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"Hauser, Peter"
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Classification and Treatment of Pediatric Gliomas in the Molecular Era
The overall survival of pediatric gliomas varies over a wide spectrum depending on the tumor grade. Low-grade gliomas have an excellent long-term survival, with a possible burden of surgery, irradiation, and chemotherapy; in contrast, high-grade gliomas generally have a short-term, devastating lethal outcome. Recent advances in understanding their molecular background will transform the classification and therapeutic approaches of pediatric gliomas. Molecularly targeted treatments may acquire a leading role in the primary treatment of low-grade gliomas and may provide alternative therapeutic strategies for high-grade glioma cases in the attempt to avoid the highly unsuccessful conventional therapeutic approaches. This review aims to overview this progress.
Journal Article
Determination of tobramycin in eye drops with an open-source hardware ion mobility spectrometer
The analysis of tobramycin was demonstrated successfully as an example for electrospray ionization on an open-source hardware ion mobility spectrometer. This instrument was assembled inexpensively in-house, and required only very few purpose-made components. The quantitative determination of tobramycin required 20 s for a reading. The calibration curve for the range from 50 to 200 μM was found to be linear with a correlation coefficient of r = 0.9994. A good reproducibility was obtained (3% relative standard deviation) and the limit of detection was determined as 8 μM. As the concentration of the active ingredient in the eye drops (ophthalmic solutions) is too high for the sensitivity of the instrument, the samples had to be diluted appropriately.
Journal Article
Fingerspelling as a Novel Gateway into Reading Fluency in Deaf Bilinguals
Studies have shown that American Sign Language (ASL) fluency has a positive impact on deaf individuals' English reading, but the cognitive and cross-linguistic mechanisms permitting the mapping of a visual-manual language onto a sound-based language have yet to be elucidated. Fingerspelling, which represents English orthography with 26 distinct hand configurations, is an integral part of ASL and has been suggested to provide deaf bilinguals with important cross-linguistic links between sign language and orthography. Using a hierarchical multiple regression analysis, this study examined the relationship of age of ASL exposure, ASL fluency, and fingerspelling skill on reading fluency in deaf college-age bilinguals. After controlling for ASL fluency, fingerspelling skill significantly predicted reading fluency, revealing for the first-time that fingerspelling, above and beyond ASL skills, contributes to reading fluency in deaf bilinguals. We suggest that both fingerspelling--in the visual-manual modality--and reading--in the visual-orthographic modality--are mutually facilitating because they share common underlying cognitive capacities of word decoding accuracy and automaticity of word recognition. The findings provide support for the hypothesis that the development of English reading proficiency may be facilitated through strengthening of the relationship among fingerspelling, sign language, and orthographic decoding en route to reading mastery, and may also reveal optimal approaches for reading instruction for deaf and hard of hearing children.
Journal Article
Internalized oppression and deaf people’s mental health
Deaf people experience ableism (able-bodied oppression), audism (hearing-ability oppression), and linguicism (sign language-use oppression) and this study investigated if internalizing these oppressive experiences predicts their mental health. Deaf participants (
N
= 134) completed a 54-item Deaf Oppression Scale, developed for this study with Ableism, Audism, and Linguicism Subtests, along with the Beck Depression Inventory-II and the State and Trait Anxiety Inventory. The Deaf Oppression Scale and its Ableism, Audism, and Linguicism Subscales carry good reliability and the model fit indices for a confirmatory factor analysis indicated a good fit. Sixteen (16%) percent (
n
= 22) of the sample had depression, 36% (
n
= 48) had state anxiety, and 64% (
n
= 86) had trait anxiety. Internalized ableism predicted greater characteristics and symptoms of depression, internalized ableism and linguicism predicted greater state anxiety, and internalized audism predicted greater trait anxiety. This is the first empirical evidence dissociating three types of oppression that deaf people experience and their separate and different effects on their psychological well-being.
