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Surveys have shown that super-Earth and Neptune-mass exoplanets are more frequent than gas giants around low-mass stars, as predicted by the core accretion theory of planet formation. We report the discovery of a giant planet around the very-low-mass star GJ 3512, as determined by optical and near-infrared radial-velocity observations. The planet has a minimum mass of 0.46 Jupiter masses, very high for such a small host star, and an eccentric 204-day orbit. Dynamical models show that the high eccentricity is most likely due to planet-planet interactions. We use simulations to demonstrate that the GJ 3512 planetary system challenges generally accepted formation theories, and that it puts constraints on the planet accretion and migration rates. Disk instabilities may be more efficient in forming planets than previously thought.

IntroductionThe recent approval of euthanasia in the Spanish legal code and its posible extension to psychiatric patients opens an unprecedented scenario in the Iberian country. We analize the experience of the Netherlands, a country where euthanasia has been in practice for over two decades, in order to foresee epidemiological trends that could be replicated in Spain.ObjectivesTo review the legislation on euthanasia in Spain and the Netherlands, as well as the epidemiological data regarding euthanasia applicants affected by mental health conditions in the Netherlands, to predict future epidemiological trends in a similar population in Spain.MethodsWe studied the legislation on euthanasia in Spain and the Netherlands, as well as the directives of the Regional Commisions for Euthanasia in the Netherlands to analize differences and similarities between the legal codes on both countries. We also sought epidemiological data regarding the application of euthanasia on psychiatric patients in the Netherlands, gathering data from seven articles in English language obtained through a search in PubMed using the MeSH terms “Euthanasia” AND “Netherlands” and “Psychiatry”.ResultsEuthanasia on psychiatric patients in the Netherlands has been a practice on the rise during the last decade, despite the elevated proportion of rejected applications and the high survival rate of this patients in later longitudinal studies. Affective disorders and personality disorders stand out as major psychiatric causes between the applicants. The Spanish legislation bears important resemblance to its Dutch predecessor, but also significant differences.ConclusionsThe available data on the application of euthanasia on mental health patients in the Netherlands show an in increasing trend regarding the execution of this practice, specially on patients who gather distinct clinical features. The data provided by the Dutch experience could have some replication in Spain, as well as anticipate possible future ethical conflicts regarding the application of this service.Disclosure of InterestNone Declared

Barnard’s star is a red dwarf, and has the largest proper motion (apparent motion across the sky) of all known stars. At a distance of 1.8 parsecs 1 , it is the closest single star to the Sun; only the three stars in the α Centauri system are closer. Barnard’s star is also among the least magnetically active red dwarfs known 2 , 3 and has an estimated age older than the Solar System. Its properties make it a prime target for planetary searches; various techniques with different sensitivity limits have been used previously, including radial-velocity imaging 4 – 6 , astrometry 7 , 8 and direct imaging 9 , but all ultimately led to negative or null results. Here we combine numerous measurements from high-precision radial-velocity instruments, revealing the presence of a low-amplitude periodic signal with a period of 233 days. Independent photometric and spectroscopic monitoring, as well as an analysis of instrumental systematic effects, suggest that this signal is best explained as arising from a planetary companion. The candidate planet around Barnard’s star is a cold super-Earth, with a minimum mass of 3.2 times that of Earth, orbiting near its snow line (the minimum distance from the star at which volatile compounds could condense). The combination of all radial-velocity datasets spanning 20 years of measurements additionally reveals a long-term modulation that could arise from a stellar magnetic-activity cycle or from a more distant planetary object. Because of its proximity to the Sun, the candidate planet has a maximum angular separation of 220 milliarcseconds from Barnard’s star, making it an excellent target for direct imaging and astrometric observations in the future. Analysis of 20 years of observations of Barnard’s star from seven facilities reveals a signal with a period of 233 days that is indicative of a companion planet.

