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Asteroid shapes and hydration levels can serve as tracers of their history and origin. For instance, the asteroids (162173) Ryugu and (101955) Bennu have an oblate spheroidal shape with a pronounced equator, but contain different surface hydration levels. Here we show, through numerical simulations of large asteroid disruptions, that oblate spheroids, some of which have a pronounced equator defining a spinning top shape, can form directly through gravitational reaccumulation. We further show that rubble piles formed in a single disruption can have similar porosities but variable degrees of hydration. The direct formation of top shapes from single disruption alone can explain the relatively old crater-retention ages of the equatorial features of Ryugu and Bennu. Two separate parent-body disruptions are not necessarily required to explain their different hydration levels. Asteroid shapes and hydration levels can serve as tracers of their history and origin. Here, the authors show top shape asteroids can form directly through gravitational reaccumulation and rubble piles formed in a single disruption can have similar porosities but variable degrees of hydration.

Understanding the physical characteristics of small Solar System bodies is important not only for refining formation and evolution models but also for space mission operations. Although several kilometre-sized asteroids have been visited by spacecraft, asteroid 1998 KY 26 —the final target of Hayabusa2#, the extended mission of the Japan Aerospace Exploration Agency’s Hayabusa2 spacecraft—will be the first decametre-scale asteroid to be explored in situ. Its small size and rapid spin place it above the upper limit on the rotation rate, indicating it may differ from previously studied bodies. In this work, we conducted a photometric campaign during 1998 KY 26 ’s close approach to Earth in 2024, revealing a high optical albedo and Xe-type colours. We determine its spin period to be (5.3516 ± 0.0001) minutes—half the period of earlier estimates. Lightcurve inversion produces retrograde pole solutions in both convex and non-convex shape models. Combined with 1998 Goldstone radar data, these results give a diameter of (11 ± 2) m, three times smaller than previously derived values. The derived cohesive strength levels necessary to keep the structure intact, which is less than 20 Pa, suggest a possibility of the asteroid’s rubble pile structure, though this finding does not rule out its monolithic structure. These results can be validated with future James Webb Space Telescope observations. Our comprehensive characterisation can inform the planning of the Hayabusa2# rendezvous in 2031 and helps pave the way for future studies of dark comets. Asteroid 1998 KY26 is the target of Hayabusa2 extended space mission. Here, authors show that it is smaller and rotates faster than known.

Marine biogenic sulphur affects Earth’s radiation budget and may be an indicator of primary productivity in the Southern Ocean, which is closely related to atmospheric CO 2 variability through the biological pump. Previous ice-core studies in Antarctica show little climate dependence of marine biogenic sulphur emissions and hence primary productivity, contradictory to marine sediment records. Here we present new 720,000-year ice core records from Dome Fuji in East Antarctica and show that a large portion of non-sea-salt sulphate, which was traditionally used as a proxy for marine biogenic sulphate, likely originates from terrestrial dust during glacials. By correcting for this, we make a revised calculation of biogenic sulphate and find that its flux is reduced in glacial periods. Our results suggest reduced dimethylsulphide emissions in the Antarctic Zone of the Southern Ocean during glacials and provide new evidence for the coupling between climate and the Southern Ocean sulphur cycle. Ice core derived marine biogenic sulphate does not agree with marine sediment records. Here based on new ice core records spanning the past 720,000 years obtained from Dome Fuji the authors propose that dust contributed a higher percentage of sulphate aerosols than previously thought.

