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If competing beliefs about political events in the world stem largely from information asymmetries, then more information and knowledge should reduce the gap in competing perceptions. Empirical studies of decision making, however, often find just the reverse: as knowledge and the stakes in play go up, the beliefs about what is happening polarize rather than converge. The theory proposed here attributes this to motivated reasoning. Emotions inside the observer shape beliefs along with information coming from the outside world. A series of experiments embedded in a national survey of Americans finds that a primary driver of the beliefs someone forms about globalization, other countries, and the politics in the Middle East is how strongly they attach their social identity to the United States. Attachment produces more intense positive and negative emotions that in turn shape the interpretation of unfolding events and lead norms to be applied in an inconsistent fashion. People, in effect, rewrite reality around their favored course of action, marrying the logic of appropriateness to their own preferences. Beliefs, consequently, are not independent of preferences but related to them. Motivated reasoning, while not consistent with rational models, is predictable and can lead to expensive mistakes and double standards that undermine liberal internationalism.

Fractional calculus is undergoing rapid and ongoing development. We can already recognize, that within its framework new concepts and strategies emerge, which lead to new challenging insights and surprising correlations between different branches of physics.

The book presents a concise introduction to the basic methods and strategies in fractional calculus and enables the reader to catch up with the state of the art in this field as well as to participate and contribute in the development of this exciting research area. The contents are devoted to the application of fractional calculus to physical problems. The fractional concept is applied to subjects in classical mechanics, group theory, quantum mechanics, nuclear physics, hadron spectroscopy and quantum field theory and it will surprise the reader with new intriguing insights.

The steady increase in greenhouse gas concentrations is inducing a detectable rise in global temperatures. The sensitivity of human societies to warming temperatures is, however, a transcendental question not comprehensively addressed to date. Here we show the link between temperature, humidity and daily numbers of deaths in nearly 200 European regions, which are subsequently used to infer transient projections of mortality under state-of-the-art high-resolution greenhouse gas scenario simulations. Our analyses point to a change in the seasonality of mortality, with maximum monthly incidence progressively shifting from winter to summer. The results also show that the rise in heat-related mortality will start to completely compensate the reduction of deaths from cold during the second half of the century, amounting to an average drop in human lifespan of up 3–4 months in 2070–2100. Nevertheless, projections suggest that human lifespan might indeed increase if a substantial degree of adaptation to warm temperatures takes place. The sensitivity of human populations to rising global temperatures is not yet fully understood. The authors describe the link between temperature and daily mortality in over 200 European regions and calculate projections of mortality from climate models under greenhouse gas scenario simulations.

In this work, we revise the precise retrieval of extinction from Raman Lidar data. This is traditionally challenging, as the derivative of a function with height-increasing noise is sought. Hence, we apply different regularization techniques for an example of the N2 387 nm profile in the Arctic under daylight conditions. Due to the decreasing lidar data quality, we split the retrieval into different intervals. This allows each interval to be smoothed individually. Although the final extinction profile depends on the chosen method, the interval selection and numerical parameters, we show that a trustful solution can be obtained even in altitudes in which a non-regularized solution will fail.

Results of preclinical studies have shown that EGFR immunoliposomes have substantial antitumour effects. We aimed to assess the tolerability, safety, pharmokinetics, and efficacy of anti-EGFR immunoliposomes loaded with doxorubicin (anti-EGFR ILs-dox) in patients with solid tumours. In this first-in-man, open-label, phase 1 clinical study, we enrolled patients at University Hospital of Basel, Switzerland, who had EGFR-overexpressing advanced solid tumours no longer amenable to standard treatment. Anti-EGFR ILs-dox nanoparticles were constructed by covalently linking pegylated liposomes containing doxorubicin to antigen-binding fragments (Fab′) of cetuximab. We intravenously infused the nanoparticle at escalating doses (doxorubicin 5 mg/m2, 10 mg/m2, 20 mg/m2, 30 mg/m2, 40 mg/m2, 50 mg/m2, and 60 mg/m2) once every 4 weeks for a maximum of six cycles. The primary endpoint was to establish the maximum tolerated dose. We analysed patients who received at least one dose of study drug. This study is registered with ClinicalTrials.gov, number NCT01702129. Between Jan 30, 2007, and March 4, 2010, we gave the drug to 29 patients, three of whom were withdrawn from the study because we could not complete a safety assessment. Of the 26 patients assessed for the primary endpoint, two who received a dose of 60 mg/m2 had dose-limiting toxicities (one had neutropenia and the other had anaemia); therefore, the maximum tolerated dose was defined as 50 mg/m2. At all lower doses, anti-EGFR ILs-dox was well tolerated; grade 1 skin toxicity occurred in two patients only. We recorded 22 serious adverse events (SAEs) in 17 patients, mostly due to tumour progression. Three SAEs were fatal. Only three SAEs (febrile neutropenia, septicaemia, and a fatal massive oral bleed) were probably or possibly related to study drug. No patients had palmar-plantar erythrodysaesthesia, alopecia, cardiotoxicity, or cumulative toxicity. Best response to treatment included one complete response, one partial response, and ten stable disease lasting 2–12 months (median 5·75 months). Because anti-EGFR ILs-dox was well tolerated up to 50 mg doxorubicin per m2, and we recorded clinical activity, further assessment of this nanoparticle at this dose in phase 2 trials is warranted. Cancer League Basel, Swiss Cancer League, Schoenmakers-Müller Foundation, and Werner Geissberger Foundation.

