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"Hisham Ismail"
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Noninvasive identification of molecular biomarkers of hepatocellular carcinoma in HCV-Egyptian patients
Background This study was performed to investigate the expression of different biomarkers in patients with hepatocellular carcinoma and its connection with detective biomarkers. To achieve this objective, seventy subjects were examined in this study, sub-grouped to forty HCC patients and thirty HCV-affected patients with matched thirty healthy individuals. The study involved several groups of participants who were matched based on their age and gender. Methods The expression pattern of biomarkers was monitored by quantitative polymerase chain reaction (qRT-PCR). Finally, we utilized a ROC curve to investigate the predictive accurateness of those distinct biomarkers as well as a traditional tumor marker, AFP, in detecting HCC cases. Results The baseline biomarker expression levels were markedly greater in HCC patients than in those affected by HCV or healthy subjects. We stated that the sensitivity and the specificity of the different biomarkers alone did not improve than that of AFP alone. When comparing AFP with different biomarkers, the diagnostic validity improves only when combining with CK-1. Conclusions Overall, our results indicate that CK-1 mRNA expression could help as a noninvasive tumor biomarker for HCC prognosis and diagnosis when combining with AFP.
Journal Article
Anti-Tumor Potential of Frankincense Essential Oil and Its Nano-Formulation in Breast Cancer: An In Vivo and In Vitro Study
Background/Objective: Breast cancer remains the most common malignancy among women worldwide, contributing to high morbidity and mortality rates. Many anti-cancer drugs have been derived from medicinal plants, and frankincense from Boswellia carterii is notable for its anti-inflammatory, anti-neoplastic, and anti-carcinogenic properties. Using gas chromatography/mass spectrometry (GC/MS), 48 components were identified in B. carterii essential oil, and the major constituent was α-pinene (35.81%). Method: In this study, we investigated the anti-tumor effects of frankincense essential oil (FEO) and its nano-formulation with chitosan (FEO-CSNPs) using in vitro breast cancer models (MCF-7, MDA-MB-231, and 4T1 cells) and in vivo mouse mammary carcinoma (4T1) models (Balb/c). Results: The results showed significant reductions in cell viability. At 10 μg/mL, the FEO showed the highest reduction in the C-166 cells, while at 100 μg/mL, the FEO exhibited a stronger cytotoxicity in the MDA-MB-231 and 4T1 cells compared to the FEO-CSNPs and CSNPs. The FEO-CSNPs exhibited cell growth arrest in the S, G2/M, and G1/S phases in the MCF-7, MDA-MB-231, and 4T1 cell lines (36.91%, 23.12%, and 33.58%), in addition to increased apoptosis rates in the MCF-7, MDA-MB-231, and 4T1 cell lines (33.04%, 36.39%, and 42.19%). The wound healing assays revealed a decreased migratory ability in the treated cells. The in vivo experiments in the balb/c mice demonstrated a reduction in the tumor volume, with a histopathological analysis confirming extensive tumor necrosis. Moreover, the FEO and FEO-CSNPs showed notable antioxidant and arginase activity. The gene expression analysis via qPCR indicated the upregulation of tumor suppressor genes and the downregulation of oncogenes. Conclusions: These findings suggest that FEO and its nano-formulation, particularly in the form of FEO-CSNPs as an oral formulation, display enhanced efficacy, warranting further preclinical and clinical research to develop innovative treatment strategies.
