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This collection of rebellious poems are a reflection of Macedonian poet Ilja Kostovski's travels across the United States, as well as his interpretations of God's purpose for man. Written over the course of a decade from the late 1970s, this work arose out of Kostovski's immersion in the 1978 San Francisco poetry scene and his experience of living in the Shaw district of Washington, DC during the 1980s.

A Glance into Ilja Kostovski's Selected Poetry It is a slightly smirking smile that accompanies the voice calling on Muses in Ilja Kostovski's epic poetry and final book, Sisiphus and I. In this seminal production of the poet's work, an eager, if slightly sarcastic, voice cries out from the woodpile of modernity: Don't tarry You envious God This minute I will go Into the deep forests And will chop for you Firewood in piles. As for Kostovski's readers, they are the \"connoisseurs of sorrow,\" the \"suicide…leaning on the railings of bridges,\" the \"self-despisers,\" for he is a poet of the lone wolves, the melancholy wanderer we read about in Blake and imagine among the happy crowds at Coney Island in the 1920s, or among the tripping multitudes of Haight Ashbury in the 1960s, or in the city where he made his last residence, the throngs of the upright and enraged of Washington, D.C. Kostovski's verse is prayer to a God who is or is not there, a nearly desperate, repeating \"Come unto me.\" It is not merely exhortation to the deity. He invokes, too, the gathering crowds of the lost and broken-hearted, as though the divine could only be conjured by those numbers, or as if the dead God of Nietzsche could be resurrected by a hoard whose suffering is the very thing that binds them. In that case, instead of a savior, the hero of these poems is a common wound: \"Come unto me those/Who have turned your roads/Into hazardous games.\" The language is straight out of the book of Micah (whose own anaphoric language begins each chapter with \"Hear\"), an Old Testament prophet no one believes, but the language pops with contemporary hideousness: \"Come, candidates for oval offices/ Come, candidates for electric chairs.\" In what is perhaps the most powerful poem in the collection, \"Sermon at the Washington Monument,\" Kostovski the poet recalls his association with Ferlinghetti, who \"Told me once/The Anglo-Saxons speak the truth/with half-closed mouths...\" From a formal angle, the collection Sisyphus and I is Kostovski's open-mouthed song to a universe that may or may not be listening. Like the fledgling with mouth turned upward, Kostovski's poetry is both artistic hallelujah and hungry yawp, whose overarching tone is a kind of \"gallows praise\": \"I hear America is not singing anymore/All songs are dead/And you are the executioner…/Have you ever known Francois Villion/ Who multiplied his life on the gallows?\" The poet calls on writers to awaken-rather like Micah, standing on his street corner-if not to save anything, then to attend it as it passes, flares out, at the height of its beauty. Kostovski, born in the Macedonian province of Greece, is the author of Dostoevsky and Goethe: Two Devils, Two Geniuses. Like his poetry, his scholarship sought out the insight of the outsider, as he himself carried the burden of his generation through exile during Communist overthrows, until he settled in Washington, D.C. The prophetic insight is this: a monument does not memorialize a country, but rather a misinterpreted ideal. The best remembrances are those that serve a human purpose. And the best invitation to the gods, in Kostovski's reckoning at least, is to chop some firewood, good for burning. This is a poet whose voice at once harkens back to the Tanakh while it recalls the beatniks of San Francisco, the homeless, and the insidious white power structures and silent mausoleums of Washington D.C. We are reminded in these pages that life is to be sung open-mouthed, if at all. David Keplinger December, 2017

Attention-deficit/hyperactivity disorder (ADHD) is a common brain developmental disorder in the general population that may be even more prevalent in elite athletes in certain sports. General population studies of ADHD are extensive and have reported on prevalence, symptoms, therapeutic and adverse effects of treatment and new clinical and research findings. However, few studies have reported on prevalence, symptoms and treatments of ADHD in elite athletes. This narrative review summarises the literature on symptoms, comorbidities, effects of ADHD on performance and management options for elite athletes with ADHD. The prevalence of ADHD in student athletes and elite athletes may be 7%–8%. The symptoms and characteristics of ADHD play a role in athletes’ choice of a sport career and further achieving elite status. Proper management of ADHD in elite athletes is important for safety and performance, and options include pharmacologic and psychosocial treatments.

Cooperative activation of actin-myosin interaction by tropomyosin (Tm) is central to regulation of contraction in muscle cells and cellular and intracellular movements in nonmuscle cells. The steric blocking model of muscle regulation proposed 40 y ago has been substantiated at both the kinetic and structural levels. Even with atomic resolution structures of the major players, how Tm binds and is designed for regulatory function has remained a mystery. Here we show that a set of periodically distributed evolutionarily conserved surface residues of Tm is required for cooperative regulation of actomyosin. Based on our results, we propose a model of Tm on a structure of actin-Tm-myosin in the “open” (on) state showing potential electrostatic interactions of the residues with both actin and myosin. The sites alternate with a second set of conserved surface residues that are important for actin binding in the inhibitory state in the absence of myosin. The transition from the closed to open states requires the sites identified here, even when troponin + Ca ²⁺ is present. The evolutionarily conserved residues are important for actomyosin regulation, a universal function of Tm that has a common structural basis and mechanism.

