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The scientific advances during the 1970ies and 1980ies within the field of dopaminergic neurotransmission enabled the development of a pharmacophore that became the template for design and synthesis of dopamine D 2 agonists during the following four decades. A major drawback, however, is that this model fails to accommodate certain classes of restrained dopamine D 2 agonists including ergoline structures. To accommodate these, a revision of the original model was required. The present study has addressed this by an extension of the original model without compromising its obvious qualities. The revised pharmacophore contains an additional hydrogen bond donor feature, which is required for it to accommodate ergoline structures in a low energy conformation and in accordance with the steric restrictions dictated by the original model. The additional pharmacophore feature suggests ambiguity in the binding mode for certain compounds, including a series of ergoline analogues, which was reported recently. The ambiguity was confirmed by docking to a homology model of the D 2 receptor as well as by pharmacological characterization of individual enantiomers of one of the analogues. The present research also addresses the potential of designing ligands that interact with the receptor in a large, distal cavity of the dopamine D 2 receptor that has not previously been studied systematically. The pharmacological data indicate that this area may be a major determinant for both the dopamine D 2 affinity and efficacy, which remains to be explored in future studies.

Observations of a stellar occultation by (10199) Chariklo, a minor body that orbits the Sun between Jupiter and Neptune, reveal that it has a ring system, a property previously observed only for the four giant planets of the Solar System. Tiny Chariklo has its own ring system Observations of a stellar occultation by (10199) Chariklo, a Centaur-class outer-system asteroid orbiting between Saturn and Uranus, reveal that it has a ring system, a feature previously observed only for the four giant planets. Chariklo, with a diameter of about 250 km, has two narrow and dense rings separated by a small gap, probably due to the presence of a (yet-to-be-found) kilometre-sized satellite. The discovery of these rings raises questions about the formation and dynamical evolution of planetary rings. For one thing, it seems likely that planetary rings are much more common than previously thought. Hitherto, rings have been found exclusively around the four giant planets in the Solar System 1 . Rings are natural laboratories in which to study dynamical processes analogous to those that take place during the formation of planetary systems and galaxies. Their presence also tells us about the origin and evolution of the body they encircle. Here we report observations of a multichord stellar occultation that revealed the presence of a ring system around (10199) Chariklo, which is a Centaur—that is, one of a class of small objects orbiting primarily between Jupiter and Neptune—with an equivalent radius of 124   9 kilometres (ref. 2 ). There are two dense rings, with respective widths of about 7 and 3 kilometres, optical depths of 0.4 and 0.06, and orbital radii of 391 and 405 kilometres. The present orientation of the ring is consistent with an edge-on geometry in 2008, which provides a simple explanation for the dimming 3 of the Chariklo system between 1997 and 2008, and for the gradual disappearance of ice and other absorption features in its spectrum over the same period 4 , 5 . This implies that the rings are partly composed of water ice. They may be the remnants of a debris disk, possibly confined by embedded, kilometre-sized satellites.

Deployment of the prototype node of the SONG project took place in April 2012 at Observatorio del Teide (Canary Islands). Its key instrument (echelle spectrograph) was installed and operational a few weeks later while its 1 m feeding telescope suffered a considerable delay to meet the required specifications. Using a fibre-feed, solar light could be fed to the spectrograph and we carried out a 1-week observing campaign in June 2012 to evaluate its performance for measuring precision radial velocities. In this work we present the first results of this campaign by comparing the sensitivity of the SONG spectrograph with other helioseismology reference instruments (Mark-I and GOLF) when simultaneous data are considered.

Issue Title: Special Issue in Honor of Povl Krogsgaard-Larsen The scientific advances during the 1970ies and 1980ies within the field of dopaminergic neurotransmission enabled the development of a pharmacophore that became the template for design and synthesis of dopamine D^sub 2^ agonists during the following four decades. A major drawback, however, is that this model fails to accommodate certain classes of restrained dopamine D^sub 2^ agonists including ergoline structures. To accommodate these, a revision of the original model was required. The present study has addressed this by an extension of the original model without compromising its obvious qualities. The revised pharmacophore contains an additional hydrogen bond donor feature, which is required for it to accommodate ergoline structures in a low energy conformation and in accordance with the steric restrictions dictated by the original model. The additional pharmacophore feature suggests ambiguity in the binding mode for certain compounds, including a series of ergoline analogues, which was reported recently. The ambiguity was confirmed by docking to a homology model of the D^sub 2^ receptor as well as by pharmacological characterization of individual enantiomers of one of the analogues. The present research also addresses the potential of designing ligands that interact with the receptor in a large, distal cavity of the dopamine D^sub 2^ receptor that has not previously been studied systematically. The pharmacological data indicate that this area may be a major determinant for both the dopamine D^sub 2^ affinity and efficacy, which remains to be explored in future studies.[PUBLICATION ABSTRACT]

Obtain time-series photometry of the very crowded central regions of Galactic globular clusters with better angular resolution than previously achieved with conventional CCDs on ground-based telescopes to complete, or improve, the census of the variable star population in those stellar systems. Images were taken using the Danish 1.54-m Telescope at the ESO observatory at La Silla in Chile. The telescope was equipped with an electron-multiplying CCD and the short-exposure-time images obtained (10 images per second) were stacked using the shift-and-add technique to produce the normal-exposure-time images (minutes). Photometry was performed via difference image analysis. Automatic detection of variable stars in the field was attempted. The light curves of 12541 stars in the cores of 10 globular clusters were statistically analysed in order to automatically extract the variable stars. We obtained light curves for 31 previously known variable stars (3 L, 2 SR, 20 RR Lyrae, 1 SX Phe, 3 cataclysmic variables, 1 EW and 1 NC) and we discovered 30 new variables (16 L, 7 SR, 4 RR Lyrae, 1 SX Phe and 2 NC).