The use of three-dimensional (3D) city models has increased in a wide range of applications beyond visualisation. However, generation and maintenance of 3D data comes at a high cost, time, and workload. The purpose of the generalisation where coarser versions are obtained from a source data is of great interest for National Mapping and Cadastral Agencies (NMCA), which would benefit obtaining multiple 3D versions of an area from a single source. The main aim of the exploration presented in this paper is to study the potential of downsizing point clouds as an approach to generate 3D city models at multiple levels of detail from a single source and evaluate the steps required to ensure the output is fit for real world applications from an NMCA context. While interesting results are obtained when testing with sample data, no software managed to semi-automatically reconstruct 3D model for buildings of rather complicated geometry.

Monothiol glutaredoxins with the CGFS sequence at the active site are widespread among prokaryotes and eukaryotes. Two subclasses exist, those with a single glutaredoxin domain and those with a thioredoxin-like region followed by one or more glutaredoxin domains. Studies in Saccharomyces cerevisiae have demonstrated the role of the Grx5 protein in the biogenesis of iron-sulfur clusters. Grx5 homologues in other eukaryotes could carry out similar functions. Two S. cerevisiae monothiol glutaredoxins with the thioredoxin-like extension, Grx3 and Grx4, are modulators of the transcriptional activator Aft1, which regulates iron uptake in yeast. The human PICOT protein is a Grx3/Grx4 homologue with the same hybrid primary structure that regulates protein kinase C activity and may participate in physiological processes such as control of cardiac function. Therefore, monothiol glutaredoxins share a common basic structural motif and biochemical mechanism of action, while participating in a diversity of cellular functions as protein redox regulators.

IntroductionWe present the case of a 23-year old woman with a history of two hospitalizations in the psychiatric ward of our hospital in the last 8 months. Prior to this age our patient had not required assistance from mental health professionals. The wide variety of symptoms shown by the patient included auditive hallucinations and persecution delusions that led to behavioral alteration and depressive symptoms.ObjectivesTo present a case report of a puerperal psychosis and to review the different kind of psyquiatric disorders that may arise in the puerperium.MethodsLiterature review of scientific papers over the last years and classic textbooks on the issue. We included references in English and Spanish languages.ResultsDuring pregnancy and the puerperium there are biochemical, hormonal, psychological and social changes that cause a vulnerability in women for the appearance of mental disorders. The differential diagnosis of puerperal psychoses must first be made with organic diseases. Once this has been discarded, several studies indicate that there is a high probability that after the onset of puerperal psychosis a cyclical mood disorder is found.Conclusions- One of the main characteristics of puerperal psychoses is the great variety of its symptomatic manifestations. They can present characteristics of both mood disorders and schizophreniform disorders. - Deep confusion and delusions are often the most prominent symptoms of psychosis in the puerperal period.DisclosureNo significant relationships.

IntroductionWe present the case of a 21 year-old male, with history of a psychotic episode, currently with monthly follow-up in an outpatient facility, with a favorable clinical evolution after one year of intensive follow-up. In the context of abandonment of his medication and a problematic family situation, the patient starts to show suspicious, with insomnia and a progressive social isolation. Despite an attempt of ambulatory treatment with oral aripiprazole, showing good tolerance, the patient refuses such treatment, showing active clinical psychotic with great distress and behavioral repercussion, finally requiring hospital admission.ObjectivesTo perform a literature review about the treatment initiation with two vials of aripiprazole long-acting injection.MethodsLiterature review of scientific articles using Pubmed as search engine. We considered articles published both in English and Spanish.ResultsDuring hospital stay, treatment with 2 intramuscular injections of 400mg of aripiprazole is started, combined with a single dose of oral aripiprazole 20mg on day 1, assuring correct dosing, with good tolerance and favoring therapeutic adherence. Progressively, the patient starts to feel calmer, adequate, collaborative and emotionally stable, recuperating chronobiological rhythms, with remission of the hallucinations and appearing more distant from delusions.ConclusionsAccording to the currently available studies, the use of this posology could avoid the potential impact that lack of adherence to oral treatment could have in the therapeutic outcome, assuring a correct dosing and favoring adherence from day 1. Furthermore, this would help simplify the medication regiment for patients, physicians and caregivers.DisclosureNo significant relationships.

IntroductionWe present the case of a 22 year old male with a history of two hospitalizations in the Psychiatric ward of our hospital with psychotic symptoms that led to a diagnosis of schizophrenia, whose later evolution arose doubts about such a diagnosis and provoked a re-examination of the case, eventually leading to a diagnosis of Dissociative Identity Disorder.ObjectivesTo present a complex case of Identity Dissociative Disorder disguised by a myriad of psychotic-like symptom and to review the links between this kind of disorders and a personal history of trauma.MethodsWe performed an extensive review of the scientific literature available regarding the topic of Dissociative Identity Disorder, using sources both in English and Spanish languages.ResultsOur patient experimented two admissions into our Psychiatric ward due to acute psychopathological symptoms (auditive pseudohallucinations and visual hallucinations attributed by the patient to two different people who could influence on his behaviour), then linked to a début of a Paranoid Schizophrenia. The follow-up of the patient in a Day Clinic related to our hospital revealed a close relationship between the described symptoms and a personal history of trauma, as well as a lack of effect of the antipsychotic medication prescribed, and the clinical case eventually evolved to the development of two distinct identities within our patient, leading to a new working diagnose of Identity Dissociative Disorder.ConclusionsIdentitive Dissociative Disorder is a complex, underestimated entity of difficult diagnosis with deep roots in personal traumatic history and whose multifaceted presentation may entail a challenge to clinicians.DisclosureNo significant relationships.

IntroductionWe present the case of a 22-year-old patient who has been followed up in a daytime hospital for personality disorders since June 2022. Of note is the presence of multiple personalities (in total of more than 20 have been identified), each of which has distinct physical and psychological characteristics.ObjectivesThe objective is to present a clinical case of dissociative identity disorder and to review the existence of scientific evidence supporting this diagnosis.MethodsLiterature review of scientific papers over the last years and classic textbooks on the issue. We included references in English and Spanish languages.ResultsNumerous studies support that dissociative disorders are the result of psychological traumas that generally begin in childhood. This is a difficult category to diagnose, since they present symptoms that also appear in other disorders such as those of the schizophrenic spectrum.One or more dissociative parts of the subject’s personality avoid the traumatic memories while others become fixed to these traumatic experiences and manifest symptoms. In the case of our patient, there are dissociative episodes with subsequent amnesia and auditory, visual and olfactory hallucinations, as well as impulsive behaviors in the form of self-injury and a flattened affect, with significant emotional distancing.Conclusions- The prevalence of dissociative identity disorder is higher than traditionally thought.- Some theories develop how trauma essentially produces a degree of dissociation of the psychobiological systems that constitute the subject’s personality.Disclosure of InterestNone Declared

IntroductionWe present the case of a 19-year-old patient who experienced a nonexisting moving sensation, increasing size and painful sensation on tongue, jaw and skull bones. Likewise, the patient showed high anguish, psychomotor restlessness and low mood, in relation to somatic symptomatology; which severely interfered in his life, dropping his university studies and his social life. He also presented thoughts of being victim of a complot of his classmates.ObjectivesTo present a case report and to review the literature of coenesthetic schizophrenia.MethodsLiterature review of scientific articles searching in EMBASE and Pubmed. We considered articles in English and Spanish.ResultsTreatment with oral aripiprazole and sertraline was started, with progressive clinical improvement, decreasing somatic sensations until they disappeared, as well as mood improvement and remission of anxiety and psychomotor restlessness.Coenesthetic schizophrenia was first described in 1957 by Gerd Huber. It is characterized by bodily sensations often combined with affective disturbances. Other symptoms that occur frequently are affective, vegetative, motor and sensory alterations. Typical schizophrenic symptoms are limited to brief psychotic episodes.ConclusionsWe consider knowledge of this entity important, given the differential clinical characteristics regarding to other presentations of schizophrenia, as well as the need to do a differential diagnosis with other disorders such as body dysmorphic disorder or hypochondriasis.Disclosure of InterestNone Declared