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Necroptosis is a tightly regulated form of necrosis that requires the activation of receptor-interacting protein (RIP) kinases RIPK1 and RIPK3, as well as the RIPK3 substrate mixed lineage kinase domain-like protein (MLKL). Because of membrane rupture, necroptotic cells release damage-associated molecular patterns (DAMPs) that evoke immune responses. Necroptosis is emerging as an important cellular response in the modulation of cancer initiation, progression, and metastasis. Necroptosis of cancer cells is considered to be an immunogenic cell death capable of activating anti-tumor immunity. Necroptosis also participates in the promotion of myeloid cell-induced adaptive immune suppression and thus contributes to oncogenesis. In addition, necroptosis of endothelial cells and tumor cells is conducive to tumor metastasis. In this review, we summarize the current knowledge of the complex role of necroptosis in cancer and discuss the potential of targeting necroptosis components for cancer therapies.

We prove some congruences on sums involving fourth powers of central q -binomial coefficients. As a conclusion, we confirm the following supercongruence observed by Long [Pacific J. Math. 249 (2011), 405–418]:$$\\sum\\limits_{k = 0}^{((p^r-1)/(2))} {\\displaystyle{{4k + 1} \\over {{256}^k}}} \\left( \\matrix{2k \\cr k} \\right)^4\\equiv p^r\\quad \\left( {\\bmod p^{r + 3}} \\right),$$where p ⩾5 is a prime and r is a positive integer. Our method is similar to but a little different from the WZ method used by Zudilin to prove Ramanujan-type supercongruences.

In this study, molecular dynamics (MD) simulations were employed to elucidate the processes and underlying mechanisms that govern the adsorption and accumulation of gas (represented by N2) at the hydrophobic solid–liquid interface, using the GROMACS program with an AMBER force field. Our findings indicate that, regardless of surface roughness, the presence of water molecules is a prerequisite for the adsorption and aggregation of N2 molecules on solid surfaces. N2 molecules dissolved in water can cluster even without a solid substrate. In the gas–solid–liquid system, the exclusion of water molecules at the hydrophobic solid–liquid interface and the adsorption of N2 molecules do not occur simultaneously. A loosely arranged layer of water molecules is initially formed on the hydrophobic solid surface. The two-stage process of N2 molecule adsorption and accumulation at the hydrophobic solid/liquid interface involves initial adsorption to the solid surface, displacing water molecules, followed by N2 accumulation via self-interaction after saturating the substrate’s surface. The process and underlying mechanisms of gas adsorption and accumulation at hydrophobic solid/liquid interfaces elucidated in this study offer a molecular-level understanding of nano-gas layer formation.

Stimuli-responsive intelligent molecular machines/devices are of current research interest due to their potential application in minimized devices. Constructing molecular machines/devices capable of accomplishing complex missions is challenging, demanding coalescence of various functions into one molecule. Here we report the construction of intelligent molecular chiroptical photoswitches based on azobenzene-fused bicyclic pillar[ n ]arene derivatives, which we defined as molecular universal joints (MUJs). The Z / E photoisomerization of the azobenzene moiety of MUJs induces rolling in/out conformational switching of the azobenzene-bearing side-ring and consequently leads to planar chirality switching of MUJs. Meanwhile, temperature variation was demonstrated to also cause conformational/chiroptical inversion due to the significant entropy change during the ring-flipping. As a result, photo-induced chiroptical switching could be prohibited when the temperature exceeded an upper limit, demonstrating an intelligent molecular photoswitch having over-temperature protection function, which is in stark contrast to the low-temperature-gating effect commonly encountered. Realizing overtemperature protection with a molecular device is challenging. Here, the authors demonstrate an overtemperature protection function by integrating thermo- and photoresponsive functions into a pillar[6]arene based pseudocatanene.

In the field of welding robotics, visual sensors, which are mainly composed of a camera and a laser, have proven to be promising devices because of their high precision, good stability, and high safety factor. In real welding environments, there are various kinds of weld joints due to the diversity of the workpieces. The location algorithms for different weld joint types are different, and the welding parameters applied in welding are also different. It is very inefficient to manually change the image processing algorithm and welding parameters according to the weld joint type before each welding task. Therefore, it will greatly improve the efficiency and automation of the welding system if a visual sensor can automatically identify the weld joint before welding. However, there are few studies regarding these problems and the accuracy and applicability of existing methods are not strong. Therefore, a weld joint identification method for visual sensor based on image features and support vector machine (SVM) is proposed in this paper. The deformation of laser around a weld joint is taken as recognition information. Two kinds of features are extracted as feature vectors to enrich the identification information. Subsequently, based on the extracted feature vectors, the optimal SVM model for weld joint type identification is established. A comparative study of proposed and conventional strategies for weld joint identification is carried out via a contrast experiment and a robustness testing experiment. The experimental results show that the identification accuracy rate achieves 98.4%. The validity and robustness of the proposed method are verified.

MXenes-based materials are considered to be one of the most promising electrode materials in the field of sodium-ion batteries due to their excellent flexibility, high conductivity and tuneable surface functional groups. However, MXenes often have severe self-agglomeration, low capacity and unsatisfactory durability, which affects their practical value. The design and synthesis of advanced heterostructures with advanced chemical structures and excellent electrochemical performance for sodium-ion batteries have been widely studied and developed in the field of energy storage devices. In this review, the design and synthesis strategies of MXenes-based sodium-ion battery anode materials and the influence of various synthesis strategies on the structure and properties of MXenes-based materials are comprehensively summarized. Then, the first-principles research progress of MXenes-based sodium-ion battery anode materials is summarized, and the relationship between the storage mechanism and structure of sodium-ion batteries and the electrochemical performance is revealed. Finally, the key challenges and future research directions of the current design and synthesis strategies and first principles of these MXenes-based sodium-ion battery anode materials are introduced.

Electrical control of magnetism in single-molecule magnets with peculiar quantum magnetic behaviours has promise for applications in molecular electronics and quantum computing. Nevertheless, such kind of magnetoelectric effects have not been achieved in such materials. Herein, we report the successful realization of significant magnetoelectric effects by introducing ferroelectricity into a dysprosium-based single-molecule magnet through spatial cooperation between flexible organic ligands and halide ions. The stair-shaped magnetization hysteresis loop, alternating current susceptibility, and magnetic relaxation can be directly modulated by applying a moderate electric field. Conversely, the electric polarization can be modulated by applying a small magnetic field. In addition, a resonant magnetodielectric effect is clearly observed, which enables detection of quantum tunnelling of magnetization by a simple electrical measurement. The integration of ferroelectricity into single-molecule magnets not only broadens the family of single-molecule magnets but also makes electrical detection and modulation of the quantum tunnelling of magnetization a reality. The significant magnetoelectric effects in a Dy-based ferroelectric single molecule magnet enable electrical manipulation and detection of resonant quantum tunneling of magnetization.

The use of carbon nanoparticles (CNPs) as a fertilizer synergist to enhance crop growth has attracted increasing interest. However, current understanding about plant growth and soil response to CNPs is limited. In the present study, we investigated the effects of CNPs at different application rates on soil properties, the plant growth and nutrient use efficiency (NUE) of corn (Zea mays L.) in two agricultural soils (Spodosol and Alfisol). The results showed that CNPs affected corn growth in a dose-dependent manner, augmenting and retarding growth at low and at high concentrations, respectively. The amendment at the optimal rate of 200 mg CNPs kg−1 significantly enhanced corn growth as indicated by improved plant height, biomass yield, nutrient uptake and nutrient use efficiency, which could be explained by the higher availability of phosphorus and nitrogen in the amended soils. The application of CNPs largely stimulated soil urease activity irrespectively of soil types. However, the responses of dehydrogenase and phosphatase to CNPs were dose dependent; their activity significantly increased with the increasing application rates of CNPs up to 200 mg kg−1 but declined at higher rates (>400 mg kg−1). These findings have important implications in the field application of CNPs for enhancing nutrient use efficiency and crop production in tropical/subtropical regions.

Under the background of the steady progress of the structural reform of the agricultural supply side, the rural ecological agriculture in the transition stage is faced with a series of bottlenecks and problems such as the lag of production technology renewal, the single management mechanism and the aggravation of environmental degradation. It is difficult to effectively form a new form of green, coordinated and sustainable development. Therefore, we should make full use of the favorable conditions such as policy support and institutional guarantee given by the structural reform of the agricultural supply side, and introduce efficient and innovative production and management models around the industrial upgrading, so as to promote the low-carbon, intensive and diversified transformation of the existing ecological agriculture operation system.

Small ubiquitin-like modifiers (SUMOs) are post-translational modifications that play crucial roles in most cellular processes. While methods exist to study exogenous SUMOylation, large-scale characterization of endogenous SUMO2/3 has remained technically daunting. Here, we describe a proteomics approach facilitating system-wide and in vivo identification of lysines modified by endogenous and native SUMO2. Using a peptide-level immunoprecipitation enrichment strategy, we identify 14,869 endogenous SUMO2/3 sites in human cells during heat stress and proteasomal inhibition, and quantitatively map 1963 SUMO sites across eight mouse tissues. Characterization of the SUMO equilibrium highlights striking differences in SUMO metabolism between cultured cancer cells and normal tissues. Targeting preferences of SUMO2/3 vary across different organ types, coinciding with markedly differential SUMOylation states of all enzymes involved in the SUMO conjugation cascade. Collectively, our systemic investigation details the SUMOylation architecture across species and organs and provides a resource of endogenous SUMOylation sites on factors important in organ-specific functions. Proteomics is a powerful method to study protein SUMOylation, but system-wide insights into endogenous SUMO2/3 modification events are still sparse. Here, the authors develop a more sensitive SUMO proteomics approach, providing detailed maps of endogenous SUMO2/3 sites in human cells and mouse tissues.