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Background The Deaf community experiences health inequalities including higher mortality rates, increased prevalence of chronic conditions, and poorer access to healthcare services compared to the general population. Despite calls for urgent research investment and meaningful community engagement, no research agenda developed by and for the Deaf community exists to address these inequalities. Traditional priority-setting exercises often exclude or dilute the perspectives of underrepresented groups. This study aimed to identify and prioritise research questions to address health inequalities experienced by Deaf British Sign Language (BSL) users in the UK, using Research Prioritisation by Affected Communities (RPAC) methodology to ensure community voices were centred without external filtering. Methods A Deaf-led steering group adapted RPAC methodology for BSL accessibility. Two rounds of focus groups were conducted entirely in BSL led by Deaf facilitators. Round one (January 2025) included 43 Deaf BSL users across eight groups who shared experiences of healthcare receipt across seven NHS services. The 294 extracted statements were categorised using a conceptual framework for understanding healthcare disparities in disability, then refined into nine research themes by Deaf public contributors. In round two, 38 participants (87% retention) prioritised themes using a resource allocation exercise where each participant distributed £1 million across themes. Themes were ranked by total allocation. Results Environmental factors (222 statements) substantially outnumbered individual factors (72 statements) in round one. The highest priority theme was ‘process’ (28% of votes), focusing on enabling direct NHS communication without telephone barriers. ‘Deaf awareness for NHS staff’ ranked second (25%), followed by ‘interpreters’ (17%) and ‘technology’ (13%). Individual-level interventions received minimal prioritisation: ‘Deaf health empowerment’ (1%) and ‘Deaf health champions’ (0.6%). Participants emphasised systemic failures including non-compliance with the Accessible Information Standard and lack of BSL interpretation. Conclusions Deaf BSL users prioritised systemic NHS changes over individual interventions, indicating that institutional barriers must be addressed before individual-level approaches can be effective. The emphasis on process improvements and staff awareness training has immediate implications for NHS policy and Accessible Information Standard (AIS) enforcement. These findings should inform research commissioning, with priority given to co-designed interventions addressing communication processes and developing effective Deaf awareness training for healthcare professionals.

BackgroundSubstantial amounts of public funds are invested in health research worldwide. Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower than anticipated rate. Many trials fail to reach their planned sample size within the envisaged trial timescale and trial funding envelope.ObjectivesTo review the consent, recruitment and retention rates for single and multicentre randomised control trials funded and published by the UK's National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme.Data sources and study selectionHTA reports of individually randomised single or multicentre RCTs published from the start of 2004 to the end of April 2016 were reviewed.Data extractionInformation was extracted, relating to the trial characteristics, sample size, recruitment and retention by two independent reviewers.Main outcome measuresTarget sample size and whether it was achieved; recruitment rates (number of participants recruited per centre per month) and retention rates (randomised participants retained and assessed with valid primary outcome data).ResultsThis review identified 151 individually RCTs from 787 NIHR HTA reports. The final recruitment target sample size was achieved in 56% (85/151) of the RCTs and more than 80% of the final target sample size was achieved for 79% of the RCTs (119/151). The median recruitment rate (participants per centre per month) was found to be 0.92 (IQR 0.43–2.79) and the median retention rate (proportion of participants with valid primary outcome data at follow-up) was estimated at 89% (IQR 79–97%).ConclusionsThere is considerable variation in the consent, recruitment and retention rates in publicly funded RCTs. Investigators should bear this in mind at the planning stage of their study and not be overly optimistic about their recruitment projections.

Protection motivation theory (PMT) shows promise as a basis for motivating healthy behaviours in healthcare settings. There has been no systematic overview of how PMT has been translated into clinical practice and which translation strategies effectively improve outcomes. This scoping review aimed to systematically map and synthesise existing literature on PMT-based interventions targeting health behaviours in healthcare contexts. Medline, PsycINFO, and EMBASE were searched for studies applying PMT within healthcare contexts. Eligible populations had a clinical condition. To be eligible, studies had to report a healthcare-delivered PMT intervention with adherence outcomes directly benefiting participants. Two reviewers extracted data on study features, intervention characteristics including behaviour change techniques employed, PMT constructs addressed, results, and research recommendations. Findings were summarised narratively and tabulated. Thirteen studies published between 1998 and 2023 met the eligibility criteria, including 12 randomised trials. Studies addressed acute and chronic conditions across primary, secondary, and non-clinical settings. Half significantly improved behaviour outcomes in intervention groups. All targeted coping-self-efficacy and perceived threat-severity PMT constructs to some degree. Combinations of behaviour change techniques did not clearly differentiate successful outcomes. Studies recommended longer follow-up, clarifying effective PMT component combinations, and drawing on multiple behaviour theories. Despite heterogeneity in how PMT interventions were operationalised, they show potential benefits for motivating adherence to healthy behaviours. To enable optimisation and dissemination, consistent nonadherence detection and reporting methods are critical. Further research should include translation of PMT to other healthcare settings, refining methodology and implementing well-powered effectiveness trials in routine care.

