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"Hayes, Amy"
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Facial Mimicry and Emotion Consistency: Influences of Memory and Context
This study investigates whether mimicry of facial emotions is a stable response or can instead be modulated and influenced by memory of the context in which the emotion was initially observed, and therefore the meaning of the expression. The study manipulated emotion consistency implicitly, where a face expressing smiles or frowns was irrelevant and to be ignored while participants categorised target scenes. Some face identities always expressed emotions consistent with the scene (e.g., smiling with a positive scene), whilst others were always inconsistent (e.g., frowning with a positive scene). During this implicit learning of face identity and emotion consistency there was evidence for encoding of face-scene emotion consistency, with slower RTs, a reduction in trust, and inhibited facial EMG for faces expressing incompatible emotions. However, in a later task where the faces were subsequently viewed expressing emotions with no additional context, there was no evidence for retrieval of prior emotion consistency, as mimicry of emotion was similar for consistent and inconsistent individuals. We conclude that facial mimicry can be influenced by current emotion context, but there is little evidence of learning, as subsequent mimicry of emotionally consistent and inconsistent faces is similar.
Journal Article
Building a Pink Dinosaur: the Effects of Gendered Construction Toys on Girls’ and Boys’ Play
Play with building toys such as LEGO® sets promotes spatial learning in children. The present study examined the effects of the color of the bricks (either pink or blue) and the femininity/masculinity of the object built on boys’ and girls’ play with LEGO® sets. Children (n = 116, Mage = 7.27 range = 5–10) were given the opportunity to build with LEGO® brick sets, both instructed and free play tasks. For the instructed task, the type of object (feminine: cat; masculine: dinosaur) and color of the bricks (pink, blue) were counterbalanced across participants. Their play was coded for accuracy of following the instructions and time to complete the task. In the free play task, brick color (pink, blue) was counterbalanced across participants, and structures were coded for femininity/masculinity and the number of bricks used. Overall, children took longer to build a feminine object with blue bricks than with pink bricks. In the free-play task, boys built more masculine objects than girls did, regardless of the color of bricks they were given. Results showed that boys completed the LEGO® tasks faster than did girls, controlling for interest in and experience with LEGO® play. These findings suggest that toy color and type can impact how children interact and play with toys.
Journal Article
Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1
Background
MicroRNA (miRNA)-mediated RNA silencing is integral to virtually every cellular process including cell cycle progression and response to virus infection. The interplay between RNA silencing and HIV-1 is multifaceted, and accumulating evidence posits a strike-counterstrike interface that alters the cellular environment to favor virus replication. For instance, miRNA-mediated RNA silencing of HIV-1 translation is antagonized by HIV-1 Tat RNA silencing suppressor activity. The activity of HIV-1 accessory proteins Vpr/Vif delays cell cycle progression, which is a process prominently modulated by miRNA. The expression profile of cellular miRNA is altered by HIV-1 infection in both cultured cells and clinical samples. The open question stands of what, if any, is the contribution of Tat RNA silencing suppressor activity or Vpr/Vif activity to the perturbation of cellular miRNA by HIV-1.
Results
Herein, we compared the perturbation of miRNA expression profiles of lymphocytes infected with HIV-1
NL4-3
or derivative strains that are deficient in Tat RNA silencing suppressor activity (Tat K51A substitution) or ablated of the vpr/vif open reading frames. Microarrays recapitulated the perturbation of the cellular miRNA profile by HIV-1 infection. The miRNA expression trends overlapped ~50% with published microarray results on clinical samples from HIV-1 infected patients. Moreover, the number of miRNA perturbed by HIV-1 was largely similar despite ablation of Tat RSS activity and Vpr/Vif; however, the Tat RSS mutation lessened HIV-1 downregulation of twenty-two miRNAs.
Conclusions
Our study identified miRNA expression changes attributable to Tat RSS activity in HIV-1
NL4-3
. The results accomplish a necessary step in the process to understand the interface of HIV-1 with host RNA silencing activity. The overlap in miRNA expression trends observed between HIV-1 infected CEMx174 lymphocytes and primary cells supports the utility of cultured lymphocytes as a tractable model to investigate interplay between HIV-1 and host RNA silencing. The subset of miRNA determined to be perturbed by Tat RSS in HIV-1 infection provides a focal point to define the gene networks that shape the cellular environment for HIV-1 replication.
Journal Article
Vision-for-action: The effects of object property discrimination and action state on affordance compatibility effects
When a person views an object, the action the object evokes appears to be activated independently of the person's intention to act. We demonstrate two further properties of this vision-to-action process. First, it is not completely automatic, but is determined by the stimulus properties of the object that are attended. Thus, when a person discriminates the shape of an object, action affordance effects are observed; but when a person discriminates an object's color, no affordance effects are observed. The former, shape property is associated with action, such as how an object might be grasped; the latter, color property is irrelevant to action. Second, we also show that the action state of an object influences evoked action. Thus, active objects, with which current action is implied, produce larger affordance effects than passive objects, with which no action is implied. We suggest that the active object activates action simulation processes similar to those proposed in mirror systems.
Journal Article
Incidental retrieval of prior emotion mimicry
When observing emotional expressions, similar sensorimotor states are activated in the observer, often resulting in physical mimicry. For example, when observing a smile, the zygomaticus muscles associated with smiling are activated in the observer, and when observing a frown, the corrugator brow muscles. We show that the consistency of an individual’s facial emotion, whether they always frown or smile, can be encoded into memory. When the individuals are viewed at a later time expressing no emotion, muscle mimicry of the prior state can be detected, even when the emotion itself is task irrelevant. The results support simulation accounts of memory, where prior embodiments of other’s states during encoding are reactivated when re-encountering a person.
Journal Article