Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
135
result(s) for
"Hinds, Peter"
Sort by:
Expression of Ror2 Mediates Invasive Phenotypes in Renal Cell Carcinoma
Ror2 is a Wnt ligand receptor that is overexpressed in a variety of tumors including clear cell renal cell carcinoma (ccRCC). Here we demonstrate that expression of wild type Ror2 results in increased tumorigenic properties in in vitro cell culture and in vivo xenograft models. In addition, Ror2 expression produced positive changes in both cell migration and invasion, which were dependent on matrix metalloprotease 2 (MMP2) activity. Mutations in key regions of the kinase domain of Ror2 resulted in the abrogation of increased tumor growth, cell migration, and cell invasion observed with expression of wild-type Ror2. Finally, we examined Ror2 expression as a prognostic biomarker for ccRCC utilizing the TCGA ccRCC dataset. High expression of Ror2 showed a significant correlation with higher clinical stage, nuclear grade, and tumor stage. Furthermore, high expression of Ror2 in ccRCC patients correlated with significant lower overall survival, cancer specific survival, and recurrence free survival. Together, these findings suggest that Ror2 plays a central role in influencing the ccRCC phenotype, and can be considered as a negative prognostic biomarker and potential therapeutic target in this cancer.
Journal Article
'A Vast Ill Nature': Roger L'Estrange, Reputation, and the Credibility of Political Discourse in the Late Seventeenth Century
Roger L'Estrange is a Surveyor and a Licenser of the Press during the reigns of Charles II and James II. Throughout the late 1670s and early 1680s, the period of the Popish Plot and the Exclusion Crisis, L'Estrange was engaged in an ongoing battle in print with Miles Prance -- one of the principal King's Witnesses in the plot -- occasionally criticising him in his many pamphlets, and consistently attacking him in his half-sheet serial publication the Observator. Here, Hinds examines L'Estrange's alleged 'Vast Ill Nature' and how he was himself 'traduced' by Prance and other contemporaries. It will consider L'Estrange's projection of his public image and defence of his reputation.
Journal Article
All one-way traffic for Roddick and co; MEN
For about 35 minutes there was an outside chance Andy Roddick might do something unprecedented to amuse the entertainment-starved centre-court crowd. Locked at 5-5 with his Georgian opponent, Irakli Labadze, it seemed possible the second-seeded American could lose a set.
Newspaper Article
All one-way traffic for Roddick and co; MEN
For about 35 minutes, there was an outside chance Andy Roddick might do something unprecedented to amuse the entertainment-starved centre-court crowd. Locked at 5-5 with his Georgian opponent Irakli Labadze, it seemed possible the second-seeded American could lose a set.
Newspaper Article
A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury
The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in 2009, according to the Centers for Disease Control and Prevention. It is a contributing factor in 30.5% of injury-related deaths among civilians. Additionally, since 2000, more than 260,000 service members were diagnosed with TBI, with the vast majority classified as mild or concussive (76%). The objective assessment of TBI via imaging is a critical research gap, both in the military and civilian communities. In 2011, the Department of Defense (DoD) prepared a congressional report summarizing the effectiveness of seven neuroimaging modalities (computed tomography [CT], magnetic resonance imaging [MRI], transcranial Doppler [TCD], positron emission tomography, single photon emission computed tomography, electrophysiologic techniques [magnetoencephalography and electroencephalography], and functional near-infrared spectroscopy) to assess the spectrum of TBI from concussion to coma. For this report, neuroimaging experts identified the most relevant peer-reviewed publications and assessed the quality of the literature for each of these imaging technique in the clinical and research settings. Although CT, MRI, and TCD were determined to be the most useful modalities in the clinical setting, no single imaging modality proved sufficient for all patients due to the heterogeneity of TBI. All imaging modalities reviewed demonstrated the potential to emerge as part of future clinical care. This paper describes and updates the results of the DoD report and also expands on the use of angiography in patients with TBI.
Journal Article
Lockett's big decision
Tony Lockett will make a decision today on whether to pursue a comeback, with the champion full-forward expected to try rejoining the Swans via the pre-season draft.
Newspaper Article
Pat goes for the trifecta as Aussies pass the Tests
Too much sporting glory was barely enough for fans at the weekend as Australia triumphed in rugby and cricket, and Pat Rafter prepared for his best, and perhaps last, chance of winning Wimbledon.
Newspaper Article