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"Haugh, Michael"
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Situated politeness
Pragmatic and sociolinguistic analyses of im/politeness have usually been dependent on context and cultural frames of reference. This study approached the concept from an original perspective, namely situatedness.
Book
The Palgrave handbook of linguistic (im)politeness
This handbook comprehensively examines social interaction by providing a critical overview of the field of linguistic politeness and impoliteness.Authored by over forty leading scholars, it offers a diverse and multidisciplinary approach to a vast array of themes that are vital to the study of interpersonal communication.
eBook
Analysing discourse around COVID-19 in the Australian Twittersphere: A real-time corpus-based analysis
Public discourse about the COVID-19 that appears on Twitter and other social media platforms provides useful insights into public concerns and responses to the pandemic. However, acknowledging that public discourse around COVID-19 is multi-faceted and evolves over time poses both analytical and ontological challenges. Studies that use text-mining approaches to analyse responses to major events commonly treat public discourse on social media as an undifferentiated whole, without systematically examining the extent to which that discourse consists of distinct sub-discourses or which phases characterize its development. They also confound structured behavioural data (i.e., tagging) with unstructured user-generated data (i.e., content of tweets) in their sampling methods. The present study aims to demonstrate how one might go about addressing both of these sets of challenges by combining corpus linguistic methods with a data-driven text-mining approach to gain a better understanding of how the public discourse around COVID-19 developed over time and what topics combine to form this discourse in the Australian Twittersphere over a period of nearly four months. By combining text mining and corpus linguistics, this study exemplifies how both approaches can complement each other productively.
Journal Article
Metabolic Maturation Exaggerates Abnormal Calcium Handling in a Lamp2 Knockout Human Pluripotent Stem Cell-Derived Cardiomyocyte Model of Danon Disease
Danon disease (DD) is caused by mutations of the gene encoding lysosomal-associated membrane protein type 2 (LAMP2), which lead to impaired autophagy, glycogen accumulation, and cardiac hypertrophy. However, it is not well understood why a large portion of DD patients develop arrhythmia and sudden cardiac death. In the current study, we generated LAMP2 knockout (KO) human iPSC-derived cardiomyocytes (CM), which mimic the LAMP2 dysfunction in DD heart. Morphologic analysis demonstrated the sarcomere disarrangement in LAMP2 KO CMs. In functional studies, LAMP2 KO CMs showed near-normal calcium handling at base level. However, treatment of pro-maturation medium (MM) exaggerated the disease phenotype in the KO cells as they exhibited impaired calcium recycling and increased irregular beating events, which recapitulates the pro-arrhythmia phenotypes of DD patients. Further mechanistic study confirmed that MM treatment significantly enhanced the autophagic stress in the LAMP2 KO CMs, which was accompanied by an increase of both cellular and mitochondrial reactive oxygen species (ROS) levels. Excess ROS accumulation in LAMP2 KO CMs resulted in the over-activation of calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) and arrhythmogenesis, which was partially rescued by the treatment of ROS scavenger. In summary, our study has revealed ROS induced CaMKIIδ overactivation as a key mechanism that promotes cardiac arrhythmia in DD patients.
Journal Article
Doing Pragmatics Interculturally
The series publishes state-of-the-art work on core areas of linguistics across theoretical frameworks as well as studies that provide new insights by building bridges to neighbouring fields such as neuroscience and cognitive science. The series considers itself a forum for cutting-edge research based on solid empirical data on language in its various manifestations, including sign languages. It regards linguistic variation in its synchronic and diachronic dimensions as well as in its social contexts as important sources of insight for a better understanding of the design of linguistic systems and the ecology and evolution of language.
eBook
Im/Politeness Implicatures
This volume brings together two highly researched but also highly controversial concepts, those of politeness and implicature. A theory of implicature as social action and im/politeness as social practice is developed that opens up new ways of examining the relationship between them. It constitutes a fresh look at the issues involved that redresses the current imbalance between social and pragmatic accounts of im/politeness.
eBook
Getting to know you
It is commonly assumed that teasing is restricted to encounters among intimates or close acquaintances. As a result of examining initial interactions among (American and Australian) speakers of English, however, this article shows that teasing also occurs between persons who are becoming acquainted. Analysis reveals that tease sequences unfold across three actions that constitute the tease as an invitation to intimacy: a teasable action on the part of the target, the tease proper and a moment of interactionally generated affiliation. Given teasing is one way of criticising another, it constitutes a potential breach of tact or interactional propriety. In initial interactions, however, participants can construe this potential impropriety as an invitation to intimacy, as it involves the proposal of a shared ironic stance that may be either accepted or declined by the target of the tease.
Journal Article
Calibration of X-ray imaging devices for accurate intensity measurement
National Security Technologies (NSTec) has developed calibration procedures for X-ray imaging systems. The X-ray sources that are used for calibration are both diode type and diode/fluorescer combinations. Calibrating the X-ray detectors is a key to accurate calibration of the X-ray sources. Both energy dispersive detectors and photodiodes measuring total flux were used. We have developed calibration techniques for the detectors using radioactive sources that are traceable to the National Institute of Standards and Technology (NIST). The German synchrotron at Physikalische Technische Bundestalt (PTB) was used to calibrate the silicon photodiodes over the energy range from 50 to 60 keV. The measurements on X-ray cameras made using the NSTec X-ray sources included quantum efficiency averaged over all pixels, camera counts per photon per pixel, and response variation across the sensor. The instrumentation required to accomplish the calibrations is described. The X-ray energies ranged from 720 to 22.7 keV. The X-ray sources produce narrow energy bands, allowing us to determine the properties as a function of X-ray energy. The calibrations were done for several types of imaging devices. There were back and front illuminated CCD (charge-coupled device) sensors, and a CID (charge injection device) type camera. The CCD and CID camera types differ significantly in some of their properties that affect the accuracy of the X-ray intensity measurements. All the cameras discussed here are silicon based. The measurements of the quantum efficiency variation with the X-ray energy are compared to the models for the sensor structure. The cameras that are not back-thinned are compared to those that are.
Journal Article
Best Practices for Spoken Corpora in Linguistic Research
A key concern of researchers involved in the creation and sharing of language resources is to attain maximum usability, reliability and longevity of these resources for present and future researchers in the language sciences. The view developed in this volume is that spoken corpora construction and sharing are major research endeavours that should also be laid open to academic debate in a manner that is more visible than is currently the case in corpus linguistics. The present volume brings.
eBook