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"Holmes, M"
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Hurricane : Hawker's fighter legend
\"The remarkable Hawker Hurricane was the true workhorse of the Royal Air Force in World War II. Entering service 80 years ago, the Hurricane came into its own in the hot summer months of 1940, valiantly defending the skies above Britain and downing more enemy aircraft than any other RAF fighter. Without the obvious elegance of the Bf109 or the Spitfire, the Hurricane was nonetheless beloved by its pilots for its ability to simultaneously take a battering and inflict serous damage from its remarkably stable gun platform....Includes fascinating first-hand accounts from the men who flew it it...\"--Jacket.
Book
Representing the \European refugee crisis\ in Germany and beyond: Deservingness and difference, life and death
The European refugee crisis has gained worldwide attention with daily media coverage both in and outside Germany. Representations of refugees in media and political discourse in relation to Germany participate in a Gramscian “war of position” over symbols, policies, and, ultimately, social and material resources, with potentially fatal consequences. These representations shift blame from historical, political‐economic structures to the displaced people themselves. They demarcate the “deserving” refugee from the “undeserving” migrant and play into fear of cultural, religious, and ethnic difference in the midst of increasing anxiety and precarity for many in Europe. Comparative perspectives suggest that anthropology can play an important role in analyzing these phenomena, highlighting sites of contestation, imagining alternatives, and working toward them. [refugee, media, immigration, crisis, Germany, Europe]
Journal Article
Yosemite and Sequoia/Kings Canyon National Parks
\"Travel to America's national parks is growing every year. Tourist visits to Yosemite in 2016 were up almost 20% over 2015, while visitation to Sequoia was up over 14%. Focused coverage on only the best places so travelers can make the most out of their limited time. Carefully vetted recommendations for all types of establishments and price points\"--Provided by publisher.
Book
The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI
The glymphatic system is a low resistance pathway, by which cerebrospinal fluid enters the brain parenchyma along perivascular spaces via AQP4 channels. It is hypothesised that the resulting convective flow of the interstitial fluid provides an efficient mechanism for the removal of waste toxins from the brain. Therefore, enhancing AQP4 function might protect against neurodegenerative diseases such as Alzheimer’s disease (AD), in which the accumulation of harmful proteins and solutes is a hallmark feature. Here, we test the effect of a putative AQP4 facilitator, TGN-073, on glymphatic transport in a normal rat brain by employing different MRI techniques. Surgical procedures were undertaken to catheterise the cisterna magna, thereby enabling infusion of the MRI tracer. Followed by the intraperitoneal injection of either TGN-073, or the vehicle. Using a paramagnetic contrast agent (Gd-DTPA) as the MRI tracer, dynamic 3D T1 weighted imaging of the glymphatic system was undertaken over two hours. Further, the apparent diffusion coefficient was measured in different brain regions using diffusion-weighted imaging (DWI). While physiological parameters and arterial blood gas analysis were monitored continuously. We found that rats treated with TGN-073 showed the distribution of Gd-DTPA was more extensive and parenchymal uptake was higher compared with the vehicle group. Water diffusivity was increased in the brain of TGN-073 treated group, which indicates greater water flux. Also, MRI showed the glymphatic transport and distribution in the brain is naturally heterogeneous, which is consistent with previous studies. Our results indicate that compounds such as TGN-073 can improve glymphatic function in the brain. Since glymphatic impairment due to AQP4 dysfunction is potentially associated with several neurological disorders such as AD, dementia and traumatic brain injury, enhancing AQP4 functionality might be a promising therapeutic target.
Journal Article
Abyssal ocean overturning shaped by seafloor distribution
The abyssal ocean is broadly characterized by northward flow of the densest waters and southward flow of less-dense waters above them. Understanding what controls the strength and structure of these interhemispheric flows—referred to as the abyssal overturning circulation—is key to quantifying the ocean’s ability to store carbon and heat on timescales exceeding a century. Here we show that, north of 32° S, the depth distribution of the seafloor compels dense southern-origin waters to flow northward below a depth of about 4 kilometres and to return southward predominantly at depths greater than 2.5 kilometres. Unless ventilated from the north, the overlying mid-depths (1 to 2.5 kilometres deep) host comparatively weak mean meridional flow. Backed by analysis of historical radiocarbon measurements, the findings imply that the geometry of the Pacific, Indian and Atlantic basins places a major external constraint on the overturning structure.
The geometry of the ocean floor sets key regime transitions in the circulation of deep ocean waters.
Motion in the deep ocean
Deep ocean circulation, below about 2.5 kilometres (km), is a key driver of oceanic uptake or release of heat and carbon. A few regions, such as the North Atlantic, are known sources of deep water formation, but the processes that control the movement of deep waters remain as opaque as the abyss itself. Now, Casimir de Lavergne and colleagues show that the characteristic flow patterns—northward below 4 km depth and southward between 2.5 km and 4 km—are tied to the distribution of the ocean floor at certain depths. Essentially, the bathymetry of the ocean, rather than extrinsic properties such as climate gradients, drives key features of deep ocean circulation. The authors incorporate an analysis of radiocarbon into their model that reveals a shadow layer between the surface and deep ocean, with stagnant properties and high potential for long-term carbon storage.
