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"Harper, Sarah"
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International handbook on ageing and public policy
This title explores the challenges arising from the ageing of populations across the globe for government, policy makers, the private sector and civil society.
BOOK
Economic and social implications of aging societies
The challenge of global population aging has been brought into sharper focus by the financial crisis of 2008. In particular, growing national debt has drawn government attention to two apparently conflicting priorities: the need to sustain public spending on pensions and health care versus the need to reduce budget deficits. A number of countries are consequently reconsidering their pension and health care provisions, which account for up to 40% of all government spending in advanced economies. Yet population aging is a global phenomenon that will continue to affect all regions of the world. By 2050 there will be the same number of old as young in the world, with 2 billion people aged 60 or over and another 2 billion under age 15, each group accounting for 21%of the world’s population.
Journal Article
5 facts a day. Science
\"Discover 5 facts a day, 5 days a week with this exciting science book for children aged 8-12. With five facts a day, every day of the year, that's more than 1,825 nuggets of knowledge! From rocks to robots, and cells to solar systems, this eye-opening book covers more than 250 different science topics in an easy-to-read, entertaining, and bite-sized way to build on your knowledge as you go. Enjoy learning something new every day or just dip in and out for fun\"-- Provided by publisher.
BOOK
Commercial fisher perceptions illuminate a need for social justice considerations in navigating climate change impacts on fisheries systems
Climate change will amplify stress on marine systems already challenged by conflicts and inequities relating to fisheries access, management decisions, and ocean uses across sectors. Understanding how those most connected to fisheries perceive the risks associated with climate change is critical to developing effective responses and establishing management priorities. Adaptation planning efforts may be hindered by perceptions of unequal or unfair distribution of resources and the processes in place to manage them. In contrast, adaptation planning that is more inclusive, transparent, and addresses social dimensions and perceptions of fisheries is more likely to garner support from fishers and fishing communities broadly. We elicited fisher perceptions of climate change impacts on fisheries, and responses to these impacts, through an online survey of commercial fishers in Canada’s Pacific region. The survey highlights substantial concern for climate change, the impacts it will have on fishers’ livelihoods and well-being, and some of the key challenges that may interfere with the ability of fishers and fisheries management to adapt. We frame the findings of the survey drawing from concepts of social justice, focusing on distributive and procedural justice, as necessary considerations, and context for climate change adaptation planning. Developing plans and processes to respond to climate change impacts on fisheries requires not only understanding ecological impacts and challenges, but also the social and institutional considerations that could help or hinder efforts to respond effectively and equitably to a changing ocean.
Journal Article
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
Functional genomics approaches can overcome limitations—such as the lack of identification of robust targets and poor clinical efficacy—that hamper cancer drug development. Here we performed genome-scale CRISPR–Cas9 screens in 324 human cancer cell lines from 30 cancer types and developed a data-driven framework to prioritize candidates for cancer therapeutics. We integrated cell fitness effects with genomic biomarkers and target tractability for drug development to systematically prioritize new targets in defined tissues and genotypes. We verified one of our most promising dependencies, the Werner syndrome ATP-dependent helicase, as a synthetic lethal target in tumours from multiple cancer types with microsatellite instability. Our analysis provides a resource of cancer dependencies, generates a framework to prioritize cancer drug targets and suggests specific new targets. The principles described in this study can inform the initial stages of drug development by contributing to a new, diverse and more effective portfolio of cancer drug targets.
In a screen of 324 human cancer cell lines and utilising a systematic target prioritization framework, the Werner syndrome ATP-dependent helicase is shown to be a synthetic lethal target in tumours from multiple cancer types with microsatellite instability, providing a new target for cancer drug development.
