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The EPOCH Measure of Adolescent Well-being measures five positive indicators of the well-being of adolescents: engagement, perseverance, optimism, connectedness and happiness. This five-factor structure along with other indicators of validity and reliability were supported for the original English version and the Chinese version. In this study, we tested the psychometric properties of the Swedish version of the EPOCH with a sample ( n = 846) of Swedish high school adolescents aged 16–21 years ( M age = 18, SD = .85). The participants answered a questionnaire containing the EPOCH, Coping Self-Efficacy Scale, and 21-item Depression, Anxiety, and Stress Scale (DASS-21). A confirmatory factor analysis supported a the five-factor, inter-correlated model. The internal consistency was good for all the EPOCH subscales (Cronbach’s α = .76–.88, McDonald’s ω = .77 –.88). The criterion validity was established by replicating correlations between the five EPOCH subscales and positive (coping self-efficacy) and negative (DASS-21) aspects of well-being. This study shows that the Swedish version of the EPOCH is suitable for assessing multiple dimensions of adolescent well-being.

Background Obsessive-compulsive disorder (OCD) typically onsets during childhood or adolescence and difficulties with executive functioning (EF) may be involved in its onset and maintenance. Yet, few studies have examined everyday EF difficulties in youth with OCD and no study has compared EF in youth with OCD to EF in youth with anxiety disorders, leaving the diagnostic specificity of EF unclear. Methods In this study, parents of treatment-seeking children and adolescents with OCD ( n  = 96, M age = 13.3, SD  = 2.7, 59% girls) or anxiety disorders ( n  = 67, M age = 14.0, SD  = 2.6, 78% girls) reported on their children’s everyday EF using the Behavior Rating Inventory of Executive Function (BRIEF) measure. Results Compared to community youth, the two clinical groups showed moderately elevated EF deficits but did not differ significantly from each other. EF deficits were not associated with the major symptom dimensions of OCD, age of OCD symptom onset, duration of OCD symptoms, and OCD severity, and did not predict treatment outcome in OCD. Conclusions Compared to peers, youth with OCD show moderate difficulties with EF, but very similar difficulties are seen in youth with anxiety disorders, and it is unclear whether these difficulties are of clinical relevance. Among youth with OCD, EF difficulties were not differentially associated with the major symptom dimensions of OCD, which is inconsistent with findings from adults. Difficulties with EF did not predict treatment outcome, indicating that integrating EF modules into OCD treatment may be of limited value, although EF may be important for treatment planning in individual cases.

Background 5-aminosalicylic acid (5-ASA) may protect against the development of inflammation-associated colorectal cancer. In vitro data suggest that, in colorectal cancer cells, 5-ASA induces cell cycle arrest, but the molecular mechanism leading to this arrest remains to be determined. Aim To dissect the signal transduction events that lead to 5-ASA mediated inhibition of proliferation of colorectal cancer cells, focusing on mammalian target of rapamycin (mTOR), a regulator of cell cycle progression. Methods The influence of 5-ASA on mTOR signalling was examined in a panel of colorectal cancer cell lines. The effects of 5-ASA on the pathways that control mTOR activity were studied in detail in two different colorectal cancer cell lines, using western blot, siRNA, a phospholipase D (PLD) activity assay, proliferation assays and cell cycle analysis. The phosphorylation status of mTOR and its downstream target, ribosomal protein S6, was studied in colorectal cancers before and after topical 5-ASA treatment. Results Treatment of colorectal cancer with 5-ASA inhibited mTOR signalling in vitro and in vivo. 5-ASA had no effect on any of the pathways that regulate the activity of the tuberous sclerosis complex in colorectal cancer cells. Both proliferation and mTOR activity depended on PLD, an enzyme that generates phosphatidic acid (PA). 5-ASA treatment inhibited PLD activity and proliferation; these effects could be rescued with exogenous PA. Conclusion 5-ASA interferes with proliferation of colorectal cancer cells via inhibition of PLD-dependent generation of PA and loss of mTOR signalling.

