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On 17 August 2017, gravitational waves (GWs) were detected from a binary neutron star merger, GW170817, along with a coincident short gamma-ray burst, GRB 170817A. An optical transient source, Swope Supernova Survey 17a (SSS17a),was subsequently identified as the counterpart of this event. We present ultraviolet, optical, and infrared light curves of SSS17a extending from 10.9 hours to 18 days postmerger. We constrain the radioactively powered transient resulting from the ejection of neutron-rich material. The fast rise of the light curves, subsequent decay, and rapid color evolution are consistent with multiple ejecta components of differing lanthanide abundance. The late-time light curve indicates that SSS17a produced at least ~0.05 solar masses of heavy elements, demonstrating that neutron star mergers play a role in rapid neutron capture (r-process) nucleosynthesis in the universe.

On 17 August 2017, Swope Supernova Survey 2017a (SSS17a) was discovered as the optical counterpart of the binary neutron star gravitational wave event GW170817. We report time-series spectroscopy of SSS17a from 11.75 hours until 8.5 days after the merger. Over the first hour of observations, the ejecta rapidly expanded and cooled. Applying blackbody fits to the spectra, we measured the photosphere cooling from 11,000 − 900 + 3400 to 9300 − 300 + 300 kelvin, and determined a photospheric velocity of roughly 30% of the speed of light. The spectra of SSS17a began displaying broad features after 1.46 days and evolved qualitatively over each subsequent day, with distinct blue (early-time) and red (late-time) components. The late-time component is consistent with theoretical models of r-process–enriched neutron star ejecta, whereas the blue component requires high-velocity, lanthanide-free material.

The Solo (Solitary Local) Dwarf Galaxy survey is a volume limited, wide-field g- and i- band survey of all known nearby (<3 Mpc) and isolated (>300 kpc from the Milky Way or M31) dwarf galaxies. This set of 44 dwarfs are homogeneously analysed for quantitative comparisons to the satellite dwarf populations of the Milky Way and M31. In this paper, an analysis of the 12 closest Solo dwarf galaxies accessible from the northern hemisphere is presented, including derivation of their distances, spatial distributions, morphology, and extended structures, including their inner integrated light properties and their outer resolved star distributions. All 12 galaxies are found to be reasonably well described by two-dimensional Sersic functions, although UGC 4879 in particular shows tentative evidence of two distinct components. No prominent extended stellar substructures, that could be signs of either faint satellites or recent mergers, are identified in the outer regions of any of the systems examined.

We introduce the Solitary Local Dwarfs Survey (Solo), a wide field photometric study targeting every isolated dwarf galaxy within 3 Mpc of the Milky Way. Solo is based on (u)gi multi-band imaging from CFHT/MegaCam for northern targets, and Magellan/Megacam for southern targets. All galaxies fainter than Mv = -18 situated beyond the nominal virial radius of the Milky Way and M31 (>300 kpc) are included in this volume-limited sample, for a total of 42 targets. In addition to reviewing the survey goals and strategy, we present results for the Sagittarius Dwarf Irregular Galaxy (Sag DIG), one of the most isolated, low mass galaxies, located at the edge of the Local Group. We analyze its resolved stellar populations and their spatial distributions. We provide updated estimates of its central surface brightness and integrated luminosity, and trace its surface brightness profile to a level fainter than 30 mag./sq.arcsec. Sag DIG is well described by a highly elliptical (disk-like) system following a single component Sersic model. However, a low-level distortion is present at the outer edges of the galaxy that, were Sag DIG not so isolated, would likely be attributed to some kind of previous tidal interaction. Further, we find evidence of an extremely low level, extended distribution of stars beyond 5 arcmins (>1.5 kpc) that suggests Sag DIG may be embedded in a very low density stellar halo. We compare the stellar and HI structures of Sag DIG, and discuss results for this galaxy in relation to other isolated, dwarf irregular galaxies in the Local Group.

