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Background: Recently we showed that antibodies to myelin oligodendrocyte glycoprotein (MOG) can be found in aquaporin-4 (AQP4)-immunoglobulin (IgG) seronegative pediatric and adult patients with definite and high-risk neuromyelitis optica (NMO). Objective: The purpose of this study was to describe the clinical characteristics and temporal dynamics of MOG-IgG in AQP4-IgG seronegative pediatric patients presenting with definite NMO. Methods: Children with definite NMO who were referred for further testing of serum antibodies for AQP4 and MOG with a cell-based assay were included in this study. Clinical disease course, cerebrospinal fluid and magnetic resonance imaging (MRI) studies of these patients were reviewed. Results: Between 2008 and 2012 eight children who fulfilled the diagnostic criteria of definite NMO were recruited. Two children with definite NMO tested positive for AQP4-IgG but were negative for MOG-IgG antibodies. Three children had an absence of AQP4-IgG and MOG-IgG antibodies. Three children with definite NMO had high titers of serum MOG-IgG antibodies (≥1: 160), but no AQP4-directed humoral immune response. Longitudinal analysis of serum samples of the latter three children showed persisting high MOG-IgG titers over time. Conclusion: Pediatric patients presenting with clinical symptoms and MRI findings highly suggestive of NMO but with high and persisting MOG-IgG antibody titers are most likely to represent a distinct subgroup of acute demyelinating diseases with important clinical and therapeutic implications.

Background Myelin oligodendrocyte glycoprotein (MOG) antibodies have been recently described in children with acute disseminating encephalomyelitis (ADEM), but the clinical and neuroradiological characterisation of this subgroup is lacking. Objective To compare the clinical and neuroradiological features of paediatric ADEM with and without MOG antibodies. Methods Clinical course, cerebrospinal fluid (CSF)-, MRI studies, outcome and MOG status of 33 paediatric ADEM prospectively studied were reviewed. Results MOG antibodies (median 1:2560; range 1:160–1:20 480) were detected in 19 children with ADEM. The majority of children showed a decline of serum MOG-IgG titres over time. Children with MOG antibodies did not differ in their age at presentation, sex ratio, the presence of oligoclonal bands, clinical symptoms or initial severity, apart from a higher CSF cell count (p=0.038), compared with children without MOG antibodies. In addition, further relapsing demyelinating episodes associated with MOG antibodies were observed only in children with MOG antibodies. All 19 children with MOG antibodies had a uniform MRI pattern, characterised by large, hazy and bilateral lesions and the absence of atypical MRI features (eg, mainly small lesions, well-defined lesions), which was significantly different compared to that of children without MOG antibodies (p=0.003; and p=0.032, respectively). In addition, children with MOG antibodies had involvement of more anatomical areas (p=0.035) including the myelon characterised by a longitudinally extensive transverse myelitis (p=0.003), more often a complete resolution of lesions (p=0.036) and a better outcome (p=0.038). Conclusions Patients with ADEM with MOG antibodies in our cohort had a uniform MRI characterised by large, bilateral and widespread lesions with an increased frequency of longitudinal extensive transverse myelitis and a favourable clinical outcome in contrast to children lacking MOG antibodies.

Fluctuations of the local gravitational field as a result of seismic and atmospheric displacements will limit the sensitivity of ground based gravitational wave detectors at frequencies below 10 Hz. We discuss the implications of Newtonian noise for future third generation gravitational wave detectors. The relevant seismic wave fields are predominately of human origin and are dependent on local infrastructure and population density. Seismic studies presented here show that considerable seismic noise reduction is possible compared to current detector locations. A realistic seismic amplitude spectral density of a suitably quiet site should not exceed 0.5 nm/(Hz/f)2 above 1 Hz. Newtonian noise models have been developed both analytically and by finite element analysis. These show that the contribution to Newtonian noise from surface waves due to distance sources significantly reduces with depth. Seismic displacements from local sources and body waves then become the dominant contributors to the Newtonian fluctuations.

Gravity gradient noise generated by seismic displacements constitute a limiting factor for the sensitivity of ground based gravitational wave detectors at frequencies below 10 Hz. We present a finite element framework to calculate the soil response to various excitations. The accompanying gravity gradients as a result of the seismic displacement field can then be evaluated. The framework is first shown to accurately model seismic waves in homogenous media. Calculations of the gravity gradient noise are then shown to be in agreement with previous analytical results. Finally results of gravity gradient noise from a single pulse excitation of a homogenous medium are discussed.

Abstract The major construction and initial-phase operation of a second-generation gravitational-wave detector, KAGRA, has been completed. The entire 3 km detector is installed underground in a mine in order to be isolated from background seismic vibrations on the surface. This allows us to achieve a good sensitivity at low frequencies and high stability of the detector. Bare-bones equipment for the interferometer operation has been installed and the first test run was accomplished in March and April of 2016 with a rather simple configuration. The initial configuration of KAGRA is called iKAGRA. In this paper, we summarize the construction of KAGRA, including a study of the advantages and challenges of building an underground detector, and the operation of the iKAGRA interferometer together with the geophysics interferometer that has been constructed in the same tunnel.

Gravity gradient noise generated by seismic displacements may be the limiting factor for the sensitivity of third-generation gravitational wave detectors at frequencies below 10 Hz. A finite element framework has been developed to calculate the soil response to various excitations. The accompanying gravity gradients as a result of the seismic displacement field can then be evaluated. The results of the gravity gradient noise are in good agreement with previous analytical results. Finally results of gravity gradient noise from a single pulse excitation of a homogenous medium are discussed for an underground detector.

The combination of low temperature and low vibration levels is key for ultrasensitive sensing applications such as scanning probe microscopy, large-mass quantum mechanics, and gravitational wave detection. Unfortunately, closed-cycle cryostats using pulse tube or GM coolers introduce strong low-frequency vibrations starting at 1 Hz. Mass-spring systems allow passive isolation, but for low-frequency applications the required spring constants and masses become impractical. Blade-based geometric anti-spring systems are compact isolators that operate from sub-Hz frequencies, but have not been demonstrated at cryogenic temperatures. Here, we characterize a geometric anti-spring system tuned to operate at cryogenic temperatures. Our cryogenic filter uses radially arranged titanium blade springs whose effective spring constant can be tuned in-situ using a magnetic actuator. Our system achieves a vertical resonance frequency of 185 mHz at 7K, which allows reduction of vibrations at the problematic 1 Hz cooler frequency by an order of magnitude.

The third-generation of gravitational wave observatories, such as the Einstein Telescope (ET) and Cosmic Explorer (CE), aim for an improvement in sensitivity of at least a factor of ten over a wide frequency range compared to the current advanced detectors. In order to inform the design of the third-generation detectors and to develop and qualify their subsystems, dedicated test facilities are required. ETpathfinder prototype uses full interferometer configurations and aims to provide a high sensitivity facility in a similar environment as ET. Along with the interferometry at 1550 nm and silicon test masses, ETpathfinder will focus on cryogenic technologies, lasers and optics at 2090 nm and advanced quantum-noise reduction schemes. This paper analyses the underpinning noise contributions and combines them into full noise budgets of the two initially targeted configurations: 1) operating with 1550 nm laser light and at a temperature of 18 K and 2) operating at 2090 nm wavelength and a temperature of 123 K.

Endometrial scratching (with the use of a pipelle biopsy) is a technique proposed to facilitate embryo implantation in women undergoing in vitro fertilization. In this multicenter, open-label, randomized, controlled trial, endometrial scratching did not result in a higher rate of live birth than no intervention among women undergoing IVF.