Objectives An increased interest in the phenomenon and process of compassion, in both clinical and non-clinical psychological research, has been seen in recent decades. In these contexts, compassion is frequently understood as a felt response to the suffering of others that involves caring and seeing the universal nature of human suffering, as well as an authentic desire to ease the distress. Based on the above, the purpose of the study was to validate a Swedish translation of the Compassion Scale. Method The manuscript reports on the analyses of the factor structure, reliability, and convergent and discriminant validity of the developed scale using data from two samples ( n  = 1712 and n  = 353) of Swedish adults, using confirmatory factor analysis and correlation analyses. Results The results show that the translated scale had the same factor structure as the original scale, with four distinct but related factors relating to the aspects of “Kindness”, “Common humanity”, “Mindfulness”, and “Indifference”. In addition, the results indicate that the developed measure provided reliable scores, both for the entire scale and for the different subscales. In addition, the performed analyses indicate that the Swedish version of the Compassion Scale generally showed the expected relationship to related measures of personality and individual differences in empathic responding. Finally, the results supported the predictions that women would generally score higher than men on the Compassion Scale, and that compassion would have negative correlations with both age and average monthly income. Conclusions In conclusion, the performed studies provide support for the adequacy of the psychometric properties of the Swedish version of the Compassion Scale, as well as for its congruent and discriminative validity.

Purpose The purpose of this paper is to explore if a ringing cell phone could impact cognitive performance as well as being agitating to provoke aggressive reactions. The study investigated variables that could impact a participant’s willingness to aggress and retaliate, such as sensitivity to arousal and dark personalities (DRPs), Machiavellianism, narcissism, and subclinical psychopathy and sadism. Design/methodology/approach There were 128 participants (77 women and 51 men). The cognitive load task consisted of forming anagrams while being in a high or low provocation condition. Participants were subsequently asked how willing they would be to allow one out-group member to be harmed in favor of saving several in-group members. Three personality measures were used: two measuring DRPs and one measuring arousal sensitivity. Findings The authors discovered that older age and subclinical psychopathy were significant predictors for the willingness to aggress. Those in the high provocation condition retaliated the most against the experimenter, and a participant’s English ability was the only variable that predicted good performance on the cognitive task. Originality/value The results warrant further research into how personality types, aggression, and everyday, multiple arousal sources intertwine to inform personalized evidence-based interventions. Organizational and educational psychologists could also use this research to in form how offices and schools are run.

Dual-factor models of mental health integrate both positive and negative indicators to provide a more comprehensive understanding of mental health profiles. In this cross-sectional study, we explored the mental health profiles of Swedish high school students by examining five positive indicators of well-being—connectedness, perseverance, optimism, happiness, and engagement—alongside three distress indicators: symptoms of depression, anxiety, and stress. We further investigated how these profiles related to gender, environmental sensitivity, coping self-efficacy, and the experience of pandemic-related distress. Utilizing latent profile analysis on a sample of 846 students ( M age  = 18, SD age  = 0.85), five distinct mental health profiles emerged: Complete mental health (42.9%) exhibited above-average well-being and below-average distress ; Moderate mental health (37.8%) showed average well-being and distress levels ; Vulnerable (9.8%) had below-average well-being with slightly elevated distress; Symptomatic but managing (5.4%) reported below-average well-being and high distress; and Troubled (4.0%) displayed significantly below-average well-being with very high distress. Gender played a significant role in differentiating these profiles, with girls particularly overrepresented in the Troubled and Symptomatic but managing profiles, suggesting a higher prevalence of mental health challenges among female students. As expected, students in the Complete mental health profile exhibited higher aesthetic sensitivity and greater coping self-efficacy, while those in the Troubled profile showed the highest ease of excitation and lowest coping self-efficacy, indicating a stark contrast in emotional regulation and resilience between the profiles. Interestingly, despite clear variations in well-being and distress, no significant differences were found between profiles in terms of distress experienced during the COVID-19 pandemic, although girls reported higher levels of pandemic-related distress overall. These findings offer critical insights into the diverse mental health experiences of adolescents, emphasizing the need for targeted interventions. Addressing the specific needs of students in compromised mental health profiles is essential to promoting a healthier and more supportive educational environment.

