Explore the vast range of titles available.

\"This book had its genesis in the mid-1990s when I began researching the trademarks used by Sheffield cutlers and the emergence of 'Sheffield'. Subsequently, collaboration with Geoff Tweedale, Mads Mordhorst and Dev Gangjee, and participation in conferences and workshops, extended my interest in IGOs. Over time, I realised that this subject had been comparatively neglected by business historians. There were, of course, exceptions. Paul Duguid, for example, is prominent in debates on how and why regulatory and institutional change affected the development of IGOs in the port industry during the nineteenth and early twentieth centuries. Nonetheless, it is fair to say that research on these indications has been dominated by scholars in legal history, marketing, and agricultural-rural development\"-- Provided by publisher.

Background Accurate evaluation of valvular pathology is crucial in the timing of surgical intervention. Whilst transthoracic echocardiography is widely available and routinely used in the assessment of valvular heart disease, it is bound by several limitations. Although cardiovascular magnetic resonance (CMR) imaging can overcome many of the challenges encountered by echocardiography, it also has a number of limitations. Main text 4D Flow CMR is a novel technique, which allows time-resolved, 3-dimensional imaging. It enables visualisation and direct quantification of flow and peak velocities of all valves simultaneously in one simple acquisition, without any geometric assumptions. It also has the unique ability to measure advanced haemodynamic parameters such as turbulent kinetic energy, viscous energy loss rate and wall shear stress, which may add further diagnostic and prognostic information. Although 4D Flow CMR acquisition can take 5–10 min, emerging acceleration techniques can significantly reduce scan times, making 4D Flow CMR applicable in contemporary clinical practice. Conclusion 4D Flow CMR is an emerging CMR technique, which has the potential to become the new reference-standard method for the evaluation of valvular lesions. In this review, we describe the clinical applications, advantages and disadvantages of 4D Flow CMR in the assessment of valvular heart disease.

Background T1 mapping is a robust and highly reproducible application to quantify myocardial relaxation of longitudinal magnetisation. Available T1 mapping methods are presently site and vendor specific, with variable accuracy and precision of T1 values between the systems and sequences. We assessed the transferability of a T1 mapping method and determined the reference values of healthy human myocardium in a multicenter setting. Methods Healthy subjects (n = 102; mean age 41 years (range 17–83), male, n = 53 (52%)), with no previous medical history, and normotensive low risk subjects (n=113) referred for clinical cardiovascular magnetic resonance (CMR) were examined. Further inclusion criteria for all were absence of regular medication and subsequently normal findings of routine CMR. All subjects underwent T1 mapping using a uniform imaging set-up (modified Look- Locker inversion recovery, MOLLI, using scheme 3(3)3(3)5)) on 1.5 Tesla (T) and 3 T Philips scanners. Native T1-maps were acquired in a single midventricular short axis slice and repeated 20 minutes following gadobutrol. Reference values were obtained for native T1 and gadolinium-based partition coefficients, λ and extracellular volume fraction (ECV) in a core lab using standardized postprocessing. Results In healthy controls, mean native T1 values were 950 ± 21 msec at 1.5 T and 1052 ± 23 at 3 T. λ and ECV values were 0.44 ± 0.06 and 0.25 ± 0.04 at 1.5 T, and 0.44 ± 0.07 and 0.26 ± 0.04 at 3 T, respectively. There were no significant differences between healthy controls and low risk subjects in routine CMR parameters and T1 values. The entire cohort showed no correlation between age, gender and native T1. Cross-center comparisons of mean values showed no significant difference for any of the T1 indices at any field strength. There were considerable regional differences in segmental T1 values. λ and ECV were found to be dose dependent. There was excellent inter- and intraobserver reproducibility for measurement of native septal T1. Conclusion We show transferability for a unifying T1 mapping methodology in a multicenter setting. We provide reference ranges for T1 values in healthy human myocardium, which can be applied across participating sites.

