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A bstract We describe a proposal to add a set of very forward detectors to the CMS experiment for the high-luminosity era of the Large Hadron Collider to search for beyond the standard model long-lived particles, such as dark photons, heavy neutral leptons, axion-like particles, and dark Higgs bosons. The proposed subsystem is called FACET for F orward- A perture C MS E x T ension, and will be sensitive to any particles that can penetrate at least 50 m of magnetized iron and decay in an 18 m long, 1 m diameter vacuum pipe. The decay products will be measured in detectors using identical technology to the planned CMS Phase-2 upgrade.

Early and accurate diagnosis of Parkinson’s disease (PD) remains challenging. Neuropathological studies using brain bank specimens have estimated that a large percentages of clinical diagnoses of PD may be incorrect especially in the early stages. In this paper, a comprehensive computer model is presented for the diagnosis of PD based on motor, non-motor, and neuroimaging features using the recently-developed enhanced probabilistic neural network (EPNN). The model is tested for differentiating PD patients from those with scans without evidence of dopaminergic deficit (SWEDDs) using the Parkinson’s Progression Markers Initiative (PPMI) database, an observational, multi-center study designed to identify PD biomarkers for diagnosis and disease progression. The results are compared to four other commonly-used machine learning algorithms: the probabilistic neural network (PNN), support vector machine (SVM), k-nearest neighbors (k-NN) algorithm, and classification tree (CT). The EPNN had the highest classification accuracy at 92.5 % followed by the PNN (91.6 %), k-NN (90.8 %) and CT (90.2 %). The EPNN exhibited an accuracy of 98.6 % when classifying healthy control (HC) versus PD, higher than any previous studies.

The High-Granularity Calorimeter (HGCAL) will replace the current CMS Endcap Calorimeter during Long-Shutdown 3. The Endcap Concentrator (ECON) ASICs represent key elements in the readout chain, processing trigger (ECON-T) and data (ECON-D) streams from the HGCROC to the lpGBT. The ECONs will operate in a radiation environment with a High-Energy Hadron (\\({E\\geq20MeV}\\)) flux up to \\(2\\cdot10^{7} cm^{-2}s^{-1}\\). This contribution describes the Universal Verification Methodology (UVM)-based functional verification of the ECON ASICs focusing on the re-use of existing components to manage the complexity of the verification environment.

The High-Granularity Calorimeter (HGCAL) will replace the current CMS Endcap Calorimeter during Long-Shutdown 3. The Endcap Concentrator (ECON) ASICs represent key elements in the readout chain, processing trigger (ECON-T) and data (ECON-D) streams from the HGCROC to the lpGBT. The ECONs will operate in a radiation environment with a High-Energy Hadron (\\({E\\geq20MeV}\\)) flux up to \\(2\\cdot10^{7} cm^{-2}s^{-1}\\). This contribution describes the Universal Verification Methodology (UVM)-based functional verification of the ECON ASICs focusing on the re-use of existing components to manage the complexity of the verification environment.

We describe a proposal to add a set of very forward detectors to the CMS experiment for the high-luminosity era of the Large Hadron Collider to search for beyond the standard model long-lived particles, such as dark photons, heavy neutral leptons, axion-like particles, and dark Higgs bosons. The proposed subsystem is called FACET for Forward-Aperture CMS ExTension, and will be sensitive to any particles that can penetrate at least 50 m of magnetized iron and decay in an 18 m long, 1 m diameter vacuum pipe. The decay products will be measured in detectors using identical technology to the planned CMS Phase-2 upgrade.

Timing differences of functional response between brain regions were tested using parametric maps generated with seizure event onset times, employed in the statistical design matrix, shifted (from +6 to +6 seconds) relative to the original EEG events. Conclusions Findings in this group of medication-resistant IGE patients, utilizing simultaneous EEG/fMRI, indicate that localized frontal lobe activity precedes GSWD events associated with absence seizures.

The 2021 Snowmass Energy Frontier panel wrote in its final report \"The realization of a Higgs factory will require an immediate, vigorous and targeted detector R&D program\". Both linear and circular \\(e^+e^-\\) collider efforts have developed a conceptual design for their detectors and are aggressively pursuing a path to formalize these detector concepts. The U.S. has world-class expertise in particle detectors, and is eager to play a leading role in the next generation \\(e^+e^-\\) collider, currently slated to become operational in the 2040s. It is urgent that the U.S. organize its efforts to provide leadership and make significant contributions in detector R&D. These investments are necessary to build and retain the U.S. expertise in detector R&D and future projects, enable significant contributions during the construction phase and maintain its leadership in the Energy Frontier regardless of the choice of the collider project. In this document, we discuss areas where the U.S. can and must play a leading role in the conceptual design and R&D for detectors for \\(e^+e^-\\) colliders.

Exciting proposals for a new Higgs factory collider, aimed at the search for new physics and precision studies of particles and forces, especially measurement of the Higgs boson couplings at the loop level, will be evaluated as part of the Snowmass process. Potential facilities include (among others) ILC, FCC-ee, C3, CEPC, CLIC, muon collider and advanced accelerator concepts being investigated by Snowmass topical group AF6, potentially located in Asia, Europe, or the United States. The European Strategy has endorsed an electron-positron Higgs factory as its highest priority after HL-LHC. Much of the detector, software, and physics preparative studies needed for these machines is in common, and is currently being implemented by physicists world-wide. In this white paper for the 2021 Snowmass process we look at current global activity on future Higgs factories and give examples of investments that could be made in these common areas over the next five years to establish a leadership role for the U.S. in a future Higgs factory, wherever it is built. The U.S. high energy physics program confronts a number of challenges that a strong role in the study of the Higgs boson can address. These include, in addition to the scientific results, maintaining leading roles in international partnerships, nurturing and advancing world-leading capabilities and expert resources, and maintaining and attracting talent. The international effort would benefit from increased U.S. participation, and the U.S., in turn, would maintain stature through the partnership.

In this White Paper for the 2021 Snowmass process, we detail the status and prospects for dual-readout calorimetry. While all calorimeters allow estimation of energy depositions in their active material, dual-readout calorimeters aim to provide additional information on the light produced in the sensitive media via, for example, wavelength and polarization, and/or a precision timing measurements, allowing an estimation of the shower-by-shower particle content. Utilizing this knowledge of the shower particle content may allow unprecedented energy resolution for hadronic particles and jets and new types of particle flow algorithms. We also discuss the impact continued development of this kind of calorimetry could have on precision on Higgs boson property measurements at future colliders.

We present preliminary measurements of time-dependent CP-violation parameters in the decays B0->omegaK0S, B0->eta'K0, B0->pi0K0S, B0->phiK0Spi0, and B0->K+K-K0S, which includes the resonant final states phiK0S and f0(980)K0S. The data sample corresponds to the full BABAAR dataset of 467 million BBbar pairs produced at the PEP-II asymmetric-energy e+e- collider at the Stanford Linear Accelerator Center.