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Artificial intelligence for edge computing
With thousands of publications appearing in AI every year, such a survey is doomed to be incomplete on arrival. It is also not a comprehensive coverage of all the problems in the space of Edge AI. Different applications pose different challenges, and a more comprehensive coverage should be more application specific. Instead, this book covers some of the more endemic challenges across the range of IoT/CPS applications. To offer coverage in some depth, we opt to cover mainly one or a few representative solutions for each of these endemic challenges in sufficient detail, rather that broadly touching on all relevant prior work. The underlying philosophy is one of illustrating by example. The solutions are curated to offer insight into a way of thinking that characterises Edge AI research and distinguishes its solutions from their more mainstream counterparts.
Book
ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells
The development and differentiation of T cells represents a long and highly coordinated, yet flexible at some points, pathway, along which the sequential and dynamic expressions of different transcriptional factors play prominent roles at multiple steps. The large ZBTB family comprises a diverse group of transcriptional factors, and many of them have emerged as critical factors that regulate the lineage commitment, differentiation and effector function of hematopoietic-derived cells as well as a variety of other developmental events. Within the T-cell lineage, several ZBTB proteins, including ZBTB1, ZBTB17, ZBTB7B (THPOK) and BCL6 (ZBTB27), mainly regulate the development and/or differentiation of conventional CD4/CD8 αβ + T cells, whereas ZBTB16 (PLZF) is essential for the development and function of innate-like unconventional γ δ + T & invariant NKT cells. Given the critical role of T cells in host defenses against infections/tumors and in the pathogenesis of many inflammatory disorders, we herein summarize the roles of fourteen ZBTB family members in the development, differentiation and effector function of both conventional and unconventional T cells as well as the underlying molecular mechanisms.
Journal Article
Approaching the activity limit of CoSe2 for oxygen evolution via Fe doping and Co vacancy
Electronic structure engineering lies at the heart of efficient catalyst design. Most previous studies, however, utilize only one technique to modulate the electronic structure, and therefore optimal electronic states are hard to be achieved. In this work, we incorporate both Fe dopants and Co vacancies into atomically thin CoSe
2
nanobelts for /coxygen evolution catalysis, and the resulted CoSe
2
-D
Fe
–V
Co
exhibits much higher catalytic activity than other defect-activated CoSe
2
and previously reported FeCo compounds. Deep characterizations and theoretical calculations identify the most active center of Co
2
site that is adjacent to the V
Co
-nearest surface Fe site. Fe doping and Co vacancy synergistically tune the electronic states of Co
2
to a near-optimal value, resulting in greatly decreased binding energy of OH* (ΔE
OH
) without changing ΔE
O
, and consequently lowering the catalytic overpotential. The proper combination of multiple defect structures is promising to unlock the catalytic power of different catalysts for various electrochemical reactions.
While electronic-structure engineering lies at the heart of catalyst design, most previous studies utilize only one technique to tune the electronic states. Here, authors demonstrate that Fe doping and Co vacancy work synergistically to approach the activity limit of CoSe
2
for oxygen evolution reaction.
Journal Article
Oriented electron transmission in polyoxometalate-metalloporphyrin organic framework for highly selective electroreduction of CO2
The design of highly stable, selective and efficient electrocatalysts for CO
2
reduction reaction is desirable while largely unmet. In this work, a series of precisely designed polyoxometalate-metalloporphyrin organic frameworks are developed. Noted that the integration of {ε-PMo
8
V
Mo
4
VI
O
40
Zn
4
} cluster and metalloporphyrin endows these polyoxometalate-metalloporphyrin organic frameworks greatly advantages in terms of electron collecting and donating, electron migration and electrocatalytic active component in the CO
2
reduction reaction. Thus-obtained catalysts finally present excellent performances and the mechanisms of catalysis processes are discussed and revealed by density functional theory calculations. Most importantly, Co-PMOF exhibits remarkable faradaic efficiency ( > 94%) over a wide potential range (−0.8 to −1.0 V). Its best faradaic efficiency can reach up to 99% (highest in reported metal-organic frameworks) and it exhibits a high turnover frequency of 1656 h
−1
and excellent catalysis stability ( > 36 h).
While CO2 reduction provides a way to remove carbon from the atmosphere, it is challenging to design effective, selective materials for this process. Here, authors construct metal-organic frameworks from polyoxometalates and porphryins to direct electron flow and improve CO2 reduction efficiencies.
Journal Article
Accelerating water dissociation kinetics by isolating cobalt atoms into ruthenium lattice
Designing highly active and robust platinum-free catalysts for hydrogen evolution reaction is of vital importance for clean energy applications yet challenging. Here we report highly active and stable cobalt-substituted ruthenium nanosheets for hydrogen evolution, in which cobalt atoms are isolated in ruthenium lattice as revealed by aberration-corrected high-resolution transmission electron microscopy and X-ray absorption fine structure measurement. Impressively, the cobalt-substituted ruthenium nanosheets only need an extremely low overpotential of 13 mV to achieve a current density of 10 mA cm
−2
in 1 M KOH media and an ultralow Tafel slope of 29 mV dec
−1
, which exhibit top-level catalytic activity among all reported platinum-free electrocatalysts. The theoretical calculations reveal that the energy barrier of water dissociation can greatly reduce after single cobalt atom substitution, leading to its superior hydrogen evolution performance. This study provides a new insight into the development of highly efficient platinum-free hydrogen evolution catalysts.
Water splitting provides an appealing route to generating carbon-neutral fuel, however the scarcity and cost of platinum, often used as a catalyst, necessitates a search for alternatives. Here, authors show cobalt atoms in ruthenium nanosheets to afford excellent hydrogen production activities.
Journal Article
Rutaecarpine Ameliorates Murine N-Methyl-N’-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway
CAG is a burdensome and progressive disease. Numerous studies have shown the effectiveness of RUT in digestive system diseases. The therapeutic effects of RUT on MNNG-induced CAG and the potential mechanisms were probed. MNNG administration was employed to establish a CAG model. The HE and ELISA methods were applied to detect the treatment effects. WB, qRT-PCR, immunohistochemistry, TUNEL, and GES-1 cell flow cytometry approaches were employed to probe the mechanisms. The CAG model was successfully established. The ELISA and HE staining data showed that the RUT treatment effects on CAG rats were reflected by the amelioration of histological damage. The qRT-PCR and WB analyses indicated that the protective effect of RUT is related to the upregulation of the SHH pathway and downregulation of the downstream of apoptosis to improve gastric cellular survival. Our data suggest that RUT induces a gastroprotective effect by upregulating the SHH signaling pathway and stimulating anti-apoptosis downstream.
Journal Article
Branched Chain Amino Acids: Beyond Nutrition Metabolism
Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut health, immunity and disease in humans and animals. As the most abundant of essential amino acids (EAAs), BCAAs are not only the substrates for synthesis of nitrogenous compounds, they also serve as signaling molecules regulating metabolism of glucose, lipid, and protein synthesis, intestinal health, and immunity via special signaling network, especially phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signal pathway. Current evidence supports BCAAs and their derivatives as the potential biomarkers of diseases such as insulin resistance (IR), type 2 diabetes mellitus (T2DM), cancer, and cardiovascular diseases (CVDs). These diseases are closely associated with catabolism and balance of BCAAs. Hence, optimizing dietary BCAA levels should have a positive effect on the parameters associated with health and diseases. This review focuses on recent findings of BCAAs in metabolic pathways and regulation, and underlying the relationship of BCAAs to related disease processes.
Journal Article
Iridium single-atom catalyst on nitrogen-doped carbon for formic acid oxidation synthesized using a general host–guest strategy
Single-atom catalysts not only maximize metal atom efficiency, they also display properties that are considerably different to their more conventional nanoparticle equivalents, making them a promising family of materials to investigate. Herein we developed a general host–guest strategy to fabricate various metal single-atom catalysts on nitrogen-doped carbon (M1/CN, M = Pt, Ir, Pd, Ru, Mo, Ga, Cu, Ni, Mn). The iridium variant Ir1/CN electrocatalyses the formic acid oxidation reaction with a mass activity of 12.9 AmgIr−1 whereas an Ir/C nanoparticle catalyst is almost inert (~4.8 × 10−3 AmgIr−1). The activity of Ir1/CN is also 16 and 19 times greater than those of Pd/C and Pt/C, respectively. Furthermore, Ir1/CN displays high tolerance to CO poisoning. First-principle density functional theory reveals that the properties of Ir1/CN stem from the spatial isolation of iridium sites and from the modified electronic structure of iridium with respect to a conventional nanoparticle catalyst.Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.
Journal Article
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection
Pre-existing immunity to seasonal endemic coronaviruses could have profound consequences for antibody responses to SARS-CoV-2, induced from natural infection or vaccination. A first step to establish whether pre-existing responses can impact SARS-CoV-2 infection is to understand the nature and extent of cross-reactivity in humans to coronaviruses. Here we compare serum antibody and memory B cell responses to coronavirus spike proteins from pre-pandemic and SARS-CoV-2 convalescent donors using binding and functional assays. We show weak evidence of pre-existing SARS-CoV-2 cross-reactive serum antibodies in pre-pandemic donors. However, we find evidence of pre-existing cross-reactive memory B cells that are activated during SARS-CoV-2 infection. Monoclonal antibodies show varying degrees of cross-reactivity with betacoronaviruses, including SARS-CoV-1 and endemic coronaviruses. We identify one cross-reactive neutralizing antibody specific to the S2 subunit of the S protein. Our results suggest that pre-existing immunity to endemic coronaviruses should be considered in evaluating antibody responses to SARS-CoV-2.
Pre-existing immune responses between antigenically related viruses can influence responses in viral infections or vaccinations. Here the authors assess and characterize the presence of antibody and memory B cell populations specific to SARS-CoV2 and endemic human coronaviruses.
Journal Article
Structural transformation of highly active metal–organic framework electrocatalysts during the oxygen evolution reaction
Metal–organic frameworks (MOFs) are increasingly being investigated as electrocatalysts for the oxygen evolution reaction (OER). Despite their promising catalytic activity, many fundamental questions concerning their structure−performance relationships—especially those regarding the roles of active species—remain to be answered. Here we show the structural transformation of a Ni
0.5
Co
0.5
-MOF-74 during the OER by operando X-ray absorption spectroscopy analysis and high-resolution transmission electron microscopy imaging. We suggest that Ni
0.5
Co
0.5
OOH
0.75
, with abundant oxygen vacancies and high oxidation states, forms in situ and is responsible for the high OER activity observed. The ratio of Ni to Co in the bimetallic centres alters the geometric and electronic structure of as-formed active species and in turn the catalytic activity. Based on our understanding of this system, we fabricate a Ni
0.9
Fe
0.1
-MOF that delivers low overpotentials of 198 mV and 231 mV at 10 mA cm
−2
and 20 mA cm
−2
, respectively.
Metal–organic frameworks (MOFs) are increasingly being explored for electrocatalytic oxygen evolution, which is half of the water splitting reaction. Here the authors show that, under reaction conditions, mixed metal oxyhydroxides form at the nodes of bimetallic MOFs, which are highly catalytically active.
Journal Article