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The design of adsorbents for rapid, selective extraction of ultra-trace amounts of gold from complex liquids is desirable from both an environmental and economical point of view. However, the development of such materials remains challenging. Herein, we report the fabrication of two vinylene-linked two-dimensional silver(I)-organic frameworks prepared via Knoevenagel condensation. This material enables selective sensing of gold with a low limit of detection of 60 ppb, as well as selective uptake of ultra-trace gold from complex aqueous mixtures including distilled water with 15 competing metal ions, leaching solution of electronic waste (e-waste), wastewater, and seawater. The present adsorbent delivers a gold adsorption capacity of 954 mg g −1 , excellent selectivity and reusability, and can rapidly and selectively extract ultra-trace gold from seawater down to ~20 ppb (94% removal in 10 minutes). In addition, the purity of recovered gold from e-waste reaches 23.8 Karat (99.17% pure). The development of adsorbents for extracting gold from solutions is desirable from an environmental and economical point of view. Here, the authors report two two-dimensional silver(I)‒organic frameworks that enable selective sensing and extraction of gold from aqueous solutions, including seawater and solutions of e-waste.

Src plays a crucial role in many signaling pathways and contributes to a variety of cancers. Therefore, Src has long been considered an attractive drug target in oncology. However, the development of Src inhibitors with selectivity and novelty has been challenging. In the present study, pharmacophore-based virtual screening and molecular docking were carried out to identify potential Src inhibitors. A total of 891 molecules were obtained after pharmacophore-based virtual screening, and 10 molecules with high docking scores and strong interactions were selected as potential active molecules for further study. Absorption, distribution, metabolism, elimination and toxicity (ADMET) property evaluation was used to ascertain the drug-like properties of the obtained molecules. The proposed inhibitor–protein complexes were further subjected to molecular dynamics (MD) simulations involving root-mean-square deviation and root-mean-square fluctuation to explore the binding mode stability inside active pockets. Finally, two molecules (ZINC3214460 and ZINC1380384) were obtained as potential lead compounds against Src kinase. All these analyses provide a reference for the further development of novel Src inhibitors.

We consider the quasinormal modes, quasibound states and superradiant instability of a rotating hairy black hole, which possesses a Horndeski hair as deviation from Kerr black hole, under the perturbation of massive scalar field. With the use of the matrix method, we mainly calculate the eigenfrequencies related to those modes of the perturbation. Under the perturbation of the massless scalar field, the Horndeski hair and spin parameter have significant influences on the quasinormal frequency, but its imaginary part is always finite negative and no unstable mode is found. Under the perturbation of the massive scalar field, we focus on the eigenfrequencies of quasibound states and find the modes of which the imaginary part of eigenfrequencies is positive, indicating that the black hole undergoes superradiant instability. Then we scan the parameters and figure out a diagram in the space of Horndeski hair and spin parameters to distinguish the rotating hairy black hole with superradiant instability from the stable one.

Beach plum ( Prunus maritima ) is an ornamental plant, famous for its strong salt and drought stress tolerance. However, the poor growth rate of transplanted seedlings has seriously restricted its application in salinized soil. This study investigated the effects of inoculation with arbuscular mycorrhizal fungus (AMF), Funneliformis mosseae , and phosphate-solubilizing fungus (PSF), Apophysomyces spartima , on the growth, nutrient (N, P, and K) uptake, and photosynthesis of beach plum under saline (170 mM NaCl) and non-saline (0 mM NaCl) conditions. We aimed to find measures to increase the growth rate of beach plum in saline-alkali land and to understand the reasons for this increase. The results showed that salinization adversely affected colonization by AMF but positively increased PSF populations (increased by 33.9–93.3% over non-NaCl treatment). The dual application of AMF and PSF mitigated the effects of salt stress on all growth parameters and nutrient uptake, significantly for roots (dry weight and P and N contents increased by 91.0%, 68.9%, and 40%, respectively, over non-NaCl treatment). Salinization caused significant reductions in net photosynthetic rate ( P n ), stomatal conductance ( G s ), transpiration rate ( E ), and intercellular CO 2 concentration ( C i ) value, while inoculation with AMF and PSF inoculations significantly abated such reductions. The maximum efficiency of photosystem II (PSII) (F v /F m ), the photochemical quenching coefficient (qP), and the nonphotochemical quenching (NPQ) values were affected little by inoculation with AMF, PSF, or both under non-NaCl treatments. However, plants inoculated with AMF and/or PSF had higher F v /F m , qP, and Ф PSII values (increased by 72.5–188.1%) than the control under NaCl treatment, but not a higher NPQ value. We concluded that inoculation with AMF or PSF increased nutrient uptake and improved the gas-exchange and Chl fluorescence parameters of beach plum under salt stress environment. These effects could be strengthened by the combination of AMF and PSF, especially for nutrient uptake, root growth, and P n , thereby alleviating the deleterious effects of NaCl stress on beach plum growth.