We show the benefits of using Electron-Multiplying CCDs and the shift-and-add technique as a tool to minimise the effects of the atmospheric turbulence such as blending between stars in crowded fields and to avoid saturated stars in the fields observed. We intend to complete, or improve, the census of the variable star population in globular cluster NGC~6715. Our aim is to obtain high-precision time-series photometry of the very crowded central region of this stellar system via the collection of better angular resolution images than has been previously achieved with conventional CCDs on ground-based telescopes. Observations were carried out using the Danish 1.54-m Telescope at the ESO La Silla observatory in Chile. The telescope is equipped with an Electron-Multiplying CCD that allowed to obtain short-exposure-time images (ten images per second) that were stacked using the shift-and-add technique to produce the normal-exposure-time images (minutes). The high precision photometry was performed via difference image analysis employing the DanDIA pipeline. We attempted automatic detection of variable stars in the field. We statistically analysed the light curves of 1405 stars in the crowded central region of NGC~6715 to automatically identify the variable stars present in this cluster. We found light curves for 17 previously known variable stars near the edges of our reference image (16 RR Lyrae and 1 semi-regular) and we discovered 67 new variables (30 RR Lyrae, 21 long-period irregular, 3 semi-regular, 1 W Virginis, 1 eclipsing binary, and 11 unclassified). Photometric measurements for these stars are available in electronic form through the Strasbourg Astronomical Data Centre.

We report on the implemented design of a two-colour instrument based on electron multiplying CCD (EMCCD) detectors. This instrument is currently installed at the Danish 1.54m telescope at ESO's La Silla Observatory in Chile, and will be available at the SONG (Stellar Observations Network Group) 1m telescope node at Tenerife and at other SONG nodes as well. We present the software system for controlling the two-colour instrument and calibrating the high frame-rate imaging data delivered by the EMCCD cameras. An analysis of the performance of the Two-Colour Instrument at the Danish telescope shows an improvement in spatial resolution of up to a factor of two when doing shift-and-add compared with conventional imaging, and that it is possible to do high-precision photometry of EMCCD data in crowded fields. The Danish telescope, which was commissioned in 1979, is limited by a triangular coma at spatial resolutions below 0.5\" and better results will thus be achieved at the near diffraction limited optical system on the SONG telescopes, where spatial resolutions close to 0.2\" have been achieved. Regular EMCCD operations have been running at the Danish telescope for several years and have produced a number of scientific discoveries, including microlensing detected exoplanets, the detection of previously unknown variable stars in dense globular clusters and the discovery of two rings around the small asteroid-like object (10199) Chariklo.

In this paper, we present the analysis of time-series observations from 2013 and 2014 of five metal rich ([Fe/H] \\(>\\) -1) globular clusters: NGC~6388, NGC~6441, NGC~6528, NGC~6638, and NGC~6652. The data have been used to perform a census of the variable stars in the central parts of these clusters. The observations were made with the electron multiplying CCD (EMCCD) camera at the Danish 1.54m Telescope at La Silla, Chile, and they were analysed using difference image analysis (DIA) to obtain high-precision light curves of the variable stars. It was possible to identify and classify all of the previously known or suspected variable stars in the central regions of the five clusters. Furthermore, we were able to identify, and in most cases classify 48, 49, 7, 8, and 2 previously unknown variables in NGC~6388, NGC~6441, NGC~6528, NGC~6638, and NGC~6652, respectively. Especially interesting is the case of NGC~6441, for which the variable star population of about 150 stars has been thoroughly examined by previous studies, including a Hubble Space Telescope study. In this paper we are able to present 49 new variable stars for this cluster, of which one (possibly two) are RR Lyrae stars, two are W Virginis stars, and the rest are long period semi-regular/irregular variables on the red giant branch. We have also detected the first double mode RR Lyrae in the cluster.

Aims: We present 11 high-precision photometric transit observations of the transiting super-Earth planet GJ1214b. Combining these data with observations from other authors, we investigate the ephemeris for possible signs of transit timing variations (TTVs) using a Bayesian approach. Methods: The observations were obtained using telescope-defocusing techniques, and achieve a high precision with random errors in the photometry as low as 1mmag per point. To investigate the possibility of TTVs in the light curve, we calculate the overall probability of a TTV signal using Bayesian methods. Results: The observations are used to determine the photometric parameters and the physical properties of the GJ1214 system. Our results are in good agreement with published values. Individual times of mid-transit are measured with uncertainties as low as 10s, allowing us to reduce the uncertainty in the orbital period by a factor of two. Conclusions: A Bayesian analysis reveals that it is highly improbable that the observed transit times is explained by TTV, when compared with the simpler alternative of a linear ephemeris.

We report the first asteroseismic results obtained with the Hertzsprung SONG Telescope from an extensive high-precision radial-velocity observing campaign of the subgiant muHerculis. The data set was collected during 215 nights in 2014 and 2015. We detected a total of 49 oscillation modes with l values from 0 to 3, including some l = 1 mixed modes. Based on the rotational splitting observed in l = 1 modes, we determine a rotational period of 52 days and a stellar inclination angle of 63 degrees. The parameters obtained through modeling of the observed oscillation frequencies agree very well with independent observations and imply a stellar mass between 1.11 and 1.15M_sun and an age of 7.8+/-0.4 Gyr. Furthermore, the high-quality data allowed us to determine the acoustic depths of the He II ionization layer and the base of the convection zone.