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"Holmes, Peter"
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Data analysis in sport
\"Making sense of sports performance data can be a challenging task but is nevertheless an essential part of performance analysis investigations. Focusing on techniques used in the analysis of sport performance, this book introduces the fundamental principles of data analysis, explores the most important tools used in data analysis, and offers guidance on the presentation of results. The book covers key topics such as: The purpose of data analysis, from statistical analysis to algorithmic processing Commercial packages for performance and data analysis, including Focus, Sportscode, Dartfish, Prozone, Excel, SPSS and Matlab Effective use of statistical procedures in sport performance analysis Analysing data from manual notation systems, player tracking systems and computerized match analysis systems Creating visually appealing 'dashboard' interfaces for presenting data Assessing reliability. The book includes worked examples from real sport, offering clear guidance to the reader and bringing the subject to life. This book is invaluable reading for any student, researcher or analyst working in sport performance or undertaking a sport-related research project or methods course\"-- Provided by publisher.
Book
First WHO Meeting of Stakeholders on Elimination of Gambiense Human African Trypanosomiasis
[...]of these outstanding efforts by national sleeping sickness programmes and the support of international organizations led by the World Health Organization (WHO), and involving key pharmaceutical companies and major international donors, remarkable results have been achieved during the past 15 years, with the number of new reported cases falling to 6,228 in 2013 [4].
Journal Article
On the Road to Elimination of Rhodesiense Human African Trypanosomiasis: First WHO Meeting of Stakeholders
[...]of these synergistic actions, the general situation improved, and the number of new reported cases has fallen steadily (6,228 in 2013) [4]. [...]the participants issued a declaration for the elimination of gambiense HAT [12].
Journal Article
Underground America : narratives of undocumented lives
Millions of immigrants risk deportation and imprisonment by living in the US without legal status. They are living underground, with little protection from exploitation at the hands of human smugglers, employers, or law enforcement. Underground America presents the remarkable oral histories of men and women living without legal status and struggling to carve lives for themselves in the U.S.
Book
Aromatica Volume 2
The second volume in the Aromatica series builds on the fundamentals found in Volume 1: Principles and Profiles. This comprehensive clinical text delves further into the different profiles of essential oils and the proper applications for physiological and psychological functions as well as energetic and Chinese Medicines.
Packed with charts depicting different functions and methods of administration, and an extensive catalogue of 40 new essential oil profiles, this is an indispensable guide for all complementary medicine practitioners.
eBook
Palaeo-landscapes and hydrology in the South African interior: Implications for human history
Recent research reveals that the arid western interior of South Africa has experienced substantially more humid conditions on several occasions during the last 70 000 years. These findings, likely regional in scope, speak to changes to the resource base available to prehistoric hunter-gatherers. Together with recent archaeological findings from this region, there has emerged a growing recognition that previously archaeologically overlooked areas of South Africa's arid interior need to be included in models of human history. This presents new challenges for archaeologists and palaeoclimatologists, particularly given the prevalence of surficial, rather than stratified, archaeological evidence throughout much of this region.
Journal Article
The Etiology of Community-Acquired Pneumonia in Australia: Why Penicillin plus Doxycycline or a Macrolide Is the Most Appropriate Therapy
Background. Available data on the etiology of community-acquired pneumonia (CAP) in Australia are very limited. Local treatment guidelines promote the use of combination therapy with agents such as penicillin or amoxycillin combined with either doxycycline or a macrolide. Methods. The Australian CAP Study (ACAPS) was a prospective, multicenter study of 885 episodes of CAP in which all patients underwent detailed assessment for bacterial and viral pathogens (cultures, urinary antigen testing, serological methods, and polymerase chain reaction). Antibiotic agents and relevant clinical outcomes were recorded. Results. The etiology was identified in 404 (45.6%) of 885 episodes, with the most frequent causes being Streptococcus pneumoniae (14%), Mycoplasma pneumoniae (9%), and respiratory viruses (15%; influenza, picornavirus, respiratory syncytial virus, parainfluenza virus, and adenovirus). Antibiotic-resistant pathogens were rare: only 5.4% of patients had an infection for which therapy with penicillin plus doxycycline would potentially fail. Concordance with local antibiotic recommendations was high (82.4%), with the most commonly prescribed regimens being a penicillin plus either doxycycline or a macrolide (55.8%) or ceftriaxone plus either doxycycline or a macrolide (36.8%). The 30-day mortality rate was 5.6% (50 of 885 episodes), and mechanical ventilation or vasopressor support were required in 94 episodes (10.6%). Outcomes were not compromised by receipt of narrower-spectrum β-lactams, and they did not differ on the basis of whether a pathogen was identified. Conclusions. The vast majority of patients with CAP can be treated successfully with narrow-spectrum β-lactam treatment, such as penicillin combined with doxycycline or a macrolide. Greater use of such therapy could potentially reduce the emergence of antibiotic resistance among common bacterial pathogens.
Journal Article
Nontypeable Haemophilus influenzae Induces Sustained Lung Oxidative Stress and Protease Expression
Nontypeable Haemophilus influenzae (NTHi) is a prevalent bacterium found in a variety of chronic respiratory diseases. The role of this bacterium in the pathogenesis of lung inflammation is not well defined. In this study we examined the effect of NTHi on two important lung inflammatory processes 1), oxidative stress and 2), protease expression. Bronchoalveolar macrophages were obtained from 121 human subjects, blood neutrophils from 15 subjects, and human-lung fibroblast and epithelial cell lines from 16 subjects. Cells were stimulated with NTHi to measure the effect on reactive oxygen species (ROS) production and extracellular trap formation. We also measured the production of the oxidant, 3-nitrotyrosine (3-NT) in the lungs of mice infected with this bacterium. NTHi induced widespread production of 3-NT in mouse lungs. This bacterium induced significantly increased ROS production in human fibroblasts, epithelial cells, macrophages and neutrophils; with the highest levels in the phagocytic cells. In human macrophages NTHi caused a sustained, extracellular production of ROS that increased over time. The production of ROS was associated with the formation of macrophage extracellular trap-like structures which co-expressed the protease metalloproteinase-12. The formation of the macrophage extracellular trap-like structures was markedly inhibited by the addition of DNase. In this study we have demonstrated that NTHi induces lung oxidative stress with macrophage extracellular trap formation and associated protease expression. DNase inhibited the formation of extracellular traps.
Journal Article
The lipoprotein Pal stabilises the bacterial outer membrane during constriction by a mobilisation-and-capture mechanism
Coordination of outer membrane constriction with septation is critical to faithful division in Gram-negative bacteria and vital to the barrier function of the membrane. This coordination requires the recruitment of the peptidoglycan-binding outer-membrane lipoprotein Pal at division sites by the Tol system. Here, we show that Pal accumulation at
Escherichia coli
division sites is a consequence of three key functions of the Tol system. First, Tol mobilises Pal molecules in dividing cells, which otherwise diffuse very slowly due to their binding of the cell wall. Second, Tol actively captures mobilised Pal molecules and deposits them at the division septum. Third, the active capture mechanism is analogous to that used by the inner membrane protein TonB to dislodge the plug domains of outer membrane TonB-dependent nutrient transporters. We conclude that outer membrane constriction is coordinated with cell division by active mobilisation-and-capture of Pal at division septa by the Tol system.
The lipoprotein Pal participates in the coordination of outer-membrane constriction with septation in Gram-negative bacteria. Here, the authors show that this coordination is mediated by active mobilisation-and-capture of Pal at division septa by the Tol system.
Journal Article