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"Harris, M."
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The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis
The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specific correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies.
The MEDLINE database (1,946 to present) was searched, and only controlled trials or trials with an established effective comparator that compared both SI and GE were included.
Studies were identified for metoclopramide (n=6), domperidone (n=6), cisapride (n=14), erythromycin (n=3), botulinum toxin (n=2), and levosulpiride (n=3). Even though most drugs concomitantly improved symptoms and accelerated GE, no study reported a significant correlation between SI and GE. Moreover, a correlation analysis over all studies using meta-regression did not show a significant relationship between SI and GE. Our findings need to be qualified by inconsistencies in study methods, which is a limitation but also suggests that our findings are robust to methodological factors.
In this review, no evidence of a relationship between SI and GE was identified for different drugs used for the treatment of gastroparesis. This finding questions the use of GE measurement to direct drug development for gastroparesis.
Journal Article
Manhattan’s Street Trees: An Unfinished Public Health Story
Stephen Smith launched a 40-year effort to bring trees to New York City streets in 1872, the year he founded the American Public Health Association (APHA). Smith argued that street trees would mitigate the adverse health effects of Manhattan’s summer heat and help purify the air. The young APHA endorsed Smith’s position and gave trees a prominent role in urban sanitation, but public health turned away from trees and urban reform movements as it adopted a biomedical public health model in the late 19th century. Nevertheless, Smith wrote and campaigned for a successful 1902 law requiring the New York City Parks Department to assume management of street trees in the name of public health. He then led a 1914 campaign to force the department to uphold his law. New York’s street tree program has had an erratic trajectory, but it now generally follows Smith’s vision. Public health could play a bigger role in creating greener cities and mitigating climate change with more field research and the health in all policies approach that Smith used to bring trees to Manhattan’s streets in 1914. ( Am J Public Health. 2025;115(1):66–74. https://doi.org/10.2105/AJPH.2024.307856 )
Journal Article
Video as method
\"Perhaps the greatest strength of choosing video as a method for social research is its flexible and almost limitless potential for gathering, analyzing, writing up, and disseminating the research findings. Understanding the rich potential of video as both method and methodology is a process inextricably linked to epistemological, study design, analysis, and dissemination choices. As technology and media have evolved, video has become a primary tool of presenting information and ideas and a means of culture making. Video as Method provides researchers with a guide to understanding, designing, conducting, and disseminating video-based research, and the rapid proliferation of approaches, uses, and designs now available. In the face of large data sets, and the great range of types and uses of video as an effective research tool, many researchers struggle to know how best to represent both video-based methodologies and research findings. Anne Harris provides in-depth examples in each chapter, and guides readers step-by-step through the chapter topics in a methodical fashion that mirrors the research journey\"-- Provided by publisher.
Book
Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability
Amino acid auxotrophies are prevalent among bacteria. They can govern ecological dynamics in microbial communities and indicate metabolic cross-feeding interactions among coexisting genotypes. Despite the ecological importance of auxotrophies, their distribution and impact on the diversity and function of the human gut microbiome remain poorly understood. This study performed the first systematic analysis of the distribution of amino acid auxotrophies in the human gut microbiome using a combined metabolomic, metagenomic, and metabolic modeling approach. Results showed that amino acid auxotrophies are ubiquitous in the colon microbiome, with tryptophan auxotrophy being the most common. Auxotrophy frequencies were higher for those amino acids that are also essential to the human host. Moreover, a higher overall abundance of auxotrophies was associated with greater microbiome diversity and stability, and the distribution of auxotrophs was found to be related to the human host’s metabolome, including trimethylamine oxide, small aromatic acids, and secondary bile acids. Thus, our results suggest that amino acid auxotrophies are important factors contributing to microbiome ecology and host-microbiome metabolic interactions.
Journal Article
Improving the use of species distribution models in conservation planning and management under climate change
Choice of variables, climate models and emissions scenarios all influence the results of species distribution models under future climatic conditions. However, an overview of applied studies suggests that the uncertainty associated with these factors is not always appropriately incorporated or even considered. We examine the effects of choice of variables, climate models and emissions scenarios can have on future species distribution models using two endangered species: one a short-lived invertebrate species (Ptunarra Brown Butterfly), and the other a long-lived paleo-endemic tree species (King Billy Pine). We show the range in projected distributions that result from different variable selection, climate models and emissions scenarios. The extent to which results are affected by these choices depends on the characteristics of the species modelled, but they all have the potential to substantially alter conclusions about the impacts of climate change. We discuss implications for conservation planning and management, and provide recommendations to conservation practitioners on variable selection and accommodating uncertainty when using future climate projections in species distribution models.
Journal Article
Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis
Body weight loss of ≥ 10% improves the metabolic derangements and liver disease in the majority of non-alcoholic steatohepatitis (NASH) patients, suggesting metabolic modulators may be effective in controlling disease. The pharmacodynamics of ALT-801, a GLP-1/glucagon receptor dual agonist optimized for NASH and weight loss, were compared to semaglutide (GLP-1 receptor agonist) and elafibranor (peroxisome proliferator-activated receptor, PPAR-α/δ, agonist) in a biopsy-confirmed, diet-induced obese (DIO) mouse model of NASH (DIO-NASH). Male C57BL/6J mice were fed Amylin Liver NASH (AMLN) diet for 32 weeks. Animals with biopsy-confirmed steatosis and fibrosis received ALT-801, semaglutide, elafibranor, or vehicle daily for 12 weeks while maintained on the AMLN diet. Study endpoints included body and liver weight, liver and plasma total cholesterol and triglycerides, plasma aminotransferases, histological analysis of liver steatosis, inflammation (galectin-3) and fibrosis (collagen type 1 alpha 1), and evaluation of individual animal changes in composite Non-alcoholic Fatty Liver Disease Activity Score (NAS), and fibrosis stage. ALT-801 demonstrated significant reductions in body weight (approx. 25%), plasma aminotransferases, plasma total cholesterol and liver triglycerides/total cholesterol in conjunction with improved liver steatosis, with greater reductions (
p
< 0.05) compared to semaglutide and elafibranor. ALT-801 significantly reduced the inflammation marker galectin-3 and the fibrosis marker collagen type 1 alpha 1 vs. vehicle (
p
< 0.05), with ALT-801 producing greater reductions in galectin-3 vs. elafibranor (
p
< 0.05). Importantly, all animals treated with ALT-801 significantly improved composite NAS compared to the active controls. This study provides evidence for a potential role for ALT-801 in the therapeutic treatment of NASH.
Journal Article