On 2017 August 17, Swope Supernova Survey 2017a (SSS17a) was discovered as the optical counterpart of the binary neutron star gravitational wave event GW170817. We report time-series spectroscopy of SSS17a from 11.75 hours until 8.5 days after merger. Over the first hour of observations the ejecta rapidly expanded and cooled. Applying blackbody fits to the spectra, we measure the photosphere cooling from \\(11,000^{+3400}_{-900}\\) K to \\(9300^{+300}_{-300}\\) K, and determine a photospheric velocity of roughly 30% of the speed of light. The spectra of SSS17a begin displaying broad features after 1.46 days, and evolve qualitatively over each subsequent day, with distinct blue (early-time) and red (late-time) components. The late-time component is consistent with theoretical models of r-process-enriched neutron star ejecta, whereas the blue component requires high velocity, lanthanide-free material.

On 2017 August 17, gravitational waves were detected from a binary neutron star merger, GW170817, along with a coincident short gamma-ray burst, GRB170817A. An optical transient source, Swope Supernova Survey 17a (SSS17a), was subsequently identified as the counterpart of this event. We present ultraviolet, optical and infrared light curves of SSS17a extending from 10.9 hours to 18 days post-merger. We constrain the radioactively-powered transient resulting from the ejection of neutron-rich material. The fast rise of the light curves, subsequent decay, and rapid color evolution are consistent with multiple ejecta components of differing lanthanide abundance. The late-time light curve indicates that SSS17a produced at least ~0.05 solar masses of heavy elements, demonstrating that neutron star mergers play a role in r-process nucleosynthesis in the Universe.

SARS-CoV-2 infections lead to a wide-range of outcomes from mild or asymptomatic illness to serious complications and death. While many studies have characterized hospitalized SARS-CoV-2 patient immune responses, we were interested in whether serious complications of SARS-CoV-2 infection could be predicted early in ambulatory subjects. To that end, we used samples from SARS-CoV-2-infected individuals from the placebo arm of the BLAZE-1 clinical trial who progressed to hospitalization or death compared to individuals in the same study who did not require medical intervention and investigated whether baseline serum cytokines and chemokines could predict severe outcome. High-risk demographic factors at baseline, including age, nasal pharyngeal viral load, duration from symptom onset, and BMI provide significant predictive capacity for a hospitalization or death with an AUC of ROC = 0.77. The predictive performance of our outcome modeling increased when baseline serum protein markers were included. In fact, the one-marker model indicated that there were 51 individual proteins (including known markers of inflammation like IL-6, MCP-3, CXCL10, IL-1Ra, and PTX3) that significantly increased the AUC of ROC beyond high-risk patient demographics alone to range between 0.78 to 0.88. Moreover, a two-marker model incorporating levels of both IL-6 and PTX3 further improved the prediction over the addition of a single protein marker to an AUC of ROC = 0.91. While the analytes identified in this study have been well-documented to be altered in SARS-CoV-2 infection, this analysis demonstrates the potential value of their use in predicting hospitalization or death in ambulatory participants infected with SARS-CoV-2 and could guide early treatment decisions.

In a phase 3 trial involving 1035 outpatients who were at increased risk for severe Covid-19, those who received two monoclonal antibodies targeting SARS-CoV-2 had a significant reduction in the viral load and a significantly lower incidence of progression to severe illness than those who received placebo.

