamma}_{min} > 50\\) at \\(\\sim1\\) hour) constraints on a GRB in the radio band. Our results demonstrate the importance of rapid radio follow-up observations with long integrations and good sensitivity for detecting the fast-evolving radio emission from short GRBs and probing their reverse shocks.
Paper
Rapid radio brightening of GRB 210702A
We observed the rapid radio brightening of GRB 210702A with the Australian Telescope Compact Array (ATCA) just 11hr post-burst, tracking early-time radio variability over a 5hr period on ~15min timescales at 9.0, 16.7, and 21.2GHz. A broken power-law fit to the 9.0GHz light curve showed that the 5hr flare peaked at a flux density of 0.4+/-0.1mJy at ~13hr post-burst with a steep rise and decline. The observed temporal and spectral evolution are not expected in the standard internal-external shock model, where forward and reverse shock radio emission evolves on much longer timescales. The early-time (<1day) optical and X-ray light curves from the Neil Gehrels Swift Observatory demonstrated typical afterglow forward shock behaviour, allowing us to use blast wave physics to determine a likely homogeneous circumburst medium and an emitting electron population power-law index of p=2.9+/-0.1. We suggest the early-time radio flare is likely due to weak interstellar scintillation (ISS), which boosted the radio afterglow emission above the ATCA sensitivity limit on minute timescales. Using weak ISS relations, we were able to place an upper limit on the size of the blast wave of \\(\\leq6 \\times 10^{16}\\)cm in the plane of the sky, which is consistent with the theoretical forward shock size prediction of \\(8\\times10^{16}\\)cm for GRB 210702A at ~13h post-burst. This represents the earliest ISS size constraint on a GRB blast wave to date, demonstrating the importance of rapid (<1day) radio follow-up of GRBs using several-hour integrations to capture the early afterglow evolution, and to track scintillation over a broad frequency range.
Paper
Multi-epoch Low Radio Frequency Surveys of the Kepler K2 Mission Campaign Fields 3, 4, and 5 with the Murchison Widefield Array
We present Murchison Widefield Array (MWA) monitoring of the Kepler K2 mission Fields 3, 4, and 5 at frequencies of 155 and 186 MHz, from observations contemporaneous with the K2 observations. This work follows from previous MWA and GMRT surveys of Field 1, with the current work benefiting from a range of improvements in the data processing and analysis. We continue to build a body of systematic low frequency blind surveys overlapping with transient/variable survey fields at other wavelengths, providing multi-wavelength data for object classes such as flare stars. From the current work, we detect no variable objects at a surface density above 2e-4 per square degree, at flux densities of ~500 mJy, and observation cadence of days to weeks, representing almost an order of magnitude decrease in measured upper limits compared to previous results in this part of observational parameter space. This continues to show that radio transients at metre and centimetre wavelengths are rare.
Paper