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The southern Murray–Darling Basin (MDB) is particularly vulnerable to salinity problems. Much of the Basin’s landscape and underlying groundwater is naturally saline with groundwater not being suitable for human or irrigation use. Since European settlement in the early 1800s, two actions—the clearance of deep-rooted native vegetation for dryland agriculture and the development of irrigation systems on the Riverine Plains and Mallee region—have resulted in more water now entering the groundwater systems, resulting in mobilization of the salt to the land surface and to rivers. While salinity has been a known issue since the 1960s, it was only in the mid-1980s that was recognized as one of the most significant environmental and economic challenges facing the MDB. Concerted and cooperative action since 1988 by the Commonwealth and Basin state governments under a salinity management approach implemented over the past 30 years has resulted in salinity now being largely under control, but still requiring on-going active management into the future. The approach has involved the development of three consecutive salinity strategies governing actions from 1988 to 2000, from 2001 to 2015, and the most recent from 2016 to 2030. The basis of the approach and all three strategies is an innovative, world-leading salinity management framework consisting of: An agreed salinity target; joint works and measures to reduce salt entering the rivers; and an agreed accountability and governance system consisting of a system of salinity credits to offset debits, a robust and agreed method to quantify the credits and debits, and a salinity register to keep track of credits and debits. This paper first provides background to the salinity issue in the MDB, then reviews the three salinity management strategies, the various actions that have been implemented through these strategies to control salinity, and the role of the recent Basin Plan in salinity management. We then discuss the future of salinity in the MDB given that climate change is forecast to lead to a hotter, drier and more variable climate (particularly more frequent droughts), and that increased salt loads to the River Murray are predicted to come from the lower reaches of the Mallee region. Finally, we identify the key success factors of the program.

Fibrosis is a pathological process with few therapeutic options. Experimental molecules are being developed to counteract the fibrotic effects through TGFβ receptor inhibition. Additionally, phosphodiesterase 5 (PDE5) inhibitors also have anti-fibrotic effects; however, the mechanism of action remains unresolved. IPW5371 is an example of an experimental TGFβ-mediated anti-fibrotic compound, and tadalafil is an example of a PDE5 inhibitor. Irradiation increases the frequency of fibrotic lesions, driven by the activation of the TGFβ pathway. We hypothesized that the TGFβ receptor and PDE5 inhibitor agents would be additive in their ability to prevent fibrosis development in tissues in a sub-lethal whole-body irradiation mouse model. However, the combined use of anti-fibrotic agents, tadalafil and IPW5371, caused increased male mouse mortality associated with ascending and thoracic aortic rupture compared to mice that only received one of the drugs. Following histopathological analysis of the mouse hearts, we also observed that irradiation protected against lesions caused by the combination therapy as non-irradiated male mice had significantly worse outcomes as compared to irradiated male mice, substantiating the drug–drug interaction independent of the radiation effects. This important drug interaction needs further investigation as these agents are developed for anti-fibrosis therapy, and PDE5 inhibitors are commonly prescribed to male patients.

Many rivers in Australia and elsewhere around the world are flow stressed. There is now considerable activity to restore crucial components of the natural flow regime of such rivers—known as environmental flows, but methods underpinning the decision-making often lack rigour and transparency. The restoration of environmental flow regimes is usually determined using historic flow data, available expertise, sometimes ad-hoc compromise between conflicting and spatio-temporally variable water needs, and then implemented through special environmental allocations or water sharing plans. However, ecological flow requirements are poorly integrated into the decision-making process. This paper reports an eco-hydrological Bayesian network model developed to assist in risk assessment and decision-making on improving the flow conditions for Australian Grayling ( Prototroctes maraena ) in the Yarra River in south-eastern Australia. The Yarra environmental flow model was adapted from previous work on Australian Grayling in the Latrobe River system, and contained the same ecological model as for the Latrobe River, but with a new hydrological sub-model developed specifically for the Yarra River. The model was used to assess the relative ecological benefits (to Australian Grayling) of restoring specific components of the natural flow regime, in particular autumn freshes and spring freshes.

Missions into deep space will expose astronauts to the harsh space environment, and the degenerative tissue effects of space radiation are largely unknown. To assess the risks, in this study, male BALB/c mice were exposed to 500 mGy 5-ion simulated GCR (GCRsim) at the NASA Space Radiation Laboratory. In addition, male and female CD1 mice were exposed to GCRsim and administered a diet containing Transforming Growth Factor-beta (TGF-β)RI kinase (ALK5) inhibitor IPW-5371 as a potential countermeasure. An ultrasound was performed to investigate cardiac function. Cardiac tissue was collected to determine collagen deposition, the density of the capillary network, and the expression of the immune mediator toll-like receptor 4 (TLR4) and immune cell markers CD2, CD4, and CD45. In male BALB/c mice, the only significant effects of GCRsim were an increase in the CD2 and TLR4 markers. In male CD1 mice, GCRsim caused a significant increase in total collagens and a decrease in the expression of TLR4, both of which were mitigated by the TGF-β inhibitor diet. In female CD1 mice, GCRsim caused an increase in the number of capillaries per tissue area in the ventricles, which may be explained by the decrease in the left ventricular mass. However, this increase was not mitigated by TGF-β inhibition. In both male and female CD1 mice, the combination of GCRsim and TGF-β inhibition caused changes in left ventricular immune cell markers that were not seen with GCRsim alone. These data suggest that GCRsim results in minor changes to cardiac tissue in both an inbred and outbred mouse strain. While there were few GCRsim effects to be mitigated, results from the combination of GCRsim and the TGF-β inhibitor do point to a role for TGF-β in maintaining markers of immune cells in the heart after exposure to GCR.

Significant progress in environmental flow management has occurred in recent years due to several factors. These include governments committing to environmental flow programs, significant progress in scientific understanding, and environmental flow assessment methods that are cognizant of stakeholder participation and co-design. However, there remain key challenges facing environmental water management. In this paper, we report on a horizon scanning exercise that identified the questions, which, if answered, would deliver much needed progress in the field of environmental water management. We distributed an online survey to ask researchers and practitioners in the field of environmental water management to identify the key questions. The authors then consolidated 268 submitted questions and organized them into key themes. The consolidated list was presented to a workshop of environmental water researchers and practitioners, where attendees were asked to review the questions, vote on the most important, and provide feedback on gaps, issues or overlaps. The breadth of issues facing environmental water management is captured by the six key themes into which questions were classified: (1) Ecological knowledge and environmental flow assessment methods (2) Adaptive management (3) Integrated management and river objectives (4) Knowledge transfer: applying best practice in a global context (5) Community knowledge and engagement, and (6) Active management. These questions provide a roadmap for research and management innovations that will improve the effectiveness of environmental flows programs.

Risk-based methods promise improved decision-making for managing of contaminants, such as salinity, sediments, nutrients, and toxicants, that can adversely affect the ecological condition of aquatic ecosystems. Two aspects of ecological risk assessment (ERA) and management-stakeholder involvement and more quantitative approaches to risk analysis-are particularly challenging. Stakeholder involvement is crucial both in the risk assessment process and the development, acceptance, and implementation of a risk management plan. Additionally, a number of quantitative approaches (particularly Bayesian approaches and multi-criteria decision-making) have been identified as having the potential to include expert-based inputs into risk-based decision-making. These offer promise for better inclusion of stakeholder knowledge and preferences into the decision-making process, and for improving the links between stakeholder inputs and potential risks to the ecological condition of the system. A major challenge for ecologists and natural resource managers is to make the ERA process more quantitative. Most ERAs conducted to date have been qualitative assessments that suffer from a number of deficiencies, the most serious being the lack of transparency and a reliance on subjective judgments. This article argues that the most productive way forward may be to use Bayesian methods to couple existing process-based models, empirical relationships based on good data, and expert opinion, to make the analysis of ecological risks more robust, consistent, and repeatable.

There is an ongoing and significant need for radiation countermeasures to reduce morbidities and mortalities associated with exposure of the heart and lungs from a radiological or nuclear incidents. Radiation-induced late effects occur months to years after exposure, stemming from significant tissue damage and remodeling, resulting in fibrosis and loss of function. TGF-β is reported to play a role in both pulmonary and cardiac fibrosis. We investigated the ability of a small molecule TGF-β receptor 1 inhibitor, IPW-5371, to mitigate the effects of thoracic irradiation in C57L/J mice, a murine model that most closely resembles that observed in humans in the induction of fibrosis and dose response. To simulate a radiological event, radiation was administered in two doses: 5 Gy total-body irradiation (eliciting a whole-body response) and immediately after that, a thoracic “top-up” of 6.5 Gy irradiation, for a total dose of 11.5 Gy to the thorax. IPW-5371 was administered once daily, orally, starting 24 h postirradiation for 6 or 20 weeks at a dose of 10 mg/kg or 30 mg/kg. Animals were monitored for a period of 180 days for survival, and cardiopulmonary injury was assessed by echocardiography, breathing rate and arterial oxygen saturation. Exposure of the thorax (11.5 Gy) induced both pulmonary and cardiac injury, resulting in a reduced life span with median survival of 135 days. IPW-5371 treatment for 6 weeks, at both 10 mg/kg and 30 mg/kg, delayed disease onset and mortality, with median survival of 165 days. Twenty weeks of IPW-5371 treatment at 30 mg/kg preserved arterial O2 saturation and cardiac contractile reserve and resulted in significant decreases in breathing frequency and cardiac and pulmonary fibrosis. This led to dramatic improvement in survival compared to the irradiated, vehicle-treated group (P < 0.001), and was statistically insignificant from the nonirradiated group. We observed that IPW-5371 treatment resulted in decreased pSmad3 tissue levels, confirming the effect of IPW-5371 on TGF-β signaling. These results demonstrate that IPW-5371 represents a potentially promising radiation countermeasure for the treatment of radiation-induced late effects.

Increasing urbanisation is occurring in Australia’s major cities and in almost every country in the world. This creates a challenge for the urban water sector, which not only needs to provide traditional water services (i.e., wastewater, domestic water) for a rapidly growing population, but also to service potential additional demands to contribute to enhanced amenity, and to do so in the context of climate change. This paper is focused on stormwater management controls for the develop of new greenfield urban sites in the three major east coast Australian cities—Melbourne, Sydney and Brisbane. While stormwater management in all three cities is focused on the protection of community values of the waterways, including environment (ecology), amenity and recreation, the scale or type of the waterways considered is considerably different—Melbourne has adopted a regional waterway strategy, while the Sydney and Brisbane approach is more localised. Pollution load reduction targets (TSS, TP, TN and litter) from new urban areas have been enforced in all three cities for many years, although there is concern that these targets primarily aimed at protecting the values of downstream bays (e.g., Port Phillip Bay, Sydney Harbour and Morton Bay) will not necessarily protect the values of the contributing waterways. However, targets to control stormwater volumes entering waterways are proving to be considerably more difficult to both develop and implement. These targets are typically expressed as volumes of stormwater to be harvested and/or infiltrated for every additional hectare of directly connected impervious (DCI) surface created as a result of urban development. The three cities have approached the setting of stormwater flow targets somewhat differently, as is apparent from the details provided in the paper. Additionally, we argue that there is a need for the development of new targets related to the reuse of stormwater and its integration with wastewater and domestic water management.

Objective: To examine the effects of electromyographic (EMG) biofeedback training on the recovery of gait in the acute phase post stroke. Design: Patients were randomly assigned to EMG biofeedback or control groups. They received treatment three times a week for six weeks. All patients were assessed prior to treatment, after 18 treatment sessions, and at three months follow-up. Setting: The study was carried out at Scunthorpe General Hospital in North Lincolnshire. The subjects were acute stroke patients who had been admitted on to the medical and elderly wards. Interventions: The EMG biofeedback group were treated using EMG as an adjunct to physiotherapy. The patients were encouraged to facilitate or inhibit abnormal muscle tone via auditory or visual signals transmitted from electrodes placed over the appropriate muscles. The control group were treated using the same techniques, electrodes were used with this group of patients, but the EMG machine was turned off and faced away from the patient and the therapist to control the placebo effect. Outcome measures: A large battery of outcome measures was used for physical and psychological assessment. The physical measures consisted of active movement, muscle tone, sensation, proprioception, mobility and activities of daily living (ADL). The psychological measures included orientation, memory, spatial performance, language and IQ. Results: Twenty-one patients were included in the study. Scores were combined into four groups: mild EMG, severe EMG, mild control and severe control. Results showed that there was an improvement in physical scores for active movement, mobility and ADL over time, but there was no significant difference between the EMG and control groups. Scores on the psychological tests were within normal limits, and there was no difference in performance between the EMG and control groups. Conclusions: This study showed no significant differences in the rate of improvement after stroke between the two groups. Although EMG biofeed-back was used as an adjunct to physiotherapy and represented clinical practice, the results provide little evidence to support the clinical significance of using EMG biofeedback to improve gait in the acute phase after stroke.

Harbison's Hawthorn (Crataegus harbisonii Beadle: Rosaceae), is a globally-rare shrub or small tree reported from five Tennessee counties (Davidson, Lawrence, Obion, Shelby, Weakley), but heretofore known to be extant only from a declining population in Davidson County. We here document discovery of the species 70 years after the initial observation in Obion County, although from a different location in the county. Descriptive data from the newly-discovered site is provided. Our studies further indicate that: (1) the 1948 voucher from Lawrence County is of questionable identity and since field studies have not located the species there, that county should be removed from distribution records for the species; and (2) Shelby and Weakley Counties are represented by annotated vouchers collected 1947-1948, but there have been no reports since then and categories of historic and possibly extirpated are appropriate for the species in those counties pending additional data.