The worldwide elimination of measles and rubella is feasible, but not without overcoming the substantial challenge of vaccine hesitancy. This challenge is complicated by the spread of misinformation and disinformation fueled by rapidly progressing technologies and evolving forms of online communication. The recent COVID-19 pandemic has only added further complexity to this challenge. However, considerable progress has been made in understanding the scope of the problem and the complex factors that influence vaccine hesitancy. Our understanding of evidence-based strategies for addressing vaccine hesitancy has grown significantly, including evidence for effective communication and behavioral interventions. In this article, we review measles and rubella vaccines and vaccine hesitancy. We then provide an overview of evidence-based strategies for addressing vaccine hesitancy, including communication strategies and behavioral interventions. This article is relevant to healthcare professionals, health system leaders, public health professionals, policymakers, community leaders, and any individuals who have a role in addressing vaccine hesitancy in their communities. Finally, we review future directions and major areas of research need.

BackgroundWhen feasible, guidelines recommend mitral valve repair (MVr) over mitral valve replacement (MVR) to treat primary mitral regurgitation (MR), based upon historic outcome studies and transthoracic echocardiography (TTE) reverse remodeling studies. Cardiovascular magnetic resonance (CMR) offers reference standard biventricular assessment with superior MR quantification compared to TTE. Using serial CMR in primary MR patients, we aimed to investigate cardiac reverse remodeling and residual MR post-MVr vs MVR with chordal preservation.Methods83 patients with ≥ moderate-severe MR on TTE were prospectively recruited. 6-min walk tests (6MWT) and CMR imaging including cine imaging, aortic/pulmonary through-plane phase contrast imaging, T1 maps and late-gadolinium-enhanced (LGE) imaging were performed at baseline and 6 months after mitral surgery or watchful waiting (control group).Results72 patients completed follow-up (Controls = 20, MVr = 30 and MVR = 22). Surgical groups demonstrated comparable baseline cardiac indices and co-morbidities. At 6-months, MVr and MVR groups demonstrated comparable improvements in 6MWT distances (+ 57 ± 54 m vs + 64 ± 76 m respectively, p = 1), reduced indexed left ventricular end-diastolic volumes (LVEDVi; − 29 ± 21 ml/m2 vs − 37 ± 22 ml/m2 respectively, p = 0.584) and left atrial volumes (− 23 ± 30 ml/m2 and − 39 ± 26 ml/m2 respectively, p = 0.545). At 6-months, compared with controls, right ventricular ejection fraction was poorer post-MVr (47 ± 6.1% vs 53 ± 8.0% respectively, p = 0.01) compared to post-MVR (50 ± 5.7% vs 53 ± 8.0% respectively, p = 0.698). MVR resulted in lower residual MR-regurgitant fraction (RF) than MVr (12 ± 8.0% vs 21 ± 11% respectively, p = 0.022). Baseline and follow-up indices of diffuse and focal myocardial fibrosis (Native T1 relaxation times, extra-cellular volume and quantified LGE respectively) were comparable between groups. Stepwise multiple linear regression of indexed variables in the surgical groups demonstrated baseline indexed mitral regurgitant volume as the sole multivariate predictor of left ventricular (LV) end-diastolic reverse remodelling, baseline LVEDVi as the most significant independent multivariate predictor of follow-up LVEDVi, baseline indexed LV end-systolic volume as the sole multivariate predictor of follow-up LV ejection fraction and undergoing MVR (vs MVr) as the most significant (p < 0.001) baseline multivariate predictor of lower residual MR.ConclusionIn primary MR, MVR with chordal preservation may offer comparable cardiac reverse remodeling and functional benefits at 6-months when compared to MVr. Larger, multicenter CMR studies are required, which if the findings are confirmed could impact future surgical practice.

