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After an incubation period of weeks to months, up to 14% of cats infected with feline coronavirus (FCoV) develop feline infectious peritonitis (FIP): a potentially lethal pyogranulomatous perivasculitis. The aim of this study was to find out if stopping FCoV faecal shedding with antivirals prevents FIP. Guardians of cats from which FCoV had been eliminated at least 6 months earlier were contacted to find out the outcome of their cats; 27 households were identified containing 147 cats. Thirteen cats were treated for FIP, 109 cats shed FCoV and 25 did not; a 4–7-day course of oral GS-441524 antiviral stopped faecal FCoV shedding. Follow-up was from 6 months to 3.5 years; 11 of 147 cats died, but none developed FIP. A previous field study of 820 FCoV-exposed cats was used as a retrospective control group; 37 of 820 cats developed FIP. The difference was statistically highly significant (p = 0.0062). Cats from eight households recovered from chronic FCoV enteropathy. Conclusions: the early treatment of FCoV-infected cats with oral antivirals prevented FIP. Nevertheless, should FCoV be re-introduced into a household, then FIP can result. Further work is required to establish the role of FCoV in the aetiology of feline inflammatory bowel disease.

Recurring prophecies of the disappearance or irrelevance of the local community in contemporary US society are critically questioned. In spite of certain trends-including the onrush of megalopolis & the decline of some small towns-it is argued that some conception of the community is still useful for guiding res & that locality-based soc systems still signif'ly shape behavior patterns. The bases for the transformation of the community are reviewed, & a reconceptualization of the community in modern society is presented in terms of a continuum of diverse locality-based soc units varying along several dimensions. 3 factors that militate against the complete disappearance or insignif of the local community are noted: (1) the growth of planned subUr 'new towns' & the revitalization of the econ base of many small communities through new industr, educ'al, or gov'al facilities; (2) the continued performance of many important functions at the local territorial level (eg, distribution of vital goods & services, soc'ization of children & fam activity, & the 'basis of operations' for daily activities); & (3) the strengthening of community maintenance through similarity of interests of residents & their common exposure to various local problems. A plea is made for res on the nature & signif of the diverse forms of community life evolving in modern society. AA.

The utility of the European immigrants' experiences in the US as a basis for understanding the present & predicting the future relation of the Negro to the larger society is critically examined. Basic dissimilarities as well as similarities between the immigrants & their descendants & the Negroes are analyzed in several critical areas: (1) visibility & racism, (2) effects of slavery & post-slavery on retention of old-world culture, self-esteem, fam stability, & group unity, (3) position in the economy & Ur migration, (4) coordinated pol'al & econ group action, (5) federal gov intervention, & (6) ethnicity, primary group relations, & group identity. 2 alternative directions are seen as possible for future Negro-white relations: (i) maximum separation ('2 nations') or (ii) an abrasive transitional period of heightened Negro group consciousness, with coordinated pol'al & econ activity in Negro-controlled org's, followed by progressive integration. Neither alternative is viewed as likely to occur in a simple, uninterrupted, mutually exclusive way, with events inside & outside of the society altering the course of direction. Esp critical is whether the pol'al process can redistribute wealth, opportunity, & power fast enough & on a sufficient scale to encourage Negro leaders to use nonviolent strategies of soc change. AA.