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"Hanson, M.B."
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Epigenetic predictors of maximum lifespan and other life history traits in mammals
2021
Maximum lifespan of a species is the oldest that individuals can survive, reflecting the genetic limit of longevity in an ideal environment. Here we report methylation-based models that accurately predict maximum lifespan (r=0.89), gestational time (r=0.96), and age at sexual maturity (r=0.87), using cytosine methylation patterns collected from over 12,000 samples derived from 192 mammalian species. Our epigenetic maximum lifespan predictor corroborated the extended lifespan in growth hormone receptor knockout mice and rapamycin treated mice. Across dog breeds, epigenetic maximum lifespan correlates positively with breed lifespan but negatively with breed size. Lifespan-related cytosines are located in transcriptional regulatory regions, such as bivalent chromatin promoters and polycomb-repressed regions, which were hypomethylated in long-lived species. The epigenetic estimators of maximum lifespan and other life history traits will be useful for characterizing understudied species and for identifying interventions that extend lifespan.
Feinstein's Husband Involved in Lawsuit for Fraud
2000
Perini Corp, a Massachusetts company controlled by an investment group headed by Sen Dianne Feinstein's (D-CA) husband, banker Richard Blum, has become the focus of a lawsuit alleging massive fraud in the construction of the Los Angeles subway system.
Magazine Article
Time to Snap Out of Victim Culture
2000
Jesse Jackson would have Americans believe that gangsters are victims, while others have applied the term almost as unctuously to gamblers, dope fiends and even Republicans. The culture of victimhood in the 1990s and how it threatens America's national character are discussed.
Magazine Article
Shark Zone
1999
Leading trial lawyers are raking in the money in class-action lawsuits against corporations, but critics say that the trend is not helping individual consumers and may be ruining the judicial system. The havoc being caused by greedy lawyers out to exploit the judicial system is discussed.
Magazine Article
Set-Asides for Insiders Only
1999
Black and white elites profit from minority-contract set-aside programs in San Francisco and Atlanta intended to assist only disadvantaged minority-owned companies.
Magazine Article
China Shaken by Mass Meditation
1999
China has outlawed the meditation movement Falun Gong and imprisoned thousands of its adherents in the worst crackdown on human rights since Tiananmen Square.
Magazine Article
The Violent World of Video Games
1999
The manufacturers of violent video games are under fire in the courts and from Congress for being partially responsible for the recent spree of teenage shootings. A look at the violence being promoted in these games is offered.
Magazine Article
Hollywood's Right Stuff
Though Hollywood makes films filled with sex and violence, it's those films with wholesome content that now make the most money and win the Christian Movieguide Awards. The Christian Film & Television Commission's 7th Annual Movieguide Awards Gala is discussed.
Magazine Article