Malignant melanoma is the most aggressive form of skin cancer and its incidence has doubled in the last two decades. It represents only 4% of skin cancer cases per year, but causes as many as 74% of skin cancer deaths. Early detection of malignant melanoma is associated with survival rates of up to 90%, but later detection (stage III to stage IV) is associated with survival rates of only 10%. Dysregulation of microRNA (miRNA) expression has been linked to tumor development and progression by functioning either as a tumor suppressor, an oncogene or a metastasis regulator in multiple cancer types. To understand the role of miRNA in the pathogenesis of malignant melanoma and identify biomarkers of metastasis, miRNA expression profiles in skin punches from 33 metastatic melanoma patients and 14 normal healthy donors were compared. We identified a cluster of 14 miRNAs on the X chromosome, termed the miR-506-514 cluster, which was consistently overexpressed in nearly all melanomas tested (30–60 fold, P <0.001), regardless of mutations in N-ras or B-raf. Inhibition of the expression of this cluster as a whole, or one of its sub-clusters (Sub-cluster A) consisting of six mature miRNAs, led to significant inhibition of cell growth, induction of apoptosis, decreased invasiveness and decreased colony formation in soft agar across multiple melanoma cell lines. Sub-cluster A of the miR-506-514 cluster was critical for maintaining the cancer phenotype, but the overexpression of the full cluster was necessary for melanocyte transformation. Our results provide new insights into the functional role of this miRNA cluster in melanoma, and suggest new approaches to treat or diagnose this disease.

Stereotactic ablative body radiotherapy (SABR) is a novel non-invasive alternative for patients with primary renal cell cancer who do not undergo surgical resection. The FASTRACK II clinical trial investigated the efficacy of SABR for primary renal cell cancer in a phase 2 trial. This international, non-randomised, phase 2 study was conducted in seven centres in Australia and one centre in the Netherlands. Eligible patients aged 18 years or older had biopsy-confirmed diagnosis of primary renal cell cancer, with only a single lesion; were medically inoperable, were at high risk of complications from surgery, or declined surgery; and had an Eastern Cooperative Oncology Group performance status of 0–2. A multidisciplinary decision that active treatment was warranted was required. Key exclusion criteria were a pre-treatment estimated glomerular filtration rate of less than 30 mL/min per 1·73 m2, previous systemic therapies for renal cell cancer, previous high-dose radiotherapy to an overlapping region, tumours larger than 10 cm, and direct contact of the renal cell cancer with the bowel. Patients received either a single fraction SABR of 26 Gy for tumours 4 cm or less in maximum diameter, or 42 Gy in three fractions for tumours more than 4 cm to 10 cm in maximum diameter. The primary endpoint was local control, defined as no progression of the primary renal cell cancer, as evaluated by the investigator per Response Evaluation Criteria in Solid Tumours (version 1.1). Assuming a 1-year local control of 90%, the null hypothesis of 80% or less was considered not to be worthy of proceeding to a future randomised controlled trial. All patients who commenced trial treatment were included in the primary outcome analysis. This trial is registered with ClinicalTrials.gov, NCT02613819, and has completed accrual. Between July 28, 2016, and Feb 27, 2020, 70 patients were enrolled and initiated treatment. Median age was 77 years (IQR 70–82). Before enrolment, 49 (70%) of 70 patients had documented serial growth on initial surveillance imaging. 49 (70%) of 70 patients were male and 21 (30%) were female. Median tumour size was 4·6 cm (IQR 3·7–5·5). All patients enrolled had T1–T2a and N0–N1 disease. 23 patients received single-fraction SABR of 26 Gy and 47 received 42 Gy in three fractions. Median follow-up was 43 months (IQR 38–60). Local control at 12 months from treatment commencement was 100% (p<0·0001). Seven (10%) patients had grade 3 treatment-related adverse events, with no grade 4 adverse events observed. Grade 3 treatment-related adverse events were nausea and vomiting (three [4%] patients), abdominal, flank, or tumour pain (four [6%]), colonic obstruction (two [3%]), and diarrhoea (one [1%]). No treatment-related or cancer-related deaths occurred. To our knowledge, this is the first multicentre prospective clinical trial of non-surgical definitive therapy in patients with primary renal cell cancer. In a cohort with predominantly T1b or larger disease, SABR was an effective treatment strategy with no observed local failures or cancer-related deaths. We observed an acceptable side-effect profile and renal function after SABR. These outcomes support the design of a future randomised trial of SABR versus surgery for primary renal cell cancer. Cancer Australia Priority-driven Collaborative Cancer Research Scheme.