Water stable isotopes in Greenland ice core data provide key paleoclimatic information, and have been compared with precipitation isotopic composition simulated by isotopically enabled atmospheric models. However, post-depositional processes linked with snow metamorphism remain poorly documented. For this purpose, monitoring of the isotopic composition (δ18O, δD) of near-surface water vapor, precipitation and samples of the top (0.5 cm) snow surface has been conducted during two summers (2011–2012) at NEEM, NW Greenland. The samples also include a subset of 17O-excess measurements over 4 days, and the measurements span the 2012 Greenland heat wave. Our observations are consistent with calculations assuming isotopic equilibrium between surface snow and water vapor. We observe a strong correlation between near-surface vapor δ18O and air temperature (0.85 ± 0.11‰ °C−1 (R = 0.76) for 2012). The correlation with air temperature is not observed in precipitation data or surface snow data. Deuterium excess (d-excess) is strongly anti-correlated with δ18O with a stronger slope for vapor than for precipitation and snow surface data. During nine 1–5-day periods between precipitation events, our data demonstrate parallel changes of δ18O and d-excess in surface snow and near-surface vapor. The changes in δ18O of the vapor are similar or larger than those of the snow δ18O. It is estimated using the CROCUS snow model that 6 to 20% of the surface snow mass is exchanged with the atmosphere. In our data, the sign of surface snow isotopic changes is not related to the sign or magnitude of sublimation or deposition. Comparisons with atmospheric models show that day-to-day variations in near-surface vapor isotopic composition are driven by synoptic variations and changes in air mass trajectories and distillation histories. We suggest that, in between precipitation events, changes in the surface snow isotopic composition are driven by these changes in near-surface vapor isotopic composition. This is consistent with an estimated 60% mass turnover of surface snow per day driven by snow recrystallization processes under NEEM summer surface snow temperature gradients. Our findings have implications for ice core data interpretation and model–data comparisons, and call for further process studies.

To report the clinical outcomes of ICL implantation for the treatment of myopia in American patients at a single center with central internal anterior chamber depth (ACD) less than the FDA-approved 3.0 mm. Data was retrospectively obtained from 943 eyes of 560 patients between 4/6/2022 and 7/15/2024 which included 231 eyes of 120 patients with internal central ACD of <3.0 mm and 712 eyes of 440 patients with internal central ACD of ≥3.0 mm as measured by the Pentacam AXL (OCULUS, Wetzlar, Germany). Demographics, biometry, postoperative vault, and any complications were recorded. Patients were seen 1 day, 1 month, and 2 months, and followed regularly by their primary eyecare provider with instructions to return in the event of any problems. Rates of ICL explantation were statistically compared using the Fisher's Exact test. Postoperative vault and IOP were compared using the Student's -test. Of the 231 eyes with ACD < 3.0 mm, 0.4% (1/231) required intraocular surgical intervention including ICL explant, exchange, or toric lens repositioning at some point in the postoperative period or were clinically judged to have a vault requiring an exchange compared to 3.7% (26/712) eyes with ACD ≥ 3.0 mm (p = 0.0103). Average postoperative vault for the eyes with ACD < 3.0 mm was 437.22 ± 191.93 microns compared to 560.73 ± 193.65 in eyes with ACD ≥ 3.0 mm (p < 0.001). IOP and visual acuity at 1 month were similar between the groups. Outside the US, the lower limit of ACD is 2.8 mm for myopia correction. This single center study demonstrates that ICL surgery in American eyes with ACDs < 3.0 mm may also be safe and result in excellent outcomes with comparable rates of exchange or enhancement to eyes meeting the FDA guidelines.

To report the incidence, reasons, and outcomes for Implantable Collamer Lens (ICL) exchanges at a high-volume center in the United States. A retrospective chart review was performed on 961 eyes of 484 patients who underwent ICL surgery in a commercial setting at Parkhurst NuVision from 04/06/2022 to 10/21/2024. 11 eyes of 8 patients out of the 961 commercial cases (1.1%) underwent ICL exchange at our institution due to sizing issues. Of these, only 5 cases (0.5%) were exchanged due to initial vault concerns with 6 cases (0.6%) exchanged due to rotated toric ICLs. Upon repeat review of these cases, we would have chosen a different size in 3 of them. ICL implantation is remarkably safe, with an incredibly low exchange rate due to inappropriate sizing. The majority of these cases also involved clinically safe vault and the exchange only occurred due to rotation of a toric ICL.

Neuronal cell death, abnormal protein aggregates, and cytoplasmic vacuolization are major pathologies observed in many neurodegenerative disorders such as the polyglutamine (polyQ) diseases, prion disease, Alzheimer disease, and the Lewy body diseases, suggesting common mechanisms underlying neurodegeneration. Here, we have identified VCP/p97, a member of the AAA+ family of ATPase proteins, as a polyQ-interacting protein in vitro and in vivo, and report on its characterization. Endogenous VCP co-localized with expanded polyQ (ex-polyQ) aggregates in cultured cells expressing ex-polyQ, with nuclear inclusions in Huntington disease patient brains, and with Lewy bodies in patient samples. Moreover, the expression of VCP mutants with mutations in the 2nd ATP binding domain created cytoplasmic vacuoles, followed by cell death. Very similar vacuoles were also induced by ex-polyQ expression or proteasome inhibitor treatment. These results suggest that VCP functions not only as a recognition factor for abnormally folded proteins but also as a pathological effector for several neurodegenerative phenotypes. VCP may thus be an ideal molecular target for the treatment of neurodegenerative disorders.

