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"Hanna, Andrew"
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Armor wars
\"Technopolis: an amazing domain of science and wonder created by the visionary genius of brothers Tony and Arno Stark. It's a real-life utopia, save for one fact: Every resident must wear armor to protect them from a deadly disease. But this near-paradise may be shattered forever when one of its few super heroes is murdered! As Baron Tony and this domain's Thor--a hammer-wielding Jim Rhodes--race to find out who killed Spyder-Man. Wilson Fisk tightens his grip on the city's underbelly. Will the Kingpin dethrone a certain genius philanthropist playboy--and plunge Technopolis into chaos? As the mystery behind the plight of Technopolis unfolds, cracks in Tony's invincible armor are exposed, and the looming crisis could pit brother against brother.\"-- Page 4 of cover.
Book
Solving the Obesity Crisis in Older Adults with the Mediterranean Diet: Policy Brief
Obesity is a chronic disease classified by excessive accumulation of fat which may impair health. The prevalence of obesity is increasing in most nations worldwide, both developed and developing. At the same time, the aging population is also growing worldwide. In the United States, approximately 38% of adults 60+ years old are obese, with similar trends in Canada and the United Kingdom. Obesity is associated with increased risk of death (mortality) and disease (morbidity) and carries specific risks for older adults, such disability and frailty. It also presents a financial burden.
The Mediterranean Diet (MedDiet) is an extensively studied healthy diet pattern which can be used to combat obesity in older populations. Specifically for older adults, the MedDiet has benefits over other common diets or weight-loss interventions. This policy brief provides suggestions specifically for the Canadian population, though they are general enough to be applied to other countries.
Journal Article
Venom. First host
\"The recent reunion of Eddie Brock and the Venom symbiote has been a shaky one. As their relationship has been fraught with secrets and lies, they have come to struggle as much with each other as with their own violent impulses. Things don't get any easier when the symbiote's long lost first host returns in need of Venom's help--only by reuniting can the two avert cosmic ruin! Can Eddie and the symbiote trust one another long enough to save the galaxy, or will THE FIRST HOST prove to be Venom's undoing?!\"--Provided by publisher.
Book
Avengers Academy : the complete collection. Vol. 2
The Avengers Academy faces Fear Itself! No, not prom night - though they have to survive that too, when the Sinister Six crash the party! We mean actual Fear Itself, as the Serpent's army assaults the Marvel Universe and the squad must battle the possessed, hammer-wielding versions of Titania and the Absorbing Man! Meanwhile, as Speedball returns to the scene of his greatest failure, can he rally the town of Stamford against the Serpent and finally earn forgiveness from its people - or himself? Plus, the students get schooled by a substitute teacher - the Amazing Spider-Man - but their lesson is interrupted by Psycho-Man! And as Hank Pym relocates the Academy to California, they come under attack by...the West Coast Avengers?!
Book
Inducible expression of (pp)pGpp synthetases in Staphylococcus aureus is associated with activation of stress response genes
The stringent response is characterized by the synthesis of the messenger molecules pppGpp, ppGpp or pGpp (here collectively designated (pp)pGpp). The phenotypic consequences resulting from (pp)pGpp accumulation vary among species and can be mediated by different underlying mechanisms. Most genome-wide analyses have been performed under stress conditions, which often mask the immediate effects of (pp)pGpp-mediated regulatory circuits. In Staphylococcus aureus , (pp)pGpp can be synthesized via the RelA-SpoT-homolog, Rel Sau upon amino acid limitation or via one of the two small (pp)pGpp synthetases RelP or RelQ upon cell wall stress. We used RNA-Seq to compare the global effects in response to induction of the synthetase of rel-Syn (coding for the enzymatic region of Rel Sau ) or relQ without the need to apply additional stress conditions. Induction of rel-Syn resulted in changes in the nucleotide pool similar to induction of the stringent response via the tRNA synthetase inhibitor mupirocin: a reduction in the GTP pool, an increase in the ATP pool and synthesis of pppGpp, ppGpp and pGpp. Induction of all three enzymes resulted in similar changes in the transcriptome. However, RelQ was less active than Rel-Syn and RelP, indicating strong restriction of its (pp)pGpp-synthesis activity in vivo . (pp)pGpp induction resulted in the downregulation of many genes involved in protein and RNA/DNA metabolism. Many of the (pp)pGpp upregulated genes are part of the GTP sensitive CodY regulon and thus likely regulated through lowering of the GTP pool. New CodY independent transcriptional changes were detected including genes involved in the SOS response, iron storage (e.g. ftnA , dps ), oxidative stress response (e.g., perR , katA , sodA ) and the psmα1–4 and psmß1-2 operons coding for cytotoxic, phenol soluble modulins (PSMs). Analyses of the ftnA , dps and psm genes in different regulatory mutants revealed that their (pp)pGpp-dependent regulation can occur independent of the regulators PerR, Fur, SarA or CodY. Moreover, psm expression is uncoupled from expression of the quorum sensing system Agr, the main known psm activator. The expression of central genes of the oxidative stress response protects the bacteria from anticipated ROS stress derived from PSMs or exogenous sources. Thus, we identified a new link between the stringent response and oxidative stress in S . aureus that is likely crucial for survival upon phagocytosis.