Journal Article
Determination of Binary Gas Mixtures by Measuring the Resonance Frequency in a Piezoelectric Tube
The composition of gas mixtures may be determined via changes of the speed of sound. As this affects the resonance frequency of the gas inside a tube, indirect measurements through a frequency analysis are also possible. It is demonstrated that this may be carried out with unprecedented simplicity by the novel employment of a piezoelectric tube which serves at the same time as a resonance tube and as transducer into the electronic domain. Experiments were run using a simple diecast aluminum box as the measuring cell, inside which the piezoelectric tube made from lead zirconium titanate with 30-mm length and 5.35-mm inner diameter was suspended. A small loudspeaker placed into the cell served for excitation of the resonance. Peak frequencies between 3910 and 14,590 Hz (for pure CO2 and He, respectively) were obtained. Two component mixtures of O2/N2, CO2/N2, and He/N2 at various composition were tested. A linear frequency change from 4790 to 5100 Hz was observed when going from pure O2 to pure N2.
Journal Article
Is Visual Selective Attention in Deaf Individuals Enhanced or Deficient? The Case of the Useful Field of View
Early deafness leads to enhanced attention in the visual periphery. Yet, whether this enhancement confers advantages in everyday life remains unknown, as deaf individuals have been shown to be more distracted by irrelevant information in the periphery than their hearing peers. Here, we show that, in a complex attentional task, a performance advantage results for deaf individuals.
We employed the Useful Field of View (UFOV) which requires central target identification concurrent with peripheral target localization in the presence of distractors - a divided, selective attention task. First, the comparison of deaf and hearing adults with or without sign language skills establishes that deafness and not sign language use drives UFOV enhancement. Second, UFOV performance was enhanced in deaf children, but only after 11 years of age.
This work demonstrates that, following early auditory deprivation, visual attention resources toward the periphery slowly get augmented to eventually result in a clear behavioral advantage by pre-adolescence on a selective visual attention task.
Journal Article
The sentence repetition task as a measure of sign language proficiency
Sign language research is important for our understanding of languages in general and for the impact it has on policy and on the lives of deaf people. There is a need for a sign language proficiency measure, to use as a grouping or continuous variable, both in psycholinguistics and in other sign language research. This article describes the development of a Swedish Sign Language Sentence Repetition Test (STS-SRT) and the evidence that supports the validity of the test’s interpretation and use. The STS-SRT was administered to 44 deaf adults and children, and was shown to have excellent internal reliability (Cronbach’s alpha of 0.915) and inter-rater reliability (Intraclass Correlation Coefficient [ICC] = 0.900, p < .001). A linear mixed model analysis revealed that adults scored 20.2% higher than children, and delayed sign language acquisition were associated with lower scores. As the sign span of sentences increased, participants relied on their implicit linguistic knowledge to scaffold their sentence repetitions beyond rote memory. The results provide reliability and validity evidence to support the use of STS-SRT in research as a measure of STS proficiency.
Journal Article
Nanotechnology, Nanomedicine, and the Kidney
The kidneys are vital organs performing several essential functions. Their primary function is the filtration of blood and the removal of metabolic waste products as well as fluid homeostasis. Renal filtration is the main pathway for drug removal, highlighting the importance of this organ to the growing field of nanomedicine. The kidneys (i) have a key role in the transport and clearance of nanoparticles (NPs), (ii) are exposed to potential NPs’ toxicity, and (iii) are the targets of diseases that nanomedicine can study, detect, and treat. In this review, we aim to summarize the latest research on kidney-nanoparticle interaction. We first give a brief overview of the kidney’s anatomy and renal filtration, describe how nanoparticle characteristics influence their renal clearance, and the approaches taken to image and treat the kidney, including drug delivery and tissue engineering. Finally, we discuss the future and some of the challenges faced by nanomedicine.
Journal Article
Advances in Organoid Research and Developmental Engineering
Over the last decade, organoid research has emerged as a transformative field in biomedical science, offering unparalleled opportunities in disease modeling, pharmacological testing, and tissue engineering [...]
Journal Article