Journal Article
Mental Well-Being and Religious Values Among Muslims Across Four Cities
Kesejahteraan mental merupakan satu bidang ilmu yang berkait rapat dengan bidang-bidang ilmu lain. Justeru itu, dalam kajian ini, pilihan angkubah kajian yang biasa ditemui dalam konstruk-konstruk kajian daripada pelbagai bidang ilmu lain seperti pembangunan diri, penerimaan diri, mattamat peribadi, daya tahan, taqwa, harapan dan kepentingan sosial diguna pakai sebagai konstruk signifikan yang dapat menunjukkan korelasi secara positif dengan kesejahteraan mental. Instrumen asal \"the Warwick-Edinburgh Mental Well-Being Scale (W-EMWS)\" digunakan dalam kajian ini untuk mengukur kesejahteraan mental responden kajian. Fokus kajian adalah untuk menyiasat kesejahteraan mental responden Muslim dari pelbagai latar belakang seperti negara, kewarganegaraan, budaya dan nilai-nilai kehidupan. Kajian juga cuba mengenalpasti sama ada faktor keagamaan menyumbang kepada kesejahteraan mental responden dari pelbagai negara tersebut. Sampel kajian seramai 989 responden dipilih dari Istanbul, Republik Turkiye; Kuala Lumpur, Malaysia; Lagos, Nigeria; dan, London, United Kingdom. Dapatan kajian menunjukkan beberapa faktor kajian seperti penerimaan diri, kepentingan sosial dan pembangunan diri berkorelasi secara signifikan dengan kesejahteraan mental responden Muslim dalam kajian ini. Seperti yang telah dijangkakan, kajian juga menunjukkan variasi korelasi antara kesejahteraan mental dan responden dari pelbagai bandaraya pilihan. Walau bagaimanapun, nilai keagamaan, seperti taqwa dan harapan berkorelasi secara sederhana dengan kesejahteraan mental responden dalam kajian ini. Kajian juga menghasilkan dapatan yang menjanjikan peluang terbaik untuk kajian susulan seperti kajian penerokaan model kesejahteraan mental dan potensi nilai-nilai keagamaan di kalangan Muslim dari pelbagai latar belakang.
Journal Article
INTEGRATION OF EMOTIONAL INTELLIGENCE IN TEACHING PRACTICE AMONG UNIVERSITY TEACHERS IN HIGHER EDUCATION
Purpose – Emotional intelligence abilities of university teachers are more likely to establish suitable emotional teaching and learning environments through their teaching practice, thus promoting learning motivation and engagement among students. Despite the emphasis on the importance of teachers’ emotional intelligence abilities in teaching, it continues to be under-acknowledged and underdeveloped. This is evidenced in a few studies reported on the relationship between emotional intelligence and teaching practice particularly in higher education. Guided by the Four-Branch Emotional Intelligence Ability Model, this study aimed to explore the integration of emotional intelligence in teaching practice among university teachers in higher education. Method – A qualitative design of a descriptive case study was applied on 10 university teachers recruited through purposeful sampling. The data gathered from semi-structured interviews conducted with the university teachers was analyzed through five phases of analysis namely; raw categorization of individual interviewees, group categorization of interviewees, raw key points, refined key points and themes. The credibility and trustworthiness of the data were achieved through prolonged engagement, member check, and interrater reliability. Results – Seven themes namely implementation of structured teaching flow, empathetic pedagogical approach, fostering student learning engagement, consideration of students’ emotions, reflection of university teachers’ characteristics, mutual teaching and learning sessions and meaningful learning sessions were generated. Significance – The study demonstrated the importance of developing emotional intelligence abilities among university teachers as these abilities directly influence teaching and learning processes. In fact, these abilities are subconsciously embedded and demonstrated through teaching practice. Thus training on emotional intelligence needs to be developed by including it as one of the competencies required for university teachers.
Journal Article
Machine-Learning-Based Classification for Pipeline Corrosion with Monte Carlo Probabilistic Analysis
Pipeline corrosion is one of the leading causes of failures in the transmission of gas and hazardous liquids in the oil and gas industry. In-line inspection is a non-destructive inspection for detecting corrosion defects in pipelines. Defects are measured in terms of their width, length and depth. Consecutive in-line inspection data are used to determine the pipeline’s corrosion growth rate and its remnant life, which set the operational and maintenance activities of the pipeline. The traditional approach of manually processing in-line inspection data has various weaknesses, including being time consuming due to huge data volume and complexity, prone to error, subject to biased judgement by experts and challenging for matching of in-line inspection datasets. This paper aimed to contribute to the adoption of machine learning approaches in classifying pipeline defects as per Pipeline Operator Forum requirements and matching in-line inspection data for determining the corrosion growth rate and remnant life of pipelines. Machine learning techniques, namely, decision tree, random forest, support vector machines and logistic regression, were applied in the classification of pipeline defects using Phyton programming. The performance of each technique in terms of the accuracy of results was compared. The results showed that the decision tree classifier model was the most accurate (99.9%) compared with the other classifiers.
