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The research on perovskite-based photovoltaics is rapidly increasing in renewable energy, particularly in solar cell fields, as its efficiency has reached upto 25.7%. Although several efforts have been made to increase the lifetime and stability, several complicated processes are still required to be optimized, to achieve better structural and chemical stability. In this paper, perovskite material is prepared in different molar ratios, in combinations of lead iodide (PbI 2 ) and methyl ammonium iodide (MAI) for better interdiffusion and structural ordering. All the measurements have been performed only using ITO as a bare substrate. The synchrotron source-based X-ray diffraction measurements together with SEM and UV–Vis spectroscopy were performed to understand the structural properties of perovskite films across the entire film thickness for three different molar ratios. The angular-dependent grazing incidence X-ray diffraction (GIXRD) under out-of-plane geometry can provide a better insight of structural properties at the film/air and film/ITO interfaces. Our GIXRD measurements summarizes that within the entire depth of the perovskite film, unreacted PbI 2 small particles are not only laying at the bottom, but such unreacted PbI 2 crystallites are also distributed along with the entire height of the perovskite film. This is completely new finding, which has been not reported yet. In combined, all these three (SEM, GIXRD, UV–Vis) states of the art techniques have not only provided the in-depth structural ordering within the entire height of the films but also reveals the surface morphology and varying optical properties of the film with varying the molar ratio’s too.

Bioactive peptides are present in most soy products and eggs and have essential protective functions. Infection is a core feature of innate immunity that affects blood pressure and the glucose level, and ageing can be delayed by killing senescent cells. Food also encrypts bioactive peptides and protein sequences produced through proteolysis or food processing. Unique food protein fragments can improve human health and avoid metabolic diseases, inflammation, hypertension, obesity, and diabetes mellitus. This review focuses on drug targets and fundamental mechanisms of bioactive peptides on metabolic syndromes, namely obesity and type 2 diabetes, to provide new ideas and knowledge on the ability of bioactive peptide to control metabolic syndromes.

We report proteogenomic analysis of locally advanced cervical cancer (LACC). Exome-seq data revealed predominant alterations of keratinization-TP53 regulation and O-glycosylation-TP53 regulation axes in squamous and adeno-LACC, respectively, compared to in early-stage cervical cancer. Integrated clustering of mRNA, protein, and phosphorylation data identified six subtypes (Sub1-6) of LACC among which Sub3, 5, and 6 showed the treatment-resistant nature with poor local recurrence-free survival. Elevated immune and extracellular matrix (ECM) activation mediated by activated stroma (PDGFD and CXCL1 high fibroblasts) characterized the immune-hot Sub3 enriched with MUC5AC high epithelial cells (ECs). Increased epithelial-mesenchymal-transition (EMT) and ECM remodeling characterized the immune-cold squamous Sub5 enriched with PGK1 and CXCL10 high ECs. We further demonstrated that CIC mutations could trigger EMT activation by upregulating ETV4, and the elevation of the immune checkpoint PVR and neutrophil-like myeloid-derived suppressive cells (FCN1 and FCGR3B high macrophages) could cause suppression of T-cell activation in Sub5. Increased O-linked glycosylation of mucin characterized adeno-LACC Sub6 enriched with MUC5AC high ECs. These results provide a battery of somatic mutations, cellular pathways, and cellular players that can be used to predict treatment-resistant LACC subtypes and can serve as potential therapeutic targets for these LACC subtypes.

The study aimed to investigate the antibacterial activity of Mustard (Brassica juncea) and Moringa (Moringa oleifera) leaf extracts and coagulant protein for their potential application in water treatment. Bacterial cell aggregation and growth kinetics studies were employed for thirteen bacterial strains with different concentrations of leaf extracts and coagulant protein. Moringa oleifera leaf extract (MOS) and coagulant protein showed cell aggregation against ten bacterial strains, whereas leaf extract alone showed growth inhibition of five bacterial strains for up to 6 h and five bacterial strains for up to 3 h. Brassica juncea leaf extract (BJS) showed growth inhibition for up to 6 h, and three bacterial strains showed inhibition for up to 3 h. The highest inhibition concentration with 2.5 mg/mL was 19 mm, and furthermore, the minimum inhibitory concentration (MIC) (0.5 mg/mL) and MBC (1.5 mg/mL) were determined to have a higher antibacterial effect for <3 KDa peptides. Based on LCMS analysis, napin was identified in both MOS and BJS; furthermore, the mode of action of napin peptide was determined on lipoprotein X complex (LpxC) and four-chained structured binding protein of bacterial type II topoisomerase (4PLB). The docking analysis has exhibited moderate to potent inhibition with a range of dock score −912.9 Kcal/mol. Thus, it possesses antibacterial-coagulant potential bioactive peptides present in the Moringa oleifera purified protein (MOP) and Brassica juncea purified protein (BJP) that could act as an effective antimicrobial agent to replace currently available antibiotics. The result implies that MOP and Brassica juncea purified coagulant (BJP) proteins may perform a wide degree of antibacterial functions against different pathogens.

