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إدارة الوقت : حلول من الخبراء لتحديات يومية
أمام برامج عمل مكتظة ورسائل لا تنتهي بالبريد الاكتروني وأوراق واردة يتزايد ارتفاعها أمامك يوميا قد ينتابك إحساس بالقهر والإرباك وتغدو قليل الفاعلية في عملك وهذا الكتاب سوف يساعدك في استعادة السيطرة على وقتك وعلى عملك من خلال وضع أولوياتك للمهام والمسؤوليات. استخدام أدوات ناجعة في وضع البرامج. إنجاز عمل كثير في زمن قليل كما أنه يفيدك في احتياجتك الإدارية اليومية بسرعة أكبر وبسلامة أكثر وفاعلية سواء كنت على كرسي عملك أو في لقاء أو في الطريق.
Book
Diversity buffers winegrowing regions from climate change losses
Agrobiodiversity-the variation within agricultural plants, animals, and practices-is often suggested as a way to mitigate the negative impacts of climate change on crops [S. A. Wood et al., Trends Ecol. Evol. 30, 531-539 (2015)]. Recently, increasing research and attention has focused on exploiting the intraspecific genetic variation within a crop [Hajjar et al., Agric. Ecosyst. Environ. 123, 261-270 (2008)], despite few relevant tests of how this diversity modifies agricultural forecasts. Here, we quantify how intraspecific diversity, via cultivars, changes global projections of growing areas. We focus on a crop that spans diverse climates, has the necessary records, and is clearly impacted by climate change: winegrapes (predominantly Vitis vinifera subspecies vinifera). We draw on long-term French records to extrapolate globally for 11 cultivars (varieties) with high diversity in a key trait for climate change adaptation-phenology. We compared scenarios where growers shift to more climatically suitable cultivars as the climate warms or do not change cultivars. We find that cultivar diversity more than halved projected losses of current winegrowing areas under a 2 degrees C warming scenario, decreasing areas lost from 56 to 24%. These benefits are more muted at higher warming scenarios, reducing areas lost by a third at 4 degrees C (85% versus 58%). Our results support the potential of in situ shifting of cultivars to adapt agriculture to climate change-including in major winegrowing regions-as long as efforts to avoid higher warming scenarios are successful.
Journal Article
قيادة فريق العمل : حلول من الخبراء لتحديات يومية
يتناول الكتاب أنه لكي تقود الفريق بفاعلية عليك أن تضع أسس النجاح لهذا الفريق وأن تتابع جهودك بخصوص القرارات المهمة يقدم هذا الكتاب لك العون من خلال تبيانه لما يأتي. كيف تتعرف على أعضاء في الفريق ذوي مهارات يكمل بعضها بعضا. وكيف ترعى الإبداع وروح المجازفة لدى فريقك، وكيف تعيد عمل فريقك إلى مساره الصحيح إن أصيب بنكسة.
Book
Composability of regulatory sequences controlling transcription and translation in Escherichia coli
The inability to predict heterologous gene expression levels precisely hinders our ability to engineer biological systems. Using well-characterized regulatory elements offers a potential solution only if such elements behave predictably when combined. We synthesized 12,563 combinations of common promoters and ribosome binding sites and simultaneously measured DNA, RNA, and protein levels from the entire library. Using a simple model, we found that RNA and protein expression were within twofold of expected levels 80% and 64% of the time, respectively. The large dataset allowed quantitation of global effects, such as translation rate on mRNA stability and mRNA secondary structure on translation rate. However, the worst 5% of constructs deviated from prediction by 13-fold on average, which could hinder large-scale genetic engineering projects. The ease and scale this of approach indicates that rather than relying on prediction or standardization, we can screen synthetic libraries for desired behavior.