Journal Article
Children’s Literature: The Significance and Other Impacts
It is worth noting that children’s literature is one of the rapidly growing fields in the literature on one hand, but on the other hand, it is also the most argumentative area of study among critics and all interested persons. The debatable feature of this literary genre underlies the broad scope of the literary texts that can include under its umbrella; fairy tales, short stories, novels, poems, and picture books. Additionally, these books’ commercial success and readability can have a long-lasting influence, and we can trace these impacts from one generation to another and from one culture to another. These books occupy a vital position in the scholar’s discussion to examine the suitability and goodness of their content to fit the mentality of children. No one can deny these books’ profound impacts on the young generation’s personal development, but we must admit that other impacts may scratch this bright image of these memorable books. In this paper, the researcher tries to detect both sides of children’s literature by referring to the role of the writer’s ideology.
Journal Article
Little Women: Louisa May Alcott’s Duality Between the Intentional Lessons and the Unconscious Messages
Undoubtedly, Little Women can be considered one of the most influential literary texts in the history of American literature in general and children’s books specifically. This novel has many essential lessons and messages that may affect the development path of any girl. Louisa May Alcott cleverly presents different female characters to shed light on the issues and obstacles women faced during the 19th century in American society. The critics vary in their critical reading and examination of this novel and their understanding of the genuine intentions of Louisa May Alcott. Definitely, the reader can elicit a kind of ambivalence in this novel between the opposing attitudes and decisions Alcott offers in this novel. Throughout the different chapters and various incidents, Alcott clearly explains the suffering of both women and men in the patriarchal society and how both may live restricted life due to society’s expectations and imposing limitations.
Journal Article
Objectification: Examples of Female Characters in Selected Traditional Fairy Tales
No one can deny the vital role that fairy tales played in forming the personalities of successive generations across various regions worldwide. All adults should have pleasant memories with these books during their early childhood. These memories make these tales enjoyable for children and adults, as all adults consider reading these books a part of the nostalgia for these past peaceful and cheerful days. On the other hand, many studies proved the passive and hazardous impacts of fairy tales' implicit themes and hidden messages. For instance, these themes heavily influenced the stereotyping of feminine roles in society. Furthermore, these books enhanced the gender roles with the advantage of the masculine, active role. Throughout the wide range of these books, the readers can quickly identify male characters as saviors, supporters, and always positioned in the center of the women's life. Moreover, the traditional happy ending should be associated with the marriage of the rich and handsome prince/ gentleman. The author will examine the portrayal of the prominent female characters in selected traditional fairy tales to shed light on the concept of \"objectification\" as a central concept in structuring these characters by making them passive, helpless, and naïve. Accordingly, these portrayals served to present these female characters as mere objects to satisfy the sexual and psychological fantasies of men.
Journal Article
Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Replacement in a Malaysian Teaching Hospital: Findings from an Eight-Year Interval Molecular Surveillance
Periodical surveillance on nosocomial pathogens is important for antimicrobial stewardship and infection control. The first methicillin-resistant Staphylococcus aureus (MRSA) molecular surveillance in Hospital Canselor Tuanku Muhriz (HCTM), a Malaysian teaching hospital, was performed in 2009. The dominant clone was identified as an MRSA carrying SCCmec type III-SCCmercury with ccrC and sea+cna toxin genes. In this study, we report the findings of the second HCTM MRSA surveillance carried out in 2017, after an interval of 8 years. Antibiotic susceptibility testing, SCCmec, toxin gene, and spa typing were performed for 222 MRSA strains isolated in 2017. Most strains were resistant to ciprofloxacin, erythromycin, clindamycin, cefoxitin, and penicillin (n = 126, 56.8%), belong to SCCmec type IV (n = 205, 92.3%), spa type t032 (n = 160, 72.1%) and harboured seg+sei toxin genes (n = 172, 77.5%). There was significant association between resistance of the aforementioned antibiotics with SCCmec type IV (p < 0.05), t032 (p < 0.001), and seg+sei carriage (p < 0.05). Results from this second MRSA surveillance revealed the occurrence of clonal replacement in HCTM during an interval of not more than 8 years. Investigation of the corresponding phenotype changes in this new dominant MRSA clone is currently on-going.
Journal Article