Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
25
result(s) for
"Haydon, Elizabeth"
Sort by:
The tree of water
Ven, Char, and the merrow Amariel explore the world beneath the sea, where beauty is more than matched by dangers, and soon they realize that in order to save thousands of innocent lives, they may have to sacrifice their own.
Book
Dickinson tributaries in the watershed of music education: Martha Dickinson Bond (1856–1936) and Clarence Dickinson (1873–1969)
The watershed of music education in the United States originated with tributaries from Puritan families, churches and communities of the 1630s. For more than three hundred years, Dickinson family members have been influenced by music educators. In turn, the Dickinsons, as ministers, educators and music educators, influenced innumerable students and communities. The purpose of this narrative case study was to describe the influence of music educators on students' lifelong learning and musicianship. Utilizing a nested case study approach focusing on two individual cases within a larger family case, this inquiry examined the ways music educators addressed critical issues in music education in Dickinson communities prior to 1860. Further, this study investigated the ways music educators influenced the lives and relationships of Martha Dickinson Bond and Clarence Dickinson and the ways the Dickinsons were influential in their students' lives. Sources of data were drawn from the Clarence Dickinson Collection of Sacred Music at William Carey College; private collections from the estate of Martha Dickinson Bond; and collections from libraries, churches, historical societies, and archives in former Dickinson communities. Data sources included interviews with students of the Dickinsons, artifacts, records, diaries, letters, recorded and written music, photographs, participant-observations, and direct observations. Content analysis involved developing chronologies and case profiles; identifying and coding patterns from data; utilizing matrix displays for within-case and between-case analysis; synthesizing emergent constructs and themes; and illustrating themes with examples from data. Data analysis revealed themes about the influence of music educators holistically over three centuries (1630s-1930s): Religion; Relationships; Character Development; Literacy; Musical Development; Community Contributions; and Inspiration. Recommendations for music educators, music therapists, and teacher educators were organized by five identified stages of musical development over the human lifespan. Recommendations for further study corresponded to guiding research questions.
Dissertation
Successful use of equine anti-thymocyte globulin (ATGAM) for fulminant myocarditis secondary to nivolumab therapy
Background:
Immune-mediated myocarditis is an uncommon adverse effect of immune checkpoint inhibition and is associated with a high rate of mortality.
Methods:
In this reported case, a 64-year-old woman with right temporo-parietal glioblastoma IDH-WT was treated with nivolumab, temozolomide and radiation therapy on a clinical trial. She developed malignant arrhythmias secondary to histologically confirmed severe immune-mediated myocarditis. She was treated with equine anti-thymocyte globulin (ATGAM) due to development of malignant arrhythmias refractory to high-dose corticosteroids.
Results:
This report describes the only case of immune-mediated myocarditis treated with ATGAM resulting in a favourable outcome.
Conclusions:
Use of ATGAM should be considered in cases of steroid-refractory immune-mediated myocarditis and administered in close consultation with a cardiac transplant team experienced in the use of this agent.
Journal Article
Sequence-Based Prediction for Vaccine Strain Selection and Identification of Antigenic Variability in Foot-and-Mouth Disease Virus
Identifying when past exposure to an infectious disease will protect against newly emerging strains is central to understanding the spread and the severity of epidemics, but the prediction of viral cross-protection remains an important unsolved problem. For foot-and-mouth disease virus (FMDV) research in particular, improved methods for predicting this cross-protection are critical for predicting the severity of outbreaks within endemic settings where multiple serotypes and subtypes commonly co-circulate, as well as for deciding whether appropriate vaccine(s) exist and how much they could mitigate the effects of any outbreak. To identify antigenic relationships and their predictors, we used linear mixed effects models to account for variation in pairwise cross-neutralization titres using only viral sequences and structural data. We identified those substitutions in surface-exposed structural proteins that are correlates of loss of cross-reactivity. These allowed prediction of both the best vaccine match for any single virus and the breadth of coverage of new vaccine candidates from their capsid sequences as effectively as or better than serology. Sub-sequences chosen by the model-building process all contained sites that are known epitopes on other serotypes. Furthermore, for the SAT1 serotype, for which epitopes have never previously been identified, we provide strong evidence – by controlling for phylogenetic structure – for the presence of three epitopes across a panel of viruses and quantify the relative significance of some individual residues in determining cross-neutralization. Identifying and quantifying the importance of sites that predict viral strain cross-reactivity not just for single viruses but across entire serotypes can help in the design of vaccines with better targeting and broader coverage. These techniques can be generalized to any infectious agents where cross-reactivity assays have been carried out. As the parameterization uses pre-existing datasets, this approach quickly and cheaply increases both our understanding of antigenic relationships and our power to control disease.