An increasingly ageing population presents many challenges for healthcare systems, including how to support older adults who are more likely to be both housebound and have complex medication needs. Community pharmacists may play a key role in medicines optimisation for this vulnerable population, however, the extent of literature exploring this topic is unclear. To map existing literature on the role of community pharmacists in medicines optimisation for housebound older adults in the United Kingdom (UK). A scoping review was conducted following PRISMA-ScR guidelines. Peer-reviewed primary research and grey literature published since 2000 were searched using relevant databases and websites. Data was charted using a standardised form based on TIDieR guidelines and EPOC taxonomies. A narrative synthesis was conducted to summarise and interpret the findings from included studies. Seven sources were included in the review - five peer-reviewed articles and two grey literature reports. Interventions consisted of domiciliary medication reviews conducted by pharmacists. Key medicines optimisation strategies addressed were medication review, deprescribing, addressing polypharmacy and facilitating communication between providers. Reported outcomes included identification of widespread issues with polypharmacy and medication-related problems, reduced hospital admissions, cost savings and improved patient care. Gaps identified were limited generalisability, lack of comparisons to standard care, and under-representation of minority groups. The literature indicates promise for the role of community pharmacists in medicines optimisation for housebound older adults through domiciliary services. However, more research is needed to evaluate the effectiveness and feasibility of pharmacist-led interventions in this setting. Addressing identified gaps will help inform pharmacists' roles in supporting medication needs of housebound patients.

ObjectivesThere is strong evidence that mobility-assistive technologies improve occupational performance, social participation, educational and employment access and overall quality of life in people with disabilities. However, people with disabilities still face barriers in accessing mobility products and related services. This review aims to summarise and synthesise: (1) theories, models and frameworks that have been used to understand mobility-assistive technology access, (2) determinants of access and (3) gaps in knowledge.DesignA scoping review using the five-step framework by Arksey and O’Malley.Data sourcesWe searched the MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature and SCOPUS databases for publications published between 2000 and 2024. We searched for articles published up to 20 March 2024.Eligibility criteriaWe included English-published literature in peer-reviewed journals that reported (a) barriers to the provision of mobility-assistive technologies, (b) including at least one theory, model or framework and (c) between 2000 and 2024.Data extraction and synthesisWe extracted the study characteristics, theories, models, framework usage, research recommendations, key findings on mobility-assistive technology barriers and theoretical propositions. We conduct a theoretical synthesis guided by Turner’s approach.ResultsWe included 18 articles that used 8 theories, models and frameworks, synthesised into 9 propositions. The synthesised theory emphasises that mobility is essential for human flourishing, and that certain health conditions may impose restrictions on mobility. This impact can be alleviated by two direct determinants: (1) the provision of suitable services and (2) their comprehensive provision. Policies and costs influence these services indirectly. Environmental and personal factors also affect the use of these services. Ineffectively addressing these determinants can limit access to mobility-assistive technologies and subsequent disabilities.ConclusionOur synthetic model describes the logic of providing evidence-based mobility-assistive technologies, and we identify the determinants of access that can act as targets for future work to improve the provision of mobility-assistive technologies.

