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In this 2-year trial involving patients with Parkinson's disease and early motor complications, subthalamic stimulation plus medical therapy resulted in better quality of life and motor function than medical therapy alone. Parkinson's disease is a progressive neurodegenerative disease that affects dopaminergic neurotransmission, resulting in bradykinesia, rigidity, and rest tremor. After an initial honeymoon period, during which there is a sustained response to dopaminergic treatment, beneficial effects are hampered by levodopa-induced motor complications, 1 progressively compromising quality of life. 2 – 4 Because levodopa-responsive parkinsonian symptoms are improved by high-frequency stimulation of the subthalamic nucleus, 5 , 6 neurostimulation has become an established treatment for advanced Parkinson's disease with medically intractable fluctuations and dyskinesia 7 – 10 and has shown long-term efficacy. 11 – 13 It is typically used after the disease has been present for 11 to 13 years, 7 – . . .

Neutrinos were assumed to be massless particles until the discovery of the neutrino oscillation process. This phenomenon indicates that the neutrinos have non-zero masses and the mass eigenstates ( ν 1 , ν 2 , ν 3 ) are mixtures of their flavour eigenstates ( ν e , ν μ , ν τ ). The oscillations between different flavour eigenstates are described by three mixing angles ( θ 12 , θ 23 , θ 13 ), two differences of the squared neutrino masses of the ν 2 / ν 1 and ν 3 / ν 1 pairs and a charge conjugation parity symmetry violating phase δ CP . The Double Chooz experiment, located near the Chooz Electricité de France reactors, measures the oscillation parameter θ 13 using reactor neutrinos. Here, the Double Chooz collaboration reports the measurement of the mixing angle θ 13 with the new total neutron capture detection technique from the full data set, yielding sin 2 (2 θ 13 ) = 0.105 ± 0.014. This measurement exploits the multidetector configuration, the isoflux baseline and data recorded when the reactors were switched off. In addition to the neutrino mixing angle measurement, Double Chooz provides a precise measurement of the reactor neutrino flux, given by the mean cross-section per fission 〈 σ f 〉 = (5.71 ± 0.06) × 10 −43  cm 2 per fission, and reports an empirical model of the distortion in the reactor neutrino spectrum. The Double Chooz collaboration reports the neutrino oscillation parameter θ 13 from a measurement of the disappearance of reactor anti-electron neutrinos with the total neutron capture technique.

We present a search for signatures of neutrino mixing of electron anti-neutrinos with additional hypothetical sterile neutrino flavors using the Double Chooz experiment. The search is based on data from 5 years of operation of Double Chooz, including 2 years in the two-detector configuration. The analysis is based on a profile likelihood, i.e. comparing the data to the model prediction of disappearance in a data-to-data comparison of the two respective detectors. The analysis is optimized for a model of three active and one sterile neutrino. It is sensitive in the typical mass range 5×10-3eV2≲Δm412≲3×10-1eV2 for mixing angles down to sin22θ14≳0.02. No significant disappearance additionally to the conventional disappearance related to θ13 is observed and correspondingly exclusion bounds on the sterile mixing parameter θ14 as a function of Δm412 are obtained.

Double Chooz is a reactor antineutrino disappearance experiment located in Chooz, France. A far detector at a distance of about 1 km from reactor cores is operating since 2011; a near detector of identical design at a distance of about 400 m is operating since begin 2015. Beyond the precise measurement of θ13, Double Chooz has a strong sensitivity to so called light sterile neutrinos. Sterile neutrinos are neutrino mass states not taking part in weak interactions, but may mix with known neutrino states. In this paper, we present an analysis method to search for sterile neutrinos and the expected sensitivity with the baselines of our detectors.

A bstract A θ 13 oscillation analysis based on the observed antineutrino rates at the Double Chooz far and near detectors for different reactor power conditions is presented. This approach provides a so far unique simultaneous determination of θ 13 and the total background rates without relying on any assumptions on the specific background contributions. The analysis comprises 865 days of data collected in both detectors with at least one reactor in operation. The oscillation results are enhanced by the use of 24.06 days (12.74 days) of reactor-off data in the far (near) detector. The analysis considers the ν ¯ e interactions up to a visible energy of 8.5 MeV, using the events at higher energies to build a cosmogenic background model considering fast-neutrons interactions and 9 Li decays. The background-model-independent determination of the mixing angle yields sin 2 (2 θ 13 ) = 0 . 094 ± 0 . 017, being the best-fit total background rates fully consistent with the cosmogenic background model. A second oscillation analysis is also performed constraining the total background rates to the cosmogenic background estimates. While the central value is not significantly modified due to the consistency between the reactor-off data and the background estimates, the addition of the background model reduces the uncertainty on θ 13 to 0.015. Along with the oscillation results, the normalization of the anti-neutrino rate is measured with a precision of 0.86%, reducing the 1.43% uncertainty associated to the expectation.

Two experiments were conducted to determine the efficacy of mannan oligosaccharides (MOS) fed at two levels of Cu on growth and feed efficiency of weanling and growing-finishing pigs, as well as the effect on the immunocompetence of weanling pigs. In Exp. 1, 216 barrows (6 kg of BW and 18 d of age) were penned in groups of six (9 pens/treatment). Dietary treatments were arranged as a 2 x 2 factorial consisting of two levels of Cu (basal level or 175 ppm supplemental Cu) with and without MOS (0.2%). Diets were fed from d 0 to 38 after weaning. Blood samples were obtained to determine lymphocyte proliferation in vitro. From d 0 to 10, ADG, ADFI, and gain:feed (G:F) increased when MOS was added to diets containing the basal level of Cu, but decreased when MOS was added to diets containing 175 ppm supplemental Cu (interaction, P < 0.01, P < 0.10, and P < 0.05, respectively). Pigs fed diets containing 175 ppm Cu from d 10 to 24 and d 24 to 38 had greater (P < 0.05) ADG and ADFI than those fed the basal level of Cu regardless of MOS addition. Pigs fed diets containing MOS from d 24 to 38 had greater ADG (P < 0.05) and G:F (P < 0.10) than those fed diets devoid of MOS. Lymphocyte proliferation was not altered by dietary treatment. In Exp. 2, 144 pigs were divided into six pigs/pen (six pens/treatment). Dietary treatments were fed throughout the starter (20 to 32 kg BW), grower (32 to 68 kg BW), and finisher (68 to 106 kg BW) phases. Diets consisted of two levels of Cu (basal level or basal diet + 175 ppm in starter and grower diets and 125 ppm in finisher diets) with and without MOS (0.2% in starter, 0.1% in grower, and 0.05% in finisher). Pigs fed supplemental Cu had greater (P < 0.05) ADG and G:F during the starter and grower phases compared to pigs fed the basal level of Cu. During the finisher phase, ADG increased when pigs were fed MOS in diets containing the basal level of Cu, but decreased when MOS was added to diets supplemented with 125 ppm Cu (interaction, P < 0.05). Results from this study indicate the response of weanling pigs fed MOS in phase 1 varied with level of dietary Cu. However, in phase 2 and phase 3, diets containing either MOS or 175 ppm Cu resulted in improved performance. Pharmacological Cu addition improved gain and efficiency during the starter and grower phases in growing-finishing pigs, while ADG response to the addition of MOS during the finisher phase seems to be dependent upon the level of Cu supplementation.

A bstract The yields and production rates of the radioisotopes 9 Li and 8 He created by cosmic muon spallation on 12 C, have been measured by the two detectors of the Double Chooz experiment. The identical detectors are located at separate sites and depths, which means that they are subject to different muon spectra. The near (far) detector has an overburden of ∼120 m.w.e. (∼300 m.w.e.) corresponding to a mean muon energy of 32.1 ± 2.0 GeV (63.7 ± 5.5 GeV). Comparing the data to a detailed simulation of the 9 Li and 8 He decays, the contribution of the 8 He radioisotope at both detectors is found to be compatible with zero. The observed 9 Li yields in the near and far detectors are 5.51 ± 0.51 and 7.90 ± 0.51, respectively, in units of 10 −8 μ −1 g −1 cm 2 . The shallow overburdens of the near and far detectors give a unique insight when combined with measurements by KamLAND and Borexino to give the first multi-experiment, data driven relationship between the 9 Li yield and the mean muon energy according to the power law Y = Y 0 E μ / 1 GeV α ¯ , giving α ¯ = 0.72 ± 0.06 and Y 0 = (0.43 ± 0.11) × 10 −8 μ −1 g −1 cm 2 . This relationship gives future liquid scintillator based experiments the ability to predict their cosmogenic 9 Li background rates.

A comprehensive look at the practice of nuclear medicine training and practice in Germany is presented. Overall there are about 1,000 registered specialists in nuclear medicine in Germany compared to nearly 7,000 radiologists.

Many communities along coastlines and riverbanks are threatened by water erosion and hence an accurate model to predict erosion events is needed in order to plan mitigation strategies. Such models need to rely on readily available meteorological data that may or may not be correlated with the occurrence of erosion events. Computing these correlations requires a quantified index that reports the magnitude of erosion events over time. This study introduces a method to create erosion indices using affordable consumer grade digital cameras. It is able to detect and quantify erosion using an image series obtained from just one such camera by segmenting each images instance into equally sized squares that can be preprocessed and analyzed separately. This approach isolates each image segment from noise and temporary disturbances that frequently occur throughout images taken with low cost cameras. In this fashion, noise may either be addressed locally or simply ignored if it is too extreme. After preprocessing, comparison of subsequent segments yields change matrices that form the basis for segment-specific erosion indices that are later combined into a composite value for the entire image instance. Whenever a segment instance is unavailable or unusable, the algorithm attempts to use neighboring instances whenever possible. When tested against human observation of erosion events during a 6 week period, the resulting index achieves a true positive rate of 67% while producing only a small number of false positives. Finally, the index is validated by significant correlation with various meteorological data streams.