Journal Article
Mobile Phones As Surveillance Tools: Implementing and Evaluating a Large-Scale Intersectoral Surveillance System for Rabies in Tanzania
Abbreviations: GPRS, General Packet Radio Service; GSM, Global System for Mobile communication; IHI, Ifakara Health Institute; LMICs, low- and middle-income countries; mHealth, mobile-phone-based health; PEP, post-exposure prophylaxis; SMS, short message service or text messaging Provenance: Not commissioned; externally peer-reviewed Summary Points * Surveillance is critical to manage preventative health services and control infectious diseases. [...]most surveillance in low-income countries is paper-based, provides negligible timely feedback, is poorly incentivised, and results in delays, limited reporting, inaccurate data, and costly processing. * The potential of mobile technologies for improving health system surveillance has been demonstrated through small-scale pilots, but large-scale evaluations under programmatic implementation remain rare. * An intersectoral mobile-phone-based system was developed and implemented for rabies surveillance across southern Tanzania. Since 2011, the system has facilitated near real-time reporting of animal bites and human and animal vaccine use (almost 30,000 reports) by over 300 frontline health and veterinary workers across a catchment area of 150,000 km2 with >10 million inhabitants, improving data quality, timeliness, and completeness while reducing costs. * The surveillance system infrastructure is a platform that can be further developed to improve services and deliver health interventions; for example, generating automated personalized text messages (SMS) to alert patients to their vaccination schedules improved their compliance with regimens.
Journal Article
Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype
Mucinous differentiation is associated with both CpG island methylator phenotype and microsatellite instability in colorectal cancer. The mucinous phenotype derives from abundant expression of the colonic goblet cell mucin, MUC2, and
de novo
expression of gastric foveolar mucin, MUC5AC. We, therefore, investigated the protein expression levels of MUC2 and MUC5AC, as well as MUC5B and MUC6, in molecular subtypes of colorectal cancer. Seven-hundred and twenty-two incident colorectal carcinomas occurring in 702 participants of the Melbourne Collaborative Cohort Study were characterized for methylator status,
MLH1
methylation, somatic
BRAF
and
KRAS
mutations, microsatellite-instability status, MLH1, MSH2, MSH6, and PMS2 mismatch repair, and p53 protein expression, and their histopathology was reviewed. Protein expression levels of MUC2, MUC5AC, MUC5B, MUC6, and the putative mucin regulator CDX2 were compared with molecular and clinicopathological features of colorectal cancers using odds ratios and corresponding 95% confidence intervals. MUC2 overexpression (>25% positive tumor cells) was observed in 33% colorectal cancers, MUC5B expression in 53%, and
de novo
MUC5AC and MUC6 expression in 50% and 39%, respectively. Co-expression of two or more of the mucins was commonly observed. Expression of MUC2, MUC5AC and MUC6 was strongly associated with features associated with tumorigenesis via the serrated neoplasia pathway, including methylator positivity, somatic
BRAF
p.V600E mutation, and mismatch repair deficiency, as well as proximal location, poor differentiation, lymphocytic response, and increased T stage (all
P
<0.001). Overexpression was observed in tumors with and without mucinous differentiation. There were inverse associations between expression of all four mucins and p53 overexpression. CDX2 expression was inversely associated with MUC2, MUC5AC and MUC6 expression. Our results suggest that, in methylator-positive tumors, mucin genes on chromosome 11p15.5 region undergo increased expression via mechanisms other than direct regulation by CDX2.
Journal Article