Hepatectomy is an effective therapeutic strategy for many benign and malignant liver diseases, while the complexity of liver anatomy and the difficulty of operation lead to complications after hepatectomy. Among them, post-hepatectomy liver failure (PHLF) is the main factor threatening the life of patients. At present, liver transplantation is an effective approach for PHLF. However, the application of liver transplantation has been largely limited due to the shortage of donors and the high cost of such operation. Therefore, it is urgently necessary to develop a new treatment for PHLF. Mesenchymal stem cells (MSCs) have become a new treatment regimen for liver diseases because of their easy access and low immunogenicity. Our study found that there were some subtle connections between MSCs and liver lipid metabolism in the PHLF model. We used MSC transplantation to treat PHLF induced by 90% hepatectomy. MSC transplantation could restore the mitochondrial function, promote the β-oxidation of fatty acid (FA), and reduce the lipid accumulation of hepatocytes. In addition, interleukin 10 (IL-10), a cytokine with immunoregulatory function, had an important role in lipid metabolism. We also found that MSCs transplantation activated the mammalian target of rapamycin (mTOR) pathway. Therefore, we explored the relationship between mitochondrial damage and lipid metabolism abnormality or PHLF. MSCs improved mitochondrial function and corrected abnormal lipid metabolism by affecting the mTOR pathway in the treatment of PHLF. Collectively, MSC transplantation could be used as a potential treatment for PHLF.

Background. Ganoderma lucidum has certain components with known pharmacological effects, including strengthening immunity and anti-inflammatory activity. G. lucidum seeds inherit all its biological characteristics. G. lucidum spore polysaccharide (GLSP) is the main active ingredient to enhance these effects. However, its specific biological mechanisms are not exact. Our research is aimed at revealing the specific biological mechanism of GLSP to enhance immunity and inhibit the growth of H22 hepatocellular carcinoma cells. Methods. We extracted primary macrophages (Mø) from BALB/c mice and treated them with GLSP (800 μg/mL, 400 μg/mL, and 200 μg/mL) to observe its effects on macrophage polarization and cytokine secretion. We used GLSP and GLSP-intervened macrophage supernatant to treat H22 tumor cells and observed their effects using MTT and flow cytometry. Moreover, real-time fluorescent quantitative PCR and western blotting were used to observe the effect of GLSP-intervened macrophage supernatant on the PI3K/AKT and mitochondrial apoptosis pathways. Results. In this study, GLSP promoted the polarization of primary macrophages to M1 type and the upregulation of some cytokines such as TNF-α, IL-1β, IL-6, and TGF-β1. The MTT assay revealed that GLSP+Mø at 400 μg/mL and 800 μg/mL significantly inhibited H22 cell proliferation in a dose-dependent manner. Flow cytometry analysis revealed that GLSP+Mø induced apoptosis and cell cycle arrest at the G2/M phase, associated with the expression of critical genes and proteins (PI3K, p-AKT, BCL-2, BAX, and caspase-9) that regulate the PI3K/AKT pathway and apoptosis. GLSP reshapes the tumor microenvironment by activating macrophages, promotes the polarization of primary macrophages to M1 type, and promotes the secretion of various inflammatory factors and cytokines. Conclusion. Therefore, as a natural nutrient, GLSP is a potential agent in hepatocellular carcinoma cell treatment and induction of apoptosis.

In this work, the authors demonstrate a novel vertically‐stacked thin film transistor (TFT) architecture for heterogeneously complementary inverter applications, composed of p‐channel polycrystalline silicon (poly‐Si) and n‐channel amorphous indium tungsten oxide (a‐IWO), with a low footprint than planar structure. The a‐IWO TFT with channel thickness of approximately 3‐4 atomic layers exhibits high mobility of 24 cm2 V−1 s−1, near ideally subthreshold swing of 63 mV dec−1, low leakage current below 10−13 A, high on/off current ratio of larger than 109, extremely small hysteresis of 0 mV, low contact resistance of 0.44 kΩ‐µm, and high stability after encapsulating a passivation layer. The electrical characteristics of n‐channel a‐IWO TFT are well‐matched with p‐channel poly‐Si TFT for superior complementary metal–oxide‐semiconductor technology applications. The inverter can exhibit a high voltage gain of 152 V V−1 at low supply voltage of 1.5 V. The noise margin can be up to 80% of supply voltage and perform the symmetrical window. The pico‐watt static power consumption inverter is achieved by the wide energy bandgap of a‐IWO channel and atomically‐thin channel. The vertically‐stacked complementary field‐effect transistors (CFET) with high energy‐efficiency can increase the circuit density in a chip to conform the development of next‐generation semiconductor technology. The 3D monolithic heterogeneous complementary field‐effect transistor (CFET) integrated with polycrystalline silicon (Poly‐Si) and atomically‐thin amorphous indium tungsten oxide (a‐IWO) TFTs for a vertically stack architecture realizes high voltage gain and low‐power logic circuit, showing the high potential to meet the requirements of next‐generation IC technology with a tiny footprint and extremely high chip density.

Single-cell RNA-seq (scRNA-seq) data from multiple species present remarkable opportunities to explore cellular origins and evolution. However, integrating and annotating scRNA-seq data across different species remains challenging due to the variations in sequencing techniques, ambiguity of homologous relationships, and limited biological knowledge. To tackle the above challenges, we introduce CAMEX, a heterogeneous Graph Neural Network (GNN) tool that leverages many-to-many homologous relationships for multi-species integration, alignment, and annotation of scRNA-seq data from multiple species. Notably, CAMEX outperforms state-of-the-art methods integration on various cross-species benchmarking datasets (ranging from one to eleven species). Besides, CAMEX facilitates the alignment of diverse species across different developmental stages, significantly enhancing our understanding of organ and organism origins. Furthermore, CAMEX enables the detection of species-specific cell types and marker genes through cell and gene embedding. In short, CAMEX holds the potential to provide invaluable insights into how evolutionary forces operate across different species at single-cell resolution. Single-cell RNA-sequencing data enable cross-species comparisons, but integrating them remains hard. Here, authors present CAMEX, which leverages many-to-many gene homology to integrate, align, and annotate multi-species single-cell data, revealing both conserved and species-specific cellular characteristics.