Regeneration of human kidneys in animal models would help combat the severe shortage of donors in transplantation therapy. Previously, we demonstrated by interspecific blastocyst complementation between mouse and rats, generation of pluripotent stem cell (PSC)-derived functional pancreas, in apancreatic Pdx1 mutant mice. We, however, were unable to obtain rat PSC-derived kidneys in anephric Sall1 mutant mice, likely due to the poor contribution of rat PSCs to the mouse metanephric mesenchyme, a nephron progenitor. Here, conversely, we show that mouse PSCs can efficiently differentiate into the metanephric mesenchyme in rat, allowing the generation of mouse PSC-derived kidney in anephric Sall1 mutant rat. Glomerular epithelium and renal tubules in the kidneys are entirely composed of mouse PSC-derived cells expressing key functional markers. Importantly, the ureter-bladder junction is normally formed. These data provide proof-of-principle for interspecific blastocyst complementation as a viable approach for kidney generation. The use of pluripotent-stem cell derived organs for transplantation would be promising, if organs can be grown in a suitable host. Here, the authors use interspecific blastocyst complementation to generate a mouse pluripotent stem cell-derived kidney in anephric Sall1 mutant rats.

Whereas ice cores from high-accumulation sites in coastal Antarctica clearly demonstrate annual layering, it is debated whether a seasonal signal is also preserved in ice cores from lower-accumulation sites further inland and particularly on the East Antarctic Plateau. In this study, we examine 5 m of early Holocene ice from the Dome Fuji (DF) ice core at a high temporal resolution by continuous flow analysis. The ice was continuously analysed for concentrations of dust, sodium, ammonium, liquid conductivity, and water isotopic composition. Furthermore, a dielectric profiling was performed on the solid ice. In most of the analysed ice, the multi-parameter impurity data set appears to resolve the seasonal variability although the identification of annual layers is not always unambiguous. The study thus provides information on the snow accumulation process in central East Antarctica. A layer counting based on the same principles as those previously applied to the NGRIP (North Greenland Ice core Project) and the Antarctic EPICA (European Project for Ice Coring in Antarctica) Dronning Maud Land (EDML) ice cores leads to a mean annual layer thickness for the DF ice of 3.0 ± 0.3 cm that compares well to existing estimates. The measured DF section is linked to the EDML ice core through a characteristic pattern of three significant acidity peaks that are present in both cores. The corresponding section of the EDML ice core has recently been dated by annual layer counting and the number of years identified independently in the two cores agree within error estimates. We therefore conclude that, to first order, the annual signal is preserved in this section of the DF core. This case study demonstrates the feasibility of determining annually deposited strata on the central East Antarctic Plateau. It also opens the possibility of resolving annual layers in the Eemian section of Antarctic ice cores where the accumulation is estimated to have been greater than in the Holocene.

We have recently reported that multiple aster formation after in vitro fertilization (IVF) was one of the factors that negatively affected the developmental competence of vitrified-warmed bovine matured oocytes, and that short-term culture of the post-warm oocytes with an inhibitor of Rho-associated coiled-coil kinase (ROCK) suppressed the multiple aster formation and improved the blastocyst yield. The present study was conducted to investigate whether increased multiple aster formation following IVF was involved in impaired developmental competence of stored ovary-derived bovine oocytes. Oocytes retrieved from 1-day stored ovaries had lower developmental potential to day 8 blastocysts when compared with those from fresh ovaries (37 versus 63%). Immunostaining of α-tubulin 10 h post-IVF revealed that a higher incidence of multiple aster formation occurred in oocytes retrieved from stored ovaries than from fresh ovaries (31 versus 15%). Treatment of post-in vitro maturated (post-IVM) oocytes with ROCK inhibitor for 2 h significantly suppressed the incidence of multiple aster formation (10 versus 32% in the control group). However, the suppression effect of ROCK inhibitor on multiple aster formation in IVM/IVF oocytes did not improve blastocyst yield from stored ovary-derived oocytes (41 versus 37% in the control group). These results suggested that the higher incidence of multiple aster formation by bovine ovary storage was not responsible for the decreased developmental competence of IVF oocytes.