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Shadow state : murder, mayhem, and Russia's remaking of the West
\"A thrilling account of how Russia is waging a hidden war against America and the West, using espionage, corruption, fake news, and KGB-style murder.\"-- Jacket.
Accent, listening assessment and the potential for a shared-L1 advantage: A DIF perspective
This paper reports on an investigation of the potential for a shared-L1 advantage on an academic English listening test featuring speakers with L2 accents. Two hundred and twelve second-language listeners (including 70 Mandarin Chinese L1 listeners and 60 Japanese L1 listeners) completed three versions of the University Test of English as a Second Language (UTESL) listening sub-test which featured an Australian English-accented speaker, a Japanese-accented speaker and a Mandarin Chinese-accented speaker. Differential item functioning (DIF) analyses were conducted on data from the tests which featured L2-accented speakers using two methods of DIF detection – the standardization procedure and the Mantel-Haenszel procedure – with candidates matched for ability on the test featuring the Australian English-accented speaker. Findings showed that Japanese L1 listeners were advantaged on a small number of items on the test featuring the Japanese-accented speaker, but these were balanced by items which favoured non-Japanese L1 listeners. By contrast, Mandarin Chinese L1 listeners were clearly advantaged across several items on the test featuring a Mandarin Chinese L1 speaker. The implications of these findings for claims of bias are discussed with reference to the role of speaker accent in the listening construct.
Journal Article
Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo
Only praziquantel is available for treating schistosomiasis, a disease affecting more than 200 million people. Praziquantel-resistant worms have been selected for in the lab and low cure rates from mass drug administration programs suggest that resistance is evolving in the field. Thioredoxin glutathione reductase (TGR) is essential for schistosome survival and a validated drug target. TGR inhibitors identified to date are irreversible and/or covalent inhibitors with unacceptable off-target effects. In this work, we identify noncovalent TGR inhibitors with efficacy against schistosome infections in mice, meeting the criteria for lead progression indicated by WHO. Comparisons with previous in vivo studies with praziquantel suggests that these inhibitors outperform the drug of choice for schistosomiasis against juvenile worms.
Only praziquantel is available for treating schistosomiasis, a disease affecting >200 million people. Here, the authors identify compounds active against schistosome infections meeting the criteria for lead progression indicated by WHO with better activity against juvenile worms than praziquantel.
Journal Article
WikiLeaks : inside Julian Assange's war on secrecy
Traces the history of the online organization WikiLeaks, which released thousands of previously secret or classified documents from numerous government agencies, and examines its impact on world politics and freedom of information.
Book
New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class
Class II Fructose-1,6-bisphosphatases (FBPaseII) (EC: 3.1.3.11) are highly conserved essential enzymes in the gluconeogenic pathway of microorganisms. Previous crystallographic studies of FBPasesII provided insights into various inactivated states of the enzyme in different species. Presented here is the first crystal structure of FBPaseII in an active state, solved for the enzyme from Francisella tularensis ( Ft FBPaseII), containing native metal cofactor Mn 2+ and complexed with catalytic product fructose-6-phosphate (F6P). Another crystal structure of the same enzyme complex is presented in the inactivated state due to the structural changes introduced by crystal packing. Analysis of the interatomic distances among the substrate, product, and divalent metal cations in the catalytic centers of the enzyme led to a revision of the catalytic mechanism suggested previously for class II FBPases. We propose that phosphate-1 is cleaved from the substrate fructose-1,6-bisphosphate (F1,6BP) by T89 in a proximal α-helix backbone ( G88-T89-T90-I91 - T92-S93-K94) in which the substrate transition state is stabilized by the positive dipole of the 〈-helix backbone. Once cleaved a water molecule found in the active site liberates the inorganic phosphate from T89 completing the catalytic mechanism. Additionally, a crystal structure of Mycobacterium tuberculosis FBPaseII ( Mt FBPaseII) containing a bound F1,6BP is presented to further support the substrate binding and novel catalytic mechanism suggested for this class of enzymes.