The classic maize mutant divergent spindle-1 (dv1) causes failures in meiotic spindle assembly and a decrease in pollen viability. By analyzing two independent dv1 alleles we demonstrate that this phenotype is caused by mutations in a member of the kinesin-14A subfamily, a class of C-terminal, minus-end directed microtubule motors. Further analysis demonstrates that defects in early spindle assembly are rare, but that later stages of spindle organization promoting the formation of finely focused spindle poles are strongly dependent on Dv1. Anaphase is error-prone in dv1 lines but not severely so, and the majority of cells show normal chromosome segregation. Live-cell imaging of wild type and mutant plants carrying CFP-tagged β-tubulin confirm that meiosis in dv1 lines fails primarily at the pole-sharpening phase of spindle assembly. These data indicate that plant kinesin-14A proteins help to enforce bipolarity by focusing spindle poles and that this stage of spindle assembly is not required for transition through the spindle checkpoint but improves the accuracy of chromosome segregation.

[...]there are systems in place to understand the epidemiology of hundreds of potential threats to the health of the American public, including both common and rare infectious diseases, cancers, environmental hazards, poor oral health, insufficient sleep, tobacco use, drug use, diabetes and other chronic medical conditions, injuries, mental health conditions-the list goes on and on.8 Yet, despite the severe threat posed by vaccine hesitancy, we have essentially no national monitoring system. [...]vaccine hesitancy surveillance must provide real-time data that can be utilized by public health and vaccination leaders. The US National Vaccine Advisory Committee (NVAC) recommends implementing vaccine hesitancy surveillance systems.11 Among other things, NVAC calls for the US Department of Health and Human Services (HHS) to fund research and data collection, which is made publicly available, to increase the timely assessment of vaccine confidence and improve knowledge that can guide the development of tailored strategies to address vaccine hesitancy. ABOUT THE AUTHORS David M. Higgins and Sean T. O'Leary are with the Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine/ Children's Hospital Colorado, Aurora.

Contemporary video games often function as digital science fictions that strive to manifest late capitalism's ultimate self-manifestation. In particular, many popular blockbuster games construct and deploy world systems that operate according to the economic principles late-capitalism proposes should, according to its fantasy vision, structure the fabric of modern economic life. These games manifest, in several perplexing ways, a variety of capitalist wish fulfillments and visions of how lived economic systems might work if capitalism were free from the limiting restraints of what some economists regard as the imperfect distortions of the real world. This article examines massively multiplayer online games (MMOs) in order to demonstrate how the planned obsolescence of goods is a mandatory and inescapable feature of economic life in many digital environments. In such games, ubiquitous obsolescence creates infinite demand which can always be met with increased profitable supply. Furthermore, these games often enact the fantasy that all property can be regarded as intellectual property; everyday objects like clothing items are licensed for limited use rather than purchased for permanent ownership. Even in MMOs that do not encode elaborate systems of planned obsolescence to manage demand, however, the principle of creative destruction is elevated to its free-market apotheosis in order to orient consumer play toward endless commodity consumption.

The Risks of Normalizing Parental Vaccine HesitancyMost parents in the United States don’t hesitate to have their children receive routine childhood vaccines. Suggesting otherwise is potentially harmful.

A substantial literature documents the importance of trademarks and brands to business success. How does this relationship change when we enlarge our focus from individual firms to industries and nations? This articles examines the dominance of Danish bacon in Britain between the late nineteenth and early twentieth centuries. We argue that this supremacy required state intervention and cooperation between government and producers to underpin high and consistent levels of quality throughout the supply chain, both of which were necessary to ensure the successful marketing of “Danish” bacon. In Britain, by contrast, state intervention to increase bacon production was only partially successful because it was undermined by a nineteenth-century legacy of uncoordination and deregulation. Such weaknesses affected the supply of appropriate pigs and the production of bacon that was uniform in quality, and ultimately negated the efforts of the Ministry of Agriculture and Fisheries to promote a “British” bacon brand.