Optimum surgical intervention for low-grade haemorrhoids is unknown. Haemorrhoidal artery ligation (HAL) has been proposed as an efficacious, safe therapy while rubber band ligation (RBL) is a commonly used outpatient treatment. We compared recurrence after HAL versus RBL in patients with grade II–III haemorrhoids. This multicentre, open-label, parallel group, randomised controlled trial included patients from 17 acute UK NHS trusts. We screened patients aged 18 years or older presenting with grade II–III haemorrhoids. We excluded patients who had previously received any haemorrhoid surgery, more than one injection treatment for haemorrhoids, or more than one RBL procedure within 3 years before recruitment. Eligible patients were randomly assigned (in a 1:1 ratio) to either RBL or HAL with Doppler. Randomisation was computer-generated and stratified by centre with blocks of random sizes. Allocation concealment was achieved using a web-based system. The study was open-label with no masking of participants, clinicians, or research staff. The primary outcome was recurrence at 1 year, derived from the patient's self-reported assessment in combination with resource use from their general practitioner and hospital records. Recurrence was analysed in patients who had undergone one of the interventions and been followed up for at least 1 year. This study is registered with the ISRCTN registry, ISRCTN41394716. From Sept 9, 2012, to May 6, 2014, of 969 patients screened, 185 were randomly assigned to the HAL group and 187 to the RBL group. Of these participants, 337 had primary outcome data (176 in the RBL group and 161 in the HAL group). At 1 year post-procedure, 87 (49%) of 176 patients in the RBL group and 48 (30%) of 161 patients in the HAL group had haemorrhoid recurrence (adjusted odds ratio [aOR] 2·23, 95% CI 1·42–3·51; p=0·0005). The main reason for this difference was the number of extra procedures required to achieve improvement (57 [32%] participants in the RBL group and 23 [14%] participants in the HAL group had a subsequent procedure for haemorrhoids). The mean pain 1 day after procedure was 3·4 (SD 2·8) in the RBL group and 4·6 (2·8) in the HAL group (difference −1·2, 95% CI −1·8 to −0·5; p=0·0002); at day 7 the scores were 1·6 (2·3) in the RBL group and 3·1 (2·4) in the HAL group (difference −1·5, −2·0 to −1·0; p<0·0001). Pain scores did not differ between groups at 21 days and 6 weeks. 15 individuals reported serious adverse events requiring hospital admission. One patient in the RBL group had a pre-existing rectal tumour. Of the remaining 14 serious adverse events, 12 (7%) were among participants treated with HAL and two (1%) were in those treated with RBL. Six patients had pain (one treated with RBL, five treated with HAL), three had bleeding not requiring transfusion (one treated with RBL, two treated with HAL), two in the HAL group had urinary retention, two in the HAL group had vasovagal upset, and one in the HAL group had possible sepsis (treated with antibiotics). Although recurrence after HAL was lower than a single RBL, HAL was more painful than RBL. The difference in recurrence was due to the need for repeat bandings in the RBL group. Patients (and health commissioners) might prefer such a course of RBL to the more invasive HAL. NIHR Health Technology Assessment programme.

Background The mental health of medical students is a national and international problem increasing in both demand and acuity. Medical students face barriers to accessing mental health support that is clinically effective, timely and appropriate for their needs. This mixed methods study aimed to explore experiences of these barriers and the challenges to health service delivery aligned to the Candidacy Framework. Methods One hundred three medical students studying at The University of Sheffield completed an online survey comprising the CCAPS-34 and follow-up questions about service access and use. Semi-structured interviews with a nested sample of 20 medical students and 10 healthcare professionals explored barriers to service access and provision. A stakeholder panel of medical students and professionals met quarterly to co-produce research materials, interpret research data and identify touchpoints by pinpointing specific areas and moments of interaction between a medical student as a service user and a mental health service. Results Medical students who experienced barriers to help-seeking and accessing support scored significantly higher for psychological symptoms on the CCAPS-34. Uncertainty and fear of fitness to practice processes were important barriers present across all seven stages of candidacy. The fragmented structure of local services, along with individual factors such as perceived stigma and confidentiality concerns, limited the progression of medical students through the Candidacy Framework (a framework for understanding the different stages of a person’s journey to healthcare). Conclusion This study outlines important areas of consideration for mental health service provision and policy development to improve access to and the quality of care for medical students.

Background At times, clinical case complexity and different types of uncertainty present challenges to less experienced clinicians or the naive application of clinical guidelines where this may not be appropriate. Cognitive task analysis (CTA) methods are used to elicit, document and transfer tacit knowledge about how experts make decisions. Methods We conducted a methodological review to describe the use of CTA methods in understanding expert clinical decision-making. We searched MEDLINE, EMBASE and PsycINFO from inception to 2019 for primary research studies which described the use of CTA methods to understand how qualified clinicians made clinical decisions in real-world clinical settings. Results We included 81 articles (80 unique studies) from 13 countries, published from 1993 to 2019, most commonly from surgical and critical care settings. The most common aims were to understand expert decision-making in particular clinical scenarios, using expert decision-making in the development of training programmes, understanding whether decision support tools were warranted and understanding procedural variability and error identification or reduction. Critical decision method (CDM) and CTA interviews were most frequently used, with hierarchical task analysis, task knowledge structures, think-aloud protocols and other methods less commonly used. Studies used interviews, observation, think-aloud exercises, surveys, focus groups and a range of more CTA-specific methodologies such as the systematic human error reduction and prediction approach. Researchers used CTA methods to investigate routine/typical ( n = 64), challenging ( n = 13) or more uncommon, rare events and anomalies ( n = 3). Conclusions In conclusion, the elicitation of expert tacit knowledge using CTA has seen increasing use in clinical specialties working under challenging time pressures, complexity and uncertainty. CTA methods have great potential in the development, refinement, modification or adaptation of complex interventions, clinical protocols and practice guidelines. Registration PROSPERO ID CRD42019128418 .