This paper provides a synopsis of discussions related to biomedical engineering core curricula that occurred at the Fourth BME Education Summit held at Case Western Reserve University in Cleveland, Ohio in May 2019. This summit was organized by the Council of Chairs of Bioengineering and Biomedical Engineering, and participants included over 300 faculty members from 100+ accredited undergraduate programs. This discussion focused on six key questions: QI: Is there a core curriculum, and if so, what are its components? QII: How does our purported core curriculum prepare students for careers, particularly in industry? QIII: How does design distinguish BME/BIOE graduates from other engineers? QIV: What is the state of engineering analysis and systems-level modeling in BME/BIOE curricula? QV: What is the role of data science in BME/BIOE undergraduate education? QVI: What core experimental skills are required for BME/BIOE undergrads? s. Indeed, BME/BIOI core curricula exists and has matured to emphasize interdisciplinary topics such as physiology, instrumentation, mechanics, computer programming, and mathematical modeling. Departments demonstrate their own identities by highlighting discipline-specific sub-specialties. In addition to technical competence, Industry partners most highly value our students’ capacity for problem solving and communication. As such, BME/BIOE curricula includes open-ended projects that address unmet patient and clinician needs as primary methods to prepare graduates for careers in industry. Culminating senior design experiences distinguish BME/BIOE graduates through their development of client-centered engineering solutions to healthcare problems. Finally, the overall BME/BIOE curriculum is not stagnant—it is clear that data science will become an ever-important element of our students’ training and that new methods to enhance student engagement will be of pedagogical importance as we embark on the next decade.

Techniques such as Stochastic Optical Reconstruction Microscopy (STORM) and Structured Illumination Microscopy (SIM) have increased the achievable resolution of optical imaging, but few fluorescent proteins are suitable for super-resolution microscopy, particularly in the far-red and near-infrared emission range. Here we demonstrate the applicability of CpcA, a subunit of the photosynthetic antenna complex in cyanobacteria, for STORM and SIM imaging. The periodicity and width of fabricated nanoarrays of CpcA, with a covalently attached phycoerythrobilin (PEB) or phycocyanobilin (PCB) chromophore, matched the lines in reconstructed STORM images. SIM and STORM reconstructions of Escherichia coli cells harbouring CpcA-labelled cytochrome bd 1 ubiquinol oxidase in the cytoplasmic membrane show that CpcA-PEB and CpcA-PCB are suitable for super-resolution imaging in vivo . The stability, ease of production, small size and brightness of CpcA-PEB and CpcA-PCB demonstrate the potential of this largely unexplored protein family as novel probes for super-resolution microscopy.

Techniques such as Stochastic Optical Reconstruction Microscopy (STORM) and Structured Illumination Microscopy (SIM) have increased the achievable resolution of optical imaging, but few fluorescent proteins are suitable for super-resolution microscopy, particularly in the far-red and near-infrared emission range. Here we demonstrate the applicability of CpcA, a subunit of the photosynthetic antenna complex in cyanobacteria, for STORM and SIM imaging. The periodicity and width of fabricated nanoarrays of CpcA, with a covalently attached phycoerythrobilin (PEB) or phycocyanobilin (PCB) chromophore, matched the lines in reconstructed STORM images. SIM and STORM reconstructions of Escherichia coli cells harbouring CpcA-labelled cytochrome bd 1 ubiquinol oxidase in the cytoplasmic membrane show that CpcA-PEB and CpcA-PCB are suitable for super-resolution imaging in vivo. The stability, ease of production, small size and brightness of CpcA-PEB and CpcA-PCB demonstrate the potential of this largely unexplored protein family as novel probes for super-resolution microscopy.

DNA replication in Escherichia coli is initiated by DnaA binding to oriC , the replication origin. During the process of assembly of the replication factory, the DnaA is released back into the cytoplasm, where it is competent to reinitiate replication. Premature reinitiation is prevented by binding SeqA to newly formed GATC sites near the replication origin. Resolution of the resulting SeqA cluster is one aspect of timing for reinitiation. A Markov model accounting for the competition between SeqA binding and methylation for one or several GATC sites relates the timing to reaction rates, and consequently to the concentrations of SeqA and methylase. A model is proposed for segregation, the motion of the two daughter DNAs into opposite poles of the cell before septation. This model assumes that the binding of SeqA and its subsequent clustering results in loops from both daughter nucleoids attached to the SeqA cluster at the GATC sites. As desequestration occurs, the cluster is divided in two, one associated with each daughter. As the loops of DNA uncoil, the two subclusters migrate apart due to the Brownian ratchet effect of the DNA loop.