Journal Article
Drivers and distribution of global ocean heat uptake over the last half century
Since the 1970s, the ocean has absorbed almost all of the additional energy in the Earth system due to greenhouse warming. However, sparse observations limit our knowledge of where ocean heat uptake (OHU) has occurred and where this heat is stored today. Here, we equilibrate a reanalysis-forced ocean-sea ice model, using a spin-up that improves on earlier approaches, to investigate recent OHU trends basin-by-basin and associated separately with surface wind trends, thermodynamic properties (temperature, humidity and radiation) or both. Wind and thermodynamic changes each explain ~ 50% of global OHU, while Southern Ocean forcing trends can account for almost all of the global OHU. This OHU is enabled by cool sea surface temperatures and sensible heat gain when atmospheric thermodynamic properties are held fixed, while downward longwave radiation dominates when winds are fixed. These results address long-standing limitations in multidecadal ocean-sea ice model simulations to reconcile estimates of OHU, transport and storage.
This study improves on limitations of the most commonly used spin-up approach for ocean-sea ice models. The authors find that, over the last 50 years, atmospheric changes over the Southern Ocean have driven almost all of the global ocean heat uptake.
Journal Article
Powder Bed Layer Characteristics: The Overseen First-Order Process Input
Powder Bed Additive Manufacturing offers unique advantages in terms of manufacturing cost, lot size, and product complexity compared to traditional processes such as casting, where a minimum lot size is mandatory to achieve economic competitiveness. Many studies—both experimental and numerical—are dedicated to the analysis of how process parameters such as heat source power, scan speed, and scan strategy affect the final material properties. Apart from the general urge to increase the build rate using thicker powder layers, the coating process and how the powder is distributed on the processing table has received very little attention to date. This paper focuses on the first step of every powder bed build process: Coating the process table. A numerical study is performed to investigate how powder is transferred from the source to the processing table. A solid coating blade is modeled to spread commercial Ti-6Al-4V powder. The resulting powder layer is analyzed statistically to determine the packing density and its variation across the processing table. The results are compared with literature reports using the so-called “rain” models. A parameter study is performed to identify the influence of process table displacement and wiper velocity on the powder distribution. The achieved packing density and how that affects subsequent heat source interaction with the powder bed is also investigated numerically.
Journal Article
mPPases create a conserved anionic membrane fingerprint as identified via multi-scale simulations
Membrane-integral pyrophosphatases (mPPases) are membrane-bound enzymes responsible for hydrolysing inorganic pyrophosphate and translocating a cation across the membrane. Their function is essential for the infectivity of clinically relevant protozoan parasites and plant maturation. Recent developments have indicated that their mechanism is more complicated than previously thought and that the membrane environment may be important for their function. In this work, we use multiscale molecular dynamics simulations to demonstrate for the first time that mPPases form specific anionic lipid interactions at 4 sites at the distal and interfacial regions of the protein. These interactions are conserved in simulations of the mPPases from Thermotoga maritima , Vigna radiata and Clostridium leptum and characterised by interactions with positive residues on helices 1, 2, 3 and 4 for the distal site, or 9, 10, 13 and 14 for the interfacial site. Due to the importance of these helices in protein stability and function, these lipid interactions may play a crucial role in the mPPase mechanism and enable future structural and functional studies.
Journal Article
PROMs data: can it be used to make decisions for individual patients? A narrative review
Patient-reported outcome measures (PROMs) are increasingly used in clinical practice providing health care professionals with patients' perceptions and views of their health. They have traditionally been utilized in health research and health service evaluation and are now starting to be used in routine clinical practice with individual patients. The repeated administration of PROMs over the course of care with individual patients has a role in patient assessment, assisting clinical decision-making, and tracking patient progress. This approach can influence the patient-clinician encounter impacting the therapeutic alliance and increasing patient engagement with care. It is also theorized to improve patient outcomes and satisfaction with care. Advances in technologies and innovations in methodology have led to the use of electronic systems to simplify the collection and reporting of PROMs. Challenges of using PROMs with individual patients include clinician knowledge and skills, and access to appropriate technology. This paper reviews the use of PROMs with individual patients, illustrating how they may affect the patient-clinician encounter impact satisfaction and health outcomes. The routine use of PROMs during a course of care rather than just at the start and end provides additional opportunity to inform clinician and patient with benefits to both. The adoption of PROMs in clinical practice can help health care professionals to make decisions for individual patients. Further work is needed to examine the implementation of PROMs and benefits of PROMs in different clinical contexts.
Journal Article
ACCESS-OM2 v1.0: a global ocean–sea ice model at three resolutions
We introduce ACCESS-OM2, a new version of the ocean–sea ice model of the Australian Community Climate and Earth System Simulator. ACCESS-OM2 is driven by a prescribed atmosphere (JRA55-do) but has been designed to form the ocean–sea ice component of the fully coupled (atmosphere–land–ocean–sea ice) ACCESS-CM2 model. Importantly, the model is available at three different horizontal resolutions: a coarse resolution (nominally 1∘ horizontal grid spacing), an eddy-permitting resolution (nominally 0.25∘), and an eddy-rich resolution (0.1∘ with 75 vertical levels); the eddy-rich model is designed to be incorporated into the Bluelink operational ocean prediction and reanalysis system. The different resolutions have been developed simultaneously, both to allow for testing at lower resolutions and to permit comparison across resolutions. In this paper, the model is introduced and the individual components are documented. The model performance is evaluated across the three different resolutions, highlighting the relative advantages and disadvantages of running ocean–sea ice models at higher resolution. We find that higher resolution is an advantage in resolving flow through small straits, the structure of western boundary currents, and the abyssal overturning cell but that there is scope for improvements in sub-grid-scale parameterizations at the highest resolution.
Journal Article