Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
31
result(s) for
"Henson, Heather"
Sort by:
Dream of Night
Told from their different points of view, twelve-year-old Shiloh, a troubled foster child, Dream of Night, an abused former racehorse, and Jess, a woman who cares for both, find healing by helping one another through their pain.
Book
Assessment of the Effect of Varying Soil Organic Matter Content on the Bioavailability of Malathion to the Common Nightcrawler, Lumbricus terrestris L
This study investigated the effect of soil organic matter content on the bioavailability of malathion to the common nightcrawler, Lumbricus terrestris. Earthworms were exposed for 72 h to malathion on two soil types, 8% organic matter and 55% organic matter. Two different measures of bioavailability, malathion body burdens and tissue cholinesterase activities, were then measured in the malathion exposed animals. There were no significant differences in body burden or cholinesterase levels in L. terrestris exposed to malathion on soils with differing organic matter content. This suggests that absorption into organic matter is not a limiting factor of malathion bioavailability to earthworm species.
Journal Article
The whole sky
Twelve-year-old Sky, a horse whisperer like her father, must put her own troubles aside when a devastating sickness strikes the foals at the multimillion dollar horse farms where they work.
Book
A Comparison of Multiple Esterases as Biomarkers of Organophosphate Exposure and Effect in Two Earthworm Species
Two different earthworm species,
Eisenia fetida
and
Lumbricus terrestris
, were exposed to 5 μg/cm
2
of malathion to evaluate their usefulness as sentinels of organophosphate exposure and to assess three different esterases, as biomarkers of malathion exposure and effect. Tissue xenobiotic burdens and esterase activity were determined for each species and each esterase in order to assess variability.
E. fetida
exhibited 4-fold less variability in tissue burdens than did
L. terrestris
and had less variable basal esterase activities. An attempt was made to correlate malathion and malaoxon tissue burdens with esterase activity post-exposure. There was no malaoxon present in the earthworm tissues. No significant correlations were determined by comparing acetylcholinesterase, butyrylcholinesterase, nor carboxylesterase activities with malathion burdens.
Journal Article
Grumpy Grandpa
Jack's grandfather is always grumpy, and a bit scary, too, but during a visit to the country house where \"Grumpy Grandpa\" lives with the brave Aunt Ellie and Uncle Wilbur, Jack learns that his grandfather was once very different.
Book
Little house parties
From the maple syrup party at her grandpa's house in the Big Woods in Wisconsin to parties with her school friends in Plum Creek and her first co-ed party in De Smet, Dakota Territory, Laura enjoys all kinds of gatherings.
BRAILLE
Development of a Dynamic Pharmacokinetic Model to Estimate Bioconcentration of Xenobiotics in Earthworms
A simple and dynamic pharmacokinetic model was developed to predict bioconcentration of organic contaminants in earthworms. The model was parameterized experimentally by placing Lumbricus terrestris in soil contaminated with 200 μg/cm² of malathion. The toxicokinetics of malathion uptake, depuration, and degradation in soil is measured. After parameterization, the model was able to accurately predict the bioconcentration factor of malathion at steady state. Sensitivity analyses were performed and the rate of absorption was determined to be the most sensitive parameter. Varying the rate of malathion elimination from earthworm tissues, malathion degradation, and the amount of malathion applied to the soil by 25-fold did not result in the bioconcentration of malathion. An increase in the rate of malathion absorption into earthworm tissues by 25-fold did result in bioconcentration. Previously published pharmacokinetic studies on xenobiotics with log K ow values ranging up to 8.05 were used to test the predictive capacity of the model. The model was able to predict from 83% to 105% of the experimentally derived bioconcentration factors.
Journal Article
Assessment of malathion environmental kinetics using earthworm and salamander models
This research was designed to assess the toxicity, toxicokinetics, and bioaccumulation of malathion in an earthworm and amphibian laboratory model. Malathion toxicity was assessed by measuring cholinesterase activity with the Ellman assay in the earthworms, Lumbricus terrestris and Eisenia foetida, and in the tiger salamander, Ambystoma tigrinum. All exposed animals had decreased tissue cholinesterase activities compared to unexposed controls. Cholinesterase activities were suppressed approximately 50% in Lumbricus and 90% in Eisenia. Additionally, there were significantly different basal enzyme activities between the two species. Ambystoma tigrinum exposed to malathion by soil or by soil and food exhibited 50-90% suppression in cholinesterase depending on exposure concentration. Regardless of the degree of cholinesterase suppression, clinical signs did not correlate well with enzyme activity in any of the malathion exposed animals. There were detectable xenobiotic burdens after exposure to malathion as measured by gas chromatography, in L. terrestris, E. foetida, and A. tigrinum. However, the tissue concentrations were not high enough when compared to soil concentrations to suggest bioaccumulation. Multiple earthworm exposure methods were compared and it was determined that exposing L. terrestris to malathion by filter paper contact significantly increased body burdens compared to exposure to similar concentrations by soil contact. The toxicokinetics of malathion absorption and elimination in L. terrestris were studied and used to parameterize a mathematical model for the estimation of the bioconcentration of xenobiotics in earthworms. The model can be used to accurately predict the bioconcentration of multiple xenobiotics within 85-103% of experimentally determined values. Published literature was used to validate the model's effectiveness and the rate of absorption was determined to be the most sensitive parameter.
Dissertation
Virome-wide detection of natural infection events and the associated antibody dynamics using longitudinal highly-multiplexed serology
Current methods for detecting infections either require a sample collected from an actively infected site, are limited in the number of agents they can query, and/or yield no information on the immune response. Here we present an approach that uses temporally coordinated changes in highly-multiplexed antibody measurements from longitudinal blood samples to monitor infection events at sub-species resolution across the human virome. In a longitudinally-sampled cohort of South African adolescents representing >100 person-years, we identify >650 events across 48 virus species and observe strong epidemic effects, including high-incidence waves of
Aichivirus A
and the D68 subtype of
Enterovirus D
earlier than their widespread circulation was appreciated. In separate cohorts of adults who were sampled at higher frequency using self-collected dried blood spots, we show that such events temporally correlate with symptoms and transient inflammatory biomarker elevations, and observe the responding antibodies to persist for periods ranging from ≤1 week to >5 years. Our approach generates a rich view of viral/host dynamics, supporting novel studies in immunology and epidemiology.
Methods to detect infections are often limited to specific viruses or do not yield information on the immune response. Here, the authors analyse temporal changes in high-dimensional antibody profiles and chart more than 650 infection events across the human virome providing a high-resolution view of host-virus dynamics.
Journal Article