Journal Article
Explorations in personality
This book sets forth a provocative agenda for the scientific study of human personality. Blending no-nonsense empiricism with the humanistic desire to understand the whole person, the book is as relevant today as it was to its many readers seventy years ago. The book sets forth a full theory of human personality, illustrated with a bevy of creative methods for personality assessment, and presenting the results of a landmark study of fifty Harvard men. The book is one of the great classics in 20th-century psychology.
eBook
Brokers of empire : Japanese settler colonialism in Korea, 1876-1945
Between 1876 and 1945, thousands of Japanese civilians-merchants, traders, prostitutes, journalists, teachers, and adventurers-left their homeland for a new life on the Korean peninsula. Although most migrants were guided primarily by personal profit and only secondarily by national interest, their mundane lives and the states ambitions were inextricably entwined in the rise of imperial Japan. Despite having formed one of the largest colonial communities in the twentieth century, these settlers and their empire-building activities have all but vanished from the public memory of Japans presence in Korea. Drawing on previously unused materials in multi-language archives, Jun Uchida looks behind the official organs of state and military control to focus on the obscured history of these settlers, especially the first generation of pioneers between the 1910s and 1930s who actively mediated the colonial management of Korea as its grassroots movers and shakers. By uncovering the downplayed but dynamic role played by settler leaders who operated among multiple parties-between the settler community and the Government-General, between Japanese colonizer and Korean colonized, between colony and metropole-this study examines how these brokers of empire advanced their commercial and political interests while contributing to the expansionist project of imperial Japan. -- Publisher description.
Book
S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive
Meiotic drivers bias gametogenesis to ensure their transmission into more than half the offspring of a heterozygote. In Schizosaccharomyces pombe , wtf meiotic drivers destroy the meiotic products (spores) that do not inherit the driver from a heterozygote, thereby reducing fertility. wtf drivers encode both a Wtf poison protein and a Wtf antidote protein using alternative transcriptional start sites. Here, we analyze how the expression and localization of the Wtf proteins are regulated to achieve drive. We show that transcriptional timing and selective protein exclusion from developing spores ensure that all spores are exposed to Wtf4 poison , but only the spores that inherit wtf4 receive a dose of Wtf4 antidote sufficient for survival. In addition, we show that the Mei4 transcription factor, a master regulator of meiosis, controls the expression of the wtf4 poison transcript. This transcriptional regulation, which includes the use of a critical meiotic transcription factor, likely complicates the universal suppression of wtf genes without concomitantly disrupting spore viability. We propose that these features contribute to the evolutionary success of the wtf drivers.
Journal Article
Voice, silence, and self : negotiations of Buraku identity in contemporary Japan
\"Based on extensive ethnographic research and interviews, this longitudinal work explores the experience of Burakumin youth from two different communities and with different social movement organizations\"-- Provided by publisher.
Book
Entrainment of the human circadian pacemaker to longer-than-24-h days
Entrainment of the circadian pacemaker to the light:dark cycle is necessary for rhythmic physiological functions to be appropriately timed over the 24-h day. Nonentrainment results in sleep, endocrine, and neurobehavioral impairments. Exposures to intermittent bright light pulses have been reported to phase shift the circadian pacemaker with great efficacy. Therefore, we tested the hypothesis that a modulated light exposure (MLE) with bright light pulses in the evening would entrain subjects to a light:dark cycle 1 h longer than their own circadian period (tau). Twelve subjects underwent a 65-day inpatient study. Individual subject's circadian period was determined in a forced desynchrony protocol. Subsequently, subjects were released into 30 longer-than-24-h days (daylength of tau + 1 h) in one of three light:dark conditions: (i) approximately 25 lux; (ii) approximately 100 lux; and (iii) MLE: approximately 25 lux followed by approximately 100 lux, plus two 45-min bright light pulses of approximately 9,500 lux near the end of scheduled wakefulness. We found that lighting levels of approximately 25 lux were insufficient to entrain all subjects tested. Exposure to approximately 100 lux was sufficient to entrain subjects, although at a significantly wider phase angle compared with baseline. Exposure to MLE was able to entrain the subjects to the imposed sleep-wake cycles but at a phase angle comparable to baseline. These results suggest that MLE can be used to entrain the circadian pacemaker to non-24-h days. The implications of these findings are important because they could be used to treat circadian misalignment associated with space flight and circadian rhythm sleep disorders such as shift-work disorder.
Journal Article