The EPOCH Measure of Adolescent Well-being measures five positive indicators of the well-being of adolescents: engagement, perseverance, optimism, connectedness and happiness. This five-factor structure along with other indicators of validity and reliability were supported for the original English version and the Chinese version. In this study, we tested the psychometric properties of the Swedish version of the EPOCH with a sample (n = 846) of Swedish high school adolescents aged 16-21 years (Mage = 18, SD = .85). The participants answered a questionnaire containing the EPOCH, Coping Self-Efficacy Scale, and 21-item Depression, Anxiety, and Stress Scale (DASS-21). A confirmatory factor analysis supported a the five-factor, inter-correlated model. The internal consistency was good for all the EPOCH subscales (Cronbach's α = .76-.88, McDonald's ω = .77 -.88). The criterion validity was established by replicating correlations between the five EPOCH subscales and positive (coping self-efficacy) and negative (DASS-21) aspects of well-being. This study shows that the Swedish version of the EPOCH is suitable for assessing multiple dimensions of adolescent well-being.

Vertebrates vary in resistance and resilience to infectious diseases, and the mechanisms that regulate the tradeoff between these often opposing protective processes are not well understood. Variability in the sensitivity of species to the induction of damaging inflammation in response to equivalent pathogen loads (resilience) complicates the use of animal models that reflect human disease. We found that induction of proinflammatory cytokines from macrophages in response to inflammatory stimuli in vitro is regulated by proteins in the sera of species in inverse proportion to their in vivo resilience to lethal doses of bacterial lipopolysaccharide over a range of 10,000-fold. This finding suggests that proteins in serum rather than intrinsic cellular differences may play a role in regulating variations in resilience to microbe-associated molecular patterns between species. The involvement of circulating proteins as key molecules raises hope that the process might be manipulated to create better animal models and potentially new drug targets.

Objectives Discrimination and prejudice are prevalent in workplaces worldwide, but there are few empirically validated interventions for combating racial bias in organizational settings. This study aims to evaluate an intervention consisting of experiential exercises derived from Acceptance and Commitment Therapy (ACT) and Compassion-Focused Therapy (CFT). The objective is to address psychological processes influential in promoting inclusive and equal workplaces in relation to race/ethnicity. Method A sample of 123 employees was randomized to an intervention or a comparison condition. The intervention involved exercises designed to increase compassion and empathic perspective-taking, decrease psychological inflexibility related to prejudiced thoughts and racial attitudes, and enhance participants’ commitment to organizational values. Participants in the intervention group were compared to those participating in traditional diversity and inclusion lectures, which served as the comparison condition. Results The study found that participants in the flexibility and compassion condition showed a significant increase in self-reported compassion. The results also showed a significant decrease in the participants’ inflexibility in relation to prejudiced and stigmatizing thoughts. However, no significant differences between the conditions were found regarding the endorsement of racist attitudes or empathic perspective-taking. Conclusions This study adds to the important but limited literature on effective diversity training in organizations. It suggests that methods derived from ACT and CFT may improve workplace diversity and inclusion interventions by increasing compassion and reducing the impact of prejudiced and stigmatizing thoughts on behavior. Preregistration The study was not preregistered.

Imaginary companions and the characteristics of the children who invent them were explored through interviews. Twenty-six children took part. The first aim was to explore the phenomenon in general, the second to investigate the functions of imaginary companions. General findings concerned the kinds of imaginary companions and some facts about the children who created them. The imaginary companions were mostly same-aged children, but some were different kinds of animal or fantasy creatures. The sources of inspiration varied, comprising friends and siblings. Having a place of their own, where the children could develop their imaginary play, was considered important. The study demonstrated various ways of conducting imaginary play. Imaginary companions functioned as inner mentors, assisting the children in their identity formation work. Imaginary companions were experienced by the children as giving comfort and company, bolstering self-regulation and motivation, enhancing their selves, expanding their personality potential, and finally, enriching their lives.