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"Hern, J"
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Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells by WNT Switch Method
The differentiation of ESCs into cardiomyocytes in vitro is an excellent and reliable model system for studying normal cardiomyocyte development in mammals, modeling cardiac diseases, and for use in drug screening. Mouse ESC differentiation still provides relevant biological information about cardiac development. However, the current methods for efficiently differentiating ESCs into cardiomyocytes are limiting. Here, we describe the “WNT Switch” method to efficiently commit mouse ESCs into cardiomyocytes using the small molecule WNT signaling modulators CHIR99021 and XAV939 in vitro. This method significantly improves the yield of beating cardiomyocytes, reduces number of treatments, and is less laborious.
Journal Article
Peri-operative complications of sphenopalatine artery ligation: a 10-year series from two secondary care centres
BackgroundThere is currently limited evidence regarding the potential complications of sphenopalatine artery ligation. The post-operative outcomes at two secondary care centres over a 10-year period were reviewed.MethodsA retrospective review was undertaken of patients undergoing emergency and elective sphenopalatine artery ligation between January 2011 and January 2021. Their demographics, peri-operative care and post-operative outcomes were recorded. The median follow-up time was 54 days (range, 0–2657 days).ResultsNinety-one patients were included. Four patients (4.4 per cent) had a septal perforation at post-operative review. Nineteen patients (20.9 per cent) had post-operative bleeding that extended their in-patient stay, with five patients (5.5 per cent) requiring revision surgery. Pre-operative non-dissolvable nasal packing was used a median of 1 time (range, 0–8 times).ConclusionFurther research on outcomes of sphenopalatine artery ligation is needed. Pre-operative non-dissolvable nasal packing, concurrent septal surgical procedures, surgical techniques, and co-morbidities such as hypertension represent potential confounding factors that could not be further assessed in this small, retrospective study.
Journal Article
RCVS retention fee for postgraduate students
A statutory fee based on income would be impossible to administer and to monitor, and would give rise to considerable scope for discrimination. [...]Council decided that the fairest arrangement for all registrants was to charge everyone practising in the UK the same fee.
Journal Article
Sinus involvement in breast cancer: case report
To report a rare and unique presentation of metastatic breast cancer.
Case report and review of related literature.
A 62-year-old female with metastatic breast cancer, who had been free from recurrence for 4 years, presented with diplopia secondary to lateral rectus palsy. This was due to a sphenoid sinus metastasis, which was eroding into her cavernous sinus, resulting in VIth cranial nerve neuropathy.
All paranasal sinuses and the orbit are potential sites for metastases. Spread to the paranasal sinuses from breast cancer has been documented previously. However, we believe this to be the only reported case with lateral rectus palsy as a result of metastasis to the sphenoid sinus in which this was the only evidence of disseminated disease. Otolaryngology clinicians need to consider metastatic disease to the sinuses in patients with a history of neoplasia, but also recognise that tamoxifen treatment can itself cause visual disturbance.
Journal Article
RCVS registration rules
[...]we do need, from time to time, to make amendments to registration details based on information from reliable third parties, particularly where address details held on our system are out of date and we have no way of contacting the individual.
Journal Article
Licence to practise
The Veterinary Surgeons Act 1966 defines 'veterinary surgery' as meaning the art and science of veterinary surgery and medicine and, without prejudice to the generality of the foregoing, shall be taken to include: the diagnosis of diseases in, and injuries to, animals including tests performed on animals for diagnostic purposes; the giving of advice based upon such diagnosis; the medical or surgical treatment of animals; and the performance of surgical operations on animals.
Journal Article
Election of members of Council of the Royal College of Veterinary Surgeons
Dr C. J. Chesney, DVetMed, DVD, DipECVD, MRCVS, The Beeches, 18 Turnpike, Sampford Peverell, Tiverton, Devon EX16 7BN Dr W. E. Harrison, BVetMed, PhD, CertLAS, MRCVS, Flat 14/A, Alexandra Mansions, 347 West End Lane, London NW6 1LU Dr J. B. Johnson, BVSc, DVSc(hc), MRCVS, Oakhill Veterinary Centre, Langley Lane, Goosnargh, Preston PR3 2JQ Mr D. M. McDowell, BVMS, MRCVS, Brantwood, Billams Hill, Otley, West Yorkshire LS21 2DZ Lt Col N. C. Smith, BVetMed, MSc, MRCVS, Medical Supplies Integrated Project Team, Building 200, Monxton Road, Andover, Hampshire SP11 8HT Mr J. S. Ware, BVM&S, MRCVS, 25 Oxford Road, Woodstock, Oxfordshire OX20 1UN Nominations for election to the Council must be submitted in writing on the prescribed form to the Registrar, duly completed, on or before January 31, 2008, along with accompanying statements and photographs.
Journal Article
Election of members of Council of the Royal College of Veterinary Surgeons
Dr L. A. Brown, BVSc, BA, PhD, MBA, FRCVS, Pharmaq, Unit 15, Sandleheath Industrial Estate, Fordingbridge, Hampshire SP6 1PA Professor S. M. Crispin, MA, VetMB, BSc, PhD, DVA, DVOphthal, DipECVO, FRCVS, Cold Harbour Farm, Underbarrow, Kendal, Cumbria LA8 8HD Mr R. G. Eddy, BVetMed, DipECBHM, FRCVS, Penmayne, North Wootton, Shepton Mallet, Somerset BA4 4ES Dr R. N. W. Ellis, BVSc, PhD, MRCVS, Llwynderw, Abergwesyn, Llanwrtyd Wells, Powys LD5 4TW Mrs L. V. Hill, MVB, MBA, MRCVS, The Eclipse Building, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA Mr R. P. Moore, BVM&S, MRCVS, Meadow Brow, Broadway, Ilminster, Somerset TA19 9RG Nominations for election to rcvs Council must be submitted in writing on the prescribed form to the Registrar, duly completed, on or before January 31, along with accompanying statements and photographs.
Journal Article