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The former Homestakegold mine in Lead, South Dakota has been transformed into a dedicated facility to pursue underground research in rare-process physics, as well as offering research opportunities in other disciplines such as biology, geology and engineering. A key component of the Sanford Underground Research Facility (SURF) is the Davis Campus, which is in operation at the 4850-foot level (4300 m.w.e.) and currently hosts two main physics projects: the LUX dark matter experiment and the MAJORANA DEMONSTRATOR neutrinolessdouble-beta decay experiment. In addition, two low-background counters currently operate at the Davis Campus in support of current and future experiments. Expansion of the underground laboratory space is underway at the 4850L Ross Campus in order to maintain and enhance low- background assay capabilities as well as to host a unique nuclear astrophysics accelerator facility. Plans to accommodate other future experiments at SURF are also underway and include the next generation of direct-search dark matter experiments and the Fermilab-led international long- baseline neutrino program. Planning to understand the infrastructure developments necessary to accommodate these future projects is well advanced and in some cases have already started. SURF is a dedicated research facility with significant expansion capability.

The Sanford Underground Research Facility (SURF) has been operating since 2007 supporting underground research in rare-process physics, as well as offering research opportunities in other disciplines. SURF laboratory facilities include a Surface Campus as well as campuses at the 4850-foot level (1500 m, 4300 m.w.e.) that host a range of significant physics experiments, including the LUX-ZEPLIN (LZ) dark matter experiment and the MAJORANA DEMONSTRATOR neutrinoless double-beta decay experiment. The CASPAR nuclear astrophysics accelerator recently completed the first phase of operation. Furthermore, the BHUC laboratory dedicated to critical material assays for current and future experiments has been operating since Fall 2015. Construction is underway for the Long-Baseline Neutrino Facility (LBNF) that will host the international Deep Underground Neutrino Experiment (DUNE). SURF is a dedicated research facility with significant expansion capability, and applications from new experiments are welcome.

The former Homestake gold mine in Lead, South Dakota, has been transformed into a dedicated facility to pursue underground research in rare-process physics, as well as offering unique research opportunities in other disciplines. The Sanford Underground Research Facility (SURF) includes two main campuses at the 4850-foot level (4300 m.w.e.) - the Davis Campus and the Ross Campus - that host a range of significant physics projects: the LUX dark matter experiment, the MAJORANA DEMONSTRATOR neutrinoless double-beta decay experiment and the CASPAR nuclear astrophysics accelerator. Furthermore, the BHUC Ross Campus laboratory dedicated to critical material assays for current and future experiments has been operating since Fall 2015. Research efforts in biology, geology and engineering have been underway at SURF for 10 years and continue to be a strong component of the SURF research program. Plans to accommodate future experiments at SURF are well advanced and include geothermal-related projects, the next generation direct-search dark matter experiment LUX-ZEPLIN (LZ) and the Fermilab-led international Deep Underground Neutrino Experiment (DUNE) at the Long Baseline Neutrino Facility (LBNF). SURF is a dedicated research facility with significant expansion capability, and applications from other experiments are welcome.

Our primary aim was to identify predictors of immediate hemodynamic decompensation during the peri-intubation period. We conducted a nested case-control study of a previously identified cohort of adult patients needing intubation admitted to a medical-surgical ICU during 2013–2014. Hemodynamic derangement was defined as cardiac arrest and/or the development of systolic blood pressure <90mmHg and/or mean arterial pressure <65mmHg 30min following intubation. Data during the peri-intubation period was analyzed. The final cohort included 420 patients. Immediate hemodynamic derangement occurred in 170 (40%) patients. On multivariate modeling, age/10year increase (OR 1.20, 95% CI 1.03–1.39, p=0.02), pre-intubation non-invasive ventilation (OR 1.71, 95% CI 1.04–2.80, p=0.03), pre-intubation shock index/1 unit (OR 5.37 95% CI 2.31–12.46, p≤0.01), and pre-intubation modified shock index/1 unit (OR 2.73 95% CI 1.48–5.06, p≤0.01) were significantly associated with hemodynamic derangement. Those experiencing hemodynamic derangement had higher ICU [47 (28%) vs. 33 (13%); p≤0.001] and hospital [69 (41%) vs. 51 (20%); p≤0.001] mortality. Hemodynamic derangement occurred at a rate of 40% and was associated with increased mortality. Increasing age, use of non-invasive ventilation before intubation, and increased pre-intubation shock and modified shock index values were significantly associated with hemodynamic derangement post-intubation.