Journal Article
Valuing invisible catches: Estimating the global contribution by women to small-scale marine capture fisheries production
The role that women play in fisheries around the world is receiving increasing international attention yet the contributions by women to fisheries catches continues to be overlooked by society, industry and policy makers. Here, we address this lack of visibility with a global estimation of small-scale fisheries catches by women. Our estimates reveal that women participate in small-scale fishing activities in all regions of the world, with approximately 2.1 million (± 86,000) women accounting for roughly 11% (± 4%) of participants in small-scale fishing activities, i.e., catching roughly 2.9 million (± 835,000) tonnes per year of marine fish and invertebrates. The landed value of the catch by women is estimated at USD 5.6 billion (± 1.5 billion), with an economic impact of USD 14.8 billion per year (± 4 billion), which is equivalent to 25.6 billion real 2010 dollars (± 7.2 billion). These catches are mostly taken along the shoreline, on foot, or from small, non-motorized vessels using low-technology, low-emission gears in coastal waters. Catches taken by women are often for home consumption, and thus considered part of the subsistence sub-sector. However, in many contexts, women also sell a portion of their catch, generating income for themselves and their families. These findings underscore the significant role of women as direct producers in small-scale fisheries value chains, making visible contributions by women to food and livelihood security, globally.
Journal Article
Educational differentials in the realisation of fertility intentions: Is sub-Saharan Africa different?
The gap between fertility outcomes and fertility ideals is notably higher in sub-Saharan Africa (SSA) than elsewhere, relating to both under- and overachievement of fertility ideals. We consider the extent to which the relationship between fertility ideals and fertility outcomes is related to educational achievement. Further, we consider if these educational differentials are the same or different in SSA, and thereby consider the extent to which increasing levels of education in SSA may decrease fertility.
We use 227 Demographic and Health Surveys (DHSs) from 58 countries worldwide to look at population- level measures of the mismatch between fertility ideals and fertility outcomes. Population level measures are used to assess whether the correspondence between fertility intentions and achievements differ by level of education. We then look at the individual-level determinants of both under- and overachieving fertility intentions. Data from the most recent DHS in 54 of the original countries is used for the individual level analysis, with five countries excluded due to the most recent available survey being out of date.
An average of 40% of women in SSA underachieve their stated fertility intentions compared to 26% in non-SSA countries. Furthermore, compared to other LMICs, higher levels of education are not related to better correspondence between fertility intentions and outcomes in SSA. In Middle/Western Africa countries, on average, 48% of women with secondary or higher education have fewer children than their ideal, compared to just 24% who have more children than their ideal.
We argue that the phenomenon of underachieving fertility ideals (or unrealized fertility) may be of particular importance for the ongoing fertility transition throughout SSA, especially as more highly educated groups do not appear to be following the patterns observed elsewhere.
Journal Article
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals and, in particular, the influence of common genetic variants during this process has not been characterised. Here, we exploit human iPS cell lines from 125 donors, a pooled experimental design, and single-cell RNA-sequencing to study population variation of endoderm differentiation. We identify molecular markers that are predictive of differentiation efficiency of individual lines, and utilise heterogeneity in the genetic background across individuals to map hundreds of expression quantitative trait loci that influence expression dynamically during differentiation and across cellular contexts.
Studying the genetic effects on early stages of human development is challenging due to a scarcity of biological material. Here, the authors utilise induced pluripotent stem cells from 125 donors to track gene expression changes and expression quantitative trait loci at single cell resolution during in vitro endoderm differentiation.
Journal Article
How population change will transform our world
In How Population Will Transform Our World, Sarah Harper looks at fertility rates and age structures of populations in different regions of the world against the backdrop of urbanization and climate change, drawing out the profound implications and challenges for societies, economies, and the environment in the decades to come.
eBook
Translanguaging and teacher authority
The purpose of the paper is to understand the connection between teacher authority and children’s language use. The data presented here was pulled from two large data sources: a set of case-studies in Grades 4 to 6 classrooms with multilingual children who were new to Canada and learning to read and write for the first time and qualitative research in a teacher education program preparing teacher candidates to educate multilingual students. Findings suggest that children translanguage in liminal spaces outside of the teachers’ authority and that multilingual students that were asked to translanguage in English authority classrooms had negative experiences.
Journal Article