Background Group interventions are interventions delivered to groups of people rather than to individuals and are used in healthcare for mental health recovery, behaviour change, peer support, self-management and/or health education. Evaluating group interventions in randomised controlled trials (RCTs) presents trialists with a set of practical problems, which are not present in RCTs of one-to-one interventions and which may not be immediately obvious. Methods Case-based approach summarising Sheffield trials unit’s experience in the design and implementation of five group interventions. We reviewed participant recruitment and attrition, facilitator training and attrition, attendance at the group sessions, group size and fidelity aspects across five RCTs. Results Median recruitment across the five trials was 3.2 (range 1.7–21.0) participants per site per month. Group intervention trials involve a delay in starting the intervention for some participants, until sufficient numbers are available to start a group. There was no evidence that the timing of consent, relative to randomisation, affected post-randomisation attrition which was a matter of concern for all trial teams. Group facilitator attrition was common in studies where facilitators were employed by the health system rather than the by the grant holder and led to the early closure of one trial; research sites responded by training ‘back-up’ and new facilitators. Trials specified that participants had to attend a median of 62.5% (range 16.7%–80%) of sessions, in order to receive a ‘therapeutic dose’; a median of 76.7% (range 42.9%–97.8%) received a therapeutic dose. Across the five trials, 75.3% of all sessions went ahead without the pre-specified ideal group size. A variety of methods were used to assess the fidelity of group interventions at a group and individual level across the five trials. Conclusion This is the first paper to provide an empirical basis for planning group intervention trials. Investigators should expect delays/difficulties in recruiting groups of the optimal size, plan for both facilitator and participant attrition, and consider how group attendance and group size affects treatment fidelity. Trial registration ISRCTN17993825 registered on 11/10/2016, ISRCTN28645428  registered on 11/04/2012, ISRCTN61215213  registered on 11/05/2011, ISRCTN67209155  registered on 22/03/2012, ISRCTN19447796  registered on 20/03/2014.

Depression and anxiety are very common in people with chronic obstructive pulmonary disease (COPD) and are associated with excess morbidity and mortality. Patients prefer non-drug treatments and clinical guidelines promote non-pharmacological interventions as first line therapy for depression and anxiety in people with long term conditions. However the comparative effectiveness of psychological and lifestyle interventions among COPD patients is not known. We assessed whether complex psychological and/or lifestyle interventions are effective in reducing symptoms of anxiety and depression in patients with COPD. We then determined what types of psychological and lifestyle interventions are most effective. Systematic review of randomised controlled trials of psychological and/or lifestyle interventions for adults with COPD that measured symptoms of depression and/or anxiety. CENTRAL, Medline, Embase, PsychINFO, CINAHL, ISI Web of Science and Scopus were searched up to April 2012. Meta-analyses using random effects models were undertaken to estimate the average effect of interventions on depression and anxiety. Thirty independent comparisons from 29 randomised controlled trials (n = 2063) were included in the meta-analysis. Overall, psychological and/or lifestyle interventions were associated with small reductions in symptoms of depression (standardised mean difference -0.28, 95% confidence interval -0.41 to -0.14) and anxiety (standardised mean difference -0.23, 95% confidence interval -0.38 to -0.09). Multi-component exercise training was the only intervention subgroup associated with significant treatment effects for depression (standardised mean difference -0.47, 95% confidence interval -0.66 to -0.28), and for anxiety (standardised mean difference -0.45, 95% confidence interval -0.71 to -0.18). Complex psychological and/or lifestyle interventions that include an exercise component significantly improve symptoms of depression and anxiety in people with COPD. Furthermore, multi-component exercise training effectively reduces symptoms of anxiety and depression in all people with COPD regardless of severity of depression or anxiety, highlighting the importance of promoting physical activity in this population.