In the era of fast transport, to create inventive stream flow management solutions that are capable of diminishing the aerodynamic drag of the vehicles, there is a need to modify the flow characteristics over the vehicle by deferring or expelling the position of the flow partition. The objective of this study involves the parameterized design of an airfoil utilizing the Bezier curve technique with the assistance of the simulation program. For flow regulations, synthetic jet modules are ingrained at different percentages of the chord to manage the stall characteristics. The parametrization system, combined with the stream control method, can give a much better insight into flow re-energization and pave some way for the reduction of the wake. Digital fabrication technique (3d printing or Rapid Prototyping method) is used to fabricate the end product for aerodynamic testing. The comparative outcome showed a reduction in drag at certain angles of attack due to the surface finish obtained. By comparing the results, the aerodynamic efficiency showed a significant rise of 13.05% at lower angles of attack when compressed gas was used in the synthetic jet closer to the frontier edge of the airfoil. Near the stall angle of attack, the coefficient of lift (Cl) and coefficient of drag (Cd) values showed no progress.

High-lift systems are designed to expand the flight envelope and have a most important effect on the size of the wing, economy, and safety of many airliner configurations. Even a small increment of lift using a high-lift system can significantly impact an aircraft’s profitability. The effective design of the airfoil shape with the required aerodynamic performance is still difficult. In the early days, the designs of airfoils were randomly set up and tested in the flow section, and then, the Wright brothers emerged with a cambered section. NACA has provided an appropriate airfoil definition that supports us in making airfoil designs using formulas, not randomly. This paper describes the influence of aerodynamic analysis of wing with flaps at various deflection angles. Aerodynamic variables for the aircraft wing, which is made up of the NACA airfoil 6412 model with and without flaps, have been studied at various angle of attack (AOA) (i.e., -4, -2, 0, 2, 4, 6, 8, 10, 12, and 16) and different Mach number at 0.2, 0.3, and 0.4. Also, the analysis was done for the 15000 ft altitude to check the density effects for the real-time applications. The coefficients of lift and drag are gained by examining the pressure distribution over the surface of the wing. Lift increases as the approach ascends from a low to a high angle of attack, and the most extreme lift is produced at a specific point. After that, when the angle of attack increases further, the drag component increases, so the stall occurs at that point in time. The results showed that the NACA 6412 airfoil obtained the maximum lift at 14°, and the lift value started to decrease. The CFD computations are performed in Ansys Fluent by performing hybrid mesh using ICEM-CFD. The analysis is performed for various configurations of the wing section, and the effects of flow parameters like angle of attack, altitude, and the gap distance between the main wing and slotted flap were compared to identify the better configurations.

This research paper aims to validate the aerodynamic performance of rotor blades using additive manufacturing techniques. Wind tunnel testing is a technique used to find the flow characteristics of the body. Computational fluid dynamics (CFD) techniques are used for aerodynamic analysis, and validation should be done using wind tunnel testing. In the aerodynamic testing of models, additive manufacturing techniques help in validating the results by making models easily for wind tunnels. Recent developments in additive manufacturing help in the aerodynamic testing of models in wind tunnels. The CFD analysis of helicopter rotor blades was analyzed in this research, and validation was done using additive manufacturing techniques. Computational analysis was carried out for static analysis for the forward speeds of Mach numbers 0.3, 0.4, and 0.5. The results obtained were satisfactory to the previous results and were validated with wind tunnel testing. Results proved that the error percentage was lower, and the computational analysis was valid. In this research, models were designed using the FDM technique for wind tunnel testing as it is cost-effective and easy to manufacture.

This study presents the design, fabrication and evaluation of a novel bladeless propulsion system inspired by the Dyson Air Multiplier principle, to advance sustainable and efficient air mobility. The proposed system eliminates conventional rotating blades by employing fluidic dynamics to generate thrust, thereby offering the potential for reduced noise, enhanced safety and improved environmental compatibility. A systematic methodology encompassing conceptual design, feasibility analysis, material selection and prototype fabrication was adopted, with 3D printing enabling precision manufacturing and rapid customisation. Experimental investigations were conducted to measure thrust performance, airflow characteristics and acoustic emissions, with the results benchmarked against theoretical predictions. The findings reveal a strong correlation between experimental and analytical outcomes, validating the feasibility of bladeless propulsion for aerospace applications. While minor discrepancies highlight areas for further refinement, the overall performance demonstrates significant promise for integration into Unmanned Aerial Vehicles (UAVs) and future aerospace platforms. This work underscores the transformative potential of bladeless propulsion technology, laying a foundation for quieter, cleaner and more efficient aviation solutions.