Journal Article
Teen Titans. Volume 5, The trial of Kid Flash
\"When Titans Fall. He trained under the Dark Knight himself. But then Red Robin stepped out from under the Batman's shadow to start a new team of teenaged heroes like himself. As the Teen Titans, they battled against threats no other, older team could face. He never could have imagined that their greatest threats would come from within. Spinning out of the events of \"Forever Evil,\" the team is lost in the timestream, repeatedly slammed together only to be torn apart again. Superboy has been targeted by the murderous Son of Superman he was cloned from. Raven's deal with her devilish father Trigon--her freedom for the Titans' soul--has almost been sealed. And the carefree crimefighter called Kid Flash is about to be called to account for crimes that defy comprehension. As the trial of the friend and hero they thought they knew nears its dreaded verdict, the Teen Titans will be forced to make a fateful decision. Will they stand together-- or fall apart?\" -- page 4 of cover.
Book
Risk of confounding variables in multivariate analysis
[...]while it has been some months since the original article was published, we would like to bring to your attention a new point to consider: In the Results section, the authors state: “…opioids use was significantly higher in patients affected by NSCLC [Non-Small Cell Lung Cancer] (p < 0.0001), in patients with a worse ECOG PS [Eastern Cooperative Oncology Group Performance Status] (p < 0.0001), in second-line setting subgroup (p = 0.009), in patients taking corticosteroids (p < 0.0001), and in patients with a high tumor burden (p = 0.006)” [1]. Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Drilon A, Wolchok JD, Carvajal RD, McHenry MB, Hosein F, Harbison CT, Grosso JF, Sznol M. Five-year survival and correlates among patients with advanced melanoma, renal cell carcinoma, or non-small cell lung cancer treated with nivolumab.
Journal Article
Batman by Grant Morrison omnibus
\"One of the greatest storytellers of his generation, Grant Morrison's arrival onto the Dark Knight was one of the most hyped debuts in industry history. This collection includes time-spanning epic graphic novels featuring the cataclysmic events of FINAL CRISIS and the introduction of Batman's son, Damian Wayne! These blockbuster stories featured a deconstruction of super hero comics like never before, with challenging, thought-provoking takes on the modern, four-color icons.\"-- Provided by publisher.
Book
Continuous palliative sedation until death: a qualitative study of palliative care clinicians’ experiences
Background
The practice of continuous palliative sedation until death is the subject of much medical and ethical debate, which is reflected in the inconsistency that persists in the literature regarding the definition and indications of palliative sedation.
Aim
This study aims to gain a better understanding of palliative care clinicians’ experiences with continuous palliative sedation.
Design
We conducted a qualitative study based on focus group discussions.
Setting/participants
We conducted six focus groups with a total of 28 palliative care clinicians (i.e., 15 nurses, 12 physicians, and 1 end-of-life doula) from diverse care settings across Canada, where assisted dying has recently been legalized.
Results
An interpretative phenomenological analysis was used to consolidate the data into six key themes: responding to suffering; grappling with uncertainty; adapting care to ensure ongoing quality; grounding clinical practice in ethics; combining medical expertise, relational tact, and reflexivity; and offering an alternative to assisted death.
Conclusions
Interaction with the patient’s family, uncertainty about the patient’s prognosis, the concurrent practice of assisted dying, and the treatment of existential suffering influence the quality of sedation and indicate a lack of clear palliative care guidelines. Nevertheless, clinicians exhibit a reflective and adaptive capacity that can facilitate good practice.
Journal Article