The climate impact of Arctic aerosols, like the Arctic Haze, and their origin are not fully understood. Therefore, long-term aerosol observations in the Arctic are performed. In this study, we present a homogenised data set from a sun and star photometer operated in the European Arctic, in Ny-Ålesund, Svalbard, of the 20 years from 2004–2023. Due to polar day and polar night, it is crucial to use observations of both instruments. Their data is evaluated in the same way and follows the cloud-screening procedure of AERONET. Additionally, an improved method for the calibration of the star photometer is presented. We found out, that autumn and winter are generally more polluted and have larger particles than summer. While the monthly median Aerosol Optical Depth (AOD) decreases in spring, the AOD increases significantly in autumn. A clear signal of large particles during the Arctic Haze can not be distinguished from large aerosols in winter. With autocorrelation analysis, we found that AOD events usually occur with a duration of several hours. We also compared AOD events with large-scale processes, like large-scale oscillation patterns, sea ice, weather conditions, or wildfires in the Northern Hemisphere but did not find one single cause that clearly determines the Arctic AOD. Therefore the observed optical depth is a superposition of different aerosol sources.

Since the rise of mass politics, the role national identities play in international relations has been debated. Do they produce a popular reservoir easily tapped for war or bestow dignity thereby fostering cooperation and a democratic peace? The evidence for either perspective is thin, beset by different conceptions of identity and few efforts to identify its effects independent of situational factors. Using data drawn from new national surveys in Italy and the United States, we advance a three-dimensional conception of national identity, theoretically connecting the dimensions to conflictive and cooperative dispositions as well as to decisions to cooperate with the United Nations in containing Iran's nuclear proliferation and Sudan's humanitarian crisis in Darfur. Attachment to the nation in Italy and the United States is found to associate with less support for militarist options and more support for international cooperation as liberal nationalists expect. This depends, however, on containing culturally exclusive conceptions of the nation and chauvinism.

Steroid-refractory acute graft versus host disease (AGVHD) and chronic graft versus host disease (CGVHD) after allogeneic haematopoietic stem cell transplantation are major causes of morbidity and mortality. We undertook a phase I trial in patients with steroid-refractory AGVHD and CGVHD utilising bone marrow-derived mesenchymal stromal cells (MSC). Additionally, all refractory patients were treated with etanercept concomitantly. The primary end point was safety, and secondary end points were best response achieved and overall survival. A median of two infusions per patient were administered. The response rate overall for AGVHD was complete in seven, partial in four and no response in one patient. Of the seven patients who achieved a complete response, six are alive. The actuarial survival for the overall group of AGVHD was 55% at 30 months. Two patients with CGVHD achieved complete response with two partial responses and three with no response. The survival for those with AGVHD who achieved a complete response compared with those who did not was significant ( p  = 0.03). We identified no early or late safety issues in the nineteen patients. In view of the poor outlook for steroid-refractory AGVHD, further trials are warranted of MSC with steroid therapy, at the onset of AGVHD before steroid resistance.

The genome of Mycoplasma pneumoniae is among the smallest found in self-replicating organisms. To study the basic principles of bacterial proteome organization, we used tandem affinity purification-mass spectrometry (TAP-MS) in a proteome-wide screen. The analysis revealed 62 homomultimeric and 116 heteromultimeric soluble protein complexes, of which the majority are novel. About a third of the heteromultimeric complexes show higher levels of proteome organization, including assembly into larger, multiprotein complex entities, suggesting sequential steps in biological processes, and extensive sharing of components, implying protein multifunctionality. Incorporation of structural models for 484 proteins, single-particle electron microscopy, and cellular electron tomograms provided supporting structural details for this proteome organization. The data set provides a blueprint of the minimal cellular machinery required for life.