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The burden of excess energy from the high renewable energy sources (RES) share creates a significant reduction of residual load for the future, resulting in reduced market prices. The higher the share of stochastic RES, the more often the price will be 0 €/MWh. The power market needs new methods to solve these problems. The development of virtual power plants (VPPs) is aimed at solving techno-economic problems with an increasing share of RES in the power market. This study analyses a possible implementation of stochastic and deterministic RES in a VPP to generate secured power, which can be implemented in the European Power Exchange (EPEX)/European Energy Exchange (EEX) power market using existing market products. In this study, the optimal economic VPP configuration for an RES-based power plant is investigated and implemented into standard power market products. The results show that the optimal economic VPP configuration for different market products varies, depending on the energy availability and the marginal costs of the VPP components. The size of the VPP components is positively correlated to the components’ share of the energy generated. It was also found that projecting or implementing VPPs in Germany at current market prices (EPEX/EEX prices) is not yet economically feasible for a small share of market products. However, the secured power can be marketed on the SPOT and in the futures market with higher and more stable prices compared with the status quo.

This paper describes an automatic sampling system for anaerobic reactors that allows taking representative samples following the guidelines of Gy’s (1998) theory of sampling. Due to the high heterogeneity degree in a digester the sampling errors are larger than the analysis error, making representative sampling a prerequisite for successful process control. In our system, samples are automatically processed, generating a higher density of data and avoiding human error by sample manipulation. The combination of a representative sampling system with a commercial automate titration unit generates a robust online monitoring system for biogas plants. The system was successfully implemented in an operating biogas plant to control a feeding-on-demand biogas system.

Sustainable energy supply is considered to be one of the most important worldwide challenges of the future. When concerning energy supply, three aspects have to be taken into account regarding sustainability. The first aspect is the limitation of fossil and nuclear resources. It is generally accepted that these resources will run out within the next decades and centuries. As a secondary aspect, due to this limitation, there is a rise in energy prices. This is contrary to the concept that energy should be affordable to every human being. The third aspect involves the emissions of the state of the art energy conversion technology harming the environment. These must therefore be reduced in the future, especially greenhouse gas emissions.Renewable energy sources are considered an answer to these problems. They are in endless supply and thought to be environmental friendly. Biomass, e.g. crops and biodegradable waste, is one kind of renewable energy sources. Biogas production is one possibility to produce electricity and heat from this biomass. Within the biogas process bacteria in an anaerobe atmosphere degrade carbon-hydrogen compounds. Methane, carbon dioxide, some trace gases, and a nutrient rich slurry result from this biogas process. The originated methane can finally be used for heating, electricity generation or fuel production. Within the last years, the government has assisted the energy production from renewable energy sources, especially biogas. This has led to a particular increase in industrial-scale biogas plants using energy crops as input.

The microphysical properties, composition and mixing state of mineral dust, sea salt and secondary compounds were measured by active and passive aerosol sampling, followed by electron microscopy and X-ray fluorescence in the Caribbean marine boundary layer. Measurements were carried out at Ragged Point, Barbados during June–July 2013 and August 2016. Techniques are presented and evaluated, which allow for statements on atmospheric aerosol concentrations and aerosol mixing state based on collected samples. It became obvious that in the diameter range with the highest dust deposition the deposition velocity models disagree by more than 2 orders of magnitude. Aerosol at Ragged Point was dominated by dust, sea salt and soluble sulfates in varying proportions. The contribution of sea salt was dependent on local wind speed. Sulfate concentrations were linked to long-range transport from Africa and Europe, and South America and the southern Atlantic Ocean. Dust sources were located in western Africa. The dust silicate composition was not significantly varied. Pure feldspar grains were 3 % of the silicate particles, of which about a third were K-feldspar. The average dust deposition observed was 10 mg m−2 d−1 (range of 0.5–47 mg m−2 d−1), of which 0.67 mg m−2 d−1 was iron and 0.001 mg m−2 d−1 phosphorus. Iron deposition was mainly driven by silicate particles from Africa. Dust particles were mixed internally to a minor fraction (10 %), mostly with sea salt and less frequently with sulfate. It was estimated that the average dust deposition velocity under ambient conditions is increased by the internal mixture by 30 %–140 % for particles between 1 and 10 µm dust aerodynamic diameter, with approximately 35 % at the mass median diameter of deposition (7.0 µm). For this size, an effective deposition velocity of 6.4 mm s−1 (geometric standard deviation of 3.1 over all individual particles) was observed.

Canine parvovirus (CPV) is the most important viral cause of acute canine enteritis leading to severe damage of the intestinal barrier. It has been speculated that dogs might develop chronic disorders after surviving CPV infection. However, no studies regarding the long-term implications of CPV infection have been published to date. The aim of this study was to evaluate whether dogs that have survived CPV infection will have an increased risk for developing chronic gastroenteritis, atopic dermatitis, or cardiac disease. Dogs that had been treated at the Clinic of Small Animal Medicine, LMU Munich, for CPV infection for which a follow-up of at least 12 months was available, were included in the study. Owners completed a questionnaire on the presence of chronic gastrointestinal and cutaneous signs, cardiac disease, and other potential disorders. An identical questionnaire was sent to owners of matched control dogs during the same time period. Seventy-one questionnaires of dogs with CPV infection and 67 of control dogs were analyzed. Significantly more CPV-infected dogs (30/71) compared to control dogs (8/67) had developed chronic gastrointestinal signs later in their lives (P < 0.001). No significant differences were observed regarding skin diseases (P = 1), cardiac problems (P = 0.160), or any other diseases (P = 0.173) later in life. Results of this study suggest that dogs that survive CPV infection have a significantly higher risk (odds ratio = 5.33) for developing a chronic gastrointestinal disease. Further prospective studies to identify the trigger for the development of chronic diarrhoea and possible targeted treatment strategies are needed.

We construct models with a spontaneously broken SU ( 3 ) F flavour symmetry where three generations of Higgs multiplets transform in a flavour-triplet representation. The models are embedded in a supersymmetric Pati–Salam GUT framework, which includes left–right symmetry. We study the possible flavon representations and show that a model with flavons in the decuplet representation is able to reproduce the hierarchy structure of the quark and lepton mass and mixing matrices. This result requires no additional structure or fine-tunings except for an extra Z 4 discrete symmetry in the superpotential.

Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC suppressive activity and a marker for their identification has hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here, we report that human MDSCs were characterized by strongly reduced metabolism and conferred this compromised metabolic state to CD8 + T cells, thereby paralyzing their effector functions. We identified accumulation of the dicarbonyl radical methylglyoxal, generated by semicarbazide-sensitive amine oxidase, to cause the metabolic phenotype of MDSCs and MDSC-mediated paralysis of CD8 + T cells. In a murine cancer model, neutralization of dicarbonyl activity overcame MDSC-mediated T cell suppression and, together with checkpoint inhibition, improved the efficacy of cancer immune therapy. Our results identify the dicarbonyl methylglyoxal as a marker metabolite for MDSCs that mediates T cell paralysis and can serve as a target to improve cancer immune therapy. Myeloid-derived suppressor cells (MDSCs) residing within tumors can impede immune responses. Knolle and colleagues show that MDSCs poison immune cells by producing methylglyoxal, which functionally alters their cellular metabolism and hence their effector responses.

When a transmission hotspot for an environmentally persistent pathogen establishes in otherwise high-quality habitat, the disease may exert a strong impact on a host population. However, fluctuating environmental conditions lead to heterogeneity in habitat quality and animal habitat preference, which may interrupt the overlap between selected and risky habitats. We evaluated spatio-temporal patterns in anthrax mortalities in a plains zebra ( Equus quagga ) population in Etosha National Park, Namibia, incorporating remote-sensing and host telemetry data. A higher proportion of anthrax mortalities of herbivores was detected in open habitats than in other habitat types. Resource selection functions showed that the zebra population shifted habitat selection in response to changes in rainfall and vegetation productivity. Average to high rainfall years supported larger anthrax outbreaks, with animals congregating in preferred open habitats, while a severe drought forced animals into otherwise less preferred habitats, leading to few anthrax mortalities. Thus, the timing of anthrax outbreaks was congruent with preference for open plains habitats and a corresponding increase in pathogen exposure. Given shifts in habitat preference, the overlap in high-quality habitat and high-risk habitat is intermittent, reducing the adverse consequences for the population.

A bstract We investigate models where gauge unification (GUT) proceeds in steps that include Pati-Salam symmetry. Beyond the Standard Model, we allow for a well-defined set of small representations of the GUT gauge group. We show that all possible chains of PatiSalam symmetry breaking can be realized in accordance with gauge-coupling unification. We identify, in particular, models with unification near the Planck scale, with intermediate left-right or SU(4) quark-lepton symmetries that are relevant for flavor physics, with new colored particles at accessible energies, and with an enlarged electroweak Higgs sector. We look both at supersymmetric and non-supersymmetric scenarios.

A bstract We construct an extension of the Standard Model (SM) which is based on grand unification with Pati-Salam symmetry. The setup is supplemented with the idea of spontaneous flavour symmetry breaking which is mediated through flavon fields with renormalizable couplings to new heavy fermions. While we argue that the new gauge bosons in this approach can be sufficiently heavy to be irrelevant at low energies, the fermionic partners of the SM quarks, in particular those for the third generation, can be relatively light and provide new sources of flavour violation. The size of the effects is constrained by the observed values of the SM Yukawa matrices, but in a way that is different from the standard minimal-flavour violation approach. We determine characteristic deviations from the SM that could eventually be observed in future precision measurements.