Journal Article
Defining the language assessment literacy gap : evidence from a parliamentary inquiry
This study identifies a unique context for exploring lay understandings of language testing and, by extension, for characterising the nature of language assessment literacy among non-practitioners, stemming from data in an inquiry into the registration processes and support for overseas trained doctors by the Australian House of Representatives Standing Committee on Health and Ageing. The data comes from Hansard transcripts of public hearings of the inquiry. Sections of the data related to language and language testing (as part of the current registration process for doctors seeking employment in Australia) were identified and coded using a thematic analysis. Findings reveal misconceptions about who is responsible for tests and for decisions based on scores in this context, as well as misconceptions about language testing procedures. Issues also emerge concerning the location of expertise in language and language testing. Discussion of these findings contributes to current debate within the language testing community about where responsibility lies for increasing language assessment literacy among non-practitioner stakeholders and how this might best be achieved. [Author abstract, ed]
Journal Article
Pronunciation assessment
After an extended period of being on the periphery, numerous advancements in the field of second language (L2) pronunciation over the past decade have led to increased activity and visibility for this subfield within applied linguistics research. As Derwing (2010) underscored in her 2009 plenary at the first annual Pronunciation in Second Language Learning and Teaching (PSLLT) conference, a record number of graduate students researching L2 pronunciation and subsequently launching into academic positions at international universities assures L2 pronunciation a bright future in research and teacher training. Other indicators of momentum include the focus of a Language Teaching timeline on the topic of pronunciation (Munro & Derwing 2011), the appearance of multiple encyclopedia volumes or handbooks of pronunciation (e.g. Levis & Munro 2013; Reed & Levis 2015), and the establishment of the specialized Journal of Second Language Pronunciation in 2015, which constitutes a milestone in the professionalization of the field and ‘an essential step toward a disciplinary identity’ (Levis 2015: 1).
Journal Article
Disagreement practices in ELF academic group discussion: verbal, nonverbal and interactional strategies
Academic group work can involve challenging pragmatic acts, and chief among these is, arguably, disagreement. There is little known, however, about how disagreement is realised in ELF academic group discussion tasks, where the tendency towards greater cooperation and mutual support in ELF communication may be at odds with the need to achieve task goals through the expression of an oppositional stance. In addressing this issue, the current study sought to answer the research question: how do postgraduate students in a UK university setting express their disagreement in ELF academic group discussion? Twelve participants from ten different linguacultural backgrounds completed two different simulated discussion tasks: one targeting opinions, and the other consensus decision-making. The same participants also took part in retrospective stimulated-recall interviews using the video-recording of their discussions as a stimulus. Discourse analysis of the transcribed interactions revealed that the ELF participants used a wide range of verbal, nonverbal and interactional strategies in their disagreeing practices. Three salient strategies are presented in detail: focus shifts, complex turn-management (other-initiated disagreement turn dependence and turn-throwing/passing), and the use of gaze. Through these examples, we show that while the discourse produced in group discussion tasks was rich in disagreement, ELF participants used complex linguistic and interactional strategies to avoid explicit displays of their oppositional stance. Results are discussed with a view to developing theory around disagreement in ELF academic contexts.
Journal Article
Diagnostic assessment of reading and listening in a second or foreign language: Elaborating on diagnostic principles
Alderson, Brunfaut and Harding (2014) recently investigated how diagnosis is practised across a range of professions in order to develop a tentative framework for a theory of diagnosis in second or foreign language (SFL) assessment. In articulating this framework, a set of five broad principles were proposed, encompassing the entire enterprise of diagnostic assessment. However, there remain questions about how best to implement these principles in practice, particularly in identifying learners’ strengths and weaknesses in the less well-documented areas of SFL reading and listening. In this paper, we elaborate on the set of principles by first outlining the stages of a diagnostic process built on these principles, and then discussing the implications of this process for the diagnostic assessment of reading and listening. In doing so, we will not only elaborate on the theory of diagnosis with respect to its application in the assessment of these skills, but also discuss the ways in which each construct might be defined and operationalized for diagnostic purposes.
Journal Article