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\"A memoir of the author's upbringing by her grandparents in a fading mansion above Sunset Boulevard in Los Angeles, California\"-- Provided by publisher.

Policy makers who embrace market-based approaches to environmental regulation, typically eschew carbon taxes in favor of the political advantages of cap and trade, which offers lower visibility of costs to consumers and the opportunity to allocate valuable permits freely to industry. Against this backdrop, the article examines two surprising proposals for carbon taxes, by the government of British Columbia (BC) and by the federal Liberal Party of Canada. Both reflected a triumph of party leaders' normative \"good policy\" motives over \"good politics.\" The BC tax alone succeeded first because it was adopted by a party already in government. Second, the onset of a recession before the next elections shifted voters' attention to the economy, which advantaged the BC Liberals but disadvantaged their federal counterparts. However, proposals for carbon taxes were unpopular in both jurisdictions, offering a cautionary tale concerning the fate of politicians' normative commitments absent electoral backing. Reprinted by permission of Wiley-Blackwell

1. Our aim was to explore plant-soil feedback in mixed grassland communities and its significance for plant productivity and community composition relative to abiotic factors of soil type and fertility. 2. We carried out a 4-year, field-based mesocosm experiment to determine the relative effects of soil type, historic management intensity and soil conditioning by a wide range of plant species of mesotrophic grassland on the productivity and evenness of subsequent mixed communities. 3. The study consisted of an initial soil conditioning phase, whereby soil from two locations each with two levels of management intensity was conditioned with monocultures of nine grassland species, and a subsequent feedback phase, where mixed communities of the nine species were grown in conditioned soil to determine relative effects of experimental factors on the productivity and evenness of mixed communities and individual plant species performance. 4. In the conditioning phase of the experiment, individual plant species differentially influenced soil microbial communities and nutrient availability. However, these biotic effects were much less important as drivers of soil microbial properties and nutrient availability than were abiotic factors of soil type and fertility. 5. Significant feedback effects of conditioning were detected during the second phase of the study in terms of individual plant growth in mixed communities. These feedback effects were generally independent of soil type or fertility, and were consistently negative in nature. In most cases, individual plant species performed less well in mixed communities planted in soil that had previously supported their own species. 6. Synthesis. These findings suggest that despite soil abiotic factors acting as major drivers of soil microbial communities and nutrient availability, biotic interactions in the form of negative feedback play a significant role in regulating individual plant performance in mixed grassland communities across a range of soil conditions.

The life and career of Tina Fey.

Centrosome amplification (CA) is a contributor to carcinogenesis, generating aneuploidy, and chromosome instability. Previous work shows that breast adenocarcinomas have a higher frequency of centrosome defects compared to normal breast tissues. Abnormal centrosome phenotypes are found in pre-malignant lesions, suggesting an early role in breast carcinogenesis. However, the role of CA in breast cancers remains elusive. Identification of pathways and regulatory molecules involved in the generation of CA is essential to understanding its role in breast tumorigenesis. We established a breast cancer model of CA using Her2-positive cells. Our goal was to identify centrosome cycle molecules that are deregulated by aberrant Her2 signaling and the mechanisms driving CA. Our results show some Her2+ breast cancer cell lines harbor both CA and binucleation. Abolishing the expression of Cdk4 abrogated both CA and binucleation in these cells. We also found the source of binucleation in these cells to be defective cytokinesis that is normalized by downregulation of Cdk4. Protein levels of Nek2 diminish upon Cdk4 knockdown and vice versa, suggesting a molecular connection between Cdk4 and Nek2. Knockdown of Nek2 reduces CA and binucleation in this model while its overexpression further enhances centrosome amplification. We conclude that CA is modulated through Cdk4 and Nek2 signaling and that binucleation is a likely source of CA in Her2+ breast cancer cells.

\"This book demonstrates how to develop and engage in successful academic collaborations that are both practical and sustainable across campuses and within local communities. Authored by experienced writing program administrators, this edited collection includes a wide range of information addressing collaborative partnerships and projects, theoretical explorations of collaborative praxis, and strategies for sustaining collaborative initiatives. Contributors offer case studies of writing program collaborations and honestly address both the challenges of academic collaboration and the hallmarks of successful partnerships.\"--Publisher description.

Background The association between diet, symptoms and health related quality of life in children and young people with Juvenile idiopathic arthritis (JIA) is not clearly understood. The objectives of this systematic review and meta-analysis were to explore the evidence for a relationship between nutritional status, dietary intake, arthritis symptoms, disease activity and health-related quality of life in children and young people with JIA considering both observational and interventional studies separately. Method The databases PubMed, CINAHL, PsycINFO, Web of Science and Cochrane were searched in October 2019, updated in September 2020 and October 2021. Searches were restricted to English language, human and age (2–18 years old). Studies were included if they measured the effect of dietary supplements, vitamins or minerals, or diet in general, on quality of life and/ or arthritis symptom management. Two researchers independently screened titles and abstracts. Full texts were sourced for relevant articles. PRISMA guidelines were used for extracting data. For variables (vitamin D and disease activity), a random-effects meta-analysis model was performed. Two authors using a standardized data extraction form, extracted data independently. Results 11,793 papers were identified through database searching, 26 studies met our inclusion criteria with 1621 participants. Overall studies quality were fair to good. Results from controlled trial and case control studies with total 146 JIA patients, found that Ɯ-3 PUFA improved the mean active joint count ( p  < 0.001), Juvenile Arthritis Disease Activity Score (JADAS-27) ( p  < 0.001) and immune system (≤ 0.05). Furthermore, n-3 and n-6 PUFAs have a negative correlation with CRP (C-reactive protein) and ESR (erythrocyte sedimentation rate) ( p  < 0.05). Improvement in JIA symptoms were observed in one case, one pilot and one exploratory study with overall 9 JIA patients after receiving Exclusive Enteral Nutrition (EEN) which contains protein and what is required for a complete nutrition, A clinical trial study found Kre-Celazine nutrition (composed of a proprietary alkali buffered, creatine monohydrate and fatty acids mixture) in 16 JIA patients improved symptoms of JIA. No association was found between vitamin D and disease activity from three studies. Height and weight values in relation to healthy controls varied across studies ( p  = 0.029). Conclusions We were only able to include small studies, of lower design hierarchy, mainly pilot studies. We found some evidence of lower height and weight across studies in JIA, but were unable to confirm an association between diet, symptoms and health-related quality of life in children and young people with JIA. Well-designed, carefully measured and controlled interventional studies of dietary patterns in combination with important contributing factors such as medication and lifestyle behaviours, including physical activity, are required to determine the impact of diet in improving symptoms and growth patterns in children and young people with JIA, with an aim to improve the quality of their life. Trial registration PROSPERO [CRD42019145587].

Background Patients experiencing a mental health crisis often present to the emergency department and are admitted to an inpatient facility for treatment. This can cause incontinuity in care, increased costs, and may worsen clinical outcomes compared to treatment in the outpatient setting. An innovative behavioral health clinic (BHC) was established to provide a number of critical mental health services such as individual therapy, crisis stabilization, partial hospitalization, substance abuse intensive outpatient services, specialized intensive adult group therapy, medication management (including long-acting injectable antipsychotic administration), and a peer living room. The primary outcome of this study was to assess the impact of the BHC on length of stay (LOS), psychiatric rehospitalization rate, and all-cause emergency department (ED) visits. The secondary outcome was to analyze the interaction of various patient characteristics with the primary outcome. Methods The study site was a community-based health system in the southeastern United States. A retrospective review of medical records was performed for adult patients with a psychiatric hospitalization in 2019 (pre-BHC) and 2022 (post-BHC). Primary outcomes were analyzed using Chi-Square testing and Mann-Whitney U testing. Secondary outcomes were analyzed using Poisson and logistic regression modeling. This study was deemed exempt from review by the health system and university institutional review boards. Results Following the establishment of the BHC, mean LOS was significantly longer (+ 1.26 days, p  = 0.001) and there was a statistically significant reduction in 30-day (-10.3%, p  < 0.001) and 1-year (-28.2%, p  < 0.001) rehospitalization as well as 30-day (-8.3%, p  = 0.004) and 1-year (-13.5%, p  < 0.001) ED visit rate. A diagnosis of schizophrenia and prescription of a LAI were associated with a significant increase in LOS, while being uninsured was associated with a significant decrease. Male gender and a diagnosis of schizophrenia were associated with a significant increase in ED visits, while identifying as White or Caucasian, being uninsured or carrying private insurance, and prescription of a LAI were associated with a significant decrease. Conclusions The implementation of an innovative BHC positively impacted patient care outcomes in the study population. Patient characteristics were identified which independently interacted with these outcomes.

Revenue recycling through lump-sum dividends may help mitigate public opposition to carbon taxes, yet evidence from real-world policies is lacking. Here we use survey data from Canada and Switzerland, the only countries with climate rebate programmes, to show low public awareness and substantial underestimation of climate rebate amounts in both countries. Information was obtained using a five-wave panel survey that tracked public attitudes before, during and after implementation of Canada’s 2019 carbon tax and dividend policy and a large-scale survey of Swiss residents. Experimental provision of individualized information about true rebate amounts had modest impacts on public support in Switzerland but potentially deleterious effects on support in Canada, especially among Conservative voters. In both countries, we find that perceptions of climate rebates are structured less by informed assessments of economic interest than by partisan identities. These results suggest limited effects of existing rebate programmes, to date, in reshaping the politics of carbon taxation.Carbon tax rebate programmes have received increasing interest with the potential to raise public support for carbon pricing. However, results of online surveys based on existing real-world policies demonstrate such programmes have had limited political impacts to date.