Abstract The ability to accurately decode others’ facial expressions is essential for successful social interaction. Previous theories suggest that aspects of parental emotionality—the frequency, persistence and intensity of parents’ own emotions—can influence children’s emotion perception. Through a combination of mechanisms, parental emotionality may shape how children’s brains specialize to respond to emotional expressions, but empirical data are lacking. The present study provides a direct empirical test of the relation between the intensity, persistence and frequency of parents’ own emotions and children’s neural responses to perceiving emotional expressions. Event-related potentials (ERPs) were recorded as typically developing 3- to 5-year-old children (final Ns = 59 and 50) passively viewed faces expressing different emotional valences (happy, angry and fearful) at full and reduced intensity (100% intense expression and 40% intense expression). We examined relations between parental emotionality and children’s mean amplitude ERP N170 and negative central responses. The findings demonstrate a clear relation between parental emotionality and children’s neural responses (in the N170 mean amplitude and latency) to emotional expressions and suggest that parents may influence children’s emotion-processing neural circuitry.

The Surviving Sepsis Campaign suggested preferential resuscitation with balanced crystalloids, such as Lactated Ringer's (LR), although the level of recommendation was weak, and the quality of evidence was low. Past studies reported an association of unbalanced solutions, such as normal saline (NS), with increased AKI risks, metabolic acidosis, and prolonged ICU stay, although some of the findings are conflicting. We have compared the outcomes with the preferential use of normal saline vs. ringer's lactate in a cohort of sepsis patients. We performed a retrospective cohort analysis of patients visiting the ED of 19 different Mayo Clinic sites between August 2018 to November 2020 with sepsis and receiving at least 30 mL/kg fluid in the first 6 h. Patients were divided into two cohorts based on the type of resuscitation fluid (LR vs. NS) and propensity-matching was done based on clinical characteristics as well as fluid amount (with 5 ml/kg). Single variable logistic regression (categorical outcomes) and Cox proportional hazards regression models were used to compare the primary and secondary outcomes between the 2 groups. Out of 2022 patients meeting our inclusion criteria; 1,428 (70.6%) received NS, and 594 (29.4%) received LR as the predominant fluid (>30 mL/kg). Patients receiving predominantly NS were more likely to be male and older in age. The LR cohort had a higher BMI, lactate level and incidence of septic shock. Propensity-matched analysis did not show a difference in 30-day and in-hospital mortality rate, mechanical ventilation, oxygen therapy, or CRRT requirement. We did observe longer hospital LOS in the LR group (median 5 vs. 4 days, = 0.047 and higher requirement for ICU post-admission (OR: 0.70; 95% CI: 0.51-0.96; = 0.026) in the NS group. However, these did not remain statistically significant after adjustment for multiple testing. In our matched cohort, we did not show any statistically significant difference in mortality rates, hospital LOS, ICU admission after diagnosis, mechanical ventilation, oxygen therapy and RRT between sepsis patients receiving lactated ringers and normal saline as predominant resuscitation fluid. Further large-scale prospective studies are needed to solidify the current guidelines on the use of balanced crystalloids.

In two studies (“App-based infection assessment in RESIST (iAR)” and “Digital infection monitoring in persons living with immunodeficiency (DIMI)” ), we monitor health related items, as vaccination against SARS-CoV-2 and conduct syndromic surveillance of acute respiratory infections in high-risk populations, i.e. elderly persons and persons living with HIV, respectively. In a third very similar study (“Sensors for measuring aerosols and reactive gases to deduce health effects (SMARAGD)”) mainly healthy adults participate. To record incident or recurring transient health events, risk factors and further health data in real-time, we developed the eResearch system “PIA - Prospective Monitoring and Management App”. Recruitment for RESIST, SMARAGD and DIMI started in March 2021 and is ongoing. The questionnaire was presented in April 2022. Preliminary results include 86 participants from the three cohorts. In total, one indicated to be not vaccinated, none were vaccinated once, three (3.5%) twice, 63 (73.3%) three times and 19 (22.1%) four times. Participants reported the following adverse events after immunization (AEFI): after 40 applied doses with Vaxzevria® 24 AEFI (60%); after 158 doses of Comirnaty® 41 AEFI (26%); after 62 doses of Spikevax® 19 AEFI (30.7%); and after three doses of Janssen®, one AEFI (33.3%). In these cohorts, 20 (23.36%) participants stated having had a SARS-CoV-2 infection, of these 16 (80%) after the last vaccination dose, three (15%) before the first dose and one (5%) in between doses. Most participants were vaccinated three times, with Comirnaty being the most applied vaccine, as in officially reported numbers. AEFI varied according to vaccine and were higher than in the German surveillance system (1.64/1000 doses). Most infections were indicated to have been diagnosed after the booster vaccination. The results are limited by the small sample size and possible bias through self-reporting and social desirability regarding vaccination status. Key messages • Overall, most participants were vaccinated with Comirnaty and had three doses of vaccine. Of the participants with a diagnosed SARS-CoV-2-infection, most got infected after the booster vaccine. • The number of reported AEFI was higher than in the official surveillance in Germany.

The discovery of afterglows associated with γ-ray bursts at X-ray 1 , optical 2 and radio 3 wavelengths and the measurement of the redshifts of some of these events 4 , 5 has established that γ-ray bursts lie at extreme distances, making them the most powerful photon-emitters known in the Universe. Here we report the discovery of transient optical emission in the error box of the γ-ray burst GRB980425, the light curve of which was very different from that of previous optical afterglows associated with γ-ray bursts. The optical transient is located in a spiral arm of the galaxy ESO184-G82, which has a redshift velocity of only 2,550 km s −1 ( ref. 6 ). Its optical spectrum and location indicate that it is a very luminous supernova 7 , which has been identified as SN1998bw. If this supernova and GRB980425 are indeed associated, the energy radiated in γ-rays is at least four orders of magnitude less than in other γ-ray bursts, although its appearance was otherwise unremarkable: this indicates that very different mechanisms can give rise to γ-ray bursts. But independent of this association, the supernova is itself unusual, exhibiting an unusual light curve at radio wavelengths that requires that the gas emitting the radio photons be expanding relativistically 8 , 9 .

The origin of γ-ray bursts (GRBs) has been enigmatic since their discovery 1 . The situation improved dramatically in 1997, when the rapid availability of precise coordinates 2 , 3 for the bursts allowed the detection of faint optical and radio afterglows — optical spectra thus obtained have demonstrated conclusively that the bursts occur at cosmological distances. But, despite efforts by several groups 4 , 5 , 6 , 7 , optical detection has not hitherto been achieved during the brief duration of a burst. Here we report the detection of bright optical emission from GRB990123 while the burst was still in progress. Our observations begin 22 seconds after the onset of the burst and show an increase in brightness by a factor of 14 during the first 25 seconds; the brightness then declines by a factor of 100, at which point (700 seconds after the burst onset) it falls below our detection threshold. The redshift of this burst, z ≈ 1.6 ( refs 8 , 9 ), implies a peak optical luminosity of 5× 10 49  erg s −1 . Optical emission from γ-ray bursts has been generally thought to take place at the shock fronts generated by interaction of the primary energy source with the surrounding medium, where the γ-rays might also be produced. The lack of a significant change in the γ-ray light curve when the optical emission develops suggests that the γ-rays are not produced at the shock front, but closer to the site of the original explosion 10 .

Researchers report the detection of an X-ray afterglow associated with the gamma-ray burst of Feb 28, 1997--the first such detection for any gamma-ray burst. The X-ray transient was found to contain a significant